David G Little

Summary

Affiliation: The Children's Hospital at Westmead
Country: Australia

Publications

  1. ncbi request reprint Effect of pamidronate on distraction osteogenesis and fixator-related osteoporosis
    D G Little
    Orthopaedic Research Unit, Royal Alexandra Hospital for Children, Locked Bag 4001, Westmead, Sydney, NSW, Australia
    Injury 32:SD14-20. 2001
  2. doi request reprint Future biologic treatments for Perthes disease
    David G Little
    Department of Orthopaedics, Orthopaedic Research, The Children s Hospital at Westmead, Westmead, NSW, Australia
    Orthop Clin North Am 42:423-7, viii. 2011
  3. ncbi request reprint Zoledronic acid treatment results in retention of femoral head structure after traumatic osteonecrosis in young Wistar rats
    David G Little
    Orthopaedic Research Unit, The Children s Hospital at Westmead, Westmead, New South Wales, Sydney, Australia
    J Bone Miner Res 18:2016-22. 2003
  4. doi request reprint Potential for bisphosphonate treatment in Legg-Calve-Perthes disease
    David G Little
    Department of Orthopaedics, Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Westmead NSW, Australia
    J Pediatr Orthop 31:S182-8. 2011
  5. ncbi request reprint The anabolic and catabolic responses in bone repair
    D G Little
    The Children s Hospital at Westmead, Locked Bag 4001, Westmead, New South Wales 2145, Australia
    J Bone Joint Surg Br 89:425-33. 2007
  6. ncbi request reprint Zoledronic acid improves femoral head sphericity in a rat model of perthes disease
    David G Little
    Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead 2145, Sydney, NSW, Australia
    J Orthop Res 23:862-8. 2005
  7. ncbi request reprint Manipulation of the anabolic and catabolic responses with OP-1 and zoledronic acid in a rat critical defect model
    David G Little
    Orthopaedic Research and Biotechnology, University of Sydney, Discipline of Paediatrics and Child Health, The Children s Hospital at Westmead, Westmead, Australia
    J Bone Miner Res 20:2044-52. 2005
  8. doi request reprint A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells
    Jad El-Hoss
    Kids Research Institute, Orthopaedic Research and Biotechnology, Westmead, Australia
    J Bone Miner Res 27:68-78. 2012
  9. ncbi request reprint Modulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separation
    Nicole Y C Yu
    Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia School of Aerospace, Mechanical and Mechatronic Engineering, J07 University of Sydney, NSW, 2006, Australia
    Eur Cell Mater 25:190-203. 2013
  10. ncbi request reprint Modeling bone morphogenetic protein and bisphosphonate combination therapy in wild-type and Nf1 haploinsufficient mice
    Aaron Schindeler
    Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Sydney, Australia
    J Orthop Res 26:65-74. 2008

Detail Information

Publications55

  1. ncbi request reprint Effect of pamidronate on distraction osteogenesis and fixator-related osteoporosis
    D G Little
    Orthopaedic Research Unit, Royal Alexandra Hospital for Children, Locked Bag 4001, Westmead, Sydney, NSW, Australia
    Injury 32:SD14-20. 2001
    ..001). The administration of a single dose of pamidronate can improve the bone mineral density, content and mechanical properties of a bone undergoing distraction osteogenesis...
  2. doi request reprint Future biologic treatments for Perthes disease
    David G Little
    Department of Orthopaedics, Orthopaedic Research, The Children s Hospital at Westmead, Westmead, NSW, Australia
    Orthop Clin North Am 42:423-7, viii. 2011
    ..This article presents a current pathophysiological model of Perthes disease, reviews experimental strategies in pharmaceutical treatments, and suggests future areas for research...
  3. ncbi request reprint Zoledronic acid treatment results in retention of femoral head structure after traumatic osteonecrosis in young Wistar rats
    David G Little
    Orthopaedic Research Unit, The Children s Hospital at Westmead, Westmead, New South Wales, Sydney, Australia
    J Bone Miner Res 18:2016-22. 2003
    ..This preliminary experiment supports the use of bisphosphonates in childhood ON...
