Simon Finfer

Summary

Affiliation: The George Institute for International Health
Country: Australia

Publications

  1. pmc Effect of baseline serum albumin concentration on outcome of resuscitation with albumin or saline in patients in intensive care units: analysis of data from the saline versus albumin fluid evaluation (SAFE) study
    Simon Finfer
    Australian and New Zealand Intensive Care Society Clinical Trials Group, Carlton, VIC 3053, Australia
    BMJ 333:1044. 2006
  2. ncbi The RENAL (Randomised Evaluation of Normal vs. Augmented Level of Replacement Therapy) study: statistical analysis plan
    Simon Finfer
    The George Institute for International Health, Sydney, NSW
    Crit Care Resusc 11:58-66. 2009
  3. pmc Hypoglycemia in critically ill adults - association yes, causation not proven
    Simon Finfer
    Intensive Care Unit, Royal North Shore Hospital, Pacific Highway, St Leonards, NSW 2065, Australia
    Crit Care 15:1012. 2011
  4. pmc Injury in China: a systematic review of injury surveillance studies conducted in Chinese hospital emergency departments
    Michael Fitzharris
    Accident Research Centre and Injury Outcomes Research Unit, Monash Injury Research Institute, Monash University, Victoria, Australia
    BMC Emerg Med 11:18. 2011
  5. pmc Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock
    Simon Finfer
    Critical Care and Trauma, The George Institute for International Health, University of Sydney, Sydney, NSW, Australia
    Intensive Care Med 34:1935-47. 2008
  6. ncbi The NICE-SUGAR (Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation) Study: statistical analysis plan
    Simon Finfer
    The George Institute for International Health, University of Sydney, Sydney, NSW
    Crit Care Resusc 11:46-57. 2009
  7. pmc Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care units
    Simon Finfer
    Critical Care and Trauma Division, The George Institute for International Health, PO Box M201, Missenden Road, NSW 2050, Australia
    Crit Care 14:R185. 2010
  8. doi Hydroxyethyl starch or saline for fluid resuscitation in intensive care
    John A Myburgh
    Division of Critical Care and Trauma, George Institute For Global Health, Sydney, NSW, Australia
    N Engl J Med 367:1901-11. 2012
  9. doi Timing and interventions of emergency teams during the MERIT study
    Arthas Flabouris
    Intensive Care Unit, Royal Adelaide Hospital, University of Adelaide, Australia
    Resuscitation 81:25-30. 2010
  10. doi Does severe non-infectious SIRS differ from severe sepsis? Results from a multi-centre Australian and New Zealand intensive care unit study
    Joel M Dulhunty
    Department of Intensive Care Medicine, Royal Brisbane and Women s Hospital, and Burns, Trauma and Critical Care Research Centre, University of Queensland, Herston, QLD, 4029, Australia
    Intensive Care Med 34:1654-61. 2008

