D A Hume

Summary

Affiliation: The University of Queensland
Country: Australia

Publications

  1. ncbi request reprint Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression
    D A Hume
    Departments of Biochemistry and Microbiology Parasitology and the Centre for Molecular and Cellular Biology, University of Queensland, Queensland, Australia
    Blood 96:2323-8. 2000
  2. ncbi request reprint Regulation of the murine TRACP gene promoter
    A I Cassady
    Institute for Molecular Biosciences and School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Queensland, Australia
    J Bone Miner Res 18:1901-4. 2003
  3. ncbi request reprint A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression
    S R Himes
    Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia
    J Leukoc Biol 70:812-20. 2001
  4. ncbi request reprint Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1
    A M Lichanska
    Department of Microbiology and Centre for Molecular and Cellular Biology, University of Queensland, Queensland, Australia
    Blood 94:127-38. 1999
  5. ncbi request reprint Comparison of the expression and function of the transcription factor PU.1 (Spi-1 proto-oncogene) between murine macrophages and B lymphocytes
    I L Ross
    Centre for Molecular Biology and Biotechnology, University of Queensland, Australia
    Oncogene 9:121-32. 1994
  6. ncbi request reprint G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease
    B J McMorran
    Institute for Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia
    Am J Physiol Lung Cell Mol Physiol 281:L740-7. 2001
  7. ncbi request reprint Murine DEP-1, a receptor protein tyrosine phosphatase, is expressed in macrophages and is regulated by CSF-1 and LPS
    J M Osborne
    Department of Microbiology, Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    J Leukoc Biol 64:692-701. 1998
  8. ncbi request reprint TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors
    M Rehli
    Department of Microbiology, Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    J Immunol 162:1559-65. 1999
  9. ncbi request reprint Cloning and characterization of the murine genes for bHLH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members
    M Rehli
    Department of Biochemistry, University of Queensland, Brisbane, Queensland, Q4072, Australia
    Genomics 56:111-20. 1999
  10. ncbi request reprint G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages
    G R Thomas
    Centre for Molecular Biology, Department of Biochemistry and Microbiology, University of Queensland, St Lucia, Australia
    J Immunol 164:3870-7. 2000

