Graeme Clark

Summary

Affiliation: The Bionic Ear Institute
Country: Australia

Publications

  1. pmc The multiple-channel cochlear implant: the interface between sound and the central nervous system for hearing, speech, and language in deaf people-a personal perspective
    Graeme M Clark
    The Bionic Ear Institute 384 388 Albert Street, East Melbourne, VIC 3002, Australia
    Philos Trans R Soc Lond B Biol Sci 361:791-810. 2006
  2. pmc Threshold shift: effects of cochlear implantation on the risk of pneumococcal meningitis
    Benjamin P C Wei
    Bionic Ear Institute, The University of Melbourne, Melbourne, Victoria, Australia
    Otolaryngol Head Neck Surg 136:589-96. 2007
  3. ncbi request reprint Assessment of the protective effect of pneumococcal vaccination in preventing meningitis after cochlear implantation
    Benjamin P C Wei
    Bionic Ear Institute, Department of Otolaryngology, University of Melbourne, Royal Victorian Eye and Ear Hospital, 32 Gisbourne St, East Melbourne, Victoria 3002, Australia
    Arch Otolaryngol Head Neck Surg 133:987-94. 2007
  4. doi request reprint Can we prevent cochlear implant recipients from developing pneumococcal meningitis?
    Benjamin P C Wei
    The Bionic Ear Institute, Melbourne East, Victoria, Australia
    Clin Infect Dis 46:e1-7. 2008
  5. ncbi request reprint Cochlear implants in children: safety as well as speech and language
    Graeme Clark
    The University of Melbourne, The Bionic Ear Institute, 384 Albert Street, East Melbourne 3002, Australia
    Int J Pediatr Otorhinolaryngol 67:S7-20. 2003
  6. ncbi request reprint Delivery of neurotrophin-3 to the cochlea using alginate beads
    Farnoosh Noushi
    University of Melbourne, Department of Otolaryngology, East Melbourne, Australia
    Otol Neurotol 26:528-33. 2005
  7. ncbi request reprint The effect of polypyrrole with incorporated neurotrophin-3 on the promotion of neurite outgrowth from auditory neurons
    Rachael T Richardson
    The Bionic Ear Institute, 384 Albert Street, East Melbourne, VIC 3002, Australia
    Biomaterials 28:513-23. 2007
  8. doi request reprint The multi-channel cochlear implant and the relief of severe-to-profound deafness
    Graeme Clark
    Department of Otolaryngology, University of Melbourne, The Royal Victoria Eye and Ear Hospital, East Melbourne, Victoria, 3002, Australia
    Cochlear Implants Int 13:69-85. 2012
  9. ncbi request reprint A single dose of neurotrophin-3 to the cochlea surrounds spiral ganglion neurons and provides trophic support
    Rachael T Richardson
    The Bionic Ear Institute, 384 388 Albert Street, East Melbourne, VIC 3002, Australia
    Hear Res 204:37-47. 2005
  10. ncbi request reprint Tracing neurotrophin-3 diffusion and uptake in the guinea pig cochlea
    Rachael T Richardson
    The Bionic Ear Institute, 384 388 Albert Street, East Melbourne 3002, Australia
    Hear Res 198:25-35. 2004

