S Cory

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. ncbi Suzanne Cory
    Carina Dennis
    Nat Med 8:203. 2002
  2. ncbi The Bcl2 family: regulators of the cellular life-or-death switch
    Suzanne Cory
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia
    Nat Rev Cancer 2:647-56. 2002
  3. ncbi The Bcl-2 family: roles in cell survival and oncogenesis
    Suzanne Cory
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Oncogene 22:8590-607. 2003
  4. ncbi Killing cancer cells by flipping the Bcl-2/Bax switch
    Suzanne Cory
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Cancer Cell 8:5-6. 2005
  5. ncbi Matters of life and death: programmed cell death at Cold Spring Harbor
    S Cory
    Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Biochim Biophys Acta 1377:R25-44. 1998
  6. ncbi Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members
    S P Holmgreen
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital Victoria 3050, Australia
    Cell Death Differ 6:525-32. 1999
  7. pmc Progenitor tumours from Emu-bcl-2-myc transgenic mice have lymphomyeloid differentiation potential and reveal developmental differences in cell survival
    A Strasser
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Melbourne, Australia 3050
    EMBO J 15:3823-34. 1996
  8. pmc Bim: a novel member of the Bcl-2 family that promotes apoptosis
    L O'Connor
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    EMBO J 17:384-95. 1998
  9. pmc Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    EMBO J 14:6136-47. 1995
  10. ncbi Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria 3050, Melbourne, Australia
    Dev Cell 1:645-53. 2001

