Research Topics
Genomes and Genes
| D J HiltonSummaryAffiliation: The Walter and Eliza Hall Institute of Medical Research Country: Australia Publications
| Collaborators
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Detail Information
Publications
Proximal genomic localization of STAT1 binding and regulated transcriptional activitySamuel Wormald
Division of Bioinformatics, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
BMC Genomics 7:254. 2006..We have examined the genomic relationship between STAT1 binding and regulated transcription using multiple tiling microarray and chromatin immunoprecipitation microarray (ChIP-chip) experiments from public repositories...- Twenty proteins containing a C-terminal SOCS box form five structural classesD J Hilton
The Walter and Eliza Hall Institute for Medical Research and The Cooperative Research Center for Cellular Growth Factors, Parkville, Victoria 3050, Australia
Proc Natl Acad Sci U S A 95:114-9. 1998..The expression of representative members of each class of proteins differs markedly, as does the regulation of expression by cytokines. The function of the WSB, SSB, and ASB protein families remains to be determined... 
Negative regulators of cytokine signal transductionD J Hilton
Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria, Australia
Cell Mol Life Sci 55:1568-77. 1999..This review describes some of the key features of SOCS proteins and contrasts their actions with other negative regulators, the PIAS proteins and SHP-1...- A family of cytokine-inducible inhibitors of signallingR Starr
The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia
Nature 387:917-21. 1997..Transcription of all four SOCS genes is increased rapidly in response to interleukin-6, in vitro and in vivo, suggesting they may act in a classic negative feedback loop to regulate cytokine signal transduction... - Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transductionS E Nicholson
The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Center for Cellular Growth Factors, Parkville, Victoria 3050, Australia
EMBO J 18:375-85. 1999..Thus, although inhibition of signaling by SOCS-1 and SOCS-3 requires both the SH2 and N-terminal domains, their mechanisms of action appear to be biochemically different... - Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4B T Kile
The Walter and Eliza Hall Institute for Medical Research and The Cooperative Research Centre for Cellular Growth Factors, Post Office, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
Gene 258:31-41. 2000..We report here the cloning, characterization, mapping and expression analysis of four members of the ankyrin repeat and SOCS box-containing (Asb) protein family... - The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradationJ G Zhang
Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, P O Royal Melbourne Hospital, Victoria 3050, Australia
Proc Natl Acad Sci U S A 96:2071-6. 1999..Analogous to the family of F-box-containing proteins, it appears that the SOCS proteins may act as adaptor molecules that target activated cell signaling proteins to the protein degradation pathway... - Functional analysis of Asb-1 using genetic modification in miceB T Kile
The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Royal Melbourne Hospital, Victoria 3050, Australia
Mol Cell Biol 21:6189-97. 2001..In contrast, the widespread overexpression of Asb-1 in the mouse has no apparent deleterious effects... - Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factorN M Gough
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
Proc Natl Acad Sci U S A 85:2623-7. 1988..This factor competed with 125I-labeled native murine LIF for binding to specific cellular receptors on murine cells, compatible with a high degree of structural similarity between the murine and human factors... - Gigantism in mice lacking suppressor of cytokine signalling-2D Metcalf
The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Royal Melbourne Hospital, Victoria, Australia
Nature 405:1069-73. 2000.... - Suppressors of cytokine signaling (SOCS): negative regulators of signal transductionW S Alexander
The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Royal Melbourne Hospital, Victoria, Australia
J Leukoc Biol 66:588-92. 1999..We propose that the absence of SOCS-1 in these mice prevents lymphocytes and liver cells from appropriately controlling signals from cytokines with cytotoxic side effects... - The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivoJ G Zhang
The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, P O Royal Melbourne Hospital, Parkville, VIC 3050, Australia
