L C Harrison

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. doi The accelerator hypothesis and increasing incidence of type 1 diabetes
    Spiros Fourlanos
    Royal Melbourne Hospital, Parkville, Melbourne, Vic, Australia
    Curr Opin Endocrinol Diabetes Obes 15:321-5. 2008
  2. pmc The insulin A-chain epitope recognized by human T cells is posttranslationally modified
    Stuart I Mannering
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Exp Med 202:1191-7. 2005
  3. doi Insulin-specific vaccination for type 1 diabetes: a step closer?
    Leonard C Harrison
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Hum Vaccin Immunother 8:834-7. 2012
  4. doi Antigen-based vaccination and prevention of type 1 diabetes
    Leonard C Harrison
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3052, Victoria, Australia
    Curr Diab Rep 13:616-23. 2013
  5. ncbi Antigen-specific therapy for autoimmune disease
    L C Harrison
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville 3050, Australia
    Curr Opin Immunol 12:704-11. 2000
  6. ncbi Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes
    Leonard C Harrison
    Autoimmunity and Transplantation Division, The WalterEliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Diabetes Care 27:2348-55. 2004
  7. ncbi The prospect of vaccination to prevent type 1 diabetes
    Leonard C Harrison
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Hum Vaccin 1:143-50. 2005
  8. doi Vaccination against self to prevent autoimmune disease: the type 1 diabetes model
    Leonard C Harrison
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 86:139-45. 2008
  9. ncbi Cow's milk and type 1 diabetes: the real debate is about mucosal immune function
    L C Harrison
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Australia
    Diabetes 48:1501-7. 1999
  10. doi Type 1 diabetes: lessons for other autoimmune diseases?
    Leonard C Harrison
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Victoria, Australia
    J Autoimmun 31:306-10. 2008

Collaborators

Detail Information

Publications99

  1. doi The accelerator hypothesis and increasing incidence of type 1 diabetes
    Spiros Fourlanos
    Royal Melbourne Hospital, Parkville, Melbourne, Vic, Australia
    Curr Opin Endocrinol Diabetes Obes 15:321-5. 2008
    ..The 'accelerator hypothesis' proposes 'three processes in type 1 diabetes which variably accelerate the loss of beta cells through apoptosis: constitution, insulin resistance and autoimmunity'...
  2. pmc The insulin A-chain epitope recognized by human T cells is posttranslationally modified
    Stuart I Mannering
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Exp Med 202:1191-7. 2005
    ..We define for the first time a novel posttranslational modification that is required for T cell recognition of the insulin A-chain in T1D...
  3. doi Insulin-specific vaccination for type 1 diabetes: a step closer?
    Leonard C Harrison
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Hum Vaccin Immunother 8:834-7. 2012
    ....
  4. doi Antigen-based vaccination and prevention of type 1 diabetes
    Leonard C Harrison
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3052, Victoria, Australia
    Curr Diab Rep 13:616-23. 2013
    ..The promise of autoantigen-specific vaccination in humans has yet to be realized, but recent trials of oral and nasal insulin vaccination in at-risk humans provide grounds for cautious optimism. ..
  5. ncbi Antigen-specific therapy for autoimmune disease
    L C Harrison
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville 3050, Australia
    Curr Opin Immunol 12:704-11. 2000
    ..Mucosa-mediated tolerance remains the predominant mode of antigen-specific therapy but awaits demonstration of clinical efficacy in human autoimmune disease...
  6. ncbi Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes
    Leonard C Harrison
    Autoimmunity and Transplantation Division, The WalterEliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Diabetes Care 27:2348-55. 2004
    ....
  7. ncbi The prospect of vaccination to prevent type 1 diabetes
    Leonard C Harrison
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Hum Vaccin 1:143-50. 2005
    ..Although effective in rodent models of autoimmune disease, these strategies have so far been disappointing in humans. This review discusses the prospects of vaccination to prevent T1D, focusing on autoantigen-specific mucosal tolerance...
  8. doi Vaccination against self to prevent autoimmune disease: the type 1 diabetes model
    Leonard C Harrison
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 86:139-45. 2008
    ..Recent trials of a nasal insulin vaccine in humans at risk of type 1 diabetes provide evidence of tolerance induction as a basis for clinical efficacy...