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression
    D A Hume
    Departments of Biochemistry and Microbiology Parasitology and the Centre for Molecular and Cellular Biology, University of Queensland, Queensland, Australia
    Blood 96:2323-8. 2000
    ..The probabilistic nature of transcriptional regulation provides one explanation for stochastic phenomena, such as stem cell lineage commitment, and monoallelic expression of inducible genes, such as lymphokines and cytokines...
  2. ncbi request reprint Regulation of the murine TRACP gene promoter
    A I Cassady
    Institute for Molecular Biosciences and School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Queensland, Australia
    J Bone Miner Res 18:1901-4. 2003
    ..This directly links two controlling factors of osteoclast differentiation to the expression of an effector of cell function...
  3. ncbi request reprint A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression
    S R Himes
    Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia
    J Leukoc Biol 70:812-20. 2001
    ..Removal of FIRE abolished reporter gene expression, revealing a suppressive activity in the remaining intronic sequences. Hence, FIRE is shown to be a key regulatory element in the fms gene...
  4. ncbi request reprint Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1
    A M Lichanska
    Department of Microbiology and Centre for Molecular and Cellular Biology, University of Queensland, Queensland, Australia
    Blood 94:127-38. 1999
    ..The results support previous evidence that yolk sac-derived fetal phagocytes are functionally distinct from those arising in the liver and develop via a different pathway...
  5. ncbi request reprint Comparison of the expression and function of the transcription factor PU.1 (Spi-1 proto-oncogene) between murine macrophages and B lymphocytes
    I L Ross
    Centre for Molecular Biology and Biotechnology, University of Queensland, Australia
    Oncogene 9:121-32. 1994
    ..1 expression. The data suggest that differences in nuclear PU.1 expression and function between macrophages and B cells may play a role in lineage divergence...
  6. ncbi request reprint G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease
    B J McMorran
    Institute for Molecular Biosciences, University of Queensland, St Lucia, Queensland 4072, Australia
    Am J Physiol Lung Cell Mol Physiol 281:L740-7. 2001
    ....
  7. ncbi request reprint Murine DEP-1, a receptor protein tyrosine phosphatase, is expressed in macrophages and is regulated by CSF-1 and LPS
    J M Osborne
    Department of Microbiology, Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    J Leukoc Biol 64:692-701. 1998
    ..Attempts to express mDEP-1 constitutively in the macrophage cell line RAW264 were unsuccessful, with results suggesting that the gene product inhibits cell proliferation...
  8. ncbi request reprint TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors
    M Rehli
    Department of Microbiology, Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    J Immunol 162:1559-65. 1999
    ....
  9. ncbi request reprint Cloning and characterization of the murine genes for bHLH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members
    M Rehli
    Department of Biochemistry, University of Queensland, Brisbane, Queensland, Q4072, Australia
    Genomics 56:111-20. 1999
    ..Evolutionary aspects and implications for structure-function relationships are discussed...
  10. ncbi request reprint G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages
    G R Thomas
    Centre for Molecular Biology, Department of Biochemistry and Microbiology, University of Queensland, St Lucia, Australia
    J Immunol 164:3870-7. 2000
    ..These results provide evidence that the pathology of CF relates to abnormal regulation of the immune system...
  11. ncbi request reprint Transgenic mice overexpressing tartrate-resistant acid phosphatase exhibit an increased rate of bone turnover
    N Z Angel
    Centre for Molecular and Cellular Biology, University of Queensland, St Lucia, Australia
    J Bone Miner Res 15:103-10. 2000
    ..These mice provide evidence that inclusion of an irrelevant enhancer does not necessarily override a tissue-specific promoter...
  12. ncbi request reprint Activation of macrophages to express cytocidal activity correlates with inhibition of their responsiveness to macrophage colony-stimulating factor (CSF-1): involvement of a pertussis toxin-sensitive reaction
    D A Hume
    Centre for Molecular Biology and Biotechnology, University of Queensland, St Lucia, Australia
    Immunol Cell Biol 67:243-9. 1989
    ..The ability of pertussis toxin to both inhibit CSF-1-induced proliferation and trigger cytotoxicity in macrophages suggests the involvement of a regulatory GTP-binding protein (G protein) in both processes...
  13. ncbi request reprint Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase
    J U Flanagan
    Cooperative Research Centre for Chronic Inflammatory Disease, Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Australia
    Gene 377:12-20. 2006
    ..These observations suggest that the sequences identified in this study represent a novel subfamily of plant-like purple acid phosphatases in animals and humans...
  14. ncbi request reprint Regulation of CSF-1 receptor expression
    D A Hume
    Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    Mol Reprod Dev 46:46-52; discussion 52-3. 1997
    ....
  15. ncbi request reprint Structure, function, and regulation of tartrate-resistant acid phosphatase
    G W Oddie
    Department of Biochemistry, Department of Microbiology and Parasitology and Institute for Molecular Bioscience, University of Queensland, Australia
    Bone 27:575-84. 2000
  16. pmc Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation
    X Yue
    Centre for Molecular Biology and Biotechnology, University of Queensland, Brisbane, Australia
    Mol Cell Biol 13:3191-201. 1993
    ..The results suggest that expression of the c-fms gene in macrophages is controlled by sequences in intron 2 that act by regulating transcription elongation...
  17. pmc Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state
    D A Hume
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Q4072, Australia
    BMC Immunol 2:11. 2001
    ..In this paper we examine whether the signal from Toll-like receptors [TLRs] is sustained for as long as the ligand is present, and whether responses to different TLR agonists are additive...
  18. ncbi request reprint Macrophage activation by immunostimulatory DNA
    K J Stacey
    Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    Curr Top Microbiol Immunol 247:41-58. 2000
    ..The macrophage response to DNA generates cytokines favouring the development of Th1-type immunity, and active oligonucleotides now show promise as Th1-promoting adjuvants and as allergy treatments...
  19. ncbi request reprint Induction of Nramp2 in activated mouse macrophages is dissociated from regulation of the Nramp1, classical inflammatory genes, and genes involved in iron metabolism
    S L Wardrop
    Institute of Molecular Biosciences and ARC Special Research Centre for Functional and Applied Genomics, University of Queensland, Brisbane, Australia
    J Leukoc Biol 71:99-106. 2002
    ..We suggest that Nramp2 is regulated independently of known iron-responsive genes in macrophages, and its function in host defense is unrelated to Nramp1...
  20. pmc Regulation of urokinase-type plasminogen activator gene transcription by macrophage colony-stimulating factor
    K J Stacey
    Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    Mol Cell Biol 15:3430-41. 1995
    ..This work is consistent with a proposed pathway for CSF-1 signalling involving sequential activation of fms, ras, and Ets factors...
  21. pmc Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations
    S J Delaney
    Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    EMBO J 15:955-63. 1996
    ..The long-term survival of these animals should provide an excellent model with which to study cystic fibrosis, and they illustrate the value of mouse models carrying relevant mutations for examining genotype-phenotype correlations...
  22. ncbi request reprint Is the osteopetrotic (op/op mutant) mouse completely deficient in expression of macrophage colony-stimulating factor?
    D A Hume
    Centre for Molecular and Cellular Biology, University of Queensland, Australia
    J Interferon Cytokine Res 15:279-84. 1995
    ..This review examines the evidence that the op/op mouse is completely CSF-1 deficient and considers the possibility that alternative splicing within the CSF-1 gene might bypass the mutation, yielding an incompletely penetrant phenotype...
  23. ncbi request reprint Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase
    A I Cassady
    Centre for Molecular Biology and Biotechnology, University of Queensland, Australia
    Gene 130:201-7. 1993
    ..These differences may result in distinctive regulation of T5AP and Utf expression...