Collaborators

Detail Information

Publications40

  1. pmc Effect of baseline serum albumin concentration on outcome of resuscitation with albumin or saline in patients in intensive care units: analysis of data from the saline versus albumin fluid evaluation (SAFE) study
    Simon Finfer
    Australian and New Zealand Intensive Care Society Clinical Trials Group, Carlton, VIC 3053, Australia
    BMJ 333:1044. 2006
    ..To determine whether outcomes of resuscitation with albumin or saline in the intensive care unit depend on patients' baseline serum albumin concentration...
  2. ncbi The RENAL (Randomised Evaluation of Normal vs. Augmented Level of Replacement Therapy) study: statistical analysis plan
    Simon Finfer
    The George Institute for International Health, Sydney, NSW
    Crit Care Resusc 11:58-66. 2009
    ..The Randomised Evaluation of Normal vs. Augmented Level of Replacement Therapy (RENAL) study is the largest interventional trial ever conducted in patients with acute renal failure...
  3. pmc Hypoglycemia in critically ill adults - association yes, causation not proven
    Simon Finfer
    Intensive Care Unit, Royal North Shore Hospital, Pacific Highway, St Leonards, NSW 2065, Australia
    Crit Care 15:1012. 2011
    ..While we await data that address the outstanding issues, common sense dictates that clinicians avoid causing hypoglycemia whenever possible...
  4. pmc Injury in China: a systematic review of injury surveillance studies conducted in Chinese hospital emergency departments
    Michael Fitzharris
    Accident Research Centre and Injury Outcomes Research Unit, Monash Injury Research Institute, Monash University, Victoria, Australia
    BMC Emerg Med 11:18. 2011
    ....
  5. pmc Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock
    Simon Finfer
    Critical Care and Trauma, The George Institute for International Health, University of Sydney, Sydney, NSW, Australia
    Intensive Care Med 34:1935-47. 2008
    ..This special article describes the process by which the trial was developed, major decisions regarding trial design, and plans for independent analysis, interpretation and reporting of the data...
  6. ncbi The NICE-SUGAR (Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation) Study: statistical analysis plan
    Simon Finfer
    The George Institute for International Health, University of Sydney, Sydney, NSW
    Crit Care Resusc 11:46-57. 2009
    ..The Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation (NICE-SUGAR) Study is the largest study to date of glycaemic control in critically ill patients...
  7. pmc Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care units
    Simon Finfer
    Critical Care and Trauma Division, The George Institute for International Health, PO Box M201, Missenden Road, NSW 2050, Australia
    Crit Care 14:R185. 2010
    ..Recent evidence suggests that choice of fluid used for resuscitation may influence mortality in critically ill patients...
  8. doi Hydroxyethyl starch or saline for fluid resuscitation in intensive care
    John A Myburgh
    Division of Critical Care and Trauma, George Institute For Global Health, Sydney, NSW, Australia
    N Engl J Med 367:1901-11. 2012
    ..The safety and efficacy of hydroxyethyl starch (HES) for fluid resuscitation have not been fully evaluated, and adverse effects of HES on survival and renal function have been reported...
  9. doi Timing and interventions of emergency teams during the MERIT study
    Arthas Flabouris
    Intensive Care Unit, Royal Adelaide Hospital, University of Adelaide, Australia
    Resuscitation 81:25-30. 2010
    ..To examine interventions and timing of emergency team calls in hospitals with or without a medical emergency team (MET)...
  10. doi Does severe non-infectious SIRS differ from severe sepsis? Results from a multi-centre Australian and New Zealand intensive care unit study
    Joel M Dulhunty
    Department of Intensive Care Medicine, Royal Brisbane and Women s Hospital, and Burns, Trauma and Critical Care Research Centre, University of Queensland, Herston, QLD, 4029, Australia
    Intensive Care Med 34:1654-61. 2008
    ..To compare the time course of organ dysfunction/failure, mortality and cause of death in patients with severe sepsis (SS) and patients with severe non-infectious systemic inflammatory response syndrome (SNISIRS)...
  11. pmc Baseline hospital performance and the impact of medical emergency teams: modelling vs. conventional subgroup analysis
    Jack Chen
    The Simpson Centre for Health Services Research, University of New South Wales, Sydney, New South Wales, Australia
    Trials 10:117. 2009
    ..To compare two approaches to the statistical analysis of the relationship between the baseline incidence of adverse events and the effect of medical emergency teams (METs)...
  12. doi Epidemiology and 12-month outcomes from traumatic brain injury in australia and new zealand
    John A Myburgh
    Department of Intensive Care, The St George Hospital, Sydney, Australia
    J Trauma 64:854-62. 2008
    ..An epidemiologic profile of traumatic brain injury (TBI) in Australia and New Zealand was obtained following the publication of international evidence-based guidelines...
  13. doi Triggers for emergency team activation: a multicenter assessment
    Jack Chen
    Simpson Centre for Health Services Research, University of New South Wales, Sydney, New South Wales, Australia
    J Crit Care 25:359.e1-7. 2010
    ..The purpose of the study was to examine triggers for emergency team activation in hospitals with or without a medical emergency team (MET) system...