  9. ncbi Cow's milk and type 1 diabetes: the real debate is about mucosal immune function
    L C Harrison
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Australia
    Diabetes 48:1501-7. 1999
    ..The mucosa is a major immunoregulatory barrier, and cow's milk happens to be the first dietary protein it encounters. The basic question is whether impaired mucosal immune function predisposes to type 1 diabetes...
  10. doi Type 1 diabetes: lessons for other autoimmune diseases?
    Leonard C Harrison
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Victoria, Australia
    J Autoimmun 31:306-10. 2008
    ..Initial trials of insulin-specific immunotherapy in humans show promise and reveal ways of optimising this approach that are also applicable to other autoimmune diseases...
  11. ncbi The Melbourne Pre-Diabetes Study: prediction of type 1 diabetes mellitus using antibody and metabolic testing
    P G Colman
    Department of Diabetes and Endocrinology, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Vic
    Med J Aust 169:81-4. 1998
    ..To determine the utility of various autoantibodies in predicting progression to clinical diabetes in first-degree relatives of patients with type 1 diabetes mellitus...
  12. pmc T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: potential for mimicry with rotavirus and other environmental agents
    M C Honeyman
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Mol Med 4:231-9. 1998
    ....
  13. ncbi Markers on distal chromosome 2q linked to insulin-dependent diabetes mellitus
    G Morahan
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Science 272:1811-3. 1996
    ..These results indicate the existence of a gene that acts at an early stage in IDDM development, screening for which may identify a specific subset of at-risk individuals...
  14. ncbi Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes
    M C Honeyman
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Diabetes 49:1319-24. 2000
    ..RV infection may therefore trigger or exacerbate islet autoimmunity in genetically susceptible children...
  15. pmc The A-chain of insulin is a hot-spot for CD4+ T cell epitopes in human type 1 diabetes
    S I Mannering
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Australia
    Clin Exp Immunol 156:226-31. 2009
    ..The finding of a further CD4(+) T cell epitope in the N-terminal A-chain region of human insulin underscores the importance of this region as a target of CD4(+) T cell responses in human T1D...
  16. ncbi Anti-CD45RB antibody deters xenograft rejection by modulating T cell priming and homing
    Robyn M Sutherland
    Walter and Eliza Hall Institute for Medical Research, PO The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Int Immunol 14:953-62. 2002
    ..We conclude that modulation of inflammation against xenografts by anti-CD45RB antibody is due to effects on both T cell priming and trafficking...
  17. ncbi Intranasal vaccination with proinsulin DNA induces regulatory CD4+ T cells that prevent experimental autoimmune diabetes
    Alison L Every
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    J Immunol 176:4608-15. 2006
    ....
  18. ncbi Molecular cloning of full-length glutamic acid decarboxylase 67 from human pancreas and islets
    K Yamashita
    Burnet Clinical Research Unit, Walter and Eliza Hall Institute of Medical Research, Parkville Victoria, Australia
    Biochem Biophys Res Commun 192:1347-52. 1993
    ..GAD67 has previously been shown to be a target of both autoantibodies and autoreactive T cells in IDD. The presence of GAD67 in human pancreas implies that this form of GAD, as well as GAD65, has a pathogenic role in IDD...
  19. pmc Ex-vivo analysis of human natural killer T cells demonstrates heterogeneity between tissues and within established CD4(+) and CD4(-) subsets
    A C Chan
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Vic, Australia
    Clin Exp Immunol 172:129-37. 2013
    ....
  20. ncbi Innate immunity and graft rejection
    A Fox
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    Immunol Rev 173:141-7. 2000
    ..The mechanisms by which grafts elicit innate immunity are a fertile subject for further investigation and an important target for therapeutic intervention...
  21. pmc Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP
    Balasubramanian Krishnamurthy
    St Vincent s Institute, Fitzroy, Victoria, Australia
    J Clin Invest 116:3258-65. 2006
    ..Our results suggest that pathogenic proinsulin-specific immunity in NOD mice subsequently spreads to other antigens such as IGRP...
  22. pmc MHCPEP, a database of MHC-binding peptides: update 1996
    V Brusic
    The Walter and Eliza Hall Institute, Parkville, Victoria 3050, Australia
    Nucleic Acids Res 25:269-71. 1997
    ..The present format of the database allows text string matching searches but can easily be converted for use in conjunction with sequence analysis packages. The database can be accessed via Internet using WWW, FTP or Gopher...
