Nicholas D Huntington

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint Developmental pathways that generate natural-killer-cell diversity in mice and humans
    Nicholas D Huntington
    Cytokines and Lymphoid Development Unit and Inserm Unit 668, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, Cedex 15, France
    Nat Rev Immunol 7:703-14. 2007
  2. doi request reprint Innate lymphoid cells: parallel checkpoints and coordinate interactions with T cells
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Victoria 3052, Australia Department of Medical Biology, University of Melbourne, Parkville 3010, Australia Electronic address
    Curr Opin Immunol 38:86-93. 2016
  3. pmc Regulation of murine natural killer cell commitment
    Nicholas D Huntington
    Molecular Immunology Division, Walter and Eliza Hall Institute of Medical Research Parkville, Vic, Australia Department of Medical Biology, The University of Melbourne Parkville, Vic, Australia
    Front Immunol 4:14. 2013
  4. ncbi request reprint CD45: direct and indirect government of immune regulation
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia
    Immunol Lett 94:167-74. 2004
  5. pmc A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Exp Med 201:1421-33. 2005
  6. pmc Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 8:856-63. 2007
  7. doi request reprint A role for Blimp1 in the transcriptional network controlling natural killer cell maturation
    Axel Kallies
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Blood 117:1869-79. 2011
  8. ncbi request reprint Lyn tyrosine kinase: accentuating the positive and the negative
    Yuekang Xu
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Immunity 22:9-18. 2005
  9. ncbi request reprint NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation
    Nicholas D Huntington
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 178:4764-70. 2007
  10. doi request reprint Phosphatidylinositol-3 kinase activity in B cells is negatively regulated by Lyn tyrosine kinase
    Yuekang Xu
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Immunol Cell Biol 90:903-11. 2012

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Developmental pathways that generate natural-killer-cell diversity in mice and humans
    Nicholas D Huntington
    Cytokines and Lymphoid Development Unit and Inserm Unit 668, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, Cedex 15, France
    Nat Rev Immunol 7:703-14. 2007
    ....
  2. doi request reprint Innate lymphoid cells: parallel checkpoints and coordinate interactions with T cells
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Victoria 3052, Australia Department of Medical Biology, University of Melbourne, Parkville 3010, Australia Electronic address
    Curr Opin Immunol 38:86-93. 2016
    ..Here, we discuss the similarities in the hardwiring and diversification of innate lymphoid cells and T cells during mammalian immune responses. ..
  3. pmc Regulation of murine natural killer cell commitment
    Nicholas D Huntington
    Molecular Immunology Division, Walter and Eliza Hall Institute of Medical Research Parkville, Vic, Australia Department of Medical Biology, The University of Melbourne Parkville, Vic, Australia
    Front Immunol 4:14. 2013
    ..Here we will summarize some recent findings in NK cell commitment and discuss how a NK cell transcriptional network might be organized, while addressing some misconceptions and anomalies along the way...
  4. ncbi request reprint CD45: direct and indirect government of immune regulation
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia
    Immunol Lett 94:167-74. 2004
    ....
  5. pmc A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Exp Med 201:1421-33. 2005
    ..Thus we identify CD45 as a pivotal enzyme in eliciting a precise subset of NK cell responses...
  6. pmc Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 8:856-63. 2007
    ..Thus, IL-15 regulates the survival of NK cells at multiple steps, with Bim and Noxa being key antagonists of Mcl-1, the critical survivor factor in this process...
  7. doi request reprint A role for Blimp1 in the transcriptional network controlling natural killer cell maturation
    Axel Kallies
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Blood 117:1869-79. 2011
    ..We have identified NK cells as the first hematopoietic cell type in which the IRF4-Blimp1-Bcl6 regulatory axis is not in operation, highlighting the distinct nature of the NK-cell gene-regulatory network...
  8. ncbi request reprint Lyn tyrosine kinase: accentuating the positive and the negative
    Yuekang Xu
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Immunity 22:9-18. 2005
    ..Here, we review the outcomes of altered Lyn activity within the framework of B cell development and differentiation and the circumstances that appear to dictate the outcome...
  9. ncbi request reprint NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation
    Nicholas D Huntington
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 178:4764-70. 2007
    ..These data indicate that NK cells acquire KLRG1 on their surface during development, and this expression correlates with functional distinctions from other peripheral NK cells in vivo...