  4. doi request reprint Potential for bisphosphonate treatment in Legg-Calve-Perthes disease
    David G Little
    Department of Orthopaedics, Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Westmead NSW, Australia
    J Pediatr Orthop 31:S182-8. 2011
    ..Robust bone catabolism in the absence of anabolism can only lead to femoral head deformity...
  5. ncbi request reprint The anabolic and catabolic responses in bone repair
    D G Little
    The Children s Hospital at Westmead, Locked Bag 4001, Westmead, New South Wales 2145, Australia
    J Bone Joint Surg Br 89:425-33. 2007
    ..The role of medical manipulation of these inter-related responses in the fracture healing have been considered...
  6. ncbi request reprint Zoledronic acid improves femoral head sphericity in a rat model of perthes disease
    David G Little
    Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead 2145, Sydney, NSW, Australia
    J Orthop Res 23:862-8. 2005
    ..Translation of these results to Perthes disease could mean that deformity of the femoral head may be modified in children, perhaps reducing the need for surgical intervention in childhood and adult life...
  7. ncbi request reprint Manipulation of the anabolic and catabolic responses with OP-1 and zoledronic acid in a rat critical defect model
    David G Little
    Orthopaedic Research and Biotechnology, University of Sydney, Discipline of Paediatrics and Child Health, The Children s Hospital at Westmead, Westmead, Australia
    J Bone Miner Res 20:2044-52. 2005
    ..In a rat critical defect, this combination therapy produced significant increases in new bone volume and strength...
  8. doi request reprint A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells
    Jad El-Hoss
    Kids Research Institute, Orthopaedic Research and Biotechnology, Westmead, Australia
    J Bone Miner Res 27:68-78. 2012
    ..This model provides valuable insight into the pathobiology of the disease, and will be helpful for trialing therapeutic compounds...
  9. ncbi request reprint Modulation of anabolic and catabolic responses via a porous polymer scaffold manufactured using thermally induced phase separation
    Nicole Y C Yu
    Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia School of Aerospace, Mechanical and Mechatronic Engineering, J07 University of Sydney, NSW, 2006, Australia
    Eur Cell Mater 25:190-203. 2013
    ....
  10. ncbi request reprint Modeling bone morphogenetic protein and bisphosphonate combination therapy in wild-type and Nf1 haploinsufficient mice
    Aaron Schindeler
    Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Sydney, Australia
    J Orthop Res 26:65-74. 2008
    ..Bisphosphonate combination therapy is superior to BMP therapy alone in terms of net bone production in vivo in both wild-type and Nf1-deficient mice...
  11. ncbi request reprint Transient retention of endochondral cartilaginous matrix with bisphosphonate treatment in a long-term rabbit model of distraction osteogenesis
    Elisabeth J Smith
    Orthopaedic Research Unit, Children s Hospital at Westmead, Sydney, Australia
    J Bone Miner Res 19:1698-705. 2004
    ..In this long-term study in 32 rabbits, zoledronic acid transiently increased trabeculae by delayed temporal progression of endochondral bone remodeling but did not prevent radiographic completion of bone repair...
  12. doi request reprint Models of tibial fracture healing in normal and Nf1-deficient mice
    Aaron Schindeler
    Department of Orthopaedic Research and Biotechnology, Reasearch Building, Locked Bag 4001, The Children s Hospital at Westmead, Sydney, NSW 2145, Australia
    J Orthop Res 26:1053-60. 2008
    ..These findings imply that the pathology of tibial pseudarthrosis in human NF1 is complex and likely to be multifactorial...
  13. pmc Myogenic progenitors contribute to open but not closed fracture repair
    Renjing Liu
    Orthopaedic Research and Biotechnology Unit, The Children s Hospital at Westmead, Sydney, Australia
    BMC Musculoskelet Disord 12:288. 2011
    ..We hypothesized that myogenic cells of the MyoD-lineage are able to contribute to bone repair...
