S Cory

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. ncbi Suzanne Cory
    Carina Dennis
    Nat Med 8:203. 2002
  2. ncbi The Bcl2 family: regulators of the cellular life-or-death switch
    Suzanne Cory
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia
    Nat Rev Cancer 2:647-56. 2002
  3. ncbi Matters of life and death: programmed cell death at Cold Spring Harbor
    S Cory
    Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Biochim Biophys Acta 1377:R25-44. 1998
  4. ncbi The Bcl-2 family: roles in cell survival and oncogenesis
    Suzanne Cory
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Oncogene 22:8590-607. 2003
  5. ncbi Killing cancer cells by flipping the Bcl-2/Bax switch
    Suzanne Cory
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Cancer Cell 8:5-6. 2005
  6. ncbi Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members
    S P Holmgreen
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital Victoria 3050, Australia
    Cell Death Differ 6:525-32. 1999
  7. pmc Progenitor tumours from Emu-bcl-2-myc transgenic mice have lymphomyeloid differentiation potential and reveal developmental differences in cell survival
    A Strasser
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Melbourne, Australia 3050
    EMBO J 15:3823-34. 1996
  8. pmc Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    EMBO J 14:6136-47. 1995
  9. pmc Bim: a novel member of the Bcl-2 family that promotes apoptosis
    L O'Connor
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    EMBO J 17:384-95. 1998
  10. ncbi Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria 3050, Melbourne, Australia
    Dev Cell 1:645-53. 2001