Research Grants

Collaborators

Detail Information

Publications40

  1. ncbi Suzanne Cory
    Carina Dennis
    Nat Med 8:203. 2002
  2. ncbi The Bcl2 family: regulators of the cellular life-or-death switch
    Suzanne Cory
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia
    Nat Rev Cancer 2:647-56. 2002
    ..Apoptosis is often impaired in cancer and can limit conventional therapy. A better understanding of how the Bcl2 family controls caspase activation should result in new, more effective therapeutic approaches...
  3. ncbi The Bcl-2 family: roles in cell survival and oncogenesis
    Suzanne Cory
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Oncogene 22:8590-607. 2003
    ..Finally, it discusses the promise of novel anticancer therapeutics that target these vital regulators...
  4. ncbi Killing cancer cells by flipping the Bcl-2/Bax switch
    Suzanne Cory
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Cancer Cell 8:5-6. 2005
    ..Hence, this work validates Bcl-2-like proteins as important new targets in cancer therapy...
  5. ncbi Matters of life and death: programmed cell death at Cold Spring Harbor
    S Cory
    Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Biochim Biophys Acta 1377:R25-44. 1998
  6. ncbi Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members
    S P Holmgreen
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital Victoria 3050, Australia
    Cell Death Differ 6:525-32. 1999
    ..The results may reflect critical threshold affinities but also suggest that certain pro-apoptotic proteins may also contribute to apoptosis by a mechanism independent of binding pro-survival proteins...
  7. pmc Progenitor tumours from Emu-bcl-2-myc transgenic mice have lymphomyeloid differentiation potential and reveal developmental differences in cell survival
    A Strasser
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Melbourne, Australia 3050
    EMBO J 15:3823-34. 1996
    ..These results provide insight into the process of lineage commitment and suggest new levels of control of cell survival during early steps in haemopoietic development...
  8. pmc Bim: a novel member of the Bcl-2 family that promotes apoptosis
    L O'Connor
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    EMBO J 17:384-95. 1998
    ..Hence, Bim appears to act as a 'death ligand' which can only neutralize certain members of the pro-survival Bcl-2 sub-family...
  9. pmc Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    EMBO J 14:6136-47. 1995
    ..These data raise the possibility that Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis...
  10. ncbi Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria 3050, Melbourne, Australia
    Dev Cell 1:645-53. 2001
    ..These results demonstrate that Bim levels set the threshold for initiation of apoptosis in several tissues and suggest that degenerative diseases might be alleviated by blocking BH3-only proteins...
  11. ncbi Bcl-2 expression promotes B- but not T-lymphoid development in scid mice
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Nature 368:457-60. 1994
    ....
  12. pmc Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 91:1376-80. 1994
    ..Thus, although bcl-2 expression hampers the deletion of immature self-reactive cells in the thymus, self-tolerance is maintained...
  13. ncbi Life-or-death decisions by the Bcl-2 protein family
    J M Adams
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, 3050, Melbourne, Australia
    Trends Biochem Sci 26:61-6. 2001
    ..Pro-apoptotic family members act as sentinels for cellular damage: cytotoxic signals induce their translocation to the organelles where they bind to their pro-survival relatives, promote organelle damage and trigger apoptosis...
  14. ncbi Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector
    J M Adams
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Oncogene 18:5268-77. 1999
    ..This novel vector should aid studies on many aspects of hematopoiesis, including the modeling of leukemogenesis...
  15. ncbi bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital Post Office, Victoria, Australia
    Cell 67:889-99. 1991
    ..These observations, together with previous findings on B cells, suggest that modulated bcl-2 expression is a determinant of life and death in normal lymphocytes...
  16. ncbi Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Nature 348:331-3. 1990
    ..Suprisingly, the tumours derive from a cell with the hallmarks of a primitive haemopoietic cell, perhaps a lymphoid-committed stem cell...
  17. ncbi Acceleration of B-lymphoid tumorigenesis in E mu-myc transgenic mice by v-H-ras and v-raf but not v-abl
    W Y Langdon
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Australia
    Oncogene Res 4:253-8. 1989
    ..These results imply that v-H-ras and v-raf synergize with deregulated myc expression to transform pre-B cells, while v-abl apparently does not...
  18. ncbi Insights from transgenic mice regarding the role of bcl-2 in normal and neoplastic lymphoid cells
    S Cory
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Philos Trans R Soc Lond B Biol Sci 345:289-95. 1994
    ..Crosses of the bcl-2 transgenic mice with p53-/- mice have addressed whether loss of p53 function and gain of bcl-2 function are synergistic for lymphoid cell survival...
  19. ncbi Immunoglobulin JH rearrangement in a T-cell line reflects fusion to the DH locus at a sequence lacking the nonamer recognition signal
    S Gerondakis
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Immunogenetics 28:255-9. 1988
    ..This result suggests that the heptamer may be the primary determinant of the specificity in V-gene assembly and that the DH locus as a whole may be preferred target for recombination...
  20. ncbi Transformation of bone marrow cells from E mu-myc transgenic mice by Abelson murine leukemia virus and Harvey murine sarcoma virus
    D Dyall-Smith
    Ludwig Institute for Cancer Research, Victoria, Australia
    Oncogene Res 2:403-9. 1988
    ..Thus expression of a deregulated c-myc gene together with either v-Ha-ras or v-abl does not ensure fully autonomous growth of early B lymphoid cells...
  21. ncbi bcl-w, a novel member of the bcl-2 family, promotes cell survival
    L Gibson
    Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Oncogene 13:665-75. 1996
    ..These findings suggest that bcl-w participates in the control of apoptosis in multiple cell types. Its functional similarity to bcl-2 also makes it an attractive candidate proto-oncogene...
  22. pmc An E mu-v-abl transgene elicits plasmacytomas in concert with an activated myc gene
    H Rosenbaum
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    EMBO J 9:897-905. 1990
    ..Moreover, progeny of a cross with analogous E mu-myc mice rapidly developed oligoclonal plasmacytomas. Thus, the collusion of v-abl with c-myc is stage specific, efficiently transforming plasma cells but not pre-B cells or B cells...
  23. ncbi Subversion of the Bcl-2 life/death switch in cancer development and therapy
    J M Adams
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Cold Spring Harb Symp Quant Biol 70:469-77. 2005