  23. ncbi Innate and adaptive immune responses to nonvascular xenografts: evidence that macrophages are direct effectors of xenograft rejection
    A Fox
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 166:2133-40. 2001
    ..The requirement for Mphi reflects their ability to mount a rapid, local innate response that stimulates T cell recruitment and, having received T cell help, to act as direct effectors of rejection...
  24. ncbi TCR gamma delta intraepithelial lymphocytes are required for self-tolerance
    Natasha R Locke
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Immunol 176:6553-9. 2006
    ..We conclude that TCRgammadelta IEL at the mucosal interface between self and nonself play a key role in maintaining peripheral tolerance both physiologically and during oral tolerance induction...
  25. doi Evidence for molecular mimicry between human T cell epitopes in rotavirus and pancreatic islet autoantigens
    Margo C Honeyman
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 184:2204-10. 2010
    ..Our findings are consistent with the hypothesis that molecular mimicry with RV could promote autoimmunity to islet Ags...
  26. pmc Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes
    Raymond J Steptoe
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Clin Invest 111:1357-63. 2003
    ..This antigen-specific immunotherapeutic strategy could be applied to prevent T1D and other autoimmune diseases in humans...
  27. ncbi Increased generation of dendritic cells from myeloid progenitors in autoimmune-prone nonobese diabetic mice
    Raymond J Steptoe
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, 3050 Victoria, Australia
    J Immunol 168:5032-41. 2002
    ..We propose that an imbalance favoring development of DC from myeloid-committed progenitors predisposes to autoimmune disease in NOD mice...
  28. pmc Beta-cell apoptosis in an accelerated model of autoimmune diabetes
    P Augstein
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Mol Med 4:495-501. 1998
    ..We created a model of accelerated beta-cell destruction mediated by T cells from spontaneously diabetic NOD mice to facilitate the direct detection of apoptosis in beta cells...
  29. ncbi Transcription and translation of two glutamate decarboxylase genes in the ileum of rat, mouse and guinea pig
    S Williamson
    Department of Anatomy and Cell Biology, University of Melbourne, Victoria, Australia
    J Auton Nerv Syst 55:18-28. 1995
    ....
  30. ncbi Strategies for identifying and predicting islet autoantigen T-cell epitopes in insulin-dependent diabetes mellitus
    M C Honeyman
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute, Royal Melbourne Hospital, Victoria, Australia
    Ann Med 29:401-4. 1997
    ....
  31. ncbi Latent autoimmune diabetes in adults (LADA) should be less latent
    S Fourlanos
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Diabetologia 48:2206-12. 2005
    ..In this perspective, we review the nomenclature, diagnostic criteria, genetics, pathology and therapy of LADA, to arrive at recommendations that might advance knowledge and management of this form of diabetes...
  32. pmc Regulation of laminin 1-induced pancreatic beta-cell differentiation by alpha6 integrin and alpha-dystroglycan
    F X Jiang
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Australia
    Mol Med 7:107-14. 2001
    ..Laminin-I had a dominant effect via alpha-DG to promote cell survival and beta-cell differentiation, which was modestly inhibited by alpha6 signaling...
  33. ncbi (Pro)insulin-specific regulatory T cells
    Leonard C Harrison
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, PO The Royal Melbourne Hospital, Parkville, 3050 Victoria, Australia
    Novartis Found Symp 252:132-41; discussion 141-5, 203-10. 2003
    ..These findings infer an immunoregulatory role for extrathymic-derived IEL, developing under the influence of the thymus and conditioned by early exposure to the exogenous environment...
  34. ncbi Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells
    Fang Xu Jiang
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, PO The Royal Melbourne Hospital, Parkville 3050, Australia
    J Cell Sci 115:753-60. 2002
    ..These findings indicate that members of the TGF-beta superfamily regulate pancreas epithelial cell development and can promote the formation of islet-like structures in vitro...
  35. ncbi SPAK, a STE20/SPS1-related kinase that activates the p38 pathway
    A M Johnston
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Parkville 3050, Australia
    Oncogene 19:4290-7. 2000
    ..Oncogene (2000) 19, 4290 - 4297..
  36. ncbi Localization and quantitation of expression of two glutamate decarboxylase genes in pancreatic beta-cells and other peripheral tissues of mouse and rat
    B E Faulkner-Jones
    Burnet Clinical Research Unit, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Royal Parade, Parkville, Australia
    Endocrinology 133:2962-72. 1993
    ..The expression of both GAD 67 and GAD 65 genes specifically in islet beta-cells indicates that both GAD forms are candidate autoantigens in rodent models of insulin-dependent diabetes mellitus...