Proc Natl Acad Sci U S A 98:13261-5. 2001..These results demonstrate that deletion of the SOCS box leads to a partial loss of function of SOCS-1... - Biochemical characterization of murine leukaemia inhibitory factor produced by Krebs ascites and by yeast cellsN M Gough
Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
Blood Cells 14:431-42. 1988..Moreover, yeast-derived recombinant LIF appears to display a different pattern of glycosylation to both forms of native LIF. From in vitro experiments, we conclude that the nature of the glycosylation is not crucial to biologic activity... - The immunoglobulin-like module of gp130 is required for signaling by interleukin-6, but not by leukemia inhibitory factorA Hammacher
Joint Protein Structure Laboratory, Ludwig Institute for Cancer Research Melbourne Tumour Biology Branch and The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
J Biol Chem 273:22701-7. 1998.... - Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chainsJ G Zhang
Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, P O Royal Melbourne Hospital, Victoria 3050, Australia
J Biol Chem 272:9474-80. 1997..Finally, unlike the cloned receptor, the IL-13BP acts as a potent inhibitor of IL-13 binding to its cell surface receptor, raising the possibility that it may be used to modulate the effects of IL-13 in vivo... - Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3A W Roberts
The Walter and Eliza Hall Institute of Medical Research and Cooperative Research Centre for Cellular Growth Factors, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
Proc Natl Acad Sci U S A 98:9324-9. 2001..These data suggest that SOCS3 is required for placental development but dispensable for normal hematopoiesis in the mouse embryo... - The human IL-11 receptor requires gp130 for signalling: demonstration by molecular cloning of the receptorH H Nandurkar
Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
Oncogene 12:585-93. 1996..Introduction of human gp130 into these cells resulted in high-affinity IL-11 binding sites and IL-11 dependent cellular proliferation. Thus these results demonstrated the absolute requirement of gp130 for signalling... - Structural characterization of a murine myeloid leukaemia inhibitory factorR J Simpson
Ludwig Institute for Cancer Research Melbourne Tumour Biology Branch Royal Melbourne Hospital, Victoria, Australia
Eur J Biochem 175:541-7. 1988..The protein sequence data reported here indicate three sites of post-translational modification (N-linked glycosylation)... - Resolution and purification of three distinct factors produced by Krebs ascites cells which have differentiation-inducing activity on murine myeloid leukemic cell linesD J Hilton
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
J Biol Chem 263:9238-43. 1988..LIF-A had no colony-stimulating activity and induced differentiation in and inhibited the proliferation of only M1 cells. Each factor bound to a unique cell surface receptor with no evidence of direct cross-reactivity... - Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signalingT E Adams
Centre for Animal Biotechnology, University of Melbourne, Parkville, Victoria, Australia
J Biol Chem 273:1285-7. 1998..Co-transfection studies revealed that constitutive expression of SOCS-1 and SOCS-3, but not SOCS-2 or CIS, blocked GH-induced transactivation of the GH-responsive serine protease inhibitor 2.1 gene promoter... - SOCS: suppressors of cytokine signallingR Starr
Cooperative Research Centre for Cellular Growth Factors, Parkville, Vic, Australia
Int J Biochem Cell Biol 30:1081-5. 1998..Small molecule effectors which modify SOCS function may potentially be useful therapeutics for the treatment of certain diseases... - Aberrant hematopoiesis in mice with inactivation of the gene encoding SOCS-1D Metcalf
The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
Leukemia 13:926-34. 1999..The suppressive effects of IFN-gamma therefore appear to involve interactions with particular growth factor-initiated signals in -/- cells--interactions that are strongly modulated by the action of the SOCS-1 protein... - Clearance and fate of leukemia-inhibitory factor (LIF) after injection into miceD J Hilton
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
J Cell Physiol 148:430-9. 1991..The appearance of a large amount of nonprecipitable 125I in the urine suggested that the kidneys were the major route of LIF clearance from the body... - SOCS proteins: negative regulators of cytokine signalingD L Krebs
