Warren S Alexander

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. ncbi request reprint Suckling defect in mice lacking the soluble haemopoietin receptor NR6
    W S Alexander
    The Walter and Eliza Hall Institute of Medical Research, The Cooperative Research Centre for Cellular Growth Factors, Post Office Royal Melbourne Hospital, Victoria, 3050, Australia
    Curr Biol 9:605-8. 1999
  2. ncbi request reprint Suppressors of cytokine signalling (SOCS) in the immune system
    Warren S Alexander
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Royal Melbourne Hospital, Victoria, Australia
    Nat Rev Immunol 2:410-6. 2002
  3. ncbi request reprint Thrombopoietin and the c-Mpl receptor: insights from gene targeting
    W S Alexander
    Walter and Eliza Hall Institute for Medical Research, Melbourne, Vic, Australia
    Int J Biochem Cell Biol 31:1027-35. 1999
  4. ncbi request reprint Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction
    W S Alexander
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Royal Melbourne Hospital, Victoria, Australia
    J Leukoc Biol 66:588-92. 1999
  5. ncbi request reprint Thrombopoietin
    W S Alexander
    Walter and Eliza Hall Institute for Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Growth Factors 17:13-24. 1999
  6. ncbi request reprint The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling
    Samuel Wormald
    Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medicial Research, Parkville, Victoria, Australia
    J Biol Chem 281:11135-43. 2006
  7. pmc Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation
    Ben A Croker
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Exp Hematol 36:786-98. 2008
  8. pmc Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice
    Maria Kauppi
    Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 112:3148-53. 2008
  9. pmc The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo
    Kristy Boyle
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 110:1466-74. 2007
  10. pmc Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage
    Elizabeth A Kruse
    Divisions of Molecular Medicine and Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Australia
    Proc Natl Acad Sci U S A 106:13814-9. 2009

Detail Information

Publications80

  1. ncbi request reprint Suckling defect in mice lacking the soluble haemopoietin receptor NR6
    W S Alexander
    The Walter and Eliza Hall Institute of Medical Research, The Cooperative Research Centre for Cellular Growth Factors, Post Office Royal Melbourne Hospital, Victoria, 3050, Australia
    Curr Biol 9:605-8. 1999
    ..In addition, NR6(-/-) mice had reduced numbers of haemopoietic progenitor cells, suggesting a potential role in the regulation of primitive haemopoiesis...
  2. ncbi request reprint Suppressors of cytokine signalling (SOCS) in the immune system
    Warren S Alexander
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Royal Melbourne Hospital, Victoria, Australia
    Nat Rev Immunol 2:410-6. 2002
    ..Evidence is emerging for the involvement of SOCS proteins in diseases of the human immune system, which raises the possibility that therapeutic strategies that are based on the manipulation of SOCS activity might be of clinical benefit...
  3. ncbi request reprint Thrombopoietin and the c-Mpl receptor: insights from gene targeting
    W S Alexander
    Walter and Eliza Hall Institute for Medical Research, Melbourne, Vic, Australia
    Int J Biochem Cell Biol 31:1027-35. 1999
    ....
  4. ncbi request reprint Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction
    W S Alexander
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Royal Melbourne Hospital, Victoria, Australia
    J Leukoc Biol 66:588-92. 1999
    ..We propose that the absence of SOCS-1 in these mice prevents lymphocytes and liver cells from appropriately controlling signals from cytokines with cytotoxic side effects...
  5. ncbi request reprint Thrombopoietin
    W S Alexander
    Walter and Eliza Hall Institute for Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Growth Factors 17:13-24. 1999
    ..It is likely that these molecules will lead to new therapeutics that will find utility in a range of clinical contexts...
  6. ncbi request reprint The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling
    Samuel Wormald
    Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medicial Research, Parkville, Victoria, Australia
    J Biol Chem 281:11135-43. 2006
    ..The kinetics with which SOCS proteins are induced by cytokine may therefore be a parameter that is "hard-wired" into specific cytokine signaling pathways as a means of tailoring the kinetics with which cells become desensitized...
