Francois Xavier Hubert

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint A specific anti-Aire antibody reveals aire expression is restricted to medullary thymic epithelial cells and not expressed in periphery
    Francois Xavier Hubert
    Division of Molecular and Medicine, Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 180:3824-32. 2008
  2. ncbi request reprint Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype
    Francois Xavier Hubert
    Division of Immunology, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 182:3902-18. 2009
  3. doi request reprint Autoimmune regulator controls T cell help for pathogenetic autoantibody production in collagen-induced arthritis
    Ian K Campbell
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Arthritis Rheum 60:1683-93. 2009
  4. doi request reprint Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance
    Francois Xavier Hubert
    Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 118:2462-72. 2011
  5. doi request reprint NKT cell development in the absence of the autoimmune regulator gene (Aire)
    Lauren A Pitt
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    Eur J Immunol 38:2689-96. 2008
  6. doi request reprint Diversity and clonotypic composition of influenza-specific CD8+ TCR repertoires remain unaltered in the absence of Aire
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, Vic, Australia
    Eur J Immunol 40:849-58. 2010

Detail Information

Publications6

  1. ncbi request reprint A specific anti-Aire antibody reveals aire expression is restricted to medullary thymic epithelial cells and not expressed in periphery
    Francois Xavier Hubert
    Division of Molecular and Medicine, Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 180:3824-32. 2008
    ..At a cellular level, Aire was expressed in perinuclear speckles within the nucleus. This report provides the first detailed analysis of Aire protein expression, highlighting the precise location at both the tissue and cellular level...
  2. ncbi request reprint Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype
    Francois Xavier Hubert
    Division of Immunology, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 182:3902-18. 2009
    ....
  3. doi request reprint Autoimmune regulator controls T cell help for pathogenetic autoantibody production in collagen-induced arthritis
    Ian K Campbell
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Arthritis Rheum 60:1683-93. 2009
    ..This study was undertaken to determine whether loss of central tolerance renders Aire-deficient (Aire-/-) mice more susceptible to the induction of autoimmune arthritis...
  4. doi request reprint Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance
    Francois Xavier Hubert
    Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 118:2462-72. 2011
    ..It also indicates that mTECs can mediate tolerance by direct presentation of Aire-regulated antigens to both CD4 and CD8 T cells...
  5. doi request reprint NKT cell development in the absence of the autoimmune regulator gene (Aire)
    Lauren A Pitt
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    Eur J Immunol 38:2689-96. 2008
    ..We conclude that Aire has little or no effect on regulatory T cell development in general and NKT cells in particular...
  6. doi request reprint Diversity and clonotypic composition of influenza-specific CD8+ TCR repertoires remain unaltered in the absence of Aire
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Melbourne, Vic, Australia
    Eur J Immunol 40:849-58. 2010
    ..This provides the first demonstration that the selection of an Ag-specific T-cell repertoire is not significantly perturbed in the absence of Aire...