Graham Lieschke

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. ncbi Animal models of human disease: zebrafish swim into view
    Graham J Lieschke
    Cancer and Haematology Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3050, Australia
    Nat Rev Genet 8:353-67. 2007
  2. ncbi The zebrafish as a model system for human disease
    Alister C Ward
    Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, Burwood, Victoria, Australia
    Front Biosci 7:d827-33. 2002
  3. ncbi Hematopoietic perturbation in zebrafish expressing a tel-jak2a fusion
    Sara M N Onnebo
    Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, Burwood, Victoria, Australia
    Exp Hematol 33:182-8. 2005
  4. ncbi Zebrafish in hematology: sushi or science?
    Duncan Carradice
    Walter and Eliza Hall Institute of Medical Reserch, Department of Medical Biology, University of Melbourne, and Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital, Parkville, Australia
    Blood 111:3331-42. 2008
  5. ncbi CREB activity modulates neural cell proliferation, midbrain-hindbrain organization and patterning in zebrafish
    Sebastian Dworkin
    Differentiation and Transcription Laboratory, Trescowthick Laboratories, Peter MacCallum Cancer Centre, Victoria, 3002, Australia
    Dev Biol 307:127-41. 2007
  6. ncbi Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning
    Graham J Lieschke
    Ludwig Institute for Cancer Research, The Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia
    Dev Biol 246:274-95. 2002
  7. ncbi Characterization of the zebrafish matrix metalloproteinase 9 gene and its developmental expression pattern
    Simon Yoong
    Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, Burwood, Vic, Australia
    Gene Expr Patterns 7:39-46. 2007
  8. ncbi Characterisation of duplicate zinc finger like 2 erythroid precursor genes in zebrafish
    Benjamin M Hogan
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
    Dev Genes Evol 216:523-9. 2006
  9. ncbi Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish
    Benjamin M Hogan
    Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Curr Biol 16:506-11. 2006
  10. ncbi Knockdown of zebrafish crim1 results in a bent tail phenotype with defects in somite and vascular development
    Genevieve Kinna
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Mech Dev 123:277-87. 2006

Research Grants

  1. Congenital myeloid failure syndromes in mutant zebrafish
    Graham Lieschke; Fiscal Year: 2007

Collaborators

  • Alister C Ward
  • Benjamin M Hogan
  • Joan K Heath
  • Meredith O Crowhurst
  • Nathan E Hall
  • Judith E Layton
  • Duncan Carradice
  • Simon Yoong
  • Sebastian Dworkin
  • Genevieve Kinna
  • Sara M N Onnebo
  • David J Mawdsley
  • Robert G Ramsay
  • Anna Soanes
  • Theo Mantamadiotis
  • Tanya A deJong-Curtain
  • Bree O'Connell
  • Jordane Malaterre
  • Adrian Carter
  • Ujwal J Pyati
  • Sony Varma
  • Luke Pase
  • John W Hayman
  • David Kimelman
  • Andrew Perkins
  • Stephen L Nutt
  • Gabriel Kolle
  • Brian Key
  • Melissa H Little
  • Melanie M Condron
  • Janine A Danks
  • Dora O McPhee
  • Victoria E Prince
  • Andrew C Oates
  • Michael P Hunter
  • Helen M Cooper
  • Stephen H Cody

