C J Greenhalgh

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)
    Christopher J Greenhalgh
    The Cooperative Research Centre for Cellular Growth Factors and The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Mol Endocrinol 16:1394-406. 2002
  2. ncbi request reprint Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling
    Christopher J Greenhalgh
    Walter and Eliza Hall Institute of Medical Research and the Cooperative Research for Cellular Growth Factors, PO Royal Melbourne Hospital, VIC 3050, Australia
    J Biol Chem 277:40181-4. 2002
  3. ncbi request reprint Negative regulation of cytokine signaling
    C J Greenhalgh
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Parkville, Victoria, Australia
    J Leukoc Biol 70:348-56. 2001
  4. ncbi request reprint The suppressors of cytokine signaling (SOCS) proteins: important feedback inhibitors of cytokine action
    N A Nicola
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Parkville, Victoria, Australia
    Exp Hematol 28:1105-12. 2000
  5. pmc The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo
    J G Zhang
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, P O Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Proc Natl Acad Sci U S A 98:13261-5. 2001
  6. ncbi request reprint Gigantism in mice lacking suppressor of cytokine signalling-2
    D Metcalf
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Royal Melbourne Hospital, Victoria, Australia
    Nature 405:1069-73. 2000
  7. ncbi request reprint cDNA cloning of galectins from third stage larvae of the parasitic nematode Teladorsagia circumcincta
    S E Newton
    Centre for Animal Biotechnology, School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia
    Mol Biochem Parasitol 86:143-53. 1997
  8. ncbi request reprint Recombinant expression of a galectin from the sheep gastrointestinal parasite Teladorsagia circumcincta: its use in isolating galectin-glycoconjugates
    C J Greenhalgh
    School of Veterinary Science, The University of Melbourne, Parkville, Victoria, 3052, Australia
    Protein Expr Purif 16:152-9. 1999
  9. ncbi request reprint Suppressor of cytokine signaling-2 modulates the fibrogenic actions of GH and IGF-I in intestinal mesenchymal cells
    Shira Fruchtman
    Dept of Cell and Molecular Physiology, CB 7545, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7545, USA
    Am J Physiol Gastrointest Liver Physiol 289:G342-50. 2005
  10. pmc SOCS2 negatively regulates growth hormone action in vitro and in vivo
    Christopher J Greenhalgh
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research WEHI and the Cooperative Centre for Cellular Growth Factors, Parkville, Victoria, Australia
    J Clin Invest 115:397-406. 2005

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)
    Christopher J Greenhalgh
    The Cooperative Research Centre for Cellular Growth Factors and The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Mol Endocrinol 16:1394-406. 2002
    ..Furthermore, the deletion of SOCS-2 from mice also lacking signal transducer and activator of transcription 5b had little effect on growth, suggesting that the action of SOCS-2 may be the regulation of the GH signaling pathway...
  2. ncbi request reprint Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling
    Christopher J Greenhalgh
    Walter and Eliza Hall Institute of Medical Research and the Cooperative Research for Cellular Growth Factors, PO Royal Melbourne Hospital, VIC 3050, Australia
    J Biol Chem 277:40181-4. 2002
    ..Together, the data implicate SOCS-2 as having dual effects on GH signaling in vivo...
  3. ncbi request reprint Negative regulation of cytokine signaling
    C J Greenhalgh
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Parkville, Victoria, Australia
    J Leukoc Biol 70:348-56. 2001
    ..These three classes of molecules form what is now emerging as an integrated system for deactivating cytokine signaling at a number of levels, from the receptor to the transcription factor...
  4. ncbi request reprint The suppressors of cytokine signaling (SOCS) proteins: important feedback inhibitors of cytokine action
    N A Nicola
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Parkville, Victoria, Australia
    Exp Hematol 28:1105-12. 2000
    ....
  5. pmc The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo
    J G Zhang
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, P O Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Proc Natl Acad Sci U S A 98:13261-5. 2001
    ..These results demonstrate that deletion of the SOCS box leads to a partial loss of function of SOCS-1...
  6. ncbi request reprint Gigantism in mice lacking suppressor of cytokine signalling-2
    D Metcalf
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Royal Melbourne Hospital, Victoria, Australia
    Nature 405:1069-73. 2000
    ....
  7. ncbi request reprint cDNA cloning of galectins from third stage larvae of the parasitic nematode Teladorsagia circumcincta
    S E Newton
    Centre for Animal Biotechnology, School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia
    Mol Biochem Parasitol 86:143-53. 1997
    ..Within the coding region there are 87 nucleotide differences but only three of these result in amino acid substitutions...