The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Center for Cellular Growth Factors, Royal Melbourne Hospital, Victoria, Australia
Stem Cells 19:378-87. 2001..Additionally, the study of embryos lacking socs3 has revealed that SOCS3 is an important regulator of fetal liver hematopoiesis. The biological role of other SOCS proteins remains to be determined... - Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1R Starr
Walter and Eliza Hall Institute of Medical Research and Cooperative Research Centre for Cellular Growth Factors, Post Office Royal Melbourne Hospital, Victoria 3050, Australia
Proc Natl Acad Sci U S A 95:14395-9. 1998..Thus, SOCS-1 is required for in vivo regulation of multiple cell types and is indispensable for normal postnatal growth and survival... - Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptorD J Hilton
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
Proc Natl Acad Sci U S A 93:497-501. 1996..These results suggest that the IL-13 receptor alpha chain (NR4) is the primary binding subunit of the IL-13 receptor and may also be a component of IL-4 receptors... - Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transductionD J Hilton
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria
EMBO J 13:4765-75. 1994..The expression of both NR1 and gp130 was also necessary for Ba/F3 cells to proliferate and M1 cells to undergo macrophage differentiation in response to IL-11... - Purification of a murine leukemia inhibitory factor from Krebs ascites cellsD J Hilton
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital Victoria, Australia
Anal Biochem 173:359-67. 1988..Sufficient quantities of the factor (12 micrograms, 200 pmol) have been purified to allow structural and functional analysis of the molecule and comparison with other know differentiation inducers... - Negative regulation of cytokine signalingC J Greenhalgh
The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Parkville, Victoria, Australia
J Leukoc Biol 70:348-56. 2001..These three classes of molecules form what is now emerging as an integrated system for deactivating cytokine signaling at a number of levels, from the receptor to the transcription factor... - SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokineW S Alexander
The Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
Cell 98:597-608. 1999..Our data indicate that SOCS1 is a key modulator of IFNgamma action, allowing the protective effects of this cytokine to occur without the risk of associated pathological responses... - Suckling defect in mice lacking the soluble haemopoietin receptor NR6W S Alexander
The Walter and Eliza Hall Institute of Medical Research, The Cooperative Research Centre for Cellular Growth Factors, Post Office Royal Melbourne Hospital, Victoria, 3050, Australia
Curr Biol 9:605-8. 1999..In addition, NR6(-/-) mice had reduced numbers of haemopoietic progenitor cells, suggesting a potential role in the regulation of primitive haemopoiesis... - Identification of a second murine interleukin-11 receptor alpha-chain gene (IL11Ra2) with a restricted pattern of expressionL Robb
Walter and Eliza Hall Institute of Medical Research, The Cooperative Centre for Cellular Growth Factors, Victoria, Victoria, 3050, Australia
Genomics 40:387-94. 1997.... - Recombinant soluble interleukin-11 (IL-11) receptor alpha-chain can act as an IL-11 antagonistD J Curtis
Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
Blood 90:4403-12. 1997..We propose that the observed IL-11 antagonism by the sIL-11R may depend on limiting numbers of gp130 molecules on cells already expressing the transmembrane IL-11R... - Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptorsA Hammacher
Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050, Australia
Biochem J 345:25-32. 2000.... - SOCS: physiological suppressors of cytokine signalingD L Krebs
The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Center for Cellular Growth Factors, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
J Cell Sci 113:2813-9. 2000..Thus, the use of gene targeting has confirmed that SOCS proteins regulate cytokine signaling in a physiological setting... - Structural analysis of the gene encoding the murine interleukin-11 receptor alpha-chain and a related locusL Robb
Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Victoria, 3050, Australia
J Biol Chem 271:13754-61. 1996..Northern analysis showed that IL-11Ralpha is expressed in many adult murine tissues. A second IL-11Ralpha-like locus containing a sequence homologous to exons 2-13 was also identified... - Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrestD J Curtis