  37. ncbi Mucosal antigen primes diabetogenic cytotoxic T-lymphocytes regardless of dose or delivery route
    A Hänninen
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Diabetes 50:771-5. 2001
    ..These findings suggest that CTL immunity is likely to be a consequence of mucosal antigen delivery, regardless of the regimen, and should be considered in the clinical application of mucosal tolerance to autoimmune disease prevention...
  38. ncbi Vascularized tissue-engineered chambers promote survival and function of transplanted islets and improve glycemic control
    K R Knight
    Bernard O Brien Institute of Microsurgery and Dept of Surgery, University of Melbourne, Melbourne, Victoria, Australia
    FASEB J 20:565-7. 2006
    ..05). It is concluded that hyperglycemia in experimental type 1 diabetes can be effectively treated by islets seeded into a vascularized chamber functioning as a "pancreatic organoid."..
  39. ncbi Application of genetic search in derivation of matrix models of peptide binding to MHC molecules
    V Brusic
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Proc Int Conf Intell Syst Mol Biol 5:75-83. 1997
    ..88. The results of this study are expected to be of practical interest to immunologists for efficient identification of peptides as candidates for immunotherapy...
  40. pmc Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity
    Arno Hänninen
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Australia
    J Clin Invest 109:261-7. 2002
    ..Transient CD40L blockade therefore dissociates pathogenic from protective immunity and should enhance the efficacy and safety of oral tolerance for preventing autoimmune disease...
  41. ncbi Autoimmune diabetes is suppressed by transfer of proinsulin-encoding Gr-1+ myeloid progenitor cells that differentiate in vivo into resting dendritic cells
    Raymond J Steptoe
    Division of Autoimmunity and Transplantation, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade Parkville, 3050 Victoria, Australia
    Diabetes 54:434-42. 2005
    ..The transfer of DC progenitors encoding a disease-specific autoantigen is, therefore, an effective immunotherapeutic strategy that could be applied to humans...
  42. pmc Evidence from twins for acquired cellular immune hyperactivity in type 1 diabetes
    Nikolai Petrovsky
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Immunology 106:584-9. 2002
    ..These findings suggest that T-cell hyperactivity in type 1 diabetes is an acquired trait and could reflect persisting virus expression...
  43. ncbi TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid-induced death
    Yifan Zhan
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne 3050, Australia
    Int Immunol 16:1315-21. 2004
    ..Our findings also have implications for GC treatment in that it would be more difficult to abrogate an ongoing T-cell mediated inflammatory response than to prevent its induction...
  44. ncbi Pancreatic islet A2B5- and 3G5-reactive gangliosides are markers of differentiation in rat insulinoma cells
    R K Bartholomeusz
    Burnet Clinical Research Unit, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Endocrinology 124:2680-5. 1989
    ..NaB-treated RIN cells may serve as a model to study the role of gangliosides in the function and lineage relationships of islet cells...
  45. ncbi Progenitor cells in the adult pancreas
    Andrew M Holland
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Diabetes Metab Res Rev 20:13-27. 2004
    ..Drawing on the expanding knowledge of pancreas development, beta-cell regeneration and stem cell research, this review focuses on progenitor cells in the adult pancreas as a potential source of beta-cells...
  46. doi The effector T cell response to ryegrass pollen is counterregulated by simultaneous induction of regulatory T cells
    Diana Mittag
    Department of Immunology, Monash University, Australia
    J Immunol 184:4708-16. 2010
    ..These results indicate that the cogeneration of Foxp3(hi) Tregs in response to allergen may be a mechanism for controlling allergic reactions in healthy individuals, which is impaired in those with allergies...
  47. ncbi Late-onset autoimmune diabetes in relatives of people with type 1 diabetes
    Spiros Fourlanos
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Ann N Y Acad Sci 1005:370-3. 2003
    ..We compared genetic, immunologic, and clinical features in relatives of people with T1D, who developed early- versus late-onset diabetes...
  48. ncbi CD4+ T cell proliferation in response to GAD and proinsulin in healthy, pre-diabetic, and diabetic donors
    Stuart I Mannering
    Virology, Victorian Infectious Diseases Reference Lab, 10 Wreckyn, North Melbourne, Victoria, 3051, Australia
    Ann N Y Acad Sci 1037:16-21. 2004
    ..In addition, the ability of the CFSE assay to allow analysis of the phenotype and function of autoantigen-responsive T cells may improve discrimination...
