Nicholas D Huntington
Affiliation: The Walter and Eliza Hall Institute of Medical Research
Jiao Y, Davis J, Rautela J, Carrington E, Ludford Menting M, Goh W, et al
. Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes. Cell Death Differ. 2018;: pubmed publisher
Rautela J, Dagley L, Kratina T, Anthony A, Goh W, Surgenor E, et al
. Generation of novel Id2 and E2-2, E2A and HEB antibodies reveals novel Id2 binding partners and species-specific expression of E-proteins in NK cells. Mol Immunol. 2018;: pubmed publisher
..Taken together, these data highlight the utility of novel Id2 and E-protein antibodies and caution against mouse models for understanding Id2/E-protein biology in NK cells given their clearly disparate expression patternbetween species. ..
Seillet C, Belz G, Huntington N. Development, Homeostasis, and Heterogeneity of NK Cells and ILC1. Curr Top Microbiol Immunol. 2016;395:37-61 pubmed publisher
..Here, we review recent advances in our understanding of peripheral cNK cell and ILC1 heterogeneity in terms of their development, phenotype, homeostasis, and effector functions. ..
Rautela J, Huntington N. IL-15 signaling in NK cell cancer immunotherapy. Curr Opin Immunol. 2017;44:1-6 pubmed publisher
..This review will focus on IL-15 biology in NK cells and proposes the development novel therapies aimed at this pathway in humans. ..
Huntington N, Carpentier S, Vivier E, Belz G. Innate lymphoid cells: parallel checkpoints and coordinate interactions with T cells. Curr Opin Immunol. 2016;38:86-93 pubmed publisher
..Here, we discuss the similarities in the hardwiring and diversification of innate lymphoid cells and T cells during mammalian immune responses. ..
Delconte R, Shi W, Sathe P, Ushiki T, Seillet C, Minnich M, et al
. The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15. Immunity. 2016;44:103-115 pubmed publisher
Huntington N, Tarlinton D. CD45: direct and indirect government of immune regulation. Immunol Lett. 2004;94:167-74 pubmed
Sathe P, Pang S, Delconte R, Elwood N, Huntington N. Identification of Novel Human NK Cell Progenitor Subsets. Int J Mol Sci. 2017;18: pubmed publisher
..Overall, we describe several stages in the process of lymphopoiesis that will form the basis of investigating the regulators of this process in humans. ..
Huntington N, Xu Y, Nutt S, Tarlinton D. A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells. J Exp Med. 2005;201:1421-33 pubmed
..Thus we identify CD45 as a pivotal enzyme in eliciting a precise subset of NK cell responses. ..