Gabrielle Belz

Summary

Affiliation: Walter and Eliza Hall Institute of Medical Research
Location: Melbourne, Australia
URL: http://www.wehi.edu.au/faculty_members/dr_gabrielle_belz
Summary:
Molecular Immunology
Viral Immunology
T cell memory
lymphocyte differentiation
dendritic cells
antigen presentation
Publications:
1. The linear range for accurately quantifying antigen-specific T-cell frequencies by tetramer staining during natural immune responses.
Seah SG, Sutherland RM, La Gruta NL, Brown LE, Carrington EM, Belz GT, Brady JL, Turner SJ, Zhan Y, Lew AM.
Eur J Immunol. 2011 May;41(5):1499-500. doi: 10.1002/eji.. Epub 2011 Apr 11. No abstract available.
PMID: [PubMed - in process]
Related citations
2. Diverse roles of inhibitor of differentiation 2 in adaptive immunity.
Rankin L, Belz GT.
Clin Dev Immunol. 2011;2011:281569. Epub 2011 Mar 17.
PMID: [PubMed - in process] Free PMC Article
Free full text Related citations
3. Identification of the earliest NK cell precursor in the mouse bone marrow.
Carotta S, Pang SH, Nutt SL, Belz GT.
Blood. 2011 Mar 21. [Epub ahead of print]
PMID: [PubMed - as supplied by publisher]
Related citations
4. The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells.
Cretney E, Xin A, Shi W, Minnich M, Masson F, Miasari M, Belz GT, Smyth GK, Busslinger M, Nutt SL, Kallies A.
Nat Immunol. 2011 Apr;12(4):304-11. Epub 2011 Mar 6.
PMID: [PubMed - in process]
Related citations
5. Bid and Bim collaborate during induction of T cell death in persistent infection.
Masson F, Kupresanin F, Mount A, Strasser A, Belz GT.
J Immunol. 2011 Apr 1;186(7):4059-66. Epub 2011 Feb 21.
PMID: [PubMed - in process]
Related citations
6. Interference with dendritic cell populations limits early antigen presentation in chronic ?-herpesvirus-68 infection.
Mount AM, Masson F, Kupresanin F, Smith CM, May JS, van Rooijen N, Stevenson PG, Belz GT.
J Immunol. 2010 Sep 15;185(6):3669-76. Epub 2010 Aug 18.
PMID: [PubMed - indexed for MEDLINE]
Related citations
7. A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity.
Gartlan KH, Belz GT, Tarrant JM, Minigo G, Katsara M, Sheng KC, Sofi M, van Spriel AB, Apostolopoulos V, Plebanski M, Robb L, Wright MD.
J Immunol. 2010 Sep 15;185(6):3158-66. Epub 2010 Aug 13.
PMID: [PubMed - indexed for MEDLINE]
Related citations
8. Current Opinion in Immunology. Editorial overview.
Belz GT, Wherry EJ.
Curr Opin Immunol. 2010 Jun;22(3):271-3. Epub 2010 May 27. No abstract available.
PMID: [PubMed - indexed for MEDLINE]
Related citations
9. Effector and memory CD8+ T cell differentiation: toward a molecular understanding of fate determination.
Belz GT, Kallies A.
Curr Opin Immunol. 2010 Jun;22(3):279-85. Epub 2010 Apr 29. Review.
PMID: [PubMed - indexed for MEDLINE]
Related citations
10. Interleukin-2 tickles T cell memory.
Belz GT, Masson F.
Immunity. 2010 Jan 29;32(1):7-9. Review.
PMID: [PubMed - indexed for MEDLINE]
Related citations
11. Mobilizing forces--CD4+ helper T cells script adaptive immunity.
Masson F, Belz GT.
Cell Res. 2010 Jan;20(1):1-3. No abstract available.
PMID: [PubMed - indexed for MEDLINE]
Related citations
12. Direct ex vivo activation of T cells for analysis of dendritic cells antigen presentation.
Belz GT.
Methods Mol Biol. 2010;595:351-69.
PMID: [PubMed - indexed for MEDLINE]
Related citations
13. Mouse models of viral infection: influenza infection in the lung.
Mount AM, Belz GT.
Methods Mol Biol. 2010;595:299-318.
PMID: [PubMed - indexed for MEDLINE]
Related citations
14. Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.
O Reilly LA, Tai L, Lee L, Kruse EA, Grabow S, Fairlie WD, Haynes NM, Tarlinton DM, Zhang JG, Belz GT, Smyth MJ, Bouillet P, Robb L, Strasser A.
Nature. 2009 Oct 1;461(7264):659-63.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
15. Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses.
Kallies A, Xin A, Belz GT, Nutt SL.
Immunity. 2009 Aug 21;31(2):283-95. Epub 2009 Aug 6.
PMID: [PubMed - indexed for MEDLINE]
Related citations
16. Life in the balance: killer T-cell self-control fends off lethal influenza?
Belz GT.
Immunol Cell Biol. 2009 Jul;87(5):364-5. Epub 2009 Apr 14. No abstract available.
PMID: [PubMed - indexed for MEDLINE]
Related citations
17. Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance.
Parish IA, Waithman J, Davey GM, Belz GT, Mintern JD, Kurts C, Sutherland RM, Carbone FR, Heath WR.
Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3901-6. Epub 2009 Feb 20.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
18. Selected Toll-like receptor ligands and viruses promote helper-independent cytotoxic T cell priming by upregulating CD40L on dendritic cells.
Johnson S, Zhan Y, Sutherland RM, Mount AM, Bedoui S, Brady JL, Carrington EM, Brown LE, Belz GT, Heath WR, Lew AM.
Immunity. 2009 Feb 20;30(2):218-27. Epub 2009 Feb 5.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
19. The race between infection and immunity: how do pathogens set the pace?
Davenport MP, Belz GT, Ribeiro RM.
Trends Immunol. 2009 Feb;30(2):61-6. Epub 2009 Jan 8.
PMID: [PubMed - indexed for MEDLINE]
Related citations
20. Kinetics of major histocompatibility class I antigen presentation in acute infection.
Lay MD, Zhang L, Ribeiro RM, Mueller SN, Belz GT, Davenport MP.
J Immunol. 2009 Jan 15;182(2):902-11.
PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations
21. Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells.
Young LJ, Wilson NS, Schnorrer P, Proietto A, ten Broeke T, Matsuki Y, Mount AM, Belz GT, OKeeffe M, Ohmura-Hoshino M, Ishido S, Stoorvogel W, Heath WR, Shortman K, Villadangos JA.
Nat Immunol. 2008 Nov;9(11):1244-52. Epub 2008 Oct 12.
PMID: [PubMed - indexed for MEDLINE]
Related citations
22. Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8alpha+ dendritic cells.
Lundie RJ, de Koning-Ward TF, Davey GM, Nie CQ, Hansen DS, Lau LS, Mintern JD, Belz GT, Schofield L, Carbone FR, Villadangos JA, Crabb BS, Heath WR.
Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14509-14. Epub 2008 Sep 17.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
23. DC migration: hard-wired for T cell activation.
Belz GT.
Immunity. 2008 Sep 19;29(3):388-90.
PMID: [PubMed - indexed for MEDLINE]
Related citations
24. The Sir Mark Oliphant Conferences: international frontiers of science and technology.
Belz GT, De Groot A.
Hum Vaccin. 2008 Jul-Aug;4(4):260-1.
PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations
25. Getting together: dendritic cells, T cells, collaboration and fates.
Belz GT.
Immunol Cell Biol. 2008 May-Jun;86(4):310-1. No abstract available.
PMID: [PubMed - indexed for MEDLINE]
Related citations
26. Dendritic cells: driving the differentiation programme of T cells in viral infections.
Masson F, Mount AM, Wilson NS, Belz GT.
Immunol Cell Biol. 2008 May-Jun;86(4):333-42. Epub 2008 Mar 18. Review.
PMID: [PubMed - indexed for MEDLINE]
Related citations
27. Multiple dendritic cell populations activate CD4+ T cells after viral stimulation.
Mount AM, Smith CM, Kupresanin F, Stoermer K, Heath WR, Belz GT.
PLoS One. 2008 Feb 27;3(2):e1691.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
28. BH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection.
Fischer SF, Belz GT, Strasser A.
Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3035-40. Epub 2008 Feb 19.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
29. Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity.
Hughes PD, Belz GT, Fortner KA, Budd RC, Strasser A, Bouillet P.
Immunity. 2008 Feb;28(2):197-205.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
30. Blimp-1 connects the intrinsic and extrinsic regulation of T cell homeostasis.
Nutt SL, Kallies A, Belz GT.
J Clin Immunol. 2008 Mar;28(2):97-106. Epub 2007 Dec 11. Review.
PMID: [PubMed - indexed for MEDLINE]
Related citations
31. Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling.
Wilson NS, Young LJ, Kupresanin F, Naik SH, Vremec D, Heath WR, Akira S, Shortman K, Boyle J, Maraskovsky E, Belz GT, Villadangos JA.
Immunol Cell Biol. 2008 Feb;86(2):200-5. Epub 2007 Nov 20.
PMID: [PubMed - indexed for MEDLINE]
Related citations
32. Dendritic cells present lytic antigens and maintain function throughout persistent gamma-herpesvirus infection.
Kupresanin F, Chow J, Mount A, Smith CM, Stevenson PG, Belz GT.
J Immunol. 2007 Dec 1;179(11):7506-13.
PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations
33. Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens.
Young LJ, Wilson NS, Schnorrer P, Mount A, Lundie RJ, La Gruta NL, Crabb BS, Belz GT, Heath WR, Villadangos JA.
Proc Natl Acad Sci U S A. 2007 Nov 6;104(45):17753-8. Epub 2007 Oct 31.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
34. Skin-derived dendritic cells can mediate deletional tolerance of class I-restricted self-reactive T cells.
Waithman J, Allan RS, Kosaka H, Azukizawa H, Shortman K, Lutz MB, Heath WR, Carbone FR, Belz GT.
J Immunol. 2007 Oct 1;179(7):4535-41.
PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations
35. Minimal activation of memory CD8+ T cell by tissue-derived dendritic cells favors the stimulation of naive CD8+ T cells.
Belz GT, Bedoui S, Kupresanin F, Carbone FR, Heath WR.
Nat Immunol. 2007 Oct;8(10):1060-6. Epub 2007 Sep 2.
PMID: [PubMed - indexed for MEDLINE]
Related citations
36. A role for plasmacytoid dendritic cells in the rapid IL-18-dependent activation of NK cells following HSV-1 infection.
Barr DP, Belz GT, Reading PC, Wojtasiak M, Whitney PG, Heath WR, Carbone FR, Brooks AG.
Eur J Immunol. 2007 May;37(5):1334-42.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
37. Killer T cells regulate antigen presentation for early expansion of memory, but not naive, CD8+ T cell.
Belz GT, Zhang L, Lay MD, Kupresanin F, Davenport MP.
Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6341-6. Epub 2007 Mar 30.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
38. Shaping naive and memory CD8+ T cell responses in pathogen infections through antigen presentation.
Belz GT, Wilson NS, Kupresanin F, Mount AM, Smith CM.
Adv Exp Med Biol. 2007;590:31-42. Review. No abstract available.
PMID: [PubMed - indexed for MEDLINE]
Related citations
39. CD4+ T cells specific for a model latency-associated antigen fail to control a gammaherpesvirus in vivo.
Smith CM, Rosa GT, May JS, Bennett NJ, Mount AM, Belz GT, Stevenson PG.
Eur J Immunol. 2006 Dec;36(12):3186-97.
PMID: [PubMed - indexed for MEDLINE]
Related citations
40. The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture.
Schnorrer P, Behrens GM, Wilson NS, Pooley JL, Smith CM, El-Sukkari D, Davey G, Kupresanin F, Li M, Maraskovsky E, Belz GT, Carbone FR, Shortman K, Heath WR, Villadangos JA.
Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10729-34. Epub 2006 Jun 28.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
41. Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance.
Kallies A, Hawkins ED, Belz GT, Metcalf D, Hommel M, Corcoran LM, Hodgkin PD, Nutt SL.
Nat Immunol. 2006 May;7(5):466-74. Epub 2006 Mar 26.
PMID: [PubMed - indexed for MEDLINE]
Related citations
42. Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity.
