P M Colman

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint Neuraminidase inhibitors as antivirals
    P M Colman
    Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Melbourne, VIC 3050, Australia
    Vaccine 20:S55-8. 2002
  2. doi request reprint Early days in drug discovery by crystallography - personal recollections
    Peter M Colman
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Acta Crystallogr A 69:60-2. 2013
  3. ncbi request reprint The structural biology of type I viral membrane fusion
    Peter M Colman
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nat Rev Mol Cell Biol 4:309-19. 2003
  4. doi request reprint New antivirals and drug resistance
    Peter M Colman
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia 3050
    Annu Rev Biochem 78:95-118. 2009
  5. ncbi request reprint Zanamivir: an influenza virus neuraminidase inhibitor
    P M Colman
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050, Australia
    Expert Rev Anti Infect Ther 3:191-9. 2005
  6. pmc Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors
    J L McKimm-Breschkin
    Biomolecular Research Institute, Parkville, Australia
    J Virol 72:2456-62. 1998
  7. ncbi request reprint Mutation in the influenza virus neuraminidase gene resulting in decreased sensitivity to the neuraminidase inhibitor 4-guanidino-Neu5Ac2en leads to instability of the enzyme
    J L McKimm-Breschkin
    Biomolecular Research Institute, Parkville, Victoria, Australia
    Virology 225:240-2. 1996
  8. ncbi request reprint Substrate, inhibitor, or antibody stabilizes the Glu 119 Gly mutant influenza virus neuraminidase
    A Sahasrabudhe
    Biomolecular Research Institute, Parkville, Victoria, Australia
    Virology 247:14-21. 1998
  9. pmc Analysis of inhibitor binding in influenza virus neuraminidase
    B J Smith
    Biomolecular Research Institute, Parkville, Victoria 3052, Australia
    Protein Sci 10:689-96. 2001
  10. ncbi request reprint Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase
    J N Varghese
    Biomolecular Research Institute 343 Royal Parade, Parkville, 3052, Australia
    Structure 6:735-46. 1998

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Neuraminidase inhibitors as antivirals
    P M Colman
    Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Melbourne, VIC 3050, Australia
    Vaccine 20:S55-8. 2002
    ..Two compounds in late development (February 1999) have similar levels of potency against influenza A viruses, different routes of administration and, surprisingly, different resistance profiles both in vitro and in vivo...
  2. doi request reprint Early days in drug discovery by crystallography - personal recollections
    Peter M Colman
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Acta Crystallogr A 69:60-2. 2013
    ..The 1962 Nobel Prizes for the structures of DNA and proteins marked the golden anniversary of the von Laue and Bragg discoveries...
  3. ncbi request reprint The structural biology of type I viral membrane fusion
    Peter M Colman
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nat Rev Mol Cell Biol 4:309-19. 2003
    ..Here, we review our understanding of the structural transitions that are involved in this fusion pathway, compare it to our understanding of influenza virus membrane fusion, and discuss the implications for retroviral membrane fusion...
  4. doi request reprint New antivirals and drug resistance
    Peter M Colman
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia 3050
    Annu Rev Biochem 78:95-118. 2009
    ..However, other factors, such as entropy compensation and solvent anchoring, might also be exploited for improved drug design...
  5. ncbi request reprint Zanamivir: an influenza virus neuraminidase inhibitor
    P M Colman
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050, Australia
    Expert Rev Anti Infect Ther 3:191-9. 2005
    ..However, patient uptake of the inhaled drug has been insufficient to conclude that drug resistance will not be an issue in the future. All zanamivir-resistant variants selected in the laboratory so far have diminished viability...
  6. pmc Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors
    J L McKimm-Breschkin
    Biomolecular Research Institute, Parkville, Australia
    J Virol 72:2456-62. 1998
    ..Altered binding of the hydrophobic side chain at the 6 position or the triol group could account for the decreased binding of both the NA inhibitors and substrate...
  7. ncbi request reprint Mutation in the influenza virus neuraminidase gene resulting in decreased sensitivity to the neuraminidase inhibitor 4-guanidino-Neu5Ac2en leads to instability of the enzyme
    J L McKimm-Breschkin
    Biomolecular Research Institute, Parkville, Victoria, Australia
    Virology 225:240-2. 1996
    ....
  8. ncbi request reprint Substrate, inhibitor, or antibody stabilizes the Glu 119 Gly mutant influenza virus neuraminidase
    A Sahasrabudhe
    Biomolecular Research Institute, Parkville, Victoria, Australia
    Virology 247:14-21. 1998
    ..Furthermore the presence of high levels of substrate, either cell or virus associated, may be sufficient to stabilize the NA during virus replication...
  9. pmc Analysis of inhibitor binding in influenza virus neuraminidase
    B J Smith
    Biomolecular Research Institute, Parkville, Victoria 3052, Australia
    Protein Sci 10:689-96. 2001
    ....
  10. ncbi request reprint Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase
    J N Varghese
    Biomolecular Research Institute 343 Royal Parade, Parkville, 3052, Australia
    Structure 6:735-46. 1998
    ..This study seeks to clarify the structural and functional consequences of replacing the glycerol sidechain of the inhibitor with other chemical constituents...