  49. ncbi An efficient method for cloning human autoantigen-specific T cells
    Stuart I Mannering
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Immunol Methods 298:83-92. 2005
    ..Sixty proinsulin- and 47 glutamic acid decarboxylase-specific clones were obtained from six and two donors, respectively. In conclusion, the CFSE-based method is ideal for cloning rare, autoantigen-specific, human CD4+ T cells...
  50. ncbi Persistence of recipient lymphocytes in NOD mice after irradiation and bone marrow transplantation
    Raymond J Steptoe
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    J Autoimmun 22:131-8. 2004
    ..This indicates that radiation resistance in the NOD hematopoietic compartment is a property primarily of mature T lymphocytes...
  51. ncbi Human T-cells recognise N-terminally Fmoc-modified peptide
    Stuart I Mannering
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, 1G Royal Parade, Parkville, VIC 3050, Australia
    Vaccine 21:3638-46. 2003
    ..This finding has important implications for the use of synthetic peptides in screening and epitope mapping studies and their use as vaccines in humans...
  52. ncbi The origin of thymic CD4+CD25+ regulatory T cells and their co-stimulatory requirements are determined after elimination of recirculating peripheral CD4+ cells
    Yifan Zhan
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Int Immunol 19:455-63. 2007
    ..Therefore, we found that the co-stimulation requirements for the thymic development of TR cells differed from those for peripheral homeostasis...
  53. ncbi Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formation
    Fang Xu Jiang
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
    Differentiation 73:45-9. 2005
    ..5 pancreatic cells to proliferate and form cystoid and solid colonies. These results demonstrate that laminin-1 and EGF signaling pathways interact to promote pancreas development...
  54. pmc The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes
    Spiros Fourlanos
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Diabetes Care 31:1546-9. 2008
    ..To examine these possibilities, human leukocyte antigen (HLA) class II DRB1 genes known to confer risk for type 1 diabetes were analyzed in relation to year of birth and age at diagnosis over the last five decades...
  55. pmc Extracellular signals and pancreatic beta-cell development: a brief review
    Fang Xu Jiang
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Parkville, Australia
    Mol Med 8:763-70. 2002
    ....
  56. pmc Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide
    Nathan R Martinez
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    J Clin Invest 111:1365-71. 2003
    ..This study identifies a novel CTL epitope in proinsulin and demonstrates that the therapeutic potential of a "tolerogenic" autoantigen peptide can be compromised by the presence of an integral CTL epitope...
  57. ncbi Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas
    Andrew M Holland
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Diabetes 54:2586-95. 2005
    ....
  58. ncbi Convergence of bone morphogenetic protein and laminin-1 signaling pathways promotes proliferation and colony formation by fetal mouse pancreatic cells
    Fang Xu Jiang
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
    Exp Cell Res 308:114-22. 2005
    ..These results demonstrate a convergence of BMP and Ln-1 signaling through P13K and MAP kinase pathways to induce proliferation and colony formation in E15.5 fetal mouse pancreatic cells...
  59. ncbi A sensitive method for detecting proliferation of rare autoantigen-specific human T cells
    Stuart I Mannering
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Immunol Methods 283:173-83. 2003
    ..Using the CFSE assay we were able to measure directly the proliferation of human CD4(+) T cells from healthy donors in response to the type 1 diabetes autoantigens glutamic acid decarboxylase (GAD) and proinsulin (PI)...
  60. ncbi Laminin-1 promotes differentiation of fetal mouse pancreatic beta-cells
    F X Jiang
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    Diabetes 48:722-30. 1999
    ..Laminin-1 was shown to be expressed in the epithelial basement membrane of the 13.5- to 17.5-day fetal pancreas. These findings provide the first evidence of a role for laminin-1 to promote differentiation of pancreatic beta-cells...
  61. ncbi Cloning and partial nucleotide sequence of human glutamic acid decarboxylase cDNA from brain and pancreatic islets
    D S Cram
    Burnet Clinical Research Unit, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Biochem Biophys Res Commun 176:1239-44. 1991
    ....
  62. pmc Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes
    H J De Aizpurua
    Burnet Clinical Research Unit, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Proc Natl Acad Sci U S A 89:9841-5. 1992
    ..The lower frequency of GAD antibodies in recent-onset IDDM subjects indicates either that immunoreactivity is lost with near-total beta-cell destruction or that GAD antibodies denote a low risk of progression to clinical disease...
