Research Topics
| Graeme ClarkSummaryAffiliation: The Bionic Ear Institute Country: Australia Publications
| Collaborators
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Detail Information
Publications
The multiple-channel cochlear implant: the interface between sound and the central nervous system for hearing, speech, and language in deaf people-a personal perspectiveGraeme M Clark
The Bionic Ear Institute 384 388 Albert Street, East Melbourne, VIC 3002, Australia
Philos Trans R Soc Lond B Biol Sci 361:791-810. 2006..Finally, the importance of the multiple-channel cochlear implant for early deafened children was established...- Threshold shift: effects of cochlear implantation on the risk of pneumococcal meningitisBenjamin P C Wei
Bionic Ear Institute, The University of Melbourne, Melbourne, Victoria, Australia
Otolaryngol Head Neck Surg 136:589-96. 2007..The study goals were to examine whether cochlear implantation increases the risk of meningitis in the absence of other risk factors and to understand the pathogenesis of pneumococcal meningitis post cochlear implantation... 
Assessment of the protective effect of pneumococcal vaccination in preventing meningitis after cochlear implantationBenjamin P C Wei
Bionic Ear Institute, Department of Otolaryngology, University of Melbourne, Royal Victorian Eye and Ear Hospital, 32 Gisbourne St, East Melbourne, Victoria 3002, Australia
Arch Otolaryngol Head Neck Surg 133:987-94. 2007..To examine if a 23-valent pneumococcal capsular polysaccharide vaccine (PPV23) reduces the risk of meningitis in healthy rats after cochlear implantation...
Can we prevent cochlear implant recipients from developing pneumococcal meningitis?Benjamin P C Wei
The Bionic Ear Institute, Melbourne East, Victoria, Australia
Clin Infect Dis 46:e1-7. 2008....- Cochlear implants in children: safety as well as speech and languageGraeme Clark
The University of Melbourne, The Bionic Ear Institute, 384 Albert Street, East Melbourne 3002, Australia
Int J Pediatr Otorhinolaryngol 67:S7-20. 2003..This demonstrated that deaf children with implants rely heavily on visual information and there is a great need to have unambiguous auditory stimuli to get best results... - Delivery of neurotrophin-3 to the cochlea using alginate beadsFarnoosh Noushi
University of Melbourne, Department of Otolaryngology, East Melbourne, Australia
Otol Neurotol 26:528-33. 2005..CONCLUSIONS: This study demonstrates alginate beads to be a safe, biodegradable and effective delivery system for NT-3 to the cochlea... - The effect of polypyrrole with incorporated neurotrophin-3 on the promotion of neurite outgrowth from auditory neuronsRachael T Richardson
The Bionic Ear Institute, 384 Albert Street, East Melbourne, VIC 3002, Australia
Biomaterials 28:513-23. 2007.... - The multi-channel cochlear implant and the relief of severe-to-profound deafnessGraeme Clark
Department of Otolaryngology, University of Melbourne, The Royal Victoria Eye and Ear Hospital, East Melbourne, Victoria, 3002, Australia
Cochlear Implants Int 13:69-85. 2012..In 1990, the US Food and Drug Administration approved the implant for deaf children, the first by any world health regulatory body making it the first major advance in helping deaf children to communicate... - A single dose of neurotrophin-3 to the cochlea surrounds spiral ganglion neurons and provides trophic supportRachael T Richardson
The Bionic Ear Institute, 384 388 Albert Street, East Melbourne, VIC 3002, Australia
Hear Res 204:37-47. 2005..The data suggest that only a small proportion of neurotrophins infused into the scala tympani diffuses to the SGNs and their processes and produces trophic effects on SGN cell bodies... - Tracing neurotrophin-3 diffusion and uptake in the guinea pig cochleaRachael T Richardson
The Bionic Ear Institute, 384 388 Albert Street, East Melbourne 3002, Australia
Hear Res 198:25-35. 2004..NT-3 microspheres remained in the cochlea for at least 28 days, suggesting a low clearance rate within cochlear tissues... - Resprouting and survival of guinea pig cochlear neurons in response to the administration of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3Andrew K Wise
The Bionic Ear Institute, East Melbourne 3002, Australia
J Comp Neurol 487:147-65. 2005..These findings have significant implications for an improvement in the performance of the cochlear implant and for future therapies to restore hearing to the deaf... - Ventral cochlear nucleus coding of voice onset time in naturally spoken syllablesJanine C Clarey
The Bionic Ear Institute, 384 388 Albert St, East Melbourne, VIC 3002, Australia
Hear Res 190:37-59. 2004.... - Protective effects of local administration of ciprofloxacin on the risk of pneumococcal meningitis after cochlear implantationBenjamin P C Wei
