Research Topics
Genomes and Genes | Nicholas D HuntingtonSummaryAffiliation: The Walter and Eliza Hall Institute of Medical Research Country: Australia Publications
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Publications
Developmental pathways that generate natural-killer-cell diversity in mice and humansNicholas D Huntington
Cytokines and Lymphoid Development Unit and Inserm Unit 668, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, Cedex 15, France
Nat Rev Immunol 7:703-14. 2007....- CD45: direct and indirect government of immune regulationNicholas D Huntington
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia
Immunol Lett 94:167-74. 2004.... - A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cellsNicholas D Huntington
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
J Exp Med 201:1421-33. 2005..Thus we identify CD45 as a pivotal enzyme in eliciting a precise subset of NK cell responses... - Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1Nicholas D Huntington
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Nat Immunol 8:856-63. 2007..Thus, IL-15 regulates the survival of NK cells at multiple steps, with Bim and Noxa being key antagonists of Mcl-1, the critical survivor factor in this process... - A role for Blimp1 in the transcriptional network controlling natural killer cell maturationAxel Kallies
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Blood 117:1869-79. 2011..We have identified NK cells as the first hematopoietic cell type in which the IRF4-Blimp1-Bcl6 regulatory axis is not in operation, highlighting the distinct nature of the NK-cell gene-regulatory network... - Lyn tyrosine kinase: accentuating the positive and the negativeYuekang Xu
The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
Immunity 22:9-18. 2005..Here, we review the outcomes of altered Lyn activity within the framework of B cell development and differentiation and the circumstances that appear to dictate the outcome... - NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulationNicholas D Huntington
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
J Immunol 178:4764-70. 2007..These data indicate that NK cells acquire KLRG1 on their surface during development, and this expression correlates with functional distinctions from other peripheral NK cells in vivo... - CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centersNicholas D Huntington
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Nat Immunol 7:190-8. 2006..These results show mechanistic differences in B cell survival during germinal center initiation and propagation; CD40 signaling is sufficient for the former, whereas the latter requires signaling from the BCR... - ER stress triggers apoptosis by activating BH3-only protein BimHamsa Puthalakath
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Cell 129:1337-49. 2007..These results define the molecular mechanisms of ER stress-induced apoptosis and identify targets for therapeutic intervention in ER stress-related diseases... - Different kinetics of blimp-1 induction in B cell subsets revealed by reporter geneKirsten A Fairfax
Immunology Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, Australia
J Immunol 178:4104-11. 2007..Transferred naive Blimp-1(GFP/+) B1 and B2 cells both gave rise to ASCs in the bone marrow, suggesting no intrinsic barriers to B1 cell entry into the long-lived ASC compartment... - Functional subsets of mouse natural killer cellsYoshihiro Hayakawa
Cancer Immunology Program, Sir Donald and Lady Trescowick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Immunol Rev 214:47-55. 2006..Extending our knowledge of mature NK cell heterogeneity between the species will be critical to further our understanding of the pathological role of NK cells in immune responses... - A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responsesNicholas D Huntington
Neuroimmunology Laboratory, Department of Biochemistry, La Trobe University, Bundoora, Victoria 3086, Australia
Int Immunol 18:1473-85. 2006..Our findings demonstrate that hBCMA-Fc acts on both effector arms of the immune response in EAE, a characteristic that may be of significant therapeutic value in the treatment of MS... - The magnitude and encephalogenic potential of autoimmune response to MOG is enhanced in MOG deficient miceDavid Linares
Department of Biochemistry, La Trobe University, Bundoora, VIC 3086, Australia
J Autoimmun 21:339-51. 2003..Taken together, our data suggests that MOG self-tolerance modulates the encephalitogenic potential of autoreactive MOG T cells in the periphery...