Wilson NS, Behrens GM, Lundie RJ, Smith CM, Waithman J, Young L, Forehan SP, Mount A, Steptoe RJ, Shortman KD, de Koning-Ward TF, Belz GT, Carbone FR, Crabb BS, Heath WR, Villadangos JA.
Nat Immunol. 2006 Feb;7(2):165-72. Epub 2006 Jan 15.
PMID: [PubMed - indexed for MEDLINE]
Related citations
43. Bone marrow-derived cells expand memory CD8+ T cells in response to viral infections of the lung and skin.
Belz GT, Wilson NS, Smith CM, Mount AM, Carbone FR, Heath WR.
Eur J Immunol. 2006 Feb;36(2):327-35.
PMID: [PubMed - indexed for MEDLINE]
Related citations
44. CD8alpha+ dendritic cells selectively present MHC class I-restricted noncytolytic viral and intracellular bacterial antigens in vivo.
Belz GT, Shortman K, Bevan MJ, Heath WR.
J Immunol. 2005 Jul 1;175(1):196-200.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
45. Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity.
Carbone FR, Belz GT, Heath WR.
Trends Immunol. 2004 Dec;25(12):655-8. Review.
PMID: [PubMed - indexed for MEDLINE]
Related citations
46. Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice.
Pellegrini M, Bouillet P, Robati M, Belz GT, Davey GM, Strasser A.
J Exp Med. 2004 Nov 1;200(9):1189-95. Epub 2004 Oct 25.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
47. Cognate CD4(+) T cell licensing of dendritic cells in CD8(+) T cell immunity.
Smith CM, Wilson NS, Waithman J, Villadangos JA, Carbone FR, Heath WR, Belz GT.
Nat Immunol. 2004 Nov;5(11):1143-8. Epub 2004 Oct 10.
PMID: [PubMed - indexed for MEDLINE]
Related citations
48. Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens.
Heath WR, Belz GT, Behrens GM, Smith CM, Forehan SP, Parish IA, Davey GM, Wilson NS, Carbone FR, Villadangos JA.
Immunol Rev. 2004 Jun;199:9-26. Review.
PMID: [PubMed - indexed for MEDLINE]
Related citations
49. DCs as targets for vaccine design.
Belz G, Smith C, Bharadwaj M, Rice A, Jackson D.
Cytotherapy. 2004;6(2):88-98. Review.
PMID: [PubMed - indexed for MEDLINE]
Related citations
50. Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus.
Belz GT, Smith CM, Kleinert L, Reading P, Brooks A, Shortman K, Carbone FR, Heath WR.
Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8670-5. Epub 2004 May 26.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
51. Helper T cells, dendritic cells and CTL Immunity.
Behrens G, Li M, Smith CM, Belz GT, Mintern J, Carbone FR, Heath WR.
Immunol Cell Biol. 2004 Feb;82(1):84-90. Review.
PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations
52. Cutting edge: conventional CD8 alpha+ dendritic cells are generally involved in priming CTL immunity to viruses.
Belz GT, Smith CM, Eichner D, Shortman K, Karupiah G, Carbone FR, Heath WR.
J Immunol. 2004 Feb 15;172(4):1996-2000.
PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations
53. Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells.
Allan RS, Smith CM, Belz GT, van Lint AL, Wakim LM, Heath WR, Carbone FR.
Science. 2003 Sep 26;301(5641):1925-8.
PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations
54. Cross-presentation of antigens by dendritic cells.
Belz GT, Carbone FR, Heath WR.
Crit Rev Immunol. 2002;22(5-6):439-48. Review.
PMID: [PubMed - indexed for MEDLINE]
Related citations
55. Most lymphoid organ dendritic cell types are phenotypically and functionally immature.
Wilson NS, El-Sukkari D, Belz GT, Smith CM, Steptoe RJ, Heath WR, Shortman K, Villadangos JA.
Blood. 2003 Sep 15;102(6):2187-94. Epub 2003 Jun 5.
PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations
56. Cutting edge: conventional CD8 alpha+ dendritic cells are preferentially involved in CTL priming after footpad infection with herpes simplex virus-1.
Smith CM, Belz GT, Wilson NS, Villadangos JA, Shortman K, Carbone FR, Heath WR.
J Immunol. 2003 May 1;170(9):4437-40.
PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations
57. Absence of a functional defect in CD8+ T cells during primary murine gammaherpesvirus-68 infection of I-A(b-/-) mice.
Belz GT, Liu H, Andreansky S, Doherty PC, Stevenson PG.
J Gen Virol. 2003 Feb;84(Pt 2):337-41.
PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations
58. Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient mice.
Belz GT, Wodarz D, Diaz G, Nowak MA, Doherty PC.
J Virol. 2002 Dec;76(23):12388-93.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
59. The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens.
Belz GT, Behrens GM, Smith CM, Miller JF, Jones C, Lejon K, Fathman CG, Mueller SN, Shortman K, Carbone FR, Heath WR.
J Exp Med. 2002 Oct 21;196(8):1099-104.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
60. The role of dendritic cell subsets in selection between tolerance and immunity.
Belz GT, Heath WR, Carbone FR.
Immunol Cell Biol. 2002 Oct;80(5):463-8. Review.
PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations
61. CD36 is differentially expressed by CD8+ splenic dendritic cells but is not required for cross-presentation in vivo.
Belz GT, Vremec D, Febbraio M, Corcoran L, Shortman K, Carbone FR, Heath WR.
J Immunol. 2002 Jun 15;168(12):6066-70.
PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations
62. Cutting edge: precursor frequency affects the helper dependence of cytotoxic T cells.
Mintern JD, Davey GM, Belz GT, Carbone FR, Heath WR.
J Immunol. 2002 Feb 1;168(3):977-80.
PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations
63. The role of antigen in the localization of naive, acutely activated, and memory CD8(+) T cells to the lung during influenza pneumonia.
Topham DJ, Castrucci MR, Wingo FS, Belz GT, Doherty PC.
J Immunol. 2001 Dec 15;167(12):6983-90.
PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations
64. Viral neuraminidase treatment of dendritic cells enhances antigen-specific CD8(+) T cell proliferation, but does not account for the CD4(+) T cell independence of the CD8(+) T cell response during influenza virus infection.
