Nicholas A Buckley

Summary

Affiliation: The Canberra Hospital
Country: Australia

Publications

  1. pmc Overcoming apathy in research on organophosphate poisoning
    Nick A Buckley
    South Asian Clinical Toxicology Research Collaboration, Department of Clinical Pharmacology and Toxicology, Canberra Hospital, PO Box 11, Woden, ACT 2606, Australia
    BMJ 329:1231-3. 2004
  2. ncbi request reprint Changes in fatalities due to overdose of anxiolytic and sedative drugs in the UK (1983-1999)
    Nicholas A Buckley
    Australian National University Medical School, Canberra, Australian Capital Territory, Australia
    Drug Saf 27:135-41. 2004
  3. pmc The limited utility of electrocardiography variables used to predict arrhythmia in psychotropic drug overdose
    Nicholas A Buckley
    Department of Clinical Pharmacology, The Canberra Hospital, Australia
    Crit Care 7:R101-7. 2003
  4. ncbi request reprint 'Atypical' antidepressants in overdose: clinical considerations with respect to safety
    Nicholas A Buckley
    Department of Clinical Toxicology and Pharmacology, The Canberra Hospital, Woden, Australian Capital Territory, Australia
    Drug Saf 26:539-51. 2003
  5. pmc The need for translational research on antidotes for pesticide poisoning
    Nick A Buckley
    South Asian Clinical Toxicology Research Collaboration, Department of Clinical Medicine, University of Colombo, Colombo
    Clin Exp Pharmacol Physiol 32:999-1005. 2005
  6. pmc Does restricting pack size of paracetamol (acetaminophen) reduce suicides?
    Nicholas A Buckley
    Department of Clinical Pharmacology and Toxicology, Australian National University Medical School, Canberra, Australian Capital Territory, Australia
    PLoS Med 4:e152. 2007
  7. pmc Fatal toxicity of serotoninergic and other antidepressant drugs: analysis of United Kingdom mortality data
    Nicholas A Buckley
    Department of Clinical Pharmacology and Toxicology, Canberra Hospital, PO Box 11, Woden, ACT 2606, Australia
    BMJ 325:1332-3. 2002
  8. ncbi request reprint Diagnostic data in clinical toxicology--should we use a Bayesian approach?
    Nicholas A Buckley
    Clinical Pharmacology and Toxicology, The Canberra Hospital, Woden, Australian Capital Territory, Australia
    J Toxicol Clin Toxicol 40:213-22. 2002
  9. doi request reprint Evaluation of the Test-mate ChE (cholinesterase) field kit in acute organophosphorus poisoning
    Bishan N Rajapakse
    South Asian Clinical Toxicology Research Collaboration, Peradeniya, Sri Lanka
    Ann Emerg Med 58:559-564.e6. 2011
  10. ncbi request reprint Of consents and CONSORTs: reporting ethics, law, and human rights in RCTs involving monitored overdose of healthy volunteers pre and post the "CONSORT" guidelines
    Thomas A Faunce
    Faculty of Medicine, Australian National University, Canberra, Australia
    J Toxicol Clin Toxicol 41:93-9. 2003

