Paul G Ekert

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. doi request reprint The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts
    Pratiti Bandopadhayay
    University of Melbourne, Royal Parade, Parkville, Melbourne, Victoria 3052, Australia
    BMC Cancer 13:585. 2013
  2. ncbi request reprint Caspase inhibitors
    P G Ekert
    The Walter and Eliza Hall Institute of Medical Research, c o Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    Cell Death Differ 6:1081-6. 1999
  3. pmc Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die
    Paul G Ekert
    The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Cell Biol 165:835-42. 2004
  4. pmc Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation
    Anissa M Jabbour
    Children s Cancer Centre, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Vic, Australia
    Blood 115:344-52. 2010
  5. pmc The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
    John Silke
    The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
    J Cell Biol 157:115-24. 2002
  6. pmc Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance
    John Silke
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 102:16182-7. 2005
  7. ncbi request reprint Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis
    John Silke
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, VIC 3050, Australia
    J Biol Chem 279:4313-21. 2004
  8. pmc Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9
    Vanessa S Marsden
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Cell Biol 165:775-80. 2004
  9. ncbi request reprint Programmed anuclear cell death delimits platelet life span
    Kylie D Mason
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Cell 128:1173-86. 2007
  10. pmc p53-Dependent transcriptional responses to interleukin-3 signaling
    Anissa M Jabbour
    Children s Cancer Centre, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    PLoS ONE 7:e31428. 2012