Oh S, Belz GT, Eichelberger MC.
Virology. 2001 Aug 1;286(2):403-11.
PMID: [PubMed - indexed for MEDLINE]
Related citations
65. Perforin and Fas in murine gammaherpesvirus-specific CD8(+) T cell control and morbidity.
Topham DJ, Cardin RC, Christensen JP, Brooks JW, Belz GT, Doherty PC.
J Gen Virol. 2001 Aug;82(Pt 8):1971-81.
PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations
66. Measuring the diaspora for virus-specific CD8+ T cells.
Marshall DR, Turner SJ, Belz GT, Wingo S, Andreansky S, Sangster MY, Riberdy JM, Liu T, Tan M, Doherty PC.
Proc Natl Acad Sci U S A. 2001 May 22;98(11):6313-8. Epub 2001 May 8.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
67. Dissecting the host response to a gamma-herpesvirus.
Doherty PC, Christensen JP, Belz GT, Stevenson PG, Sangster MY.
Philos Trans R Soc Lond B Biol Sci. 2001 Apr 29;356(1408):581-93. Review.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
68. Virus-specific and bystander CD8+ T-cell proliferation in the acute and persistent phases of a gammaherpesvirus infection.
Belz GT, Doherty PC.
J Virol. 2001 May;75(9):4435-8.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
69. Diversity of epitope and cytokine profiles for primary and secondary influenza a virus-specific CD8+ T cell responses.
Belz GT, Xie W, Doherty PC.
J Immunol. 2001 Apr 1;166(7):4627-33. Erratum in: J Immunol 2001 Aug 1;167(3):1839.
PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations
70. Quantitative analysis of the CD8+ T-cell response to readily eliminated and persistent viruses.
Doherty PC, Riberdy JM, Belz GT.
Philos Trans R Soc Lond B Biol Sci. 2000 Aug 29;355(1400):1093-101. Review.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
71. Contemporary analysis of MHC-related immunodominance hierarchies in the CD8+ T cell response to influenza A viruses.
Belz GT, Stevenson PG, Doherty PC.
J Immunol. 2000 Sep 1;165(5):2404-9.
PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations
72. A previously unrecognized H-2D(b)-restricted peptide prominent in the primary influenza A virus-specific CD8(+) T-cell response is much less apparent following secondary challenge.
Belz GT, Xie W, Altman JD, Doherty PC.
J Virol. 2000 Apr;74(8):3486-93.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
73. Postexposure vaccination massively increases the prevalence of gamma-herpesvirus-specific CD8+ T cells but confers minimal survival advantage on CD4-deficient mice.
Belz GT, Stevenson PG, Castrucci MR, Altman JD, Doherty PC.
Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2725-30.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
74. A gamma-herpesvirus sneaks through a CD8(+) T cell response primed to a lytic-phase epitope.
Stevenson PG, Belz GT, Castrucci MR, Altman JD, Doherty PC.
Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9281-6.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
75. Changing patterns of dominance in the CD8+ T cell response during acute and persistent murine gamma-herpesvirus infection.
Stevenson PG, Belz GT, Altman JD, Doherty PC.
Eur J Immunol. 1999 Apr;29(4):1059-67.
PMID: [PubMed - indexed for MEDLINE]
Related citations
76. Virus-specific CD8(+) T cell numbers are maintained during gamma-herpesvirus reactivation in CD4-deficient mice.
Stevenson PG, Belz GT, Altman JD, Doherty PC.
Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15565-70.
PMID: 9861009 [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
77. Characteristics of virus-specific CD8(+) T cells in the liver during the control and resolution phases of influenza pneumonia.
Belz GT, Altman JD, Doherty PC.
Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13812-7.
PMID: 9811883 [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
78. Virus-specific CD8+ T cells in primary and secondary influenza pneumonia.
Flynn KJ, Belz GT, Altman JD, Ahmed R, Woodland DL, Doherty PC.
Immunity. 1998 Jun;8(6):683-91.
PMID: 9655482 [PubMed - indexed for MEDLINE]
Related citations
79. Intercellular and lymphatic pathways associated with tonsils of the soft palate in young pigs.
Belz GT.
Anat Embryol (Berl). 1998 Apr;197(4):331-40.
PMID: 9565326 [PubMed - indexed for MEDLINE]
Related citations
80. An unusual structure of venules in tonsils of the soft palate of young pigs.
Belz GT.
J Anat. 1998 Jan;192 ( Pt 1):131-5.
PMID: 9568568 [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
81. Tonsils of the soft palate of young pigs: crypt structure and lymphoepithelium.
Belz GT, Heath TJ.
Anat Rec. 1996 May;245(1):102-13.
PMID: 8731046 [PubMed - indexed for MEDLINE]
Related citations
82. Lymphatic drainage from the tonsil of the soft palate in pigs.
Belz GT, Heath TJ.
J Anat. 1995 Oct;187 ( Pt 2):491-5.
PMID: 7592012 [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
83. Pathways of blood flow to and through superficial lymph nodes in the dog.
Belz GT, Heath TJ.
J Anat. 1995 Oct;187 ( Pt 2):413-21.
PMID: 7592004 [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
84. Intercellular and lymphatic pathways of the canine palatine tonsils.
Belz GT, Heath TJ.
J Anat. 1995 Aug;187 ( Pt 1):93-105.
PMID: 7591989 [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
85. The epithelium of canine palatine tonsils.
Belz GT, Heath TJ.
Anat Embryol (Berl). 1995 Aug;192(2):189-94.
PMID: 7486015 [PubMed - indexed for MEDLINE]
Related citations
86. Lymph pathways of the medial retropharyngeal lymph node in dogs.
Belz GT, Heath TJ.
J Anat. 1995 Jun;186 ( Pt 3):517-26.
PMID: 7559125 [PubMed - indexed for MEDLINE] Free PMC Article
Free full text Related citations
87. An investigation of the use of chromium, platinum and gold coating for scanning electron microscopy of casts of lymphoid tissues.
Belz GT, Auchterlonie GJ.
Micron. 1995;26(2):141-4.