Collaborators

Detail Information

Publications41

  1. ncbi Suzanne Cory
    Carina Dennis
    Nat Med 8:203. 2002
  2. ncbi The Bcl2 family: regulators of the cellular life-or-death switch
    Suzanne Cory
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia
    Nat Rev Cancer 2:647-56. 2002
    ..Apoptosis is often impaired in cancer and can limit conventional therapy. A better understanding of how the Bcl2 family controls caspase activation should result in new, more effective therapeutic approaches...
  3. ncbi Matters of life and death: programmed cell death at Cold Spring Harbor
    S Cory
    Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Biochim Biophys Acta 1377:R25-44. 1998
  4. ncbi The Bcl-2 family: roles in cell survival and oncogenesis
    Suzanne Cory
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Oncogene 22:8590-607. 2003
    ..Finally, it discusses the promise of novel anticancer therapeutics that target these vital regulators...
  5. ncbi Killing cancer cells by flipping the Bcl-2/Bax switch
    Suzanne Cory
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Cancer Cell 8:5-6. 2005
    ..Hence, this work validates Bcl-2-like proteins as important new targets in cancer therapy...
  6. ncbi Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members
    S P Holmgreen
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital Victoria 3050, Australia
    Cell Death Differ 6:525-32. 1999
    ..The results may reflect critical threshold affinities but also suggest that certain pro-apoptotic proteins may also contribute to apoptosis by a mechanism independent of binding pro-survival proteins...
  7. pmc Progenitor tumours from Emu-bcl-2-myc transgenic mice have lymphomyeloid differentiation potential and reveal developmental differences in cell survival
    A Strasser
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Melbourne, Australia 3050
    EMBO J 15:3823-34. 1996
    ..These results provide insight into the process of lineage commitment and suggest new levels of control of cell survival during early steps in haemopoietic development...
  8. pmc Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    EMBO J 14:6136-47. 1995
    ..These data raise the possibility that Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis...
  9. pmc Bim: a novel member of the Bcl-2 family that promotes apoptosis
    L O'Connor
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    EMBO J 17:384-95. 1998
    ..Hence, Bim appears to act as a 'death ligand' which can only neutralize certain members of the pro-survival Bcl-2 sub-family...
  10. ncbi Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria 3050, Melbourne, Australia
    Dev Cell 1:645-53. 2001
    ..These results demonstrate that Bim levels set the threshold for initiation of apoptosis in several tissues and suggest that degenerative diseases might be alleviated by blocking BH3-only proteins...
  11. ncbi Bcl-2 expression promotes B- but not T-lymphoid development in scid mice
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Nature 368:457-60. 1994
    ....
  12. ncbi Life-or-death decisions by the Bcl-2 protein family
    J M Adams
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, 3050, Melbourne, Australia
    Trends Biochem Sci 26:61-6. 2001
    ..Pro-apoptotic family members act as sentinels for cellular damage: cytotoxic signals induce their translocation to the organelles where they bind to their pro-survival relatives, promote organelle damage and trigger apoptosis...
  13. pmc Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 91:1376-80. 1994
    ..Thus, although bcl-2 expression hampers the deletion of immature self-reactive cells in the thymus, self-tolerance is maintained...
  14. ncbi Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector
    J M Adams
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Oncogene 18:5268-77. 1999
    ..This novel vector should aid studies on many aspects of hematopoiesis, including the modeling of leukemogenesis...
  15. ncbi Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Nature 348:331-3. 1990
    ..Suprisingly, the tumours derive from a cell with the hallmarks of a primitive haemopoietic cell, perhaps a lymphoid-committed stem cell...
  16. ncbi Insights from transgenic mice regarding the role of bcl-2 in normal and neoplastic lymphoid cells
    S Cory
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Philos Trans R Soc Lond B Biol Sci 345:289-95. 1994
    ..Crosses of the bcl-2 transgenic mice with p53-/- mice have addressed whether loss of p53 function and gain of bcl-2 function are synergistic for lymphoid cell survival...
  17. ncbi Acceleration of B-lymphoid tumorigenesis in E mu-myc transgenic mice by v-H-ras and v-raf but not v-abl
    W Y Langdon
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Australia
    Oncogene Res 4:253-8. 1989
    ..These results imply that v-H-ras and v-raf synergize with deregulated myc expression to transform pre-B cells, while v-abl apparently does not...
  18. ncbi Immunoglobulin JH rearrangement in a T-cell line reflects fusion to the DH locus at a sequence lacking the nonamer recognition signal
    S Gerondakis
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Immunogenetics 28:255-9. 1988
    ..This result suggests that the heptamer may be the primary determinant of the specificity in V-gene assembly and that the DH locus as a whole may be preferred target for recombination...
  19. ncbi bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital Post Office, Victoria, Australia
    Cell 67:889-99. 1991
    ..These observations, together with previous findings on B cells, suggest that modulated bcl-2 expression is a determinant of life and death in normal lymphocytes...
  20. ncbi Subversion of the Bcl-2 life/death switch in cancer development and therapy
    J M Adams
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Cold Spring Harb Symp Quant Biol 70:469-77. 2005
    ..We find that, like Bad, ABT-737 kills cells efficiently only if Mcl-1 is absent or down-regulated. Thus, manipulation of apoptosis by targeting the Bcl-2 family has exciting potential for cancer treatment...
  21. ncbi Transformation of bone marrow cells from E mu-myc transgenic mice by Abelson murine leukemia virus and Harvey murine sarcoma virus
    D Dyall-Smith
    Ludwig Institute for Cancer Research, Victoria, Australia
    Oncogene Res 2:403-9. 1988
    ..Thus expression of a deregulated c-myc gene together with either v-Ha-ras or v-abl does not ensure fully autonomous growth of early B lymphoid cells...
  22. pmc The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4
    D C Huang
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    EMBO J 17:1029-39. 1998
    ..These results favour the hypothesis that the BH4 domain of pro-survival Bcl-2 family members allows them to sequester CED-4 relatives and thereby prevent apoptosis...
  23. pmc An E mu-v-abl transgene elicits plasmacytomas in concert with an activated myc gene
