A N Hodder

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. pmc Insights into Duffy binding-like domains through the crystal structure and function of the merozoite surface protein MSPDBL2 from Plasmodium falciparum
    Anthony N Hodder
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3052, Australia
    J Biol Chem 287:32922-39. 2012
  2. pmc Specificity of the protective antibody response to apical membrane antigen 1
    A N Hodder
    The Cooperative Research Center for Vaccine Technology, Melbourne, Victoria, 3052, Australia
    Infect Immun 69:3286-94. 2001
  3. ncbi request reprint Enzymic, phylogenetic, and structural characterization of the unusual papain-like protease domain of Plasmodium falciparum SERA5
    Anthony N Hodder
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Biol Chem 278:48169-77. 2003
  4. ncbi request reprint Rapid and precise epitope mapping of monoclonal antibodies against Plasmodium falciparum AMA1 by combined phage display of fragments and random peptides
    A M Coley
    Department of Biochemistry, La Trobe University, Bundoora, 3083, Victoria, Australia
    Protein Eng 14:691-8. 2001
  5. pmc Identification of glycosaminoglycan binding domains in Plasmodium falciparum erythrocyte membrane protein 1 of a chondroitin sulfate A-adherent parasite
    J C Reeder
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Infect Immun 68:3923-6. 2000
  6. ncbi request reprint Identification of antigenically active tryptic fragments of apical membrane antigen-1 (AMA1) of Plasmodium chabaudi malaria: strategies for assembly of immunologically active peptides
    Daniela Salvatore
    Department of Microbiology and Immunology, Cooperative Research Centre for Vaccine Technology, The University of Melbourne, 3052, Vic, Parkville, Australia
    Vaccine 20:3477-84. 2002
  7. ncbi request reprint A human phase 1 vaccine clinical trial of the Plasmodium falciparum malaria vaccine candidate apical membrane antigen 1 in Montanide ISA720 adjuvant
    Allan Saul
    The Cooperative Research Centre for Vaccine Technology, Brisbane, QLD, Australia
    Vaccine 23:3076-83. 2005
  8. pmc Functional analysis of Plasmodium falciparum apical membrane antigen 1 utilizing interspecies domains
    Julie Healer
    Walter and Eliza Hall Institute, Melbourne, Australia
    Infect Immun 73:2444-51. 2005
  9. pmc Evidence for a common role for the serine-type Plasmodium falciparum serine repeat antigen proteases: implications for vaccine and drug design
    Joanne E McCoubrie
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Infect Immun 75:5565-74. 2007
  10. ncbi request reprint The alanine-rich heptad repeats are intact in the processed form of Plasmodium falciparum MSP3
    J Andrew Pearce
    Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3050, Australia
    Exp Parasitol 108:186-9. 2004