Detail Information

Publications25

  1. pmc The multiple-channel cochlear implant: the interface between sound and the central nervous system for hearing, speech, and language in deaf people-a personal perspective
    Graeme M Clark
    The Bionic Ear Institute 384 388 Albert Street, East Melbourne, VIC 3002, Australia
    Philos Trans R Soc Lond B Biol Sci 361:791-810. 2006
    ..Finally, the importance of the multiple-channel cochlear implant for early deafened children was established...
  2. pmc Threshold shift: effects of cochlear implantation on the risk of pneumococcal meningitis
    Benjamin P C Wei
    Bionic Ear Institute, The University of Melbourne, Melbourne, Victoria, Australia
    Otolaryngol Head Neck Surg 136:589-96. 2007
    ..The study goals were to examine whether cochlear implantation increases the risk of meningitis in the absence of other risk factors and to understand the pathogenesis of pneumococcal meningitis post cochlear implantation...
  3. ncbi request reprint Assessment of the protective effect of pneumococcal vaccination in preventing meningitis after cochlear implantation
    Benjamin P C Wei
    Bionic Ear Institute, Department of Otolaryngology, University of Melbourne, Royal Victorian Eye and Ear Hospital, 32 Gisbourne St, East Melbourne, Victoria 3002, Australia
    Arch Otolaryngol Head Neck Surg 133:987-94. 2007
    ..To examine if a 23-valent pneumococcal capsular polysaccharide vaccine (PPV23) reduces the risk of meningitis in healthy rats after cochlear implantation...
  4. doi request reprint Can we prevent cochlear implant recipients from developing pneumococcal meningitis?
    Benjamin P C Wei
    The Bionic Ear Institute, Melbourne East, Victoria, Australia
    Clin Infect Dis 46:e1-7. 2008
    ....
  5. ncbi request reprint Cochlear implants in children: safety as well as speech and language
    Graeme Clark
    The University of Melbourne, The Bionic Ear Institute, 384 Albert Street, East Melbourne 3002, Australia
    Int J Pediatr Otorhinolaryngol 67:S7-20. 2003
    ..This demonstrated that deaf children with implants rely heavily on visual information and there is a great need to have unambiguous auditory stimuli to get best results...
  6. ncbi request reprint Delivery of neurotrophin-3 to the cochlea using alginate beads
    Farnoosh Noushi
    University of Melbourne, Department of Otolaryngology, East Melbourne, Australia
    Otol Neurotol 26:528-33. 2005
    ..The aim of this study was to design a novel cochlear neurotrophin (NT) delivery system for the rescue of auditory neurons after ototoxicity-induced deafening...
  7. ncbi request reprint The effect of polypyrrole with incorporated neurotrophin-3 on the promotion of neurite outgrowth from auditory neurons
    Rachael T Richardson
    The Bionic Ear Institute, 384 Albert Street, East Melbourne, VIC 3002, Australia
    Biomaterials 28:513-23. 2007
    ....
  8. doi request reprint The multi-channel cochlear implant and the relief of severe-to-profound deafness
    Graeme Clark
    Department of Otolaryngology, University of Melbourne, The Royal Victoria Eye and Ear Hospital, East Melbourne, Victoria, 3002, Australia
    Cochlear Implants Int 13:69-85. 2012
    ..In 1990, the US Food and Drug Administration approved the implant for deaf children, the first by any world health regulatory body making it the first major advance in helping deaf children to communicate...
  9. ncbi request reprint A single dose of neurotrophin-3 to the cochlea surrounds spiral ganglion neurons and provides trophic support
    Rachael T Richardson
    The Bionic Ear Institute, 384 388 Albert Street, East Melbourne, VIC 3002, Australia
    Hear Res 204:37-47. 2005
    ..The data suggest that only a small proportion of neurotrophins infused into the scala tympani diffuses to the SGNs and their processes and produces trophic effects on SGN cell bodies...
  10. ncbi request reprint Tracing neurotrophin-3 diffusion and uptake in the guinea pig cochlea
    Rachael T Richardson
    The Bionic Ear Institute, 384 388 Albert Street, East Melbourne 3002, Australia
    Hear Res 198:25-35. 2004
    ..NT-3 microspheres remained in the cochlea for at least 28 days, suggesting a low clearance rate within cochlear tissues...
  11. ncbi request reprint Resprouting and survival of guinea pig cochlear neurons in response to the administration of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3
    Andrew K Wise
    The Bionic Ear Institute, East Melbourne 3002, Australia
    J Comp Neurol 487:147-65. 2005
    ..These findings have significant implications for an improvement in the performance of the cochlear implant and for future therapies to restore hearing to the deaf...
  12. ncbi request reprint Ventral cochlear nucleus coding of voice onset time in naturally spoken syllables
    Janine C Clarey
    The Bionic Ear Institute, 384 388 Albert St, East Melbourne, VIC 3002, Australia
    Hear Res 190:37-59. 2004
    ....
  13. pmc Protective effects of local administration of ciprofloxacin on the risk of pneumococcal meningitis after cochlear implantation
    Benjamin P C Wei
    Department of Otolaryngology, Bionic Ear Institute, University of Melbourne, Royal Victorian Eye and Eye Hospiatl, Melbourne, Victoria, Australia