Detail Information

Publications15

  1. ncbi Animal models of human disease: zebrafish swim into view
    Graham J Lieschke
    Cancer and Haematology Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3050, Australia
    Nat Rev Genet 8:353-67. 2007
    ..This Review surveys the achievements and potential of zebrafish for modelling human diseases and for drug discovery and development...
  2. ncbi The zebrafish as a model system for human disease
    Alister C Ward
    Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, Burwood, Victoria, Australia
    Front Biosci 7:d827-33. 2002
    ..This review aims to describe several representative examples of how the zebrafish can be successfully used to identify novel genes and assign gene function, providing invaluable clues to human pathophysiology...
  3. ncbi Hematopoietic perturbation in zebrafish expressing a tel-jak2a fusion
    Sara M N Onnebo
    Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, Burwood, Victoria, Australia
    Exp Hematol 33:182-8. 2005
    ..Such fusions can mediate factor-independent growth of hematopoietic cell lines and induction of malignancy in mouse models...
  4. ncbi Zebrafish in hematology: sushi or science?
    Duncan Carradice
    Walter and Eliza Hall Institute of Medical Reserch, Department of Medical Biology, University of Melbourne, and Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital, Parkville, Australia
    Blood 111:3331-42. 2008
    ..Despite some limitations and challenges, their successes and discovery potential mean that zebrafish are here to stay in hematology research...
  5. ncbi CREB activity modulates neural cell proliferation, midbrain-hindbrain organization and patterning in zebrafish
    Sebastian Dworkin
    Differentiation and Transcription Laboratory, Trescowthick Laboratories, Peter MacCallum Cancer Centre, Victoria, 3002, Australia
    Dev Biol 307:127-41. 2007
    ..These findings reveal broader and stage-specific physiological roles of CREB function during vertebrate neural development and proliferation...
  6. ncbi Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning
    Graham J Lieschke
    Ludwig Institute for Cancer Research, The Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia
    Dev Biol 246:274-95. 2002
    ....
  7. ncbi Characterization of the zebrafish matrix metalloproteinase 9 gene and its developmental expression pattern
    Simon Yoong
    Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, Burwood, Vic, Australia
    Gene Expr Patterns 7:39-46. 2007
    ..In the adult, mmp9 expression was most prominent in the splenic cords, a site occupied by mature myeloid cells in other species. These results suggest that mmp9 will serve as a useful marker of mature myeloid cells in the zebrafish...
  8. ncbi Characterisation of duplicate zinc finger like 2 erythroid precursor genes in zebrafish
    Benjamin M Hogan
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
    Dev Genes Evol 216:523-9. 2006
    ..The production of loss-of-function models for znfl2, znfl2b and znfl2/znfl2b together suggested that these erythrocyte specific zinc finger genes are dispensible for erythropoiesis...
  9. ncbi Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish
    Benjamin M Hogan
    Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Curr Biol 16:506-11. 2006
    ..1 expression, but the role of alk8 was independent of the scl-dependent cell-fate pathway. Furthermore, the role of Alk8 in myelopoiesis was genetically separable from its earlier role in dorsal-ventral embryonic patterning...
  10. ncbi Knockdown of zebrafish crim1 results in a bent tail phenotype with defects in somite and vascular development
    Genevieve Kinna
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Mech Dev 123:277-87. 2006
    ..Hence, the primary role of zebrafish crim1 is likely to be the regulation of somitic and vascular development...
  11. ncbi Developmental biology of zebrafish myeloid cells
    Meredith O Crowhurst
    Ludwig Institute for Cancer Research, The Royal Melbourne Hospital, Victoria, Australia
    Int J Dev Biol 46:483-92. 2002
    ....
  12. ncbi Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm
    Benjamin M Hogan
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050, Australia
    Dev Biol 276:508-22. 2004
    ..This study identifies yet another role for a GCM gene in embryonic development and indicates a role for gcm2 during the evolution of divergent pharyngeal morphologies...
  13. ncbi Duplicate zebrafish pth genes are expressed along the lateral line and in the central nervous system during embryogenesis
    Benjamin M Hogan
    Ludwig Institute for Cancer Research, P O Box 2008, The Royal Melbourne Hospital, Victoria 3050, Australia
    Endocrinology 146:547-51. 2005
    ..These temporally and anatomically restricted expression patterns imply a novel role for PTH family hormones during embryonic development of the zebrafish and allow for the genetic dissection of PTH function in this model organism...
  14. ncbi The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish
    David J Mawdsley
    Colon Molecular and Cell Biology Laboratory, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Dev Biol 269:302-15. 2004
    ..These observations suggest a role for Neogenin in determining cell polarity or migrational directionality of both neuroectodermal and mesodermal cells during early embryonic development...
  15. ncbi The zebrafish spi1 promoter drives myeloid-specific expression in stable transgenic fish
    Alister C Ward
    Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, Burwood, Victoria, Australia
    Blood 102:3238-40. 2003
    ..These TG(spi1:EGFP)pA301 transgenic zebrafish represent a valuable tool for further studies of myeloid development and its perturbation...

Research Grants5

  1. Congenital myeloid failure syndromes in mutant zebrafish
    Graham Lieschke; Fiscal Year: 2007
    ..A better understanding of normal myeloid cell development will also help understand the basis for the dysregulation of these processes in myeloproliferative and leukemic diseases. ..