PMID: 7767633 [PubMed - indexed for MEDLINE]
Related citations

Publications

  1. ncbi Cross-presentation of antigens by dendritic cells
    Gabrielle T Belz
    Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Crit Rev Immunol 22:439-48. 2002
  2. ncbi Minimal activation of memory CD8+ T cell by tissue-derived dendritic cells favors the stimulation of naive CD8+ T cells
    Gabrielle T Belz
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Nat Immunol 8:1060-6. 2007
  3. doi Effector and memory CD8+ T cell differentiation: toward a molecular understanding of fate determination
    Gabrielle T Belz
    Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Curr Opin Immunol 22:279-85. 2010
  4. pmc Diverse roles of inhibitor of differentiation 2 in adaptive immunity
    Lucille Rankin
    Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic, Australia
    Clin Dev Immunol 2011:281569. 2011
  5. ncbi Skin-derived dendritic cells can mediate deletional tolerance of class I-restricted self-reactive T cells
    Jason Waithman
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
    J Immunol 179:4535-41. 2007
  6. pmc Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens
    Louise J Young
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 104:17753-8. 2007
  7. ncbi Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling
    Nicholas S Wilson
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 86:200-5. 2008
  8. ncbi Blimp-1 connects the intrinsic and extrinsic regulation of T cell homeostasis
    Stephen L Nutt
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3050, Australia
    J Clin Immunol 28:97-106. 2008
  9. pmc BH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection
    Silke F Fischer
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne VIC 3050, Australia
    Proc Natl Acad Sci U S A 105:3035-40. 2008
  10. pmc A role for plasmacytoid dendritic cells in the rapid IL-18-dependent activation of NK cells following HSV-1 infection
    Daniel P Barr
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Australia
    Eur J Immunol 37:1334-42. 2007

Detail Information

Publications75

  1. ncbi Cross-presentation of antigens by dendritic cells
    Gabrielle T Belz
    Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Crit Rev Immunol 22:439-48. 2002
    ....
  2. ncbi Minimal activation of memory CD8+ T cell by tissue-derived dendritic cells favors the stimulation of naive CD8+ T cells
    Gabrielle T Belz
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Nat Immunol 8:1060-6. 2007
    ....
  3. doi Effector and memory CD8+ T cell differentiation: toward a molecular understanding of fate determination
    Gabrielle T Belz
    Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Curr Opin Immunol 22:279-85. 2010
    ..This review focuses on the recent progress in our understanding of the molecular wiring of this differentiation process...
  4. pmc Diverse roles of inhibitor of differentiation 2 in adaptive immunity
    Lucille Rankin
    Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic, Australia
    Clin Dev Immunol 2011:281569. 2011
    ..Here, we review the current understanding of the role of Id2 in lymphopoiesis and in the development of the adaptive immune response required for maintaining immune homeostasis and immune protection...
  5. ncbi Skin-derived dendritic cells can mediate deletional tolerance of class I-restricted self-reactive T cells
    Jason Waithman
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
    J Immunol 179:4535-41. 2007
    ..Thus, self-Ag can be carried to the draining lymph nodes by skin-derived DCs and there presented by these same cells for tolerization of the circulating T cell pool...
  6. pmc Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens
    Louise J Young
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 104:17753-8. 2007
    ..These observations have important implications for the design of prophylactic and therapeutic DC vaccines and contribute to the understanding of the mechanisms causing immunosuppression during systemic blood infections...
  7. ncbi Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling
    Nicholas S Wilson
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 86:200-5. 2008
    ....
  8. ncbi Blimp-1 connects the intrinsic and extrinsic regulation of T cell homeostasis
    Stephen L Nutt
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3050, Australia
    J Clin Immunol 28:97-106. 2008
    ..Interestingly, Blimp-1 expression is controlled by the same cgammaC cytokines that regulate T cell homeostasis suggesting a direct link between the extrinsic and intrinsic arms of the process...
  9. pmc BH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection
    Silke F Fischer
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne VIC 3050, Australia
    Proc Natl Acad Sci U S A 105:3035-40. 2008
    ..Collectively, these findings show that Puma contributes to the death of antigen-specific T cells during shutdown of an immune response...
  10. pmc A role for plasmacytoid dendritic cells in the rapid IL-18-dependent activation of NK cells following HSV-1 infection
    Daniel P Barr
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Australia
    Eur J Immunol 37:1334-42. 2007
    ..These data identify IL-18 as a crucial factor for pDC-mediated NK cell regulation...
  11. pmc Killer T cells regulate antigen presentation for early expansion of memory, but not naive, CD8+ T cell
    Gabrielle T Belz
    Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 104:6341-6. 2007
    ..The ability of the memory T cells to remove antigen-presenting cells provides a negative-feedback loop to directly limit the duration of antigen presentation in vivo...
  12. ncbi Shaping naive and memory CD8+ T cell responses in pathogen infections through antigen presentation
    Gabrielle T Belz
    Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, 3050 Australia
    Adv Exp Med Biol 590:31-42. 2007
  13. ncbi CD4+ T cells specific for a model latency-associated antigen fail to control a gammaherpesvirus in vivo
    Christopher M Smith
    Division of Virology, Department of Pathology, University of Cambridge, Cambridge, UK
    Eur J Immunol 36:3186-97. 2006
    ..Latent antigen-specific CD4(+) T cells therefore either failed to recognize key virus-infected cell populations in vivo or lacked the effector functions required to control them...
  14. pmc The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture
    Petra Schnorrer
    Immunology Division and Cooperative Research Centre for Vaccine Technology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 103:10729-34. 2006
    ..This conclusion has important implications for the design of vaccination strategies based on antigen targeting to DC...
  15. ncbi Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity
    Nicholas S Wilson
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 7:165-72. 2006
    ..Moreover, inhibition of cross-presentation was overcome by injection of dendritic cells bearing antigen, which provides a new strategy for generating immunity during immunosuppressive blood infections...
  16. ncbi Bone marrow-derived cells expand memory CD8+ T cells in response to viral infections of the lung and skin
    Gabrielle T Belz
    Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Eur J Immunol 36:327-35. 2006
    ..As Langerhans cells are radioresistant, unlike other DC populations, these studies also demonstrate that the radiosensitive DC responsible for secondary expansion of HSV-specific memory are not Langerhans cells...