  14. doi The impact of introducing medical emergency team system on the documentations of vital signs
    Jack Chen
    The Simpson Centre for Health Services Research, University of New South Wales, Liverpool Health Service, Locked Bag 7103, Liverpool BC, Sydney, NSW 1871, Australia
    Resuscitation 80:35-43. 2009
    ....
  15. doi Fluid resuscitation with 6 % hydroxyethyl starch (130/0.4 and 130/0.42) in acutely ill patients: systematic review of effects on mortality and treatment with renal replacement therapy
    David J Gattas
    The George Institute for Global Health, Sydney, Australia
    Intensive Care Med 39:558-68. 2013
    ..4 (6 % HES 130) compared with other resuscitation fluids results in a difference in the relative risk of death or treatment with renal replacement therapy (RRT)...
  16. doi The role of albumin as a resuscitation fluid for patients with sepsis: a systematic review and meta-analysis
    Anthony P Delaney
    Northern Clinical School, Sydney Medical School, University of Sydney, Sydney, Australia
    Crit Care Med 39:386-91. 2011
    ..To assess whether resuscitation with albumin-containing solutions, compared with other fluids, is associated with lower mortality in patients with sepsis...
  17. ncbi A comparison of albumin and saline for fluid resuscitation in the intensive care unit
    Simon Finfer
    ANZICS CTG, Level 3, 10 Ievers St, Carlton, VIC 3053, Australia
    N Engl J Med 350:2247-56. 2004
    ..We conducted a multicenter, randomized, double-blind trial to compare the effect of fluid resuscitation with albumin or saline on mortality in a heterogeneous population of patients in the ICU...
  18. ncbi Saline or albumin for fluid resuscitation in patients with traumatic brain injury
    John Myburgh
    ANZICS Clinical Trials Group, Level 3, 10 Ievers Terrace, Carlton, VIC 3053, Australia
    N Engl J Med 357:874-84. 2007
    ..We conducted a post hoc follow-up study of patients with traumatic brain injury who were enrolled in the study...
  19. doi Fluid resuscitation with 6% hydroxyethyl starch (130/0.4) in acutely ill patients: an updated systematic review and meta-analysis
    David J Gattas
    Critical Care and Trauma Division, The George Institute for Global Health, University of Sydney, Australia
    Anesth Analg 114:159-69. 2012
    ..4 is one of the most frequently used resuscitation fluids worldwide. The retraction of studies evaluating its use necessitates a reevaluation of available evidence regarding its safety and efficacy...
  20. ncbi Management of blood glucose in the critically ill in Australia and New Zealand: a practice survey and inception cohort study
    Imogen Mitchell
    The Canberra Hospital, Intensive Care Unit, Garran, 2605, ACT, Australia
    Intensive Care Med 32:867-74. 2006
    ..To document current management of blood glucose in Australian and New Zealand intensive care units (ICUs) and to investigate the association between insulin administration, blood glucose concentration and hospital outcome...
  21. doi Effect of evidence-based feeding guidelines on mortality of critically ill adults: a cluster randomized controlled trial
    Gordon S Doig
    Northern Clinical School, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia, 2006
    JAMA 300:2731-41. 2008
    ..Changing practice in complex multidisciplinary environments is difficult. Evidence supporting whether guidelines can improve ICU feeding practices and patient outcomes is contradictory...
  22. doi The relationship between early emergency team calls and serious adverse events
    Jack Chen
    Simpson Centre for Health Services Research, University of New South Wales, Sydney, New South Wales, Australia
    Crit Care Med 37:148-53. 2009
    ....
  23. doi Reappraising the role of albumin for resuscitation
    Simon Finfer
    Royal North Shore Hospital and the George Institute for Global Health, University of Sydney, Australia
    Curr Opin Crit Care 19:315-20. 2013
    ..Human albumin solutions have been available since the 1940s, but their use varies greatly around the world. This review examines the current evidence for and against the use of albumin as a resuscitation fluid...
  24. doi Long-term survival and dialysis dependency following acute kidney injury in intensive care: extended follow-up of a randomized controlled trial
    Martin Gallagher
    The George Institute for Global Health, Sydney, Australia University of Sydney, Sydney, Australia
    PLoS Med 11:e1001601. 2014
    ..We used the prolonged follow-up of a large clinical trial to prospectively examine the long-term outcomes and effect of RRT dosing in patients with AKI...
  25. ncbi Respiratory rate: the neglected vital sign
    Michelle A Cretikos
    Centre for Epidemiology and Research, NSW Health, Sydney, NSW, Australia
    Med J Aust 188:657-9. 2008
    ..Hospital systems that encourage appropriate responses to an elevated respiratory rate and other abnormal vital signs can be rapidly implemented. Such systems help to raise and sustain awareness of the importance of vital signs...
  26. pmc Pro/con debate: Is intensive insulin therapy targeting tight blood glucose control of benefit in critically ill patients?
    Tobias M Merz
    Department of Intensive Care Medicine, Royal North Shore Hospital of Sydney, St Leonards, 2065 NSW, Australia
    Crit Care 12:212. 2008
    ..You have decided to develop a protocol for insulin therapy in your intensive care unit (ICU). You wonder about the merit of using intensive insulin therapy (IIT) to maintain tight blood glucose control in your patients...