  7. pmc Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation
    Ben A Croker
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Exp Hematol 36:786-98. 2008
    ..The tight regulation by Socs3 of signal transducer and activator of transcription 3 phosphorylation and gene transcription after cytokine receptor ligation significantly influences the fate of myeloid progenitor cells...
  8. pmc Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice
    Maria Kauppi
    Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 112:3148-53. 2008
    ....
  9. pmc The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo
    Kristy Boyle
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 110:1466-74. 2007
    ..Overall, the results establish a role for the SOCS box of SOCS3 in the in vivo regulation of G-CSF signaling and the response to inflammatory stimuli...
  10. pmc Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage
    Elizabeth A Kruse
    Divisions of Molecular Medicine and Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Australia
    Proc Natl Acad Sci U S A 106:13814-9. 2009
    ..These results illustrate an indispensable requirement for both Fli-1 and Erg in normal HSC and megakaryocyte homeostasis, and suggest these transcription factors may coregulate common target genes...
  11. pmc Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2
    Hiu Kiu
    Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3050, Australia
    Growth Factors 27:384-93. 2009
    ..Our results suggest that SOCS2 is not a physiological regulator of SOCS3 expression and action in primary haemopoietic cells...
  12. pmc Regulation of hematopoietic stem cells by their mature progeny
    Carolyn A de Graaf
    Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Proc Natl Acad Sci U S A 107:21689-94. 2010
    ..These studies suggest that disorders of platelet number can have profound effects on the HSC compartment via effects on the feedback regulation of circulating TPO concentration...
  13. ncbi request reprint SOCS3 negatively regulates IL-6 signaling in vivo
    Ben A Croker
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nat Immunol 4:540-5. 2003
    ..Our data indicate that SOCS3 and SOCS1 have reciprocal functions in IL-6 and IFN-gamma regulation and imply that SOCS3 has a role in preventing IFN-gamma-like responses in cells stimulated by IL-6...
  14. pmc SOCS2 negatively regulates growth hormone action in vitro and in vivo
    Christopher J Greenhalgh
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research WEHI and the Cooperative Centre for Cellular Growth Factors, Parkville, Victoria, Australia
    J Clin Invest 115:397-406. 2005
    ..Together, the data provide clear evidence that SOCS2 is a negative regulator of GH signaling...
  15. ncbi request reprint Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene
    Donald Metcalf
    Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Blood 105:3480-7. 2005
    ....
  16. ncbi request reprint Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells
    Ann L Cornish
    The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
    J Biol Chem 278:22755-61. 2003
    ..Hypersensitivity to gammac-dependent cytokines may contribute to abnormal T cell function, as well as the pathology observed in mice lacking SOCS-1...
  17. ncbi request reprint SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis
    Ben A Croker
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Parkville, Victoria 3050, Australia
    Immunity 20:153-65. 2004
    ..We conclude that SOCS3 is a key negative regulator of G-CSF signaling in myeloid cells and that this is of particular significance during G-CSF-driven emergency granulopoiesis...
  18. pmc Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia
    Catherine L Carmichael
    Cancer and Hematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Vic, Australia
    Proc Natl Acad Sci U S A 109:15437-42. 2012
    ..Thus, in mice, Erg overexpression induces the development of not only lymphoid leukemia but also erythro-megakaryocytic leukemia...
  19. doi request reprint The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells
    Stephen J Loughran
    Division of Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 9:810-9. 2008
    ..We show that Erg is required for definitive hematopoiesis, adult hematopoietic stem cell function and the maintenance of normal peripheral blood platelet numbers...
  20. doi request reprint Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome
    Ashley P Ng
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 115:3966-9. 2010
    ....