Collaborators

Detail Information

Publications20

  1. pmc Insights into Duffy binding-like domains through the crystal structure and function of the merozoite surface protein MSPDBL2 from Plasmodium falciparum
    Anthony N Hodder
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3052, Australia
    J Biol Chem 287:32922-39. 2012
    ....
  2. pmc Specificity of the protective antibody response to apical membrane antigen 1
    A N Hodder
    The Cooperative Research Center for Vaccine Technology, Melbourne, Victoria, 3052, Australia
    Infect Immun 69:3286-94. 2001
    ....
  3. ncbi request reprint Enzymic, phylogenetic, and structural characterization of the unusual papain-like protease domain of Plasmodium falciparum SERA5
    Anthony N Hodder
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Biol Chem 278:48169-77. 2003
    ..This study provides impetus for the examination of SERA5 as a target for antimalarial drug design...
  4. ncbi request reprint Rapid and precise epitope mapping of monoclonal antibodies against Plasmodium falciparum AMA1 by combined phage display of fragments and random peptides
    A M Coley
    Department of Biochemistry, La Trobe University, Bundoora, 3083, Victoria, Australia
    Protein Eng 14:691-8. 2001
    ..Phage displaying random peptide libraries and mutant AMA1 fragments were employed for fine mapping of the MAb5G8 core epitope to a three-residue sequence in the AMA1 prodomain...
  5. pmc Identification of glycosaminoglycan binding domains in Plasmodium falciparum erythrocyte membrane protein 1 of a chondroitin sulfate A-adherent parasite
    J C Reeder
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Infect Immun 68:3923-6. 2000
    ..Characterization of this binding region provides an opportunity to investigate further its potential as a target for antiadhesion therapy...
  6. ncbi request reprint Identification of antigenically active tryptic fragments of apical membrane antigen-1 (AMA1) of Plasmodium chabaudi malaria: strategies for assembly of immunologically active peptides
    Daniela Salvatore
    Department of Microbiology and Immunology, Cooperative Research Centre for Vaccine Technology, The University of Melbourne, 3052, Vic, Parkville, Australia
    Vaccine 20:3477-84. 2002
    ..chabaudi adami suggesting that although highly immunogenic, the peptides represented inadequate or inappropriate epitopes for vaccination purposes...
  7. ncbi request reprint A human phase 1 vaccine clinical trial of the Plasmodium falciparum malaria vaccine candidate apical membrane antigen 1 in Montanide ISA720 adjuvant
    Allan Saul
    The Cooperative Research Centre for Vaccine Technology, Brisbane, QLD, Australia
    Vaccine 23:3076-83. 2005
    ..Six of the 29 subjects seroconverted. Only one of these developed a high antibody titre. However, the interpretation of this trial was compromised by a loss of potency of the formulated vaccine during the course of the study...
  8. pmc Functional analysis of Plasmodium falciparum apical membrane antigen 1 utilizing interspecies domains
    Julie Healer
    Walter and Eliza Hall Institute, Melbourne, Australia
    Infect Immun 73:2444-51. 2005
    ..Furthermore, we generated a parasite line in which the N-terminal pro region of PfAMA1 does not undergo proteolytic cleavage and show that its removal is necessary for PfAMA1 function...
  9. pmc Evidence for a common role for the serine-type Plasmodium falciparum serine repeat antigen proteases: implications for vaccine and drug design
    Joanne E McCoubrie
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Infect Immun 75:5565-74. 2007
    ..While SERA5 is to some extent further validated as a target for vaccine and drug development, our data suggest that the expression level of other serine-type SERAs is the only barrier to escape from anti-SERA5-specific interventions...
  10. ncbi request reprint The alanine-rich heptad repeats are intact in the processed form of Plasmodium falciparum MSP3
    J Andrew Pearce
    Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3050, Australia
    Exp Parasitol 108:186-9. 2004
    ..The common cellular location and similar cleavage-site motifs suggest that these merozoite proteins may be cleaved by the same or related proteases...
  11. ncbi request reprint A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycle
    Susanne K Miller
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    J Biol Chem 277:47524-32. 2002
    ..The inability to disrupt SERA4, -5, and -6 is consistent with their apparent dominant expression and implies an important role for these genes in maintenance of the erythrocytic cycle...
  12. ncbi request reprint Allelic polymorphisms in apical membrane antigen-1 are responsible for evasion of antibody-mediated inhibition in Plasmodium falciparum
    Julie Healer
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, 3050, Australia
    Mol Microbiol 52:159-68. 2004
    ..falciparum allelic exchange to examine the relationship between genetic diversity and susceptibility to protective antibodies. The findings have important implications for the development of an AMA-1-based malaria vaccine...
  13. pmc Plasmodium falciparum merozoite surface protein 6 is a dimorphic antigen
    J Andrew Pearce
    Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Infect Immun 72:2321-8. 2004
    ..Antibodies from hyperimmune individuals affinity purified on an MSP3 peptide cross-reacted with MSP6; therefore, MSP6 may also be a target of antibody-dependent cellular inhibition...
  14. pmc Inhibition of malaria parasite development by a cyclic peptide that targets the vital parasite protein SERA5
    W Douglas Fairlie
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Infect Immun 76:4332-44. 2008
    ..These data implicate an important role for SERA5 in the regulation of the intraerythrocytic development of late-stage parasites and as a target for drug development...
  15. ncbi request reprint Structure of domain III of the blood-stage malaria vaccine candidate, Plasmodium falciparum apical membrane antigen 1 (AMA1)
    Margie Nair
    Biomolecular Research Institute, 343 Royal Parade, Parkville, VIC 3052, Australia
    J Mol Biol 322:741-53. 2002
    ....
  16. ncbi request reprint Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum
    Paul R Sanders
    The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050 Australia
    J Biol Chem 280:40169-76. 2005
    ..This insight into merozoite surfaces provides new opportunities for understanding both erythrocyte invasion and anti-parasite immunity...
  17. ncbi request reprint Identification of protein complexes in detergent-resistant membranes of Plasmodium falciparum schizonts
    Paul R Sanders
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3050, Australia
    Mol Biochem Parasitol 154:148-57. 2007
    ..Confirmation of MSP-1 oligomerization, together with the isolation of a number of known complexes by BN-PAGE, makes it highly likely that novel interactions occur amongst members of this proteome...
  18. ncbi request reprint The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast
    Bernardo J Foth
    Plant Cell Biology Research Centre, School of Botany, University of Melbourne, Parkville, VIC 3010, Australia
    Mol Microbiol 55:39-53. 2005
    ..The recombinantly expressed catalytic domain of the PDH subunit E2 showed high enzymatic activity in vitro indicating that pyruvate is converted to acetyl-CoA in the apicoplast, possibly for use in fatty acid biosynthesis...
  19. ncbi request reprint Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana
    Antony J Davis
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    J Biol Chem 279:12462-8. 2004
    ..Our studies provide insight into the structure of a novel target for the development of anti-Leishmania drugs...
  20. ncbi request reprint The serine repeat antigen (SERA) gene family phylogeny in Plasmodium: the impact of GC content and reconciliation of gene and species trees
    Richard Bourgon
    Department of Statistics, University of California, Berkeley, USA
    Mol Biol Evol 21:2161-71. 2004
    ..Parsimony of reconciliation and a second criterion--implied mutational pattern at two key active sites in the SERA proteins-were also seen to be useful supplements to standard "bootstrap" analysis for inferred topologies...