Paul G Ekert

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. ncbi Caspase inhibitors
    P G Ekert
    The Walter and Eliza Hall Institute of Medical Research, c o Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    Cell Death Differ 6:1081-6. 1999
  2. ncbi Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die
    Paul G Ekert
    The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Cell Biol 165:835-42. 2004
  3. ncbi The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
    John Silke
    The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
    J Cell Biol 157:115-24. 2002
  4. ncbi Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation
    Anissa M Jabbour
    Children s Cancer Centre, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Vic, Australia
    Blood 115:344-52. 2010
  5. ncbi Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis
    John Silke
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, VIC 3050, Australia
    J Biol Chem 279:4313-21. 2004
  6. ncbi Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance
    John Silke
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 102:16182-7. 2005
  7. ncbi p53-Dependent transcriptional responses to interleukin-3 signaling
    Anissa M Jabbour
    Children s Cancer Centre, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    PLoS ONE 7:e31428. 2012
  8. ncbi Programmed anuclear cell death delimits platelet life span
    Kylie D Mason
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Cell 128:1173-86. 2007
  9. ncbi Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9
    Vanessa S Marsden
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Cell Biol 165:775-80. 2004
  10. ncbi Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma
    Paul G Ekert
    Children s Cancer Centre, Murdoch Children s Research Centre, Royal Children s Hospital, Flemington Rd, Parkville, Victoria 3052, Australia
    Blood 108:1461-8. 2006

Collaborators

Detail Information

Publications20

  1. ncbi Caspase inhibitors
    P G Ekert
    The Walter and Eliza Hall Institute of Medical Research, c o Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    Cell Death Differ 6:1081-6. 1999
    ....
  2. ncbi Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die
    Paul G Ekert
    The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Cell Biol 165:835-42. 2004
    ..Unlike expression of Bcl-2, loss of Apaf-1, caspase-2, or caspase-9 would therefore be unlikely to enhance the survival of cancer cells...
  3. ncbi The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
    John Silke
    The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
    J Cell Biol 157:115-24. 2002
    ....
  4. ncbi Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation
    Anissa M Jabbour
    Children s Cancer Centre, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Vic, Australia
    Blood 115:344-52. 2010
    ..Thus, we conclude that p53 protein is activated after IL-3 deprivation by loss of MDM2. Activated p53 transcriptionally up-regulates Puma, which initiates apoptosis...
  5. ncbi Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis
    John Silke
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, VIC 3050, Australia
    J Biol Chem 279:4313-21. 2004
    ....
  6. ncbi Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance
    John Silke
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 102:16182-7. 2005
    ..Cross control of protein levels by RING domains may therefore enable their levels to be manipulated therapeutically...
  7. ncbi p53-Dependent transcriptional responses to interleukin-3 signaling
    Anissa M Jabbour
    Children s Cancer Centre, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    PLoS ONE 7:e31428. 2012
    ..Contrastingly, we find that p53(-/-) cells are independent on AKT for their survival. Thus, loss of p53 in myeloid cells results in an altered transcriptional and kinase signaling environment that favors enhanced cytokine signaling...
  8. ncbi Programmed anuclear cell death delimits platelet life span
    Kylie D Mason
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Cell 128:1173-86. 2007
    ....
  9. ncbi Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9
    Vanessa S Marsden
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Cell Biol 165:775-80. 2004
    ..These findings suggest that caspases other than caspases 2 and 9 can promote cytochrome c release and initiate Bcl-2-regulated apoptosis...
  10. ncbi Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma
    Paul G Ekert
    Children s Cancer Centre, Murdoch Children s Research Centre, Royal Children s Hospital, Flemington Rd, Parkville, Victoria 3052, Australia
    Blood 108:1461-8. 2006
    ..Inhibition of the PI3 kinase pathway promoted apoptosis in the presence or absence of IL-3 and did not require Bad, Bim, or Puma, suggesting IL-3 receptor survival signals and PI3 kinase survival signals are independent...
  11. ncbi The mitochondrial death squad: hardened killers or innocent bystanders?
    Paul G Ekert
    The Walter and Eliza Hall Institute, 1G Royal Parade Parkville, Victoria 3050, Australia
    Curr Opin Cell Biol 17:626-30. 2005
    ..Gene knockout experiments suggest that many were wrongly convicted on circumstantial evidence, and just happened to be in the wrong place at the wrong time...
  12. ncbi Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7
    Po-Ki Ho
    Murdoch Children's Research Institute, Parkville, Australia
    FEBS J 272:1401-14. 2005
    ..Consistent with its proposed identity as an upstream caspase, caspase-2 could provoke the activation of caspase-7. Caspase-2 was not subject to inhibition by members of the IAP family of apoptosis inhibitors...
  13. ncbi Caspase-8 levels affect necessity for mitochondrial amplification in death ligand-induced glioma cell apoptosis
    Melissa J Knight
    Department of Haematology and Oncology, Royal Children s Hospital, Parkville, Victoria, Australia
    Mol Carcinog 39:173-82. 2004
    ..This indicates that caspase-8 levels can influence the requirement for mitochondrial involvement in death receptor apoptotic signaling in glioma cells...
  14. ncbi The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest
    Thomas Kaufmann
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Australia
    Cell 129:423-33. 2007
    ..We conclude that Bid has no role in DNA damage- or replicative stress-induced apoptosis or cell-cycle arrest...
  15. ncbi Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors
    Elizabeth M Algar
    Children s Cancer Centre research laboratory, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Australia
    PLoS ONE 4:e4482. 2009
    ....
  16. ncbi HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
    Anne M Verhagen
    Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    J Biol Chem 277:445-54. 2002
    ....
  17. ncbi A novel Apaf-1-independent putative caspase-2 activation complex
    Stuart H Read
    Hanson Institute, Adelaide, Australia 5000
    J Cell Biol 159:739-45. 2002
    ..Our data are consistent with a model where caspase-2 activation occurs by oligomerization, independent of the Apaf-1 apoptosome...
  18. ncbi Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
    Vanessa S Marsden
    The Walter and Eliza Hall Institute, Melbourne, 3050, Australia
    Nature 419:634-7. 2002
    ..We conclude that Bcl-2 regulates a caspase activation programme independently of the cytochrome c/Apaf-1/caspase-9 'apoptosome', which seems to amplify rather than initiate the caspase cascade...
  19. ncbi The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice
    Julian Pardo
    Metschnikoff Laboratory, Max Planck Institut fur Immunbiologie, D 79108 Freiburg, Germany
    J Cell Biol 174:509-19. 2006
    ..The elucidation of the molecular basis opens new strategies for the development of therapeutic regimens to combat A. fumigatus and related fungal infections...
  20. ncbi Monolysocardiolipins accumulate in Barth syndrome but do not lead to enhanced apoptosis
    Fredoen Valianpour
    Laboratory of Genetic Metabolic Diseases, Department of Clinical Chemistry, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    J Lipid Res 46:1182-95. 2005
    ....