  63. ncbi Antibodies to the protein tyrosine phosphatases IAR and IA-2 are associated with progression to insulin-dependent diabetes (IDDM) in first-degree relatives at-risk for IDDM
    R S Schmidli
    Burnet Clinical Research Unit, The Walter and Eliza Hall Institute, Melbourne, Victoria, Australia
    Autoimmunity 28:15-23. 1998
    ..IAR Ab may play an important role in the prediction of IDDM...
  64. doi Fulminant type 1 diabetes in Australia in the absence of humoral and cellular immune responses to pancreatic islet autoantigens
    I Lee
    Department of Diabetes and Endocrinology, Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia
    Diabetes Res Clin Pract 95:e4-6. 2012
    ..Fulminant diabetes occurs primarily in Asia, particularly in Japan, but with widespread population migration clinicians need to be aware of this form of diabetes...
  65. ncbi Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele
    G Morahan
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Nat Genet 27:218-21. 2001
    ..The IL12B 3' UTR alleles showed different levels of expression in cell lines. Variation in IL-12p40 production may influence T-cell responses crucial for either mediating or protecting against this and other autoimmune diseases...
  66. pmc Immune characterization of an individual with an exceptionally high natural killer T cell frequency and her immediate family
    A C Chan
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    Clin Exp Immunol 156:238-45. 2009
    ..This has important implications for understanding how the human NKT compartment is regulated, and supports the concept that the human NKT compartment might be expanded successfully for therapeutic benefit...
  67. ncbi Insulin resistance is a risk factor for progression to type 1 diabetes
    S Fourlanos
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Diabetologia 47:1661-7. 2004
    ..We investigated whether insulin resistance was a risk factor for progression to type 1 diabetes...
  68. ncbi Cytotoxic T cells to an epitope in the islet autoantigen IA-2 are not disease-specific
    K Takahashi
    Autoimmunity and Transplantation Division, Royal Melbourne Hospital, Parkville, 3050, Australia
    Clin Immunol 99:360-4. 2001
    ..CTL to the IA-2 self-peptide were therefore not disease-specific, consistent with other evidence that autoreactive T cells are present in healthy individuals...
  69. ncbi Endocrine cells develop within pancreatic bud-like structures derived from mouse ES cells differentiated in response to BMP4 and retinoic acid
    Suzanne J Micallef
    Monash University, Clayton, Victoria, Australia
    Stem Cell Res 1:25-36. 2007
    ..The readily detectable co-expression of GFP and RFP in grafts derived from transplanted EBs demonstrated the utility of Pdx1(GFP/w)Ins1(RFP/w) ESCs for investigating pancreatic differentiation in vitro and in vivo...
  70. ncbi Cognate CD4+ help elicited by resting dendritic cells does not impair the induction of peripheral tolerance in CD8+ T cells
    Raymond J Steptoe
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 178:2094-103. 2007
    ..Thus, effective peripheral tolerance can be induced by resting DC in the presence of CD4(+) and CD8(+) T cells with specificity for the same Ag...
  71. pmc Proinsulin is encoded by an RNA splice variant in human blood myeloid cells
    Parth Narendran
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 103:16430-5. 2006
    ..Self-antigen expression by peripheral myeloid cells extends the umbrella of "immunological self" and, by analogy with the thymus, may be implicated in peripheral immune tolerance...
  72. ncbi Proinsulin-a pathogenic autoantigen in type 1 diabetes
    Parth Narendran
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, 3050 Parkville, Australia
    Autoimmun Rev 2:204-10. 2003
    ..We conclude that proinsulin satisfies these criteria. As a corollary, proinsulin is a potential immunotherapeutic tool for the prevention of T1D...
  73. ncbi Homeostatic proliferation of intestinal intraepithelial lymphocytes precedes their migration to extra-intestinal sites
    Sanda Stankovic
    The Walter and Eliza Hall Institute for Medical Research, Parkville, Australia
    Eur J Immunol 37:2226-33. 2007
    ..IEL proliferation and emigration under lymphopenic conditions suggests similar IEL turnover, albeit at a lower level, under physiological conditions...
  74. ncbi Fms-like tyrosine kinase 3 ligand administration overcomes a genetically determined dendritic cell deficiency in NOD mice and protects against diabetes development
    Meredith O'Keeffe
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Int Immunol 17:307-14. 2005
    ..This points to a possible clinical use of FL to prevent autoimmune disease...