Detail Information

Publications31

  1. pmc Overcoming apathy in research on organophosphate poisoning
    Nick A Buckley
    South Asian Clinical Toxicology Research Collaboration, Department of Clinical Pharmacology and Toxicology, Canberra Hospital, PO Box 11, Woden, ACT 2606, Australia
    BMJ 329:1231-3. 2004
  2. ncbi request reprint Changes in fatalities due to overdose of anxiolytic and sedative drugs in the UK (1983-1999)
    Nicholas A Buckley
    Australian National University Medical School, Canberra, Australian Capital Territory, Australia
    Drug Saf 27:135-41. 2004
    ..To establish the frequency with which anxiolytic and sedative drugs result in fatal poisonings and to examine longitudinal changes in poisoning deaths...
  3. pmc The limited utility of electrocardiography variables used to predict arrhythmia in psychotropic drug overdose
    Nicholas A Buckley
    Department of Clinical Pharmacology, The Canberra Hospital, Australia
    Crit Care 7:R101-7. 2003
    ..The aim of the present study was to examine the relationship between serious arrhythmias in patients with psychotropic drug overdose and electrocardiography (ECG) findings that have been suggested previously to predict this complication...
  4. ncbi request reprint 'Atypical' antidepressants in overdose: clinical considerations with respect to safety
    Nicholas A Buckley
    Department of Clinical Toxicology and Pharmacology, The Canberra Hospital, Woden, Australian Capital Territory, Australia
    Drug Saf 26:539-51. 2003
    ..This tension is between respecting patient autonomy through frank communication of the material risk of overdose and non-disclosure to avoid such harm...
  5. pmc The need for translational research on antidotes for pesticide poisoning
    Nick A Buckley
    South Asian Clinical Toxicology Research Collaboration, Department of Clinical Medicine, University of Colombo, Colombo
    Clin Exp Pharmacol Physiol 32:999-1005. 2005
    ..4. The few effective treatments are not being recommended or delivered in an optimal and timely fashion to poisoned patients. A regional approach to facilitate appropriate pricing, packaging and delivery of antidotes is required...
  6. pmc Does restricting pack size of paracetamol (acetaminophen) reduce suicides?
    Nicholas A Buckley
    Department of Clinical Pharmacology and Toxicology, Australian National University Medical School, Canberra, Australian Capital Territory, Australia
    PLoS Med 4:e152. 2007
  7. pmc Fatal toxicity of serotoninergic and other antidepressant drugs: analysis of United Kingdom mortality data
    Nicholas A Buckley
    Department of Clinical Pharmacology and Toxicology, Canberra Hospital, PO Box 11, Woden, ACT 2606, Australia
    BMJ 325:1332-3. 2002
  8. ncbi request reprint Diagnostic data in clinical toxicology--should we use a Bayesian approach?
    Nicholas A Buckley
    Clinical Pharmacology and Toxicology, The Canberra Hospital, Woden, Australian Capital Territory, Australia
    J Toxicol Clin Toxicol 40:213-22. 2002
    ..The usefulness (i.e., external validity) of clinical research from other centers can also be determined...
  9. doi request reprint Evaluation of the Test-mate ChE (cholinesterase) field kit in acute organophosphorus poisoning
    Bishan N Rajapakse
    South Asian Clinical Toxicology Research Collaboration, Peradeniya, Sri Lanka
    Ann Emerg Med 58:559-564.e6. 2011
    ..We evaluate Test-mate against a reference laboratory test in patients with acute organophosphorus self-poisoning...
  10. ncbi request reprint Of consents and CONSORTs: reporting ethics, law, and human rights in RCTs involving monitored overdose of healthy volunteers pre and post the "CONSORT" guidelines
    Thomas A Faunce
    Faculty of Medicine, Australian National University, Canberra, Australia
    J Toxicol Clin Toxicol 41:93-9. 2003
    ..Reporting did not improve with the publication of CONSORT even in relation to requirements specifically included in the guidelines...
  11. ncbi request reprint Prolonged absorption and delayed peak paracetamol concentration following poisoning with extended-release formulation
    Darren M Roberts
    Medical School, Australian National University, Canberra, ACT, Australia
    Med J Aust 188:310-1. 2008
    ..Current treatment recommendations, based on experience with a different formulation in the United States, may not be appropriate for the Australian formulation...
  12. ncbi request reprint Should a lower treatment line be used when treating paracetamol poisoning in patients with chronic alcoholism?: a case for
    Nicholas A Buckley
    Department of Clinical Pharmacology and Toxicology, The Canberra Hospital, Woden, Australian Capital Territory, Australia
    Drug Saf 25:619-24. 2002
    ..In overdose, the potential benefits of treatment at this lower threshold clearly outweigh the minimal risks of acetylcysteine...
  13. ncbi request reprint Life-threatening interaction between complementary medicines: cyanide toxicity following ingestion of amygdalin and vitamin C
    Jonathan Bromley
    Department of Clinical Pharmacology and Toxicology, The Canberra Hospital, Garran, Australia
    Ann Pharmacother 39:1566-9. 2005
    ..To describe a case of severe accidental cyanide poisoning following a single ingestion of amygdalin with therapeutic intent...
  14. ncbi request reprint Hyperbaric oxygen for carbon monoxide poisoning : a systematic review and critical analysis of the evidence
    Nicholas A Buckley
    Department of Clinical Pharmacology and Toxicology, Australian National University Medical School, Canberra, Australian Capital Territory
    Toxicol Rev 24:75-92. 2005