Collaborators

Detail Information

Publications24

  1. doi request reprint The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts
    Pratiti Bandopadhayay
    University of Melbourne, Royal Parade, Parkville, Melbourne, Victoria 3052, Australia
    BMC Cancer 13:585. 2013
    ..Here we examine the oncogenic properties of two splice variants of EWS/WT1, EWS/WT1-KTS and EWS/WT1 + KTS...
  2. ncbi request reprint Caspase inhibitors
    P G Ekert
    The Walter and Eliza Hall Institute of Medical Research, c o Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    Cell Death Differ 6:1081-6. 1999
    ....
  3. pmc Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die
    Paul G Ekert
    The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Cell Biol 165:835-42. 2004
    ..Unlike expression of Bcl-2, loss of Apaf-1, caspase-2, or caspase-9 would therefore be unlikely to enhance the survival of cancer cells...
  4. pmc Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation
    Anissa M Jabbour
    Children s Cancer Centre, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Vic, Australia
    Blood 115:344-52. 2010
    ..Thus, we conclude that p53 protein is activated after IL-3 deprivation by loss of MDM2. Activated p53 transcriptionally up-regulates Puma, which initiates apoptosis...
  5. pmc The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
    John Silke
    The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
    J Cell Biol 157:115-24. 2002
    ....
  6. pmc Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance
    John Silke
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 102:16182-7. 2005
    ..Cross control of protein levels by RING domains may therefore enable their levels to be manipulated therapeutically...
  7. ncbi request reprint Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis
    John Silke
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, VIC 3050, Australia
    J Biol Chem 279:4313-21. 2004
    ....
  8. pmc Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9
    Vanessa S Marsden
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Cell Biol 165:775-80. 2004
    ..These findings suggest that caspases other than caspases 2 and 9 can promote cytochrome c release and initiate Bcl-2-regulated apoptosis...
  9. ncbi request reprint Programmed anuclear cell death delimits platelet life span
    Kylie D Mason
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Cell 128:1173-86. 2007
    ....
  10. pmc p53-Dependent transcriptional responses to interleukin-3 signaling
    Anissa M Jabbour
    Children s Cancer Centre, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    PLoS ONE 7:e31428. 2012
    ..Contrastingly, we find that p53(-/-) cells are independent on AKT for their survival. Thus, loss of p53 in myeloid cells results in an altered transcriptional and kinase signaling environment that favors enhanced cytokine signaling...
  11. ncbi request reprint The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest
    Thomas Kaufmann
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Australia
    Cell 129:423-33. 2007
    ..We conclude that Bid has no role in DNA damage- or replicative stress-induced apoptosis or cell-cycle arrest...
  12. ncbi request reprint Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma
    Paul G Ekert
    Children s Cancer Centre, Murdoch Children s Research Centre, Royal Children s Hospital, Flemington Rd, Parkville, Victoria 3052, Australia
    Blood 108:1461-8. 2006
    ..Inhibition of the PI3 kinase pathway promoted apoptosis in the presence or absence of IL-3 and did not require Bad, Bim, or Puma, suggesting IL-3 receptor survival signals and PI3 kinase survival signals are independent...
  13. ncbi request reprint Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
    Vanessa S Marsden
    The Walter and Eliza Hall Institute, Melbourne, 3050, Australia
    Nature 419:634-7. 2002
    ..We conclude that Bcl-2 regulates a caspase activation programme independently of the cytochrome c/Apaf-1/caspase-9 'apoptosome', which seems to amplify rather than initiate the caspase cascade...
  14. ncbi request reprint Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7
    Po Ki Ho
    Murdoch Children s Research Institute, Parkville, Australia
    FEBS J 272:1401-14. 2005
    ..Consistent with its proposed identity as an upstream caspase, caspase-2 could provoke the activation of caspase-7. Caspase-2 was not subject to inhibition by members of the IAP family of apoptosis inhibitors...
  15. ncbi request reprint Caspase-8 levels affect necessity for mitochondrial amplification in death ligand-induced glioma cell apoptosis
    Melissa J Knight
    Department of Haematology and Oncology, Royal Children s Hospital, Parkville, Victoria, Australia
    Mol Carcinog 39:173-82. 2004
    ..This indicates that caspase-8 levels can influence the requirement for mitochondrial involvement in death receptor apoptotic signaling in glioma cells...
  16. ncbi request reprint The mitochondrial death squad: hardened killers or innocent bystanders?
    Paul G Ekert
    The Walter and Eliza Hall Institute, 1G Royal Parade Parkville, Victoria 3050, Australia
    Curr Opin Cell Biol 17:626-30. 2005
    ..Gene knockout experiments suggest that many were wrongly convicted on circumstantial evidence, and just happened to be in the wrong place at the wrong time...
  17. doi request reprint Crossing paths: interactions between the cell death machinery and growth factor survival signals
    Gabriela Brumatti
    Children s Cancer Centre, Murdoch Children s Research Institute, Royal Children s Hospital, Department of Paediatrics, University of Melbourne, Flemington Rd Parkville, Melbourne, 3052, Australia
    Cell Mol Life Sci 67:1619-30. 2010
    ....
  18. pmc HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia
    Gabriela Brumatti
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Australia
    Oncotarget 4:1933-47. 2013
    ..This is the first description of a molecular link between HoxA9 and the regulation of Bcl-2 family members in acute myeloid leukemia. ..
  19. doi request reprint Exploring the utility of human DNA methylation arrays for profiling mouse genomic DNA
    Nicholas C Wong
    Cancer and Disease Epigenetics Group, Murdoch Childrens Research Institute, Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Genomics 102:38-46. 2013
    ..In the absence of a mouse counterpart, the Infinium Human Methylation BeadChip arrays have utility for methylation profiling in non-human species...
  20. pmc Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors
    Elizabeth M Algar
    Children s Cancer Centre research laboratory, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Australia
    PLoS ONE 4:e4482. 2009
    ....
  21. ncbi request reprint HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
    Anne M Verhagen
    Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    J Biol Chem 277:445-54. 2002
    ....
  22. ncbi request reprint Monolysocardiolipins accumulate in Barth syndrome but do not lead to enhanced apoptosis
    Fredoen Valianpour
    Laboratory of Genetic Metabolic Diseases, Department of Clinical Chemistry, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    J Lipid Res 46:1182-95. 2005
    ....
  23. pmc The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice
    Julian Pardo
    Metschnikoff Laboratory, Max Planck Institut fur Immunbiologie, D 79108 Freiburg, Germany
    J Cell Biol 174:509-19. 2006
    ..The elucidation of the molecular basis opens new strategies for the development of therapeutic regimens to combat A. fumigatus and related fungal infections...
  24. pmc A novel Apaf-1-independent putative caspase-2 activation complex
    Stuart H Read
    Hanson Institute, Adelaide, Australia 5000
    J Cell Biol 159:739-45. 2002
    ..Our data are consistent with a model where caspase-2 activation occurs by oligomerization, independent of the Apaf-1 apoptosome...