    H Rosenbaum
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    EMBO J 9:897-905. 1990
    ..Moreover, progeny of a cross with analogous E mu-myc mice rapidly developed oligoclonal plasmacytomas. Thus, the collusion of v-abl with c-myc is stage specific, efficiently transforming plasma cells but not pre-B cells or B cells...
  24. ncbi bcl-w, a novel member of the bcl-2 family, promotes cell survival
    L Gibson
    Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Oncogene 13:665-75. 1996
    ..These findings suggest that bcl-w participates in the control of apoptosis in multiple cell types. Its functional similarity to bcl-2 also makes it an attractive candidate proto-oncogene...
  25. pmc Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant
    C G Print
    The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 95:12424-31. 1998
    ..The bcl-w-/- mouse provides a unique model of failed spermatogenesis in the adult that may be relevant to some cases of human male sterility...
  26. ncbi Regulation of lymphocyte survival by the bcl-2 gene family
    S Cory
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Annu Rev Immunol 13:513-43. 1995
    ..Expression in tumors of bcl-2 and other cell survival genes may constitute a major barrier to the success of genotoxic cancer therapy...
  27. pmc The Bcl-2 apoptotic switch in cancer development and therapy
    J M Adams
    Department of Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Oncogene 26:1324-37. 2007
    ..Better understanding of the Bcl-2 family is clarifying its role in cancer development, revealing how conventional therapy works and stimulating the search for "BH3 mimetics" as a novel class of anticancer drugs...
  28. pmc Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 88:8661-5. 1991
    ..Thus E mu-bcl-2-22 mice constitute a transgenic model for a systemic autoimmune disease resembling the human disorder systemic lupus erythematosus...
  29. ncbi The role of bim, a proapoptotic BH3-only member of the Bcl-2 family in cell-death control
    A Strasser
    Walter and Eliza Hall Institute, Post Office Royal Melbourne Hospital, 3050 Vic, Melbourne, Australia
    Ann N Y Acad Sci 917:541-8. 2000
    ..Unleashed BH3-only proteins neutralize the prosurvival function of Bcl-2-like molecules, and this is thought to liberate Apaf-l-like adapters to activate caspase zymogens, which then initiate cell degradation...
  30. ncbi Apoptosomes: engines for caspase activation
    Jerry M Adams
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, 3050, Victoria, Australia
    Curr Opin Cell Biol 14:715-20. 2002
    ..CED-4 is essential for apoptosis in the worm and Dark for many apoptotic responses in the fly, but the Apaf-1/caspase-9 system probably amplifies rather than initiates the mammalian caspase cascade...
  31. pmc In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas
    Kylie D Mason
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 105:17961-6. 2008
    ..Our data suggest that antagonism of Bcl-2 with small organic compounds is an attractive approach to enhance the efficacy of conventional therapy for the treatment of Myc-driven lymphomas that over-express this prosurvival molecule...
  32. pmc Bcl-2-regulated apoptosis: mechanism and therapeutic potential
    Jerry M Adams
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne 3050 Australia
    Curr Opin Immunol 19:488-96. 2007
    ..The Bcl-2 family may also regulate autophagy and mitochondrial fission/fusion. Its pro-survival members are attractive therapeutic targets in cancer and perhaps autoimmunity and viral infections...
  33. pmc The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
    Mark F van Delft
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Cancer Cell 10:389-99. 2006
    ..Hence, ABT-737 should prove efficacious in tumors with low Mcl-1 levels, or when combined with agents that inactivate Mcl-1, even to treat those tumors that overexpress Bcl-2...
  34. pmc Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance
    Kirsteen J Campbell
    Molecular Genetics of CancerDivision, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Victoria, Australia
    Blood 116:3197-207. 2010
    ..Collectively, these results demonstrate that Mcl-1 overexpression renders hematopoietic cells refractory to many cytotoxic insults, perturbs lymphopoiesis and promotes malignant transformation of hematopoietic stem and progenitor cells...
  35. pmc Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice
    C J Vandenberg
    1 Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3052, Australia 2 Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3010, Australia
    Cell Death Differ 21:676-84. 2014
    ..However, in Rag1(-/-) BCL-2tg mice, platelet levels were normal, implying that elevated lymphocytes are primarily responsible for BCL-2tg-induced thrombocytopaenia. ..
  36. pmc Elevated Mcl-1 inhibits thymocyte apoptosis and alters thymic selection
    K J Campbell
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3052, Australia
    Cell Death Differ 19:1962-71. 2012
    ....
  37. pmc Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene
    A C Perkins
    Walter and Eliza Hall Institute of Medical Research, Australia
    EMBO J 12:3835-46. 1993
    ..Thus ectopic expression of Hox-2.4 enhances self-renewal of immature myeloid progenitors and progression to a fully malignant state is favoured by somatic mutations conferring autocrine production of IL-3...
  38. ncbi BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
    Philippe Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, P O The Royal Melbourne Hospital, Victoria 3050, Australia
    Nature 415:922-6. 2002
    ..TCR ligation upregulated Bim expression and promoted interaction of Bim with Bcl-XL, inhibiting its survival function. These findings identify Bim as an essential initiator of apoptosis in thymocyte-negative selection...
  39. pmc MYC levels govern hematopoietic tumor type and latency in transgenic mice
    Darrin P Smith
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Blood 108:653-61. 2006
    ..The implication is that MYC level affects the spontaneous acquisition of synergistic oncogenic mutations...
  40. ncbi VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia
    Alexander Egle
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Blood 103:2276-83. 2004
    ..We suggest that the increased survival capacity of B and T cells fosters prolonged germinal center reactions, and that autoreactivity and hypermutation conspire to generate follicular lymphoma...
  41. pmc Bim is a suppressor of Myc-induced mouse B cell leukemia
    Alexander Egle
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 101:6164-9. 2004
    ..Whereas the p19Arf/p53 pathway is frequently mutated in tumors arising in Bim(+/+) Emicro-Myc mice, it was unaffected in most Bim-deficient tumors, indicating that Bim reduction is an effective alternative to loss of p53 function...