    ..Such research should not exclude patients with severe poisoning, have a primary outcome that is clinically meaningful and have oversight from an independent data monitoring and ethics committee...
  15. ncbi request reprint Xmas (brand substitution not permitted)
    Jonathan Bromley
    Department of Clinical Pharmacology and Toxicology, Canberra Hospital, Canberra, ACT jonathan bromleyATact gov au
    Med J Aust 185:687. 2006
    ..To study drug prescribing by brand name versus generic name in an Australian teaching hospital...
  16. ncbi request reprint Serotonin syndrome induced by fluvoxamine and oxycodone
    Harindra Karunatilake
    The Canberra Hospital, Canberra, New South Wales, Australia
    Ann Pharmacother 40:155-7. 2006
    ..To report a case of severe serotonergic symptoms following the addition of oxycodone to fluvoxamine...
  17. ncbi request reprint A meta-analysis of prognostic indicators to predict seizures, arrhythmias or death after tricyclic antidepressant overdose
    Benoit Bailey
    Division of Emergency Medicine and Clinical Pharmacology, Department of Pediatrics, Hopital Ste Justine, Universite de Montreal, Montreal, Canada
    J Toxicol Clin Toxicol 42:877-88. 2004
    ..To systematically review and summarize studies on the accuracy of ECG and tricyclic antidepressant (TCA) concentration as prognostic indicators of the risk of seizures, ventricular arrhythmia (VA) or death in patients with TCA overdose...
  18. pmc The spectrum of intermediate syndrome following acute organophosphate poisoning: a prospective cohort study from Sri Lanka
    Pradeepa Jayawardane
    South Asian Clinical Toxicology Research Collaboration SACTRC, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    PLoS Med 5:e147. 2008
    ..The objective of this study was to determine repetitive nerve stimulation (RNS) predictors of IMS that would assist in patient management and clinical research...
  19. ncbi request reprint Guidelines for the management of paracetamol poisoning in Australia and New Zealand--explanation and elaboration. A consensus statement from clinical toxicologists consulting to the Australasian poisons information centres
    Frank F S Daly
    Emergency Medicine, Royal Perth Hospital, and University of Western Australia, Perth, WA, Australia
    Med J Aust 188:296-301. 2008
    ..This article summarises the rationale for the recommendations made in these new guidelines...
  20. ncbi request reprint Activated Charcoal RCT
    Gabrielle M Cooper
    Am J Ther 10:235-6. 2003
  21. ncbi request reprint Data collection in clinical toxicology: are there too many variables?
    Ian M Whyte
    Faculty of Medicine and Health Sciences, School of Population Health Sciences, University of Newcastle, New South Wales, Australia
    J Toxicol Clin Toxicol 40:223-30. 2002
    ..In the area of research, an appropriately designed database can be both a source of hypotheses as well as a vehicle to test them. It can also serve as a repository of research data in subsequent randomized controlled trials...
  22. pmc Improvement in survival after paraquat ingestion following introduction of a new formulation in Sri Lanka
    Martin F Wilks
    Syngenta Crop Protection AG, Basel, Switzerland
    PLoS Med 5:e49. 2008
    ..We compared the outcome of paraquat self-poisoning with the standard formulation against the new INTEON formulation following its introduction into Sri Lanka...
  23. ncbi request reprint Serotonin toxicity: a practical approach to diagnosis and treatment
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
    Med J Aust 187:361-5. 2007
    ..Treatment should focus on cessation of the serotonergic medication and supportive care. Some antiserotonergic agents have been used in clinical practice, but the preferred agent, dose and indications are not well defined...
  24. ncbi request reprint Activated charcoal decreases the risk of QT prolongation after citalopram overdose
    Geoffrey K Isbister
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Ann Emerg Med 50:593-600, 600.e1-46. 2007
    ..We determine whether single-dose activated charcoal (SDAC) administration after citalopram overdose reduces the proportion of patients developing abnormal QT prolongation...
  25. ncbi request reprint Paracetamol poisoning and the international normalized ratio
    Ian M Whyte
    Eur J Gastroenterol Hepatol 15:105; author reply 105-6. 2003
  26. ncbi request reprint Severe neurotoxicity following oral meperidine (pethidine) overdose
    Harindra Karunatilake
    Clin Toxicol (Phila) 45:200-1. 2007
  27. ncbi request reprint Effect of paracetamol poisoning on international normalised ratio
    Ian M Whyte
    Lancet 361:429; author reply 429-30. 2003
  28. ncbi request reprint Randomized controlled trial of topical aspirin in the treatment of bee and wasp stings
    Corrine R Balit
    NSW Poisons Information Centre, The Children s Hospital Westmead, Westmead, Australia
    J Toxicol Clin Toxicol 41:801-8. 2003
    ..Anecdotal evidence from calls suggested it was effective in reducing the swelling and duration of pain, but a literature search found no evidence to support this...
  29. pmc Where is the evidence for treatments used in pesticide poisoning? Is clinical toxicology fiddling while the developing world burns?
    Nicholas A Buckley
    J Toxicol Clin Toxicol 42:113-6. 2004
  30. pmc Clomipramine and neuroleptic malignant syndrome: literature on adverse reactions to psychotropic drugs continues to confuse
    Geoffrey K Isbister
    BMJ 330:790-1; author reply 791. 2005
  31. ncbi request reprint Reporting clinical research: an example of balancing a simple clinical message with data required to help future research
    Nicholas A Buckley
    Emerg Med Australas 17:102-3. 2005