  75. pmc Cloning from the thyroid of a protein related to actin binding protein that is recognized by Graves disease immunoglobulins
    P J Leedman
    Burnet Clinical Research Unit, Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    Proc Natl Acad Sci U S A 90:5994-8. 1993
    ..We suggest, therefore, that signal transduction by TSH in the thyroid involves direct linkage of the TSH receptor to actin microfilaments by ABP and that TABP may interact with ABP to mediate TSH-induced actin microfilament disruption...
  76. ncbi Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulin
    L Chang
    Department of Microbiology and Immunology and ImmunoID, University of Melbourne, Vic, Australia
    Tissue Antigens 62:408-17. 2003
    ..Peptides from the library were used to initiate assembly of recombinant HLA-B8, HLA-B15 and HLA-A2, facilitating the identification of candidate T-cell epitopes from preproinsulin...
  77. ncbi High avidity antibodies to fetal pig pancreas endocrine cells transfer rejection but are not normally generated to fetal pig pancreas xenografts
    Annette Fox
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Xenotransplantation 9:382-92. 2002
    ..Such Abs are not elicited by transplanting FPP into immunocompetent mice. Nevertheless, a contribution of Ab to rejection in immunocompetent mice cannot be excluded...
  78. pmc Delineation of atypical insulin receptors from classical insulin and type I insulin-like growth factor receptors in human placenta
    H A Jonas
    University of Melbourne Department of Medicine, Royal Melbourne Hospital, Victoria, Australia
    Biochem J 257:101-7. 1989
    ..They provide an explanation for the unusual IGF-II binding properties of human placental membranes and may have a specific role in placental growth and/or function...
  79. pmc MHCPEP, a database of MHC-binding peptides: update 1997
    V Brusic
    The Walter and Eliza Hall Institute, Parkville, Victoria 3050, Australia
    Nucleic Acids Res 26:368-71. 1998
    ..The present format of the database allows text string matching searches but can easily be converted for use in conjunction with sequence analysis packages. The database can be accessed via Internet using WWW or FTP...
  80. ncbi An ELISA for antibodies to recombinant glutamic acid decarboxylase in IDDM
    H J Deaizpurua
    Burnet Clinical Research Unit, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Diabetes 41:1182-7. 1992
    ..The ELISA should facilitate screening to evaluate the role of autoimmunity to GAD in the development of IDDM...
  81. doi Reappraising the stereotypes of diabetes in the modern diabetogenic environment
    John M Wentworth
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Nat Rev Endocrinol 5:483-9. 2009
    ..Embracing a holistic view of the diabetes syndrome will help us to understand the environmental basis for the epidemic of diabetes and improve preventative strategies...
  82. ncbi Distinct distribution of laminin and its integrin receptors in the pancreas
    Fang Xu Jiang
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Parkville, Australia
    J Histochem Cytochem 50:1625-32. 2002
    ..These findings are a basis for further investigation of the role of extracellular matrix molecules and their receptors in pancreas function...
  83. pmc Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity
    John M Wentworth
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    Diabetes 59:1648-56. 2010
    ..We aimed to characterize macrophage phenotype and function in human subcutaneous and omental adipose tissue in relation to insulin resistance in obesity...
  84. ncbi A clinical screening tool identifies autoimmune diabetes in adults
    Spiros Fourlanos
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Diabetes Care 29:970-5. 2006
    ..Currently, there are no recommendations for islet antibody testing in adult-onset diabetes. In this study, we aimed to develop a clinical screening tool to identify adults at high risk of LADA who require islet antibody testing...
  85. pmc Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes
    Spiros Fourlanos
    Autoimmunity and Transplantation Division, Walter and Eliza Hall, Institute of Medical Research, Parkville, Victoria, Australia
    Diabetes 60:1237-45. 2011
    ..Adults with recent-onset type 1 diabetes in whom the disease process is subacute afford an opportunity to determine whether mucosal insulin induces tolerance to insulin subsequently injected for treatment...
  86. pmc Pancreatic expression and mitochondrial localization of the progestin-adipoQ receptor PAQR10
    L Jorge Gonez
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Mol Med 14:697-704. 2008
    ..We propose that PAQR10 may act at the level of the mitochondrion to regulate pancreatic endocrine cell development/survival...
  87. ncbi Emerging evidence that molecules expressed by mammalian tissue grafts are recognized by the innate immune system
    Annette Fox-Marsh
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    J Leukoc Biol 71:401-9. 2002
    ....