  14. doi request reprint JNK inhibitors increase osteogenesis in Nf1-deficient cells
    Kate Sullivan
    Orthopaedic Research and Biotechnology Unit, The Children s Hospital at Westmead, Sydney, Australia
    Bone 49:1311-6. 2011
    ..In summary, JNK inhibitors represent a class of potentially useful adjunctive agents for orthopedic medicine, particularly in the context of NF1...
  15. doi request reprint Characterization of the bone phenotype and fracture repair in osteopetrotic incisors absent rats
    Michelle M McDonald
    Orthopaedic Research and Biotechnology Unit, The Children s Hospital at Westmead, Sydney, Australia
    J Orthop Res 29:726-33. 2011
    ..This is consistent with an essential role for osteoclasts in only the latter stages of endochondral bone repair. This delay in hard callus remodeling was offset by an increase in moment of inertia...
  16. ncbi request reprint Transient disturbance in physeal morphology is associated with long-term effects of nitrogen-containing bisphosphonates in growing rabbits
    Elisabeth J Smith
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital and University of New South Wales, Sydney, Australia
    J Bone Miner Res 20:1731-41. 2005
    ..In 44 growing rabbits, zoledronic acid caused a transient disruption of physeal morphology, retention of cartilaginous matrix in trabeculae and cortical bone of the metaphysis, and a minor decrement in tibial bone length at maturity...
  17. doi request reprint Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats
    Michelle M McDonald
    The Children s Hospital, Locked Bag 4001, Westmead, New South Wales 2145, Australia
    J Orthop Res 30:1541-8. 2012
    ..With its powerful anabolic potential, bone-specific activity, and potential for low dosing frequency, Scl-Ab treatment could provide enhanced bone repair, particularly in situations of compromised bone repair such as osteoporotic bone...
  18. ncbi request reprint In vivo local co-delivery of recombinant human bone morphogenetic protein-7 and pamidronate via poly-D, L-lactic acid
    Nicole Y C Yu
    Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Westmead, Sydney, NSW, Australia
    Eur Cell Mater 20:431-41; discussion 441-2. 2010
    ..This is the first study to validate the utility of local co-delivery of BMP/bisphosphonate via biodegradable polymer and supports the continued refinement of more advanced bioresorbable delivery systems for clinical applications...
  19. pmc Rapid cell culture and pre-clinical screening of a transforming growth factor-beta (TGF-beta) inhibitor for orthopaedics
    Aaron Schindeler
    Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia
    BMC Musculoskelet Disord 11:105. 2010
    ..We have explored this concept using an approach that represents a template for the testing of agents with prospective orthopaedic applications...
  20. doi request reprint Bolus or weekly zoledronic acid administration does not delay endochondral fracture repair but weekly dosing enhances delays in hard callus remodeling
    Michelle M McDonald
    Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Westmead, Australia
    Bone 43:653-62. 2008
    ..We aimed to examine the effect of different dosing regimes of the potent BP zoledronic acid (ZA) on early endochondral fracture repair and later callus remodeling in a normal bone healing environment...
  21. doi request reprint Matrix metalloproteinase-driven endochondral fracture union proceeds independently of osteoclast activity
    Michelle M McDonald
    The Children s Hospital Westmead, Westmead, Australia
    J Bone Miner Res 28:1550-60. 2013
    ..This study provides new insight into cellular contributions to bone repair and may abate concerns regarding antiresorptive therapies impeding initial fracture union...
  22. pmc Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight
    Paul A Baldock
    Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    PLoS ONE 4:e8415. 2009
    ....
  23. doi request reprint Zoledronic acid improves bone mineral density, reduces bone turnover and improves skeletal architecture over 2 years of treatment in children with secondary osteoporosis
    Peter J Simm
    Institute of Endocrinology and Diabetes, The Children s Hospital at Westmead, Sydney, Australia
    Bone 49:939-43. 2011
    ..Further evidence is required to confirm efficacy, with long term follow up required to assess the impact of treatment on fracture risk...