The Walter and Eliza Hall Institute of Medical Research and The Co operative Research Centre for Cellular Growth Factors, Royal Melbourne Hospital, Victoria, Australia
Exp Hematol 28:1250-9. 2000..In contrast, a tyrosine 260 mutant mSKAP55R had no effect on in vitro growth. These studies implicate mSKAP55R in the processes of myeloid differentiation and growth arrest... - Cellular processing of murine colony-stimulating factor (Multi-CSF, GM-CSF, G-CSF) receptors by normal hemopoietic cells and cell linesN A Nicola
Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria, Australia
Growth Factors 1:41-9. 1988..This resulted in a flexibility of the kinetic parameters that matched the variety of biological responses elicited by CSFs in different cell types... - Generating mouse models of retinal disease using ENU mutagenesisP N Baird
University of Melbourne, Centre for Eye Research Australia CERA, University of Melbourne, 32 Gisborne Street, East Melbourne, 3002, Victoria, Australia
Vision Res 42:479-85. 2002..Genetic inheritance was confirmed in several of these lines including three with retinal changes... - Characterization of cDNA and genomic clones encoding human myelin oligodendrocyte glycoproteinA A Hilton
Neuroimmunology Laboratory, La Trobe University, Bundoora, Victoria, Australia
J Neurochem 65:309-18. 1995..Furthermore, we describe several restriction fragment length polymorphisms of the human MOG gene, one of which may be associated with MS susceptibility... - Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF)D P Gearing
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
EMBO J 6:3995-4002. 1987..Cloning, sequencing and expressing LIF has resolved several discrepancies in the literature concerning the identity of factors capable of inducing differentiation of murine myeloid leukaemic cells in vitro... - Activation and inhibition of erythropoietin receptor function: role of receptor dimerizationS S Watowich
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
Mol Cell Biol 14:3535-49. 1994..Taken together, these results strengthen the hypothesis that an initial step in EPO- and EPO-R-mediated signal transduction is ligand-induced receptor dimerization... - SOCS-3 is involved in the downregulation of the acute insulin-like effects of growth hormone in rat adipocytes by inhibition of Jak2/IRS-1 signalingM Ridderstrale
Department of Endocrinology, Lund University, Wallenberg Laboratory, University Hospital Malmo, Malmo, Sweden
Horm Metab Res 35:169-77. 2003.... - Tissue-specific induction of SOCS gene expression by PRLS P Tam
Department of Physiology and Pharmacology, and Institute for Molecular Bioscience, University of Queensland, St. Lucia, Brisbane 4072, Australia
Endocrinology 142:5015-26. 2001.... - SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese miceB Emanuelli
INSERM U145, IFR 50, , 06107 Nice Cedex 2, France
J Biol Chem 276:47944-9. 2001..As SOCS-3 appears as a TNF-alpha target gene that is elevated during obesity, and as SOCS-3 antagonizes insulin-induced IRS-1 tyrosine phosphorylation, we suggest that it is a player in the development of insulin resistance... - Suppressor of cytokine signaling-1 attenuates the duration of interferon gamma signal transduction in vitro and in vivoM Brysha
Cooperative Research Center for Cellular Growth Factors and the Walter and Eliza Hall Institute for Medical Research, PO Royal Melbourne Hospital, Newtown New South Wales 2042, Australia
J Biol Chem 276:22086-9. 2001..Thus, SOCS-1 is required for the timely attenuation of IFNgamma signaling in vivo... - Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cellsR L Williams
European Molecular Biology Laboratory, Heidelberg, FRG
Nature 336:684-7. 1988..We demonstrate here that purified, recombinant LIF can substitute for DIA in the maintenance of totipotent ES cell lines that retain the potential to form chimaeric mice... - Saturation mutagenesis of the WSXWS motif of the erythropoietin receptorD J Hilton
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
J Biol Chem 271:4699-708. 1996..These results are discussed in terms of a general model for WSXWS function in which the motif contributes to efficient receptor folding... - SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient miceG J Lindeman
The Walter and Eliza Hall Institute of Medical Research, Bone Marrow Research Laboratories, PO Royal Melbourne Hospital, VIC 3050, Australia
Genes Dev 15:1631-6. 2001..These findings establish a role for SOCS1 as a negative regulator of prolactin signaling and suggest that SOCS1 is required for the prevention of lactation prior to parturition...