  8. ncbi request reprint Recombinant expression of a galectin from the sheep gastrointestinal parasite Teladorsagia circumcincta: its use in isolating galectin-glycoconjugates
    C J Greenhalgh
    School of Veterinary Science, The University of Melbourne, Parkville, Victoria, 3052, Australia
    Protein Expr Purif 16:152-9. 1999
    ..The full-length fusion protein was used to successfully isolate potential galectin-glycoconjugates from within the parasite and from sheep serum...
  9. ncbi request reprint Suppressor of cytokine signaling-2 modulates the fibrogenic actions of GH and IGF-I in intestinal mesenchymal cells
    Shira Fruchtman
    Dept of Cell and Molecular Physiology, CB 7545, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7545, USA
    Am J Physiol Gastrointest Liver Physiol 289:G342-50. 2005
    ....
  10. pmc SOCS2 negatively regulates growth hormone action in vitro and in vivo
    Christopher J Greenhalgh
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research WEHI and the Cooperative Centre for Cellular Growth Factors, Parkville, Victoria, Australia
    J Clin Invest 115:397-406. 2005
    ..Together, the data provide clear evidence that SOCS2 is a negative regulator of GH signaling...
  11. ncbi request reprint Suppressor of cytokine signaling-2 deficiency induces molecular and metabolic changes that partially overlap with growth hormone-dependent effects
    Elizabeth Rico-Bautista
    Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Mol Endocrinol 19:781-93. 2005
    ..Our data indicate that SOCS2 deficiency partially mimics a state of increased GH activity, but also results in changes that cannot be related to known GH effects...
  12. ncbi request reprint Suppressor of cytokine signalling-2 and epidermal growth factor regulate neurite outgrowth of cortical neurons
    Yona Goldshmit
    Neural Regeneration Laboratory, Centre for Neuroscience, The University of Melbourne, Parkville, Victoria 3010, Australia
    Eur J Neurosci 20:2260-6. 2004
    ....
  13. ncbi request reprint Suppressors of cytokine signalling and regulation of growth hormone action
    Christopher J Greenhalgh
    Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Parkville, VIC 3050, Australia
    Growth Horm IGF Res 14:200-6. 2004
    ..A precise understanding of the actions of SOCS proteins in GH signalling may offer new opportunities for therapeutic intervention in growth disorders and other conditions involving GH action...
  14. ncbi request reprint SOCS2 induces neurite outgrowth by regulation of epidermal growth factor receptor activation
    Yona Goldshmit
    Neural Regeneration Laboratory, Centre for Neuroscience, The University of Melbourne, Parkville, Victoria 3010, Australia
    J Biol Chem 279:16349-55. 2004
    ..Our findings suggest that SOCS2 regulates EGFR phosphorylation, leading to regulation of neurite outgrowth through a novel pathway that is distinct from GH...
  15. ncbi request reprint SOCS3 negatively regulates IL-6 signaling in vivo
    Ben A Croker
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nat Immunol 4:540-5. 2003
    ..Our data indicate that SOCS3 and SOCS1 have reciprocal functions in IL-6 and IFN-gamma regulation and imply that SOCS3 has a role in preventing IFN-gamma-like responses in cells stimulated by IL-6...
  16. ncbi request reprint Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis
    Ann L Cornish
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 170:878-86. 2003
    ..Thus, SOCS-1 is a critical regulator of T cell activation and homeostasis, and its influence extends beyond regulating IFN-gamma signaling...
  17. ncbi request reprint Suppressors of cytokine signaling: Relevance to gastrointestinal function and disease
    Christopher J Greenhalgh
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Royal Melbourne Hospital, Australia
    Gastroenterology 123:2064-81. 2002
    ..Currently, there are 8 members of the SOCS family, of which a number have been implicated strongly in the negative regulation of cytokine signal transduction pathways...
  18. ncbi request reprint Haplotype insufficiency for suppressor of cytokine signaling-2 enhances intestinal growth and promotes polyp formation in growth hormone-transgenic mice
    Carmen Z Michaylira
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, 27599 7545, USA
    Endocrinology 147:1632-41. 2006
    ..Small variations in SOCS2 expression levels may significantly influence the outcome of therapeutic GH or acromegaly in intestine...
  19. ncbi request reprint Negative regulation of growth hormone receptor signaling
    Amilcar Flores-Morales
    Center of Molecular Medicine, Karolinska Hospital, 17176 Stockholm, Sweden
    Mol Endocrinol 20:241-53. 2006
    ..It can help to understand growth-related disease conditions, to explain GH resistance, and may be used to develop pharmaceuticals that enhance some the beneficial actions of endogenously secreted GH in a tissue-specific manner...