  24. doi request reprint Intermittent PTH(1-34) does not increase union rates in open rat femoral fractures and exhibits attenuated anabolic effects compared to closed fractures
    Magnus Tagil
    Orthopaedic Research and Biotechnology, The Children s Hospital, Westmead, Australia
    Bone 46:852-9. 2010
    ..In the open fractures that did unite, a muted response to PTH was seen compared to closed fractures. Further research is required to determine if PTH((1-34)) is an appropriate anabolic treatment for open fractures...
  25. doi request reprint α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse
    Nan Yang
    Institute for Neuroscience and Muscle Research, The Children s Hospital at Westmead, Sydney 2145, NSW, Australia
    Bone 49:790-8. 2011
    ..Given the high frequency of R577X in the general population, the potential role of ACTN3 R577X as a factor influencing variations in BMD in elderly humans warrants further study...
  26. ncbi request reprint Bisphosphonate rescue in distraction osteogenesis: a case series
    Patrick Kiely
    Department of Orthopaedics, The Children s Hospital at Westmead, Sydney, Australia
    J Pediatr Orthop 27:467-71. 2007
    ..These minimally invasive approaches may lessen the need for surgery in a group where significant surgical reintervention could otherwise be required...
  27. ncbi request reprint Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis
    Paul A Baldock
    Bone and Mineral Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Biol Chem 282:19092-102. 2007
    ..Thus Y1 receptor pathways act powerfully to inhibit bone production and adiposity by nonhypothalamic pathways, with potentially direct effects on bone tissue through a single pathway with Y2 receptors...
  28. ncbi request reprint Zoledronic acid prevents osteopenia and increases bone strength in a rabbit model of distraction osteogenesis
    David G Little
    Orthopaedic Research and Biotechnology, Children s Hospital at Westmead, Sydney, NSW, Australia
    J Bone Miner Res 18:1300-7. 2003
    ..Translation to the clinical setting, if safe, could improve outcomes in distraction osteogenesis in children...
  29. doi request reprint Systemic effects of zoledronic acid in children with traumatic femoral head avascular necrosis and Legg-Calve-Perthes disease
    Jesper Johannesen
    The Children s Hospital at Westmead, Institute of Endocrinology and Diabetes, Westmead NSW 2145, Sydney, Australia
    Bone 45:898-902. 2009
    ..Further efficacy and safety data are required before this therapy can be widely recommended...
  30. doi request reprint Bisphosphonate-laden acrylic bone cement: mechanical properties, elution performance, and in vivo activity
    Nicole Y C Yu
    School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, Sydney, Australia
    J Biomed Mater Res B Appl Biomater 87:482-91. 2008
    ..In contrast, systemic ZA delivery (0.1 mg/kg) led to a large (48.6%) and significant increase in BMD. Thus, systemic delivery appears more effective than local delivery...
  31. doi request reprint Bone remodeling during fracture repair: The cellular picture
    Aaron Schindeler
    Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Sydney, Australia
    Semin Cell Dev Biol 19:459-66. 2008
    ..Finally, the fourth section examines the effects of delaying osteoclast-dependent hard callus remodeling and also poses questions regarding the crosstalk between anabolism and catabolism in the latter stages of fracture repair...
  32. doi request reprint The contribution of different cell lineages to bone repair: exploring a role for muscle stem cells
    Aaron Schindeler
    Department of Orthopaedic Research and Biotechnology, Research Building, The Children s Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia
    Differentiation 77:12-8. 2009
    ....
  33. ncbi request reprint The effect of zoledronic acid on the intrinsic material properties of healing bone: an indentation study
    Negin Amanata
    Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Westmead, Australia negin
    Med Eng Phys 30:843-7. 2008
    ..There is concern, however, that BPs may negatively affect bone material properties...
  34. ncbi request reprint Use of BMPs and bisphosphonates in improving bone fracture healing
    Nicole Y C Yu
    Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia
    Front Biosci (Elite Ed) 4:2647-53. 2012
    ..This short review discusses the current literature underlying the anabolic-catabolic paradigm for bone repair with a focus on BMP and bisphosphonate combination approaches...
  35. ncbi request reprint A single systemic dose of pamidronate improves bone mineral content and accelerates restoration of strength in a rat model of fracture repair
    Negin Amanat
    School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, NSW 2006, Australia
    J Orthop Res 23:1029-34. 2005
    ....