Research Grants21

  1. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANSGENIC MICE
    Suzanne Cory; Fiscal Year: 2001
    ....
  2. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANSGENIC MICE
    Suzanne Cory; Fiscal Year: 2002
    ....
  3. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANSGENIC MICE
    Suzanne Cory; Fiscal Year: 2003
    ....
  4. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANSGENIC MICE
    Suzanne Cory; Fiscal Year: 2004
    ....
  5. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANGENIC MICE
    Suzanne Cory; Fiscal Year: 2005
    ..abstract_text> ..
  6. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANGENIC MICE
    Suzanne Cory; Fiscal Year: 2006
    ..abstract_text> ..
  7. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANGENIC MICE
    Suzanne Cory; Fiscal Year: 2007
    ..abstract_text> ..
  8. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANSGENIC MICE
    Suzanne Cory; Fiscal Year: 2000
    ....
  9. ONCOGENE-INDUCED LEUKEMOGENESIS IN TRANSGENIC MICE
    Suzanne Cory; Fiscal Year: 1993
    ..The results will be directly relevant to many human lymphomas and leukemias and have wide ramifications for malignancy in general...
  10. ONCOGENE-INDUCED LEUKEMOGENESIS IN TRANSGENIC MICE
    Suzanne Cory; Fiscal Year: 1992
    ..The results will be directly relevant to many human lymphomas and leukemias and have wide ramifications for malignancy in general...
  11. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANSGENIC MICE
    Suzanne Cory; Fiscal Year: 1999
    ....
  12. ONCOGENE-INDUCED LEUKEMOGENESIS IN TRANSGENIC MICE
    Suzanne Cory; Fiscal Year: 1991
    ..The results will be directly relevant to many human lymphomas and leukemias and have wide ramifications for malignancy in general...
  13. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANGENIC MICE
    Suzanne Cory; Fiscal Year: 2009
    ..abstract_text> ..