  21. pmc SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis
    Peter K K Wong
    Reid Rheumatology Laboratory, Division of Autoimmunity and Transplantation, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Clin Invest 116:1571-81. 2006
    ..These findings provide direct in vivo evidence that endogenous SOCS-3 is a critical negative regulator of multiple cell types orchestrating inflammatory joint disease...
  22. ncbi request reprint Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27
    Christine Brender
    Signal Transduction Laboratory, St Vincent s Institute, Fitzroy, Victoria, Australia
    Blood 110:2528-36. 2007
    ..We conclude that enhanced responses to TCR ligation by SOCS3-deficient CD8 T cells are not caused by aberrant TCR-signaling pathways but, rather, that increased IL-27 signaling drives unregulated proliferation in the absence of SOCS3...
  23. doi request reprint Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFalpha
    Hiu Kiu
    Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Growth Factors 25:319-28. 2007
    ..Finally, we have identified an additional, novel mechanism of crosstalk inhibition: a reduction in total cellular levels of gp130 following stimulation with LPS and TNFalpha...
  24. pmc SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential
    Gayle M Davey
    The Walter and Eliza Hall Institute of Medical Research, Parkville, 3050 Victoria, Australia
    J Exp Med 202:1099-108. 2005
    ..Therefore, impaired deletion of highly autoreactive CD8 T cells, together with uncontrolled activation of naive CD8 T cells by homeostatic survival ligands, may provide a basis for the T cell-mediated disease of SOCS-1-/- mice...
  25. pmc SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function
    Christine Brender
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Mol Cell Biol 24:6094-103. 2004
    ..Therefore, although SOCS5 is expressed in primary B and T cells, it appears to be dispensable for the regulation of lymphocyte function...
  26. ncbi request reprint Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation
    Mark M W Chong
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Immunity 18:475-87. 2003
    ..These phenotypes were found to correlate with hypersensitivity to the gamma-common family of cytokines...
  27. doi request reprint Hematopoietic defects in the Ts1Cje mouse model of Down syndrome
    Catherine L Carmichael
    Molecular Medicine, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 113:1929-37. 2009
    ..Thus, loss of Gata1 and partial trisomy of chromosome 21 orthologs, when combined, do not appear to be sufficient to induce TMD or AMKL-like phenotypes in mice...
  28. pmc A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia
    Ian J Majewski
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 103:14146-51. 2006
    ..Although the equivalent mutation to Gata-1Plt13 in humans results in production of GATA-1s, a short protein isoform initiated from a start codon downstream of the mutated initiation codon, Gata-1s was not detected in Gata-1Plt13/+ mice...
  29. pmc Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease
    Lorraine Robb
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 102:16333-8. 2005
    ....
  30. pmc Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity
    Ian J Majewski
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    PLoS Biol 6:e93. 2008
    ..These data suggest that PRC2 is required to maintain a specific gene expression pattern in hematopoiesis that is indispensable to normal stem cell function...
  31. pmc Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling
    Marina R Carpinelli
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville VIC 3052, Australia
    Proc Natl Acad Sci U S A 101:6553-8. 2004
    ....
  32. ncbi request reprint Persistence of lesions in suppressor of cytokine signaling-1-deficient mice infected with Leishmania major
    Denise V R Bullen
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Center for Cellular Growth Factors, Royal Melbourne Hospital, Victoria, Australia
    J Immunol 170:4267-72. 2003
    ..These results suggest that SOCS1 plays an important role in the regulation of appropriate inflammatory responses during the resolution of L. major infection...
  33. ncbi request reprint Suppressor of cytokine signaling-1 has IFN-gamma-independent actions in T cell homeostasis
    Ann L Cornish
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 170:878-86. 2003
    ..Thus, SOCS-1 is a critical regulator of T cell activation and homeostasis, and its influence extends beyond regulating IFN-gamma signaling...
  34. pmc The lethal effects of transplantation of Socs1-/- bone marrow cells into irradiated adult syngeneic recipients
    Donald Metcalf
    Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 100:8436-41. 2003
    ....