    Laryngoscope 116:2138-44. 2006
    ..pneumoniae...
  14. pmc Effects of inner ear trauma on the risk of pneumococcal meningitis
    Benjamin P C Wei
    Bionic Ear Institute and Departments of Otolaryngology and Microbiology and Immunology, University of Melbourne, Melbourne, Australia
    Arch Otolaryngol Head Neck Surg 133:250-9. 2007
    ..To examine the risk of pneumococcal meningitis in healthy rats that received a severe surgical trauma to the modiolus and osseous spiral lamina or the standard insertion technique for acute cochlear implantation...
  15. pmc Meningitis after cochlear implantation
    Benjamin P C Wei
    BMJ 335:1058. 2007
  16. ncbi request reprint Cognitive processing in children using cochlear implants: the relationship between visual memory, attention, and executive functions and developing language skills
    Vanessa N Surowiecki
    Department of Otolaryngology, Bionic Ear Institute, Melbourne, Victoria, Australia
    Ann Otol Rhinol Laryngol Suppl 189:119-26. 2002
    ..The results suggested that differences in visual memory skills may account for some of the variance seen in the language abilities of children using implants and children using hearing aids...
  17. pmc Pneumococcal meningitis threshold model: A potential tool to assess infectious risk of new or existing inner ear surgical interventions
    Benjamin P C Wei
    Department of Otolaryngology, University of Melbourne, Melbourne, Victoria, Australia
    Otol Neurotol 27:1152-61. 2006
    ..A minimal threshold of Streptococcus pneumoniae is required to induce meningitis in healthy animals for intraperitoneal (hematogenous), middle ear, and inner ear inoculations, and this threshold may be altered via recent inner ear surgery...
  18. pmc Pneumococcal meningitis: development of a new animal model
    Benjamin P C Wei
    Bionic Ear Institute, Department of Otolaryngology, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
    Otol Neurotol 27:844-54. 2006
    ..The rat is a suitable animal to establish a model for the study of pneumococcal meningitis postcochlear implantation...
  19. ncbi request reprint Speech perception outcomes in older children who use multichannel cochlear implants: older is not always poorer
    Richard C Dowell
    Department of Otolaryngology, University of Melbourne, Royal Victorian Eye and Ear Hospital, Victoria, Australia
    Ann Otol Rhinol Laryngol Suppl 189:97-101. 2002
    ..The mean sentence score for this group, 47%, was not significantly different from the mean result across all children in the Melbourne program...
  20. ncbi request reprint BDNF-induced survival of auditory neurons in vivo: Cessation of treatment leads to accelerated loss of survival effects
    Lisa N Gillespie
    Department of Otolaryngology, The University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia
    J Neurosci Res 71:785-90. 2003
    ..These findings indicate that much work remains to be done to establish a technique for the long-term survival of auditory neurons in the deaf ear...
  21. ncbi request reprint Balanced inhibition and excitation underlies spike firing regularity in ventral cochlear nucleus chopper neurons
    Antonio G Paolini
    School of Psychological Science, La Trobe University, Bundoora, Victoria 3086, Australia
    Eur J Neurosci 21:1236-48. 2005
    ....
  22. ncbi request reprint Netrin-1 as a guidance molecule in the postnatal rat cochlea
    Lisa N Gillespie
    Department of Otolaryngology, The University of Melbourne, Second Floor, Eye and Ear Hospital, East Melbourne, Victoria 3002, Australia
    Hear Res 199:117-23. 2005
    ..These results suggest that netrin-1 may be involved in guiding axonal growth from SGNs for the onset of innervation, but is not required for maintenance of synaptic connections...
  23. ncbi request reprint Fast inhibition alters first spike timing in auditory brainstem neurons
    Antonio G Paolini
    School of Psychological Science, La Trobe Univ, Bundoora, Victoria 3086, Australia
    J Neurophysiol 92:2615-21. 2004
    ..These findings suggest that the traditional view of lateral inhibition within the VCN should incorporate delay as one of its principle outcomes...
  24. ncbi request reprint Delayed neurotrophin treatment supports auditory neuron survival in deaf guinea pigs
    Lisa N Gillespie
    Department of Otolaryngology, The University of Melbourne, 2nd Floor, Eye and Ear Hospital, East Melbourne, Victoria, Australia 3002
    Neuroreport 15:1121-5. 2004
    ..Although delayed, the treatment with each neurotrophin prevented further degeneration with similar efficacy...
  25. ncbi request reprint Summation of spatiotemporal input patterns in leaky integrate-and-fire neurons: application to neurons in the cochlear nucleus receiving converging auditory nerve fiber input
    Levin Kuhlmann
    Department of Otolaryngology, The University of Melbourne, Royal Victorian Eye and Ear Hospital, 32 Gisborne Street, East Melbourne, VIC 3002, Australia
    J Comput Neurosci 12:55-73. 2002
    ..It also shows under what conditions an enhancement of synchronization of the output relative to the input takes place...