Department of Otolaryngology, Bionic Ear Institute, University of Melbourne, Royal Victorian Eye and Eye Hospiatl, Melbourne, Victoria, Australia
Laryngoscope 116:2138-44. 2006..pneumoniae... - Effects of inner ear trauma on the risk of pneumococcal meningitisBenjamin P C Wei
Bionic Ear Institute and Departments of Otolaryngology and Microbiology and Immunology, University of Melbourne, Melbourne, Australia
Arch Otolaryngol Head Neck Surg 133:250-9. 2007..To examine the risk of pneumococcal meningitis in healthy rats that received a severe surgical trauma to the modiolus and osseous spiral lamina or the standard insertion technique for acute cochlear implantation... - Meningitis after cochlear implantationBenjamin P C Wei
BMJ 335:1058. 2007 - Cognitive processing in children using cochlear implants: the relationship between visual memory, attention, and executive functions and developing language skillsVanessa N Surowiecki
Department of Otolaryngology, Bionic Ear Institute, Melbourne, Victoria, Australia
Ann Otol Rhinol Laryngol Suppl 189:119-26. 2002..The results suggested that differences in visual memory skills may account for some of the variance seen in the language abilities of children using implants and children using hearing aids... - Pneumococcal meningitis threshold model: A potential tool to assess infectious risk of new or existing inner ear surgical interventionsBenjamin P C Wei
Department of Otolaryngology, University of Melbourne, Melbourne, Victoria, Australia
Otol Neurotol 27:1152-61. 2006..A minimal threshold of Streptococcus pneumoniae is required to induce meningitis in healthy animals for intraperitoneal (hematogenous), middle ear, and inner ear inoculations, and this threshold may be altered via recent inner ear surgery... - Pneumococcal meningitis: development of a new animal modelBenjamin P C Wei
Bionic Ear Institute, Department of Otolaryngology, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
Otol Neurotol 27:844-54. 2006..The rat is a suitable animal to establish a model for the study of pneumococcal meningitis postcochlear implantation... - Speech perception outcomes in older children who use multichannel cochlear implants: older is not always poorerRichard C Dowell
Department of Otolaryngology, University of Melbourne, Royal Victorian Eye and Ear Hospital, Victoria, Australia
Ann Otol Rhinol Laryngol Suppl 189:97-101. 2002..The mean sentence score for this group, 47%, was not significantly different from the mean result across all children in the Melbourne program... - BDNF-induced survival of auditory neurons in vivo: Cessation of treatment leads to accelerated loss of survival effectsLisa N Gillespie
Department of Otolaryngology, The University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia
J Neurosci Res 71:785-90. 2003..These findings indicate that much work remains to be done to establish a technique for the long-term survival of auditory neurons in the deaf ear... - Balanced inhibition and excitation underlies spike firing regularity in ventral cochlear nucleus chopper neuronsAntonio G Paolini
School of Psychological Science, La Trobe University, Bundoora, Victoria 3086, Australia
Eur J Neurosci 21:1236-48. 2005.... - Netrin-1 as a guidance molecule in the postnatal rat cochleaLisa N Gillespie
Department of Otolaryngology, The University of Melbourne, Second Floor, Eye and Ear Hospital, East Melbourne, Victoria 3002, Australia
Hear Res 199:117-23. 2005..These results suggest that netrin-1 may be involved in guiding axonal growth from SGNs for the onset of innervation, but is not required for maintenance of synaptic connections... - Fast inhibition alters first spike timing in auditory brainstem neuronsAntonio G Paolini
School of Psychological Science, La Trobe Univ, Bundoora, Victoria 3086, Australia
J Neurophysiol 92:2615-21. 2004..These findings suggest that the traditional view of lateral inhibition within the VCN should incorporate delay as one of its principle outcomes... - Delayed neurotrophin treatment supports auditory neuron survival in deaf guinea pigsLisa N Gillespie
Department of Otolaryngology, The University of Melbourne, 2nd Floor, Eye and Ear Hospital, East Melbourne, Victoria, Australia 3002
Neuroreport 15:1121-5. 2004..Although delayed, the treatment with each neurotrophin prevented further degeneration with similar efficacy... - Summation of spatiotemporal input patterns in leaky integrate-and-fire neurons: application to neurons in the cochlear nucleus receiving converging auditory nerve fiber inputLevin Kuhlmann
Department of Otolaryngology, The University of Melbourne, Royal Victorian Eye and Ear Hospital, 32 Gisborne Street, East Melbourne, VIC 3002, Australia
J Comput Neurosci 12:55-73. 2002..It also shows under what conditions an enhancement of synchronization of the output relative to the input takes place...