  35. pmc Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene
    Warren S Alexander
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 103:16442-7. 2006
    ..The disease in plt1/plt1 mice suggests that, in addition to immune-mediated effects, intrinsic C1Gal-T1 deficiency in megakaryocytes and the kidney may contribute to pathology...
  36. pmc Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development
    Kylie T Greig
    Division of Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    Mol Cell Biol 27:5849-59. 2007
    ....
  37. pmc IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3
    Ben A Croker
    Department of Inflammation, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 90:124-9. 2012
    ..We conclude that SOCS3 is required for survival during inflammatory responses and is a critical regulator of IL-6 in vivo...
  38. ncbi request reprint Absence of suppressor of cytokine signalling 3 reduces self-renewal and promotes differentiation in murine embryonic stem cells
    Ariel Forrai
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Stem Cells 24:604-14. 2006
    ..Its absence perturbs the balance between activation of the JAK-STAT and SHP-2-ERK-1/2-MAPK pathways, resulting in less self-renewal and a greater potential for differentiation into the primitive endoderm lineage...
  39. ncbi request reprint Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation
    Marlyse A Debrincat
    Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Biol Chem 282:4728-37. 2007
    ..The targeting of CKB for degradation by Asb-9 was primarily SOCS box-dependent and suggests that Asb-9 acts as a specific ubiquitin ligase regulating levels of this evolutionarily conserved enzyme...
  40. pmc Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potential
    Ashley P Ng
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Proc Natl Acad Sci U S A 109:2364-9. 2012
    ....
  41. pmc Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain
    Maria Kauppi
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia
    Proc Natl Acad Sci U S A 109:576-81. 2012
    ..The Plt12 mouse is a model of high O(2)-affinity hemoglobinopathy and provides insights into hematopoiesis under conditions of chronic hypoxia...
  42. doi request reprint A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency
    Anne M Verhagen
    Signal Transduction Laboratory, St Vincent s Institute, Fitzroy, Victoria, Australia
    J Immunol 182:2020-9. 2009
    ..Furthermore, our results provide evidence for an additional role for Lyn kinase, distinct from its catalytic activity, in regulating intracellular signaling pathways...
  43. pmc Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling
    Sandra E Nicholson
    The Walter and Eliza Hall Institute of Medical Research, Cooperative Research Centre for Cellular Growth Factors, Parkville, Victoria 3052, Australia
    Proc Natl Acad Sci U S A 102:2328-33. 2005
    ..This result suggests that the inhibition of signaling occurs through enhanced proteasomal degradation of the EGF-R through SOCS box recruitment of E3 ubiquitin ligase activity...
  44. ncbi request reprint A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor"
    Elena Tucker
    St Vincent s Institute, Fitzroy, Victoria, Australia
    J Immunol 179:7514-22. 2007
    ..These findings demonstrate a key role for NF-kappaB2 in the regulation of RelA activation and suggest overlap in the function of NF-kappaB members in canonical and noncanonical pathway signaling...
  45. pmc Development of hydrocephalus in mice lacking SOCS7
    Danielle L Krebs
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 101:15446-51. 2004
    ..In situ hybridization studies revealed prominent expression of Socs7 in the brain, suggestive of an important functional role of SOCS7 in this organ...
  46. pmc Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia
    Jian Zhong Tang
    The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia
    Proc Natl Acad Sci U S A 110:6091-6. 2013
    ....
  47. doi request reprint NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells
    Seth L Masters
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia
    Immunity 37:1009-23. 2012
    ..Conversely, NLRP1-deficient mice showed enhanced recovery from chemotherapy and LCMV infection, demonstrating that NLRP1 acts as a cellular sentinel to alert Caspase-1 to hematopoietic and infectious stress...
  48. pmc Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation
    Paul J Egan
    Reid Rheumatology Laboratory, Division of Autoimmunity and Transplantation, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Clin Invest 111:915-24. 2003
    ..SOCS-1 is therefore expressed in hematopoietic and nonhematopoietic cell types in vivo and is an important regulator of acute inflammatory arthritis and of CD4(+) T cell activation...