  36. ncbi request reprint Intravenous bisphosphonate therapy for traumatic osteonecrosis of the femoral head in adolescents
    Manoj Ramachandran
    The Children s Hospital at Westmead, Locked Bag 4001, Westmead NSW 2145, Australia
    J Bone Joint Surg Am 89:1727-34. 2007
    ..We evaluated bisphosphonate therapy for femoral head osteonecrosis following trauma in adolescents...
  37. ncbi request reprint A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates
    Ciara M Murphy
    Orthopaedic Research and Biotechnology Unit, The Children s Hospital at Westmead, Sydney, NSW, Australia Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, Sydney, NSW, Australia Electronic address
    Acta Biomater 10:2250-8. 2014
    ..This study has implications for future clinical treatments of critical bone defects. It demonstrates the relative advantages of co-delivering anabolic and anti-catabolic agents using a multicomponent scaffold system. ..
  38. ncbi request reprint Cell-scaffold interactions in the bone tissue engineering triad
    Ciara M Murphy
    Orthopaedic Research and Biotechnology, Research Building, The Children s Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145
    Eur Cell Mater 26:120-32. 2013
    ..Understanding these interactions will be critical for enhancing the progress of bone tissue engineering towards clinical applications...
  39. ncbi request reprint Hypothalamic regulation of cortical bone mass: opposing activity of Y2 receptor and leptin pathways
    Paul A Baldock
    Bone and Mineral Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, Sydney, New South Wales, Australia
    J Bone Miner Res 21:1600-7. 2006
    ..Cortical bone mass is elevated in Y2(-/-) mice through greater osteoblast activity. In contrast, leptin deficiency results in reduced bone mass. We show opposing central regulation of cortical bone...
  40. doi request reprint Biodegradable poly(alpha-hydroxy acid) polymer scaffolds for bone tissue engineering
    Nicole Y C Yu
    Biomedical Engineering, School of AMME J07, University of Sydney, Sydney, Australia
    J Biomed Mater Res B Appl Biomater 93:285-95. 2010
    ..Different fabrication techniques will also be discussed...
  41. doi request reprint Use of zoledronic acid for treatment of chemotherapy related osteonecrosis in children and adolescents: a retrospective analysis
    Bhavna Padhye
    Department of Oncology, The Children s Hospital at Westmead, Sydney, Australia
    Pediatr Blood Cancer 60:1539-45. 2013
    ..There are few reports in the literature of non-surgical management of ON. Patients with chemotherapy related ON, treated with zoledronic acid (ZA) were analyzed for clinical and radiological outcome...
  42. ncbi request reprint Osteoclasts but not osteoblasts are affected by a calcified surface treated with zoledronic acid in vitro
    Aaron Schindeler
    Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Sydney, Australia
    Biochem Biophys Res Commun 338:710-6. 2005
    ..This study represents a pharmacologically more relevant approach to modeling bisphosphonate treatment on cultured bone cells and implies that bisphosphonate therapies may not directly affect osteoblasts at bone surfaces...
  43. pmc Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1a
    Renjing Liu
    Orthopaedic Research and Biotechnology Unit, The Children s Hospital at Westmead, Sydney, NSW, Australia
    BMC Musculoskelet Disord 10:51. 2009
    ..We further hypothesized that the sensitivity of cells to BMP-2 would correlate with BMP receptor expression...
  44. ncbi request reprint Evaluation of biodistribution by local versus systemic administration of 99mTc-labeled pamidronate
    Divesh Kumar
    Department of Nuclear Medicine, University of Macquarie, Department of Biological Science, The Children s Hospital at Westmead and the Westmead Hospital, Westmead, Australia
    J Orthop Sci 11:512-20. 2006
    ..The primary objective of this study was to use (99m)Tc-pamidronate ((99m)Tc-PAM) as a tool and compare bone and tissue uptake by local versus systemic administration...
  45. ncbi request reprint Bisphosphonate action: revelations and deceptions from in vitro studies
    Aaron Schindeler
    Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Sydney, Australia
    J Pharm Sci 96:1872-8. 2007
    ..Auspiciously, several groups have reported on revised culture systems that better reflect the pharmacology of BP dosing...