  27. doi Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome
    Andrew Davies
    FRACP, FJFICM, Intensive Care Unit, Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia
    JAMA 302:1888-95. 2009
    ..It caused an epidemic of critical illness and some patients developed severe acute respiratory distress syndrome (ARDS) and were treated with extracorporeal membrane oxygenation (ECMO)...
  28. doi The Medical Emergency Team System and not-for-resuscitation orders: results from the MERIT study
    Jack Chen
    The Simpson Centre for Health Services Research, University of New South Wales, Liverpool Health Service, Locked Bag 7103, Liverpool BC, Sydney, NSW 1871, Australia
    Resuscitation 79:391-7. 2008
    ..To examine NFR orders in relation to adverse events and emergency team calls in hospitals with or without a Medical Emergency Team (MET) system during the MERIT study...
  29. ncbi The objective medical emergency team activation criteria: a case-control study
    Michelle Cretikos
    The Simpson Centre for Health Services Research and the University of New South Wales, Sydney, Australia
    Resuscitation 73:62-72. 2007
    ....
  30. ncbi Albumin is a blood product too - is it safe for all patients?
    John A Myburgh
    Faculty of Medicine, University of New South Wales, and Department of Intensive Care Medicine, St George Hospital, Sydney, NSW
    Crit Care Resusc 11:67-70. 2009
    ..However, the acquisition costs of albumin and synthetic colloids are more than those of crystalloids, and, as yet, colloids have not been proven to confer substantive benefits over crystalloids such as saline...
  31. doi Glycemic control in the ICU
    Moritoki Egi
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama, Japan
    Chest 140:212-20. 2011
    ..Until such time, clinicians would be well advised to abide by the age-old adage to "first, do no harm."..
  32. doi Early acid-base and blood pressure effects of continuous renal replacement therapy intensity in patients with metabolic acidosis
    Rinaldo Bellomo
    ANZICS CTG, Level 3, 10 Ievers St, Carlton, VIC 3053, Australia
    Intensive Care Med 39:429-36. 2013
    ..We aimed to compare key aspects of acidosis and MAP and vasopressor therapy in patients treated with two different CRRT intensities...
  33. pmc Bench-to-bedside review: the evaluation of complex interventions in critical care
    Anthony Delaney
    Northern Clinical School, Faculty of Medicine, University of Sydney, Intensive Care Unit, Royal North Shore Hospital, Pacific Highway, St Leonards, NSW, 2065, Australia
    Crit Care 12:210. 2008
    ..These aspects of study design impact upon the evaluation of complex interventions in critical care. Clinicians should also consider these specific issues when implementing new complex interventions into their practice...
  34. pmc Intensities of renal replacement therapy in acute kidney injury: a systematic review and meta-analysis
    Min Jun
    The George Institute for International Health, University of Sydney, Sydney, New South Wales, Australia
    Clin J Am Soc Nephrol 5:956-63. 2010
    ..A systematic review and meta-analysis was undertaken to assess the effect of different intensities of RRT on all-cause mortality and renal recovery in AKI patients...
  35. ncbi Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units
    Simon Finfer
    ANZICS Clinical Trials Group, 10 Iavers Terrace, Carlton, Victoria 3053, Australia
    Intensive Care Med 30:589-96. 2004
    ..To determine the population incidence and outcome of severe sepsis occurring in adult patients treated in Australian and New Zealand intensive care units (ICUs), and compare with recent retrospective estimates from the USA and UK...
  36. ncbi Delayed hemorrhage following resection of an arteriovenous malformation in the brain
    Michael K Morgan
    Department of Radiology, Sydney Aneurysm and AVM Neurosurgical Centre, The University of Sydney, Royal North Shore Hospital, Sydney, NSW, Australia
    J Neurosurg 99:967-71. 2003
    ..Between 1989 and 2002 the authors treated 416 cases of angiographically confirmed arteriovenous malformations (AVMs) of the brain...
  37. ncbi A phase II randomised controlled trial of intensive insulin therapy in general intensive care patients
    Imogen Mitchell
    Department of Intensive Care, The Canberra Hospital, Canberra, ACT, Australia
    Crit Care Resusc 8:289-93. 2006
    ..To determine the safety and efficacy of an intensive insulin regimen compared with a conventional insulin regimen in general intensive care unit patients...
  38. ncbi Thromboprophylaxis for intensive care patients in Australia and New Zealand: a brief survey report
    D James Cooper
    Alfred Hospital, Monash University, Victoria 3800, Australia
    J Crit Care 20:354-6. 2005
    ..Internationally, there is practice variation concerning optimal thromboprophylaxis for patients in the intensive care unit (ICU). The current practice in Australia and New Zealand is unknown...
  39. ncbi Clinician discomfort with life support plans for mechanically ventilated patients
    Lauren Griffith
    Department of Clinical Epidemiology, Medical Center, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
    Intensive Care Med 30:1783-90. 2004
    ..To examine the incidence and predictors of clinician discomfort with life support plans for ICU patients...
  40. pmc Efficacy of albumin in critically ill patients
    Simon Finfer
    BMJ 326:559-60. 2003