  17. pmc CD8alpha+ dendritic cells selectively present MHC class I-restricted noncytolytic viral and intracellular bacterial antigens in vivo
    Gabrielle T Belz
    Division of Immunology and Cooperative Research Centre for Vaccine Technology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    J Immunol 175:196-200. 2005
    ..We show that regardless of the type of intracellular infection, CD8alpha(+) DCs are the principal DC subset that initiate CD8(+) T cell immunity...
  18. doi Getting together: dendritic cells, T cells, collaboration and fates
    Gabrielle T Belz
    Immunol Cell Biol 86:310-1. 2008
  19. ncbi The Sir Mark Oliphant Conferences: international frontiers of science and technology
    Gabrielle T Belz
    Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Hum Vaccin 4:260-1. 2008
    ..The conference was funded by the Australian Department of Innovation, Industry, Science and Research...
  20. pmc Bid and Bim collaborate during induction of T cell death in persistent infection
    Frederick Masson
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia
    J Immunol 186:4059-66. 2011
    ..Thus, these data uncover a role for Bid in coordinating apoptotic signaling pathways to ensure appropriate shutdown of T cell immune responses in the setting of persistent Ag exposure...
  21. doi Interference with dendritic cell populations limits early antigen presentation in chronic γ-herpesvirus-68 infection
    Adele M Mount
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    J Immunol 185:3669-76. 2010
    ..These results show that a pathogen with the capacity to interfere with early Ag presentation can establish suboptimal conditions for rapid induction of the adaptive immune response and thus favor establishment of viral persistence...
  22. doi A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity
    Kate H Gartlan
    Department of Immunology, Monash University, Melbourne, Victoria, Australia
    J Immunol 185:3158-66. 2010
    ..Therefore, in the absence of both CD37 and Tssc6, immune function is further altered when compared with CD37(-/-) or Tssc6(-/-) mice, demonstrating a complementary role for these two molecules in cellular immunity...
  23. doi Interleukin-2 tickles T cell memory
    Gabrielle T Belz
    Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3052, Australia
    Immunity 32:7-9. 2010
    ..In this issue of Immunity, Pipkin et al. (2010) and Kalia et al. (2010) link differential interleukin-2 signaling and inflammation with the transcriptional events leading to the development of effector and memory cells...
  24. doi Direct ex vivo activation of T cells for analysis of dendritic cells antigen presentation
    Gabrielle T Belz
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Methods Mol Biol 595:351-69. 2010
    ..Understanding these interactions has begun to allow us to understand how integration of different populations in the DC network responds to multiple scenarios of infection...
  25. pmc Membrane-bound Fas ligand only is essential for Fas-induced apoptosis
    Lorraine A O' Reilly
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Nature 461:659-63. 2009
    ....
  26. doi Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses
    Axel Kallies
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Immunity 31:283-95. 2009
    ..This study identifies Blimp-1 as a master regulator of the terminal differentiation of CD8(+) effector T cells and uncovers a conservation of the pathways that regulate the terminal differentiation of T and B cells...
  27. ncbi Life in the balance: killer T-cell self-control fends off lethal influenza?
    Gabrielle T Belz
    Immunol Cell Biol 87:364-5. 2009
  28. pmc Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance
    Ian A Parish
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 106:3901-6. 2009
    ..These findings indicate that despite the capacity of CTLs to produce inflammatory cytokines and to cause tissue damage, their responses are not sustaining, but instead favor induction of self-tolerance...
  29. pmc Selected Toll-like receptor ligands and viruses promote helper-independent cytotoxic T cell priming by upregulating CD40L on dendritic cells
    Susan Johnson
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australiaia
    Immunity 30:218-27. 2009
    ..Thus, CD40L upregulation on DCs promoted optimal priming of CD8(+) T cells without CD4(+) T cells, providing a mechanism by which pathogens may elicit helper-independent CTL immunity...
  30. doi The race between infection and immunity: how do pathogens set the pace?
    Miles P Davenport
    Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales, Kensington NSW 2052, Australia
    Trends Immunol 30:61-6. 2009
    ..Understanding the 'rules of the race' for slow growing pathogens has important implications for vaccine design and immune control of many chronic infections...
  31. ncbi Kinetics of major histocompatibility class I antigen presentation in acute infection
    Matthew D H Lay
    Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales, Kensington, Australia
    J Immunol 182:902-11. 2009
    ..Understanding how such contrasting kinetics of Ag presentation impacts on the growth and size of developing protective T cell populations has important implications for the design of vaccines and immunotherapies...
  32. doi Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells
    Louise J Young
    The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Victoria 3050, Australia
    Nat Immunol 9:1244-52. 2008
    ..As the antigen-presenting abilities of cDCs and pDCs are fundamentally distinct, these two cell types may activate largely nonoverlapping repertoires of CD4(+) T cells...
  33. pmc Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8alpha+ dendritic cells
    Rachel J Lundie
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 105:14509-14. 2008
    ..Finally, using three different experimental approaches, we provide evidence that CTL specific for parasite-expressed antigens contribute to ECM...
  34. doi DC migration: hard-wired for T cell activation
    Gabrielle T Belz
    Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Immunity 29:388-90. 2008
    ..In this issue of Immunity, Aoshi et al. (2008) highlight the fact that the migratory route DCs take to drive T cell activation is independent of the architecture of lymphoid tissues...
  35. ncbi Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity
    Francis R Carbone
    The Department of Microbiology and Immunology, The University of Melbourne, Parkville 3010, Victoria, Australia
    Trends Immunol 25:655-8. 2004
    ..This Opinion describes this finding in the context of antigen transfer between migrating and lymphoid-resident DCs in cases of T-cell priming and tolerance induction...
  36. pmc Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice
    Marc Pellegrini
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Exp Med 200:1189-95. 2004
    ..This indicates that pharmacological inhibition of Bim function might be useful for boosting immune responses in immunodeficient patients...
  37. ncbi Cognate CD4(+) T cell licensing of dendritic cells in CD8(+) T cell immunity
    Christopher M Smith
    Division of Immunology, The Co operative Research Centre for Vaccine Technology at The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Nat Immunol 5:1143-8. 2004
    ..In situations in which DCs are poorly licensed by pathogen-derived signals, our findings suggest that CTL immunity may be heavily dependent on cognate DC licensing...