  46. ncbi request reprint Acute phase response and mineral status following low dose intravenous zoledronic acid in children
    Craig F Munns
    Institute of Endocrinology and Diabetes, The Children s Hospital at Westmead, and Department of Paediatrics and Child Health, University of Sydney, Sydney, Australia
    Bone 41:366-70. 2007
    ..Previous reports have shown a high frequency of hypocalcaemia and flu-like symptoms following an initial first zoledronic acid dose of 0.02-0.025 mg/kg in children...
  47. doi request reprint Recent insights into bone development, homeostasis, and repair in type 1 neurofibromatosis (NF1)
    Aaron Schindeler
    Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Sydney, Australia
    Bone 42:616-22. 2008
    ..This paper reviews the current literature on NF1 bone development, homeostatic regulation, and repair, and highlights some emerging themes that may have relevance for managing orthopaedic disorders that can arise in individuals with NF1...
  48. ncbi request reprint Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs
    Tegan L Cheng
    Orthopaedic Research and Biotechnology Unit, The Children s Hospital at Westmead, Research Building, Locked Bag 4001, Westmead, Sydney, NSW, 2145, Australia
    Int Orthop 38:1527-33. 2014
    ..Preventing collapse and the need for subsequent joint replacement remains the major goal of clinical management. This exploratory study utilises a porcine model of surgically induced ONFH...
  49. pmc Posterolateral inter-transverse lumbar fusion in a mouse model
    Justin Bobyn
    Orthopaedic Research and Biotechnology Unit, The Children s Hospital at Westmead, Locked Bag 4001, Westmead, NSW, 2145, Australia
    J Orthop Surg Res 8:2. 2013
    ..Despite the increasing availability of genetically modified mouse strains, murine models have only been infrequently described...
  50. ncbi request reprint Quantification of metaphyseal modeling in children treated with bisphosphonates
    Kate Ward
    Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Locked Bag 4001, Westmead NSW 2145, Australia
    Bone 36:999-1002. 2005
    ..Clinically relevant doses of bisphosphonates given for appropriate indications do not necessarily disturb this process, while the beneficial clinical effect is maintained...
  51. ncbi request reprint Maximizing bone formation in posterior spine fusion using rhBMP-2 and zoledronic acid in wild type and NF1 deficient mice
    Justin Bobyn
    The Centre for Children s Bone Health, Sydney Children s Hospital Network, Sydney, Australia Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, Sydney, Australia
    J Orthop Res 32:1090-4. 2014
    ..S/BS) in Nf1(+/-) mice relative to wild type mice, and this was reduced with ZA treatment. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:1090-1094, 2014. ..
  52. pmc Cellular transitions and tissue engineering
    Aaron Schindeler
    Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmead, Sydney, Australia
    Cell Reprogram 15:101-6. 2013
    ..This review will discuss the potential for EMT and EndMT to impact on tissue engineering and regenerative medicine...
  53. doi request reprint The murine stanniocalcin 2 gene is a negative regulator of postnatal growth
    Andy C M Chang
    Cancer Research Unit, The Children s Hospital, Westmead, New South Wales 2145, Australia
    Endocrinology 149:2403-10. 2008
    ..This effect was not mediated through the GH/IGF-I axis. The results are consistent with STC2 being a negative regulator of postnatal growth...
  54. ncbi request reprint Ras-MAPK signaling in osteogenic differentiation: friend or foe?
    Aaron Schindeler
    Department of Orthopaedic Research and Biotechnology, The Children s Hospital at Westmeade, Sydney, Australia
    J Bone Miner Res 21:1331-8. 2006
  55. doi request reprint The effect of hip position upon the location of the sciatic nerve: an MRI Study
    Oliver Birke
    Orthopaedic Department, The Children s Hospital at Westmead, Sydney, Australia
    J Pediatr Orthop 31:165-9. 2011
    ..This is the first in-vivo study that demonstrates the effect of hip position upon the location of the sciatic nerve...