  10. doi request reprint Phosphatidylinositol-3 kinase activity in B cells is negatively regulated by Lyn tyrosine kinase
    Yuekang Xu
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Immunol Cell Biol 90:903-11. 2012
    ..Regulating SFK activity may thus be a central mechanism by which Lyn regulates PI3K activity in B cells. This study defines the molecular connection between the BCR and PI3K and reveals this to be a point of Lyn-mediated regulation...
  11. ncbi request reprint CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 7:190-8. 2006
    ..These results show mechanistic differences in B cell survival during germinal center initiation and propagation; CD40 signaling is sufficient for the former, whereas the latter requires signaling from the BCR...
  12. pmc Peripheral natural killer cell maturation depends on the transcription factor Aiolos
    Melissa L Holmes
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    EMBO J 33:2721-34. 2014
    ..These data place Aiolos in the emerging gene regulatory network controlling NK-cell maturation and function...
  13. doi request reprint Differential requirement for Nfil3 during NK cell development
    Cyril Seillet
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    J Immunol 192:2667-76. 2014
    ..Collectively, these findings demonstrate that Nfil3 drives the formation of mature NK cells by inducing Eomes expression and reveal the differential requirements of NK cell subsets for Nfil3. ..
  14. ncbi request reprint ER stress triggers apoptosis by activating BH3-only protein Bim
    Hamsa Puthalakath
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Cell 129:1337-49. 2007
    ..These results define the molecular mechanisms of ER stress-induced apoptosis and identify targets for therapeutic intervention in ER stress-related diseases...
  15. doi request reprint The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15
    Rebecca B Delconte
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia Department of Medical Biology, University of Melbourne, VIC 3010 Australia
    Immunity 44:103-15. 2016
    ....
  16. doi request reprint CD19 differentially regulates BCR signalling through the recruitment of PI3K
    Yuekang Xu
    The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, The University of Melbourne, Australia
    Autoimmunity 47:430-7. 2014
    ..Thus, we propose that CD19 can modulate BCR signalling in both a positive and negative manner depending on the receptor/ligand interaction in vivo...
  17. pmc Nfil3 is required for the development of all innate lymphoid cell subsets
    Cyril Seillet
    Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3010, Australia
    J Exp Med 211:1733-40. 2014
    ..Thus, we demonstrate that Nfil3 is a key regulator of the development of ILC subsets essential for immune protection in the lung and gut. ..
  18. ncbi request reprint Different kinetics of blimp-1 induction in B cell subsets revealed by reporter gene
    Kirsten A Fairfax
    Immunology Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, Australia
    J Immunol 178:4104-11. 2007
    ..Transferred naive Blimp-1(GFP/+) B1 and B2 cells both gave rise to ASCs in the bone marrow, suggesting no intrinsic barriers to B1 cell entry into the long-lived ASC compartment...
  19. doi request reprint Complementarity and redundancy of IL-22-producing innate lymphoid cells
    Lucille C Rankin
    The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of Melbourne, Parkville, Australia
    Nat Immunol 17:179-86. 2016
    ..However, NCR(+) ILC3 cells were essential for cecal homeostasis. Our data show that interplay between intestinal ILC3 cells and adaptive lymphocytes results in robust complementary failsafe mechanisms that ensure gut homeostasis. ..
  20. ncbi request reprint Functional subsets of mouse natural killer cells
    Yoshihiro Hayakawa
    Cancer Immunology Program, Sir Donald and Lady Trescowick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Immunol Rev 214:47-55. 2006
    ..Extending our knowledge of mature NK cell heterogeneity between the species will be critical to further our understanding of the pathological role of NK cells in immune responses...
  21. ncbi request reprint A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responses
    Nicholas D Huntington
    Neuroimmunology Laboratory, Department of Biochemistry, La Trobe University, Bundoora, Victoria 3086, Australia
    Int Immunol 18:1473-85. 2006
    ..Our findings demonstrate that hBCMA-Fc acts on both effector arms of the immune response in EAE, a characteristic that may be of significant therapeutic value in the treatment of MS...
  22. ncbi request reprint The magnitude and encephalogenic potential of autoimmune response to MOG is enhanced in MOG deficient mice
    David Linares
    Department of Biochemistry, La Trobe University, Bundoora, VIC 3086, Australia
    J Autoimmun 21:339-51. 2003
    ..Taken together, our data suggests that MOG self-tolerance modulates the encephalitogenic potential of autoreactive MOG T cells in the periphery...