  38. pmc Measuring the diaspora for virus-specific CD8+ T cells
    D R Marshall
    Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 98:6313-8. 2001
    ..Any population of "resting" CD8(+) memory T cells is thus phenotypically heterogeneous, widely dispersed, and subject to broad homeostatic and local environmental effects irrespective of epitope specificity or magnitude...
  39. pmc Dissecting the host response to a gamma-herpesvirus
    P C Doherty
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Philos Trans R Soc Lond B Biol Sci 356:581-93. 2001
    ..Perhaps the main lesson learned to date is that all the components of immunity are likely to be important for the control of these complex viruses...
  40. pmc Virus-specific and bystander CD8+ T-cell proliferation in the acute and persistent phases of a gammaherpesvirus infection
    G T Belz
    Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 75:4435-8. 2001
    ..The overall conclusion is that turnover rates substantially in excess of 5 to 10% over 6 days for CD8+ "memory" T-cell populations are likely to be reflective of continued antigenic exposure...
  41. ncbi Diversity of epitope and cytokine profiles for primary and secondary influenza a virus-specific CD8+ T cell responses
    G T Belz
    Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
    J Immunol 166:4627-33. 2001
    ..The results for the K(b)PB1(703) epitope and the PB2(198) mimotope also provide a cautionary tale for those using the cytokine staining approach to identity antigenic peptides...
  42. ncbi Contemporary analysis of MHC-related immunodominance hierarchies in the CD8+ T cell response to influenza A viruses
    G T Belz
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 165:2404-9. 2000
    ....
  43. pmc A previously unrecognized H-2D(b)-restricted peptide prominent in the primary influenza A virus-specific CD8(+) T-cell response is much less apparent following secondary challenge
    G T Belz
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    J Virol 74:3486-93. 2000
    ..Previous CD8(+)-T-cell immunodominance heirarchies defined largely by cytotoxic T-lymphocyte assays may need to be revised...
  44. pmc Postexposure vaccination massively increases the prevalence of gamma-herpesvirus-specific CD8+ T cells but confers minimal survival advantage on CD4-deficient mice
    G T Belz
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 97:2725-30. 2000
    ..Even very high levels of virus-specific CD8(+) T cells thus provide only transient protection against the uniformly lethal consequences of gammaHV-68 infection under conditions of CD4(+) T cell deficiency...
  45. pmc A gamma-herpesvirus sneaks through a CD8(+) T cell response primed to a lytic-phase epitope
    P G Stevenson
    Department of Immunology, St Jude Children s Research Hospital, Memphis TN 38105, USA
    Proc Natl Acad Sci U S A 96:9281-6. 1999
    ....
  46. ncbi Changing patterns of dominance in the CD8+ T cell response during acute and persistent murine gamma-herpesvirus infection
    P G Stevenson
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Eur J Immunol 29:1059-67. 1999
    ..The CD8+ T cell population recognizing productively infected epithelial cells thus differed substantially from that responding during the IM illness...
  47. pmc Virus-specific CD8(+) T cell numbers are maintained during gamma-herpesvirus reactivation in CD4-deficient mice
    P G Stevenson
    The Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 95:15565-70. 1998
    ..It seems that CD8(+) T cells alone are insufficient to maintain long-term control of this persistent gamma-herpesvirus...
  48. pmc An unusual structure of venules in tonsils of the soft palate of young pigs
    G T Belz
    Department of Anatomical Sciences, University of Queensland, Australia
    J Anat 192:131-5. 1998
    ..In the tonsils of the soft palate of pigs, HEV may mediate both lymphocyte migration to and from the lymphoid tissue. Further investigation is required to determine the importance of these 2 migration pathways...
  49. ncbi Intercellular and lymphatic pathways associated with tonsils of the soft palate in young pigs
    G T Belz
    Department of Anatomical Sciences, The University of Queensland, Australia
    Anat Embryol (Berl) 197:331-40. 1998
    ..Septal, basal and efferent lymphatic vessels contain prominent valves and many lymphocytes. Lymphatic sinuses appear to be a significant pathway for lymphocytes migrating from the tonsillar lymphoid tissue...
  50. ncbi Tonsils of the soft palate of young pigs: crypt structure and lymphoepithelium
    G T Belz
    Department of Anatomical Sciences, University of Queensland, Brisbane, Australia
    Anat Rec 245:102-13. 1996
    ..The aim of this study was to describe the architecture of the tonsillar crypst and the morphology of their epithelial surface...
  51. pmc Lymphatic drainage from the tonsil of the soft palate in pigs
    G T Belz
    Department of Anatomical Sciences, University of Queensland, Australia
    J Anat 187:491-5. 1995
    ..As the vessels from the tonsils course over the surface of the pharynx, the muscular movements of swallowing may help propel lymph towards the primary nodes and the bloodstream...
  52. pmc Pathways of blood flow to and through superficial lymph nodes in the dog
    G T Belz
    Department of Anatomical Sciences, University of Queensland, Australia
    J Anat 187:413-21. 1995
    ..This contrasts with the commonly accepted description which implies that all blood vessels to all lymph nodes pass through a well defined hilus...
  53. pmc Intercellular and lymphatic pathways of the canine palatine tonsils
    G T Belz
    Department of Anatomical Sciences, University of Queensland, Australia
    J Anat 187:93-105. 1995
    ..Basal vessels course within the central lamina and converge to form efferent lymphatic vessels which emerge at the caudal region of the palatine tonsil and convey lymph to the medial retropharyngeal lymph node...
  54. pmc Lymph pathways of the medial retropharyngeal lymph node in dogs
    G T Belz
    Department of Anatomical Sciences, University of Queensland, Australia
    J Anat 186:517-26. 1995
    ..Efferent vessels emerge along the hilus and coalesce to form the tracheal trunk. The tracheal trunk has several layers of smooth muscle cells, well developed elastic laminae and connective tissue, surrounding the lymphatic endothelium...
  55. ncbi Perforin and Fas in murine gammaherpesvirus-specific CD8(+) T cell control and morbidity
    D J Topham
    Department of Immunology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38101, USA
    J Gen Virol 82:1971-81. 2001
    ..These studies demonstrate that some degree of cytotoxicity via either perforin or Fas is essential for CD8(+) T cells to control this DNA virus...