    ..We find that, like Bad, ABT-737 kills cells efficiently only if Mcl-1 is absent or down-regulated. Thus, manipulation of apoptosis by targeting the Bcl-2 family has exciting potential for cancer treatment...
  24. pmc The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4
    D C Huang
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    EMBO J 17:1029-39. 1998
    ..These results favour the hypothesis that the BH4 domain of pro-survival Bcl-2 family members allows them to sequester CED-4 relatives and thereby prevent apoptosis...
  25. pmc Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant
    C G Print
    The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 95:12424-31. 1998
    ..The bcl-w-/- mouse provides a unique model of failed spermatogenesis in the adult that may be relevant to some cases of human male sterility...
  26. pmc The Bcl-2 apoptotic switch in cancer development and therapy
    J M Adams
    Department of Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Oncogene 26:1324-37. 2007
    ..Better understanding of the Bcl-2 family is clarifying its role in cancer development, revealing how conventional therapy works and stimulating the search for "BH3 mimetics" as a novel class of anticancer drugs...
  27. ncbi Regulation of lymphocyte survival by the bcl-2 gene family
    S Cory
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Annu Rev Immunol 13:513-43. 1995
    ..Expression in tumors of bcl-2 and other cell survival genes may constitute a major barrier to the success of genotoxic cancer therapy...
  28. pmc Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 88:8661-5. 1991
    ..Thus E mu-bcl-2-22 mice constitute a transgenic model for a systemic autoimmune disease resembling the human disorder systemic lupus erythematosus...
  29. ncbi The role of bim, a proapoptotic BH3-only member of the Bcl-2 family in cell-death control
    A Strasser
    Walter and Eliza Hall Institute, Post Office Royal Melbourne Hospital, 3050 Vic, Melbourne, Australia
    Ann N Y Acad Sci 917:541-8. 2000
    ..Unleashed BH3-only proteins neutralize the prosurvival function of Bcl-2-like molecules, and this is thought to liberate Apaf-l-like adapters to activate caspase zymogens, which then initiate cell degradation...
  30. pmc The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
    Mark F van Delft
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Cancer Cell 10:389-99. 2006
    ..Hence, ABT-737 should prove efficacious in tumors with low Mcl-1 levels, or when combined with agents that inactivate Mcl-1, even to treat those tumors that overexpress Bcl-2...
  31. pmc Bcl-2-regulated apoptosis: mechanism and therapeutic potential
    Jerry M Adams
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne 3050 Australia
    Curr Opin Immunol 19:488-96. 2007
    ..The Bcl-2 family may also regulate autophagy and mitochondrial fission/fusion. Its pro-survival members are attractive therapeutic targets in cancer and perhaps autoimmunity and viral infections...
  32. pmc In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas
    Kylie D Mason
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 105:17961-6. 2008
    ..Our data suggest that antagonism of Bcl-2 with small organic compounds is an attractive approach to enhance the efficacy of conventional therapy for the treatment of Myc-driven lymphomas that over-express this prosurvival molecule...
  33. ncbi Apoptosomes: engines for caspase activation
    Jerry M Adams
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, 3050, Victoria, Australia
    Curr Opin Cell Biol 14:715-20. 2002
    ..CED-4 is essential for apoptosis in the worm and Dark for many apoptotic responses in the fly, but the Apaf-1/caspase-9 system probably amplifies rather than initiates the mammalian caspase cascade...
  34. pmc Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance
    Kirsteen J Campbell
    Molecular Genetics of CancerDivision, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Victoria, Australia
    Blood 116:3197-207. 2010
    ..Collectively, these results demonstrate that Mcl-1 overexpression renders hematopoietic cells refractory to many cytotoxic insults, perturbs lymphopoiesis and promotes malignant transformation of hematopoietic stem and progenitor cells...
  35. pmc Elevated Mcl-1 inhibits thymocyte apoptosis and alters thymic selection
    K J Campbell
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3052, Australia
    Cell Death Differ 19:1962-71. 2012
    ....
  36. pmc Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene
    A C Perkins
    Walter and Eliza Hall Institute of Medical Research, Australia
    EMBO J 12:3835-46. 1993
    ..Thus ectopic expression of Hox-2.4 enhances self-renewal of immature myeloid progenitors and progression to a fully malignant state is favoured by somatic mutations conferring autocrine production of IL-3...
  37. ncbi BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
    Philippe Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, P O The Royal Melbourne Hospital, Victoria 3050, Australia
    Nature 415:922-6. 2002
    ..TCR ligation upregulated Bim expression and promoted interaction of Bim with Bcl-XL, inhibiting its survival function. These findings identify Bim as an essential initiator of apoptosis in thymocyte-negative selection...
  38. pmc MYC levels govern hematopoietic tumor type and latency in transgenic mice
    Darrin P Smith
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Blood 108:653-61. 2006
    ..The implication is that MYC level affects the spontaneous acquisition of synergistic oncogenic mutations...
  39. pmc Bim is a suppressor of Myc-induced mouse B cell leukemia
    Alexander Egle
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 101:6164-9. 2004
    ..Whereas the p19Arf/p53 pathway is frequently mutated in tumors arising in Bim(+/+) Emicro-Myc mice, it was unaffected in most Bim-deficient tumors, indicating that Bim reduction is an effective alternative to loss of p53 function...
  40. ncbi VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia
    Alexander Egle
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Blood 103:2276-83. 2004
    ..We suggest that the increased survival capacity of B and T cells fosters prolonged germinal center reactions, and that autoreactivity and hypermutation conspire to generate follicular lymphoma...

Research Grants21

  1. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANSGENIC MICE
    Suzanne Cory; Fiscal Year: 2004
    ....
  2. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANGENIC MICE
    Suzanne Cory; Fiscal Year: 2007
    ..abstract_text> ..
  3. ONCOGENE-INDUCED LEUKEMOGENESIS IN TRANSGENIC MICE
    Suzanne Cory; Fiscal Year: 1993
    ..The results will be directly relevant to many human lymphomas and leukemias and have wide ramifications for malignancy in general...
  4. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANSGENIC MICE
    Suzanne Cory; Fiscal Year: 1999
    ....
  5. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANGENIC MICE
    Suzanne Cory; Fiscal Year: 2009
    ..abstract_text> ..