  11. ncbi request reprint A novel approach to antiviral therapy for influenza
    P M Colman
    Biomolecular Research Institute, Parkville, Victoria, Australia
    J Antimicrob Chemother 44:17-22. 1999
    ..To deliver zanamivir directly to the lungs of patients the agent has been formulated for inhalation using a modified Diskhaler, which ensures high local concentrations and maximizes inhibition of viral neuraminidase...
  12. doi request reprint Bax activation by Bim?
    P E Czabotar
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Cell Death Differ 16:1187-91. 2009
    ..Here, we review these intriguing observations and discuss their implications for our understanding of how the BH3-only proteins initiate apoptosis...
  13. ncbi request reprint CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13
    W D Fairlie
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Cell Death Differ 13:426-34. 2006
    ..Surprisingly, the ability of worm BH3 domains to dissociate CED-4 was specific since mammalian BH3-only proteins could not do so...
  14. doi request reprint EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency
    E F Lee
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Cell Death Differ 15:1609-18. 2008
    ..These results demonstrate how levels of BH3-only proteins, target affinity and the spectrum of neutralization of pro-survival proteins all contribute to killing activity...
  15. ncbi request reprint Recombinant antineuraminidase single chain antibody: expression, characterization, and crystallization in complex with antigen
    R L Malby
    Biomolecular Research Institute, Parkville, Vic, Australia
    Proteins 16:57-63. 1993
    ..The complex between NA and the scFv has been crystallized by the vapor diffusion method. The crystals are tetragonal, space group P42(1)2, with unit cell dimensions a = b = 141 A, c = 218 A...
  16. ncbi request reprint Virus versus antibody
    P M Colman
    Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria 3052, Australia
    Structure 5:591-3. 1997
    ..The fundamental characteristics of proteins and their interactions with each other suggest that this may not be so much of a constraint at all...
  17. doi request reprint Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands
    M Kvansakul
    The Walter and Eliza Hall Institute of Medical Research, 1G Poyal Parade, Parkville, Victoria 3050, Australia
    Cell Death Differ 15:1564-71. 2008
    ....
  18. ncbi request reprint The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusion
    L Chen
    Biomolecular Research Institute, Parkville, Victoria 3052, Australia
    Structure 9:255-66. 2001
    ..The structure of NDV-F is fundamentally different than that of influenza virus hemagglutinin, in that the central coiled coil is in the opposite orientation with respect to the viral membrane...
  19. ncbi request reprint The three-dimensional structure of N-acetylneuraminate lyase from Escherichia coli
    T Izard
    Biomolecular Research Institute, Parkville, Australia
    Structure 2:361-9. 1994
    ..The enzyme plays an important role in the regulation of sialic acid metabolism in bacteria. The reverse reaction can be exploited for the synthesis of sialic acid and some of its derivatives...
  20. pmc Three-dimensional structures of two plant beta-glucan endohydrolases with distinct substrate specificities
    J N Varghese
    Biomolecular Research Institute, Parkville, Victoria, Australia
    Proc Natl Acad Sci U S A 91:2785-9. 1994
    ....
  21. ncbi request reprint Structural studies of the resistance of influenza virus neuramindase to inhibitors
    Brian J Smith
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Med Chem 45:2207-12. 2002
    ..A structural explanation of the mechanism of resistance of BCX-1812, relative to zanamivir and oseltamivir in particular, is provided...
  22. ncbi request reprint Modelling the structure of the fusion protein from human respiratory syncytial virus
    Brian J Smith
    Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria 3052, Australia
    Protein Eng 15:365-71. 2002
    ..The location of residues involved in point mutations in several drug-resistant variants is also examined...
  23. ncbi request reprint Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III
    Michael C Lawrence
    CSIRO Health Sciences and Nutrition, 343 Royal Parade, Parkville, VIC 3052, Australia
    J Mol Biol 335:1343-57. 2004
    ..However, in contrast to the NDV structures, we observe no ligand-induced structural changes that extend beyond the active site and modify the dimer interface...
  24. pmc A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation
    Erinna F Lee
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Cell Biol 180:341-55. 2008
    ..Our data have important implications for the discovery of compounds that might kill cells whose survival depends on Mcl-1...
  25. ncbi request reprint Structure of Leishmania mexicana phosphomannomutase highlights similarities with human isoforms
    Lukasz Kedzierski
    Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    J Mol Biol 363:215-27. 2006
    ..Similarities in the structure of the parasite enzyme and its human isoforms suggest that the development of parasite-selective inhibitors will not be an easy task...
  26. ncbi request reprint Tethered neuraminidase inhibitors that bind an influenza virus: a first step towards a diagnostic method for influenza
    Jennifer L McKimm-Breschkin
    Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria 3052, Australia
    Angew Chem Int Ed Engl 42:3118-21. 2003
  27. ncbi request reprint Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum
    Jacqueline F Satchell
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Acta Crystallogr D Biol Crystallogr 61:1213-21. 2005
    ....
  28. ncbi request reprint The trypanosomal trans-sialidase: two catalytic functions associated with one catalytic site
    Peter M Colman
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, Australia
    Structure 10:1466-8. 2002
    ..The structure of the trypanosomal trans-sialidase reveals a canonical sialidase catalytic site elaborated with a conformational switch that creates an adjacent binding pocket for lactose...