  88. ncbi Difference in generating mouse pancreatic epithelial cell colonies in vitro
    Fang Xu Jiang
    Pancreas 27:204-6. 2003
  89. ncbi Autoimmunity to both proinsulin and IGRP is required for diabetes in nonobese diabetic 8.3 TCR transgenic mice
    Balasubramanian Krishnamurthy
    St Vincent s Institute, Fitzroy, Vic, Australia
    J Immunol 180:4458-64. 2008
    ..This suggests that islet inflammation can substitute for proinsulin-specific CD4(+) T cell help to activate IGRP(206-214)-specific T cells...
  90. pmc Growth of rotaviruses in primary pancreatic cells
    Barbara S Coulson
    Department of Microbiology and Immunology, The University of Melbourne, Royal Parade, Victoria 3010, Australia
    J Virol 76:9537-44. 2002
    ..Human rotaviruses replicated in monkey islets only. This islet susceptibility shows that rotavirus infection of the pancreas in vivo might be possible...
  91. ncbi Antigen-induced regulatory T cells in autoimmunity
    Matthias G Von Herrath
    La Jolla Institute for Allergy and Immunology, Division of Immune Regulation, 10355 Science Center Drive, San Diego, California 92121, USA
    Nat Rev Immunol 3:223-32. 2003
    ..In this review, we consider the nature and function of such antigen-specific T(Reg) cells, and strategies for their therapeutic induction are discussed...
  92. ncbi Cytokines activate caspase-3 in insulinoma cells of diabetes-prone NOD mice directly and via upregulation of Fas
    Petra Augstein
    Institute of Diabetes Gerhardt Katsch Karlsburg e V, Greifswalder Strasse 11e, 17495 Karlsburg, Germany
    J Autoimmun 23:301-9. 2004
    ..Compared to thymocytes, insulinoma cells and islets from NOD mice were characterised by low basal and cytokine-induced caspase-3 activity...
  93. pmc The non-immune RIP-Kb mouse is a useful host for islet transplantation, as the diabetes is spontaneous, mild and predictable
    Robyn M Sutherland
    Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Australia
    Int J Exp Diabetes Res 3:37-45. 2002
    ..The diabetes is mild enough so that most diabetic mice can be maintained to 40 weeks of age without parenteral insulin. This consistency of diabetes avails that outcomes of intervention can be interpreted with confidence...
  94. ncbi Understanding autoimmune diabetes: insights from mouse models
    Luciano Adorini
    Roche Milano Ricerche, Via Olgettina 58, I 20132 Milan, Italy
    Trends Mol Med 8:31-8. 2002
    ..In this review, we will focus on these areas to highlight recent advances in understanding the pathogenesis of autoimmune diabetes, drawing extensively on insights gained by studying the non-obese diabetic (NOD) mouse...
  95. pmc Pre-type 1 diabetes dysmetabolism: maximal sensitivity achieved with both oral and intravenous glucose tolerance testing
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Pediatr 150:31-36.e6. 2007
    ....
  96. ncbi Guidelines for intervention trials in subjects with newly diagnosed type 1 diabetes
    Carla J Greenbaum
    Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    Diabetes 52:1059-65. 2003
  97. ncbi Pulmonary CD4+ cytokine responses in mice reveal differences in the relative immunogenicity of cold-adapted influenza A vaccine donor strains
    Mark D Wareing
    Department of Biotechnology and Environmental Biology, RMIT University, P O Box 71, Bundoora, VIC 3083, Australia
    Vaccine 23:4075-81. 2005
    ..The CD4+ cytokine response in the lungs may be a useful measure of immunogenicity to determine the most effective influenza reassortant for inclusion in vaccines...
  98. ncbi Seasonal changes in preprandial glucose, A1C, and blood pressure in diabetic patients: response to Liang
    Margo C Honeyman
    Diabetes Care 30:e118; author reply e119. 2007
  99. doi Dominance of cytokine- over FasL-induced impairment of the mitochondrial transmembrane potential (Deltapsim) in the pancreatic beta-cell line NIT-1
    Petra Augstein
    Institute of Diabetes Gerhardt Katsch Karlsburg e V, Karlsburg, Germany
    Diab Vasc Dis Res 5:198-204. 2008
    ..Furthermore, at least in NIT-1 cells, the extrinsic FasL/Fas pathway has only a minor additive effect on cytokine-induced Deltapsim impairment...