  56. ncbi The epithelium of canine palatine tonsils
    G T Belz
    Department of Anatomical Sciences, University of Queensland, Brisbane, Australia
    Anat Embryol (Berl) 192:189-94. 1995
    ..A fenestrated basement membrane allows cell transport between the intraepithelial passageways of the reticular epithelium and the subepithelial lymphoid tissues...
  57. ncbi Cutting edge: conventional CD8 alpha+ dendritic cells are generally involved in priming CTL immunity to viruses
    Gabrielle T Belz
    Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    J Immunol 172:1996-2000. 2004
    ..These data highlight the general role played by CD8alpha(+) DCs in CTL priming to viral infection and raises the possibility that this DC subset is specialized for viral immunity...
  58. ncbi Helper T cells, dendritic cells and CTL Immunity
    Georg Behrens
    Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 82:84-90. 2004
    ..CD4 T cells may only be capable of activating one dendritic cell during the period that CD8 T cells are primed. In this case, corecognition of this same dendritic cell would be essential...
  59. pmc Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus
    Gabrielle T Belz
    Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 101:8670-5. 2004
    ..Presentation by a nonairway-derived DC population argues that cytotoxic T lymphocyte priming may involve interplay between different DC subsets, not all of which originate within the site of infection...
  60. pmc The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens
    Gabrielle T Belz
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
    J Exp Med 196:1099-104. 2002
    ....
  61. ncbi DCs as targets for vaccine design
    Gt Belz
    Cooperative Research Centre for Vaccine Technology, Department of Microbiology and Immunology, The University of Melbourne, Victoria, Parkville, Australia
    Cytotherapy 6:88-98. 2004
    ..In this review, we identify some of the features and properties of DCs, and how these properties can be exploited in the design of smart vaccines...
  62. ncbi The role of dendritic cell subsets in selection between tolerance and immunity
    Gabrielle T Belz
    Immunology Divison, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 80:463-8. 2002
    ..Here we review recent experiments that provide insights into how DC subsets control the outcome of T cell activation and in so doing select between immunity and tolerance induction...
  63. ncbi CD36 is differentially expressed by CD8+ splenic dendritic cells but is not required for cross-presentation in vivo
    Gabrielle T Belz
    Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 168:6066-70. 2002
    ..In these models, CD36 knockout DCs were equivalent to wild-type DCs in their capacity to cross-present either foreign or self Ags, indicating that CD36 is not essential for cross-presentation of cellular Ags in vivo...
  64. ncbi Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens
    William R Heath
    Department of Immunology and The Cooperative Research Center for Vaccine Technology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Immunol Rev 199:9-26. 2004
    ..In this review, we examine the molecular basis for cross-presentation, discuss the role of DC subsets, and examine the contribution of this process to immunity, with some emphasis on DNA vaccination...
  65. ncbi Cutting edge: precursor frequency affects the helper dependence of cytotoxic T cells
    Justine D Mintern
    Immunology Division, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville 3050, Victoria, Australia
    J Immunol 168:977-80. 2002
    ..These findings suggest that when precursor frequencies are high, priming of CD8 T cell responses may not require CD4 T cell help...
  66. ncbi Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance
    Axel Kallies
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 7:466-74. 2006
    ..These data identify Blimp-1 as an essential regulator of T cell homeostasis and suggest that Blimp-1 regulates both B cell and T cell differentiation...
  67. pmc Multiple dendritic cell populations activate CD4+ T cells after viral stimulation
    Adele M Mount
    Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    PLoS ONE 3:e1691. 2008
    ..CD4(+) T cell priming by DC subsets that is dependent upon the route of administration raises the possibility that vaccination approaches could be tailored to prime helper T cell immunity...
  68. ncbi Most lymphoid organ dendritic cell types are phenotypically and functionally immature
    Nicholas S Wilson
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3050, Australia
    Blood 102:2187-94. 2003
    ..Therefore, the lymphoid organs contain a large cohort of immature DCs, most likely for the maintenance of peripheral tolerance, which can respond to infections reaching those organs and mature in situ...
  69. ncbi Cutting edge: conventional CD8 alpha+ dendritic cells are preferentially involved in CTL priming after footpad infection with herpes simplex virus-1
    Christopher M Smith
    Cooperative Research Center for Vaccine Technology, University of Melbourne, Victoria, Australia
    J Immunol 170:4437-40. 2003
    ..Given that such class I-restricted presentation is essential for CTL priming, this implies that these conventional CD8alpha(+) dendritic cells are the key subset involved in CTL immunity to this virus...
  70. doi Dendritic cells: driving the differentiation programme of T cells in viral infections
    Frederick Masson
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Immunol Cell Biol 86:333-42. 2008
    ..Further, we endeavour to examine how the molecular signals imparted by DCs coordinate to generate protective CD8(+) T-cell immunity...
  71. ncbi Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells
    Rhys S Allan
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Science 301:1925-8. 2003
    ..Thus, the traditional view of Langerhans cells in epidermal immunity needs to be revisited to accommodate a requirement for other dendritic cells in this response...
  72. pmc Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient mice
    Gabrielle T Belz
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 76:12388-93. 2002
    ..These findings are consistent with mathematical models that predict virus-host dynamics in this, and other, models of infection...
  73. ncbi Dendritic cells present lytic antigens and maintain function throughout persistent gamma-herpesvirus infection
    Fiona Kupresanin
    The Walter and Eliza Hall Institute of Medical, Melbourne, Victoria, Australia
    J Immunol 179:7506-13. 2007
    ..Our results support that, during persistent viral infection, continual presentation of lytic Ags by DC leads to T cell activation critical for maintaining CD8(+) T cells capable of limiting persistent viral infection...
  74. pmc Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity
    Peter D Hughes
    Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Immunity 28:197-205. 2008
    ..These results identify critical overlapping roles for Fas and Bim in T cell death in immune response shutdown and prevention of immunopathology and thereby resolve a long-standing controversy...
  75. ncbi Absence of a functional defect in CD8+ T cells during primary murine gammaherpesvirus-68 infection of I-A(b-/-) mice
    Gabrielle T Belz
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Gen Virol 84:337-41. 2003
    ..Thus CTL immunity was independent of CD4+ T cells in a chronic herpesvirus infection, but was still inadequate to control virus replication...