  49. ncbi request reprint Suppressors of cytokine signalling and regulation of growth hormone action
    Christopher J Greenhalgh
    Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Parkville, VIC 3050, Australia
    Growth Horm IGF Res 14:200-6. 2004
    ..A precise understanding of the actions of SOCS proteins in GH signalling may offer new opportunities for therapeutic intervention in growth disorders and other conditions involving GH action...
  50. pmc ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification
    Samir Taoudi
    Molecular Medicine Division, The Walter and Eliza Institute of Medical Research, Melbourne, Parkville, Victoria 3052, Australia
    Genes Dev 25:251-62. 2011
    ..We show that, from the fetal period, ERG acts as a direct upstream regulator of Gata2 and Runx1 gene activity. Without ERG, physiological HSC maintenance fails, leading to the rapid exhaustion of definitive hematopoiesis...
  51. pmc Clonogenic mast cell progenitors and their excess numbers in chimeric BALB/c mice with inactivated GATA-1
    Donald Metcalf
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Proc Natl Acad Sci U S A 104:18642-7. 2007
    ..No excess tissue mast cells were observed in GATA-1(Plt13/+) mice, suggesting that the excess mast cell progenitors in these mice might be generating mast cells with a defective in vivo proliferative or tissue homing capacity...
  52. doi request reprint Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor
    Nima Etemadi
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia Department of Medical Biology, University of Melbourne, Parkville, Australia
    FEBS J 280:5283-97. 2013
    ..Our results imply that the reasons for the conservation of LTα are most likely due either to differential regulation, the ability to signal through Herpes Virus Entry Mediator or the ability of LTα to form heterotrimers with LTβ...
  53. pmc c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3
    Kate D Sutherland
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    EMBO J 25:5805-15. 2006
    ..Our data establish Socs3 as a critical attenuator of pro-apoptotic pathways that act in the developing mammary gland and provide evidence that c-myc regulates apoptosis during involution...
  54. ncbi request reprint Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)
    Christopher J Greenhalgh
    The Cooperative Research Centre for Cellular Growth Factors and The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Mol Endocrinol 16:1394-406. 2002
    ..Furthermore, the deletion of SOCS-2 from mice also lacking signal transducer and activator of transcription 5b had little effect on growth, suggesting that the action of SOCS-2 may be the regulation of the GH signaling pathway...
  55. doi request reprint Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma
    Stanley C W Lee
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia and
    Blood 122:2654-63. 2013
    ..This finding provides new insight regarding the functional contribution of mutations in PRC2 in a range of leukemias. ..
  56. ncbi request reprint The SOCS box: a tale of destruction and degradation
    Benjamin T Kile
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Parkville, Victoria, Australia
    Trends Biochem Sci 27:235-41. 2002
    ..In this way, SOCS proteins regulate protein turnover by targeting proteins for polyubiquitination and, therefore, for proteasome-mediated degradation...
  57. pmc SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation
    Danielle L Krebs
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Royal Melbourne Hospital, Victoria 3050, Australia
    Mol Cell Biol 22:4567-78. 2002
    ..However, both male and female SOCS-6(-/-) mice weighed approximately 10% less than wild-type littermates...
  58. doi request reprint Epigenetic regulator Smchd1 functions as a tumor suppressor
    Huei San Leong
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Cancer Res 73:1591-9. 2013
    ..Together, our observations collectively highlight a hitherto uncharacterized role for SMCHD1 as a candidate tumor suppressor gene in hematopoietic cancers...
  59. ncbi request reprint Genetic heterogeneity of granulocytes for the JAK2 V617F mutation in essential thrombocythaemia: implications for mutation detection in peripheral blood
    William S Stevenson
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Pathology 38:336-42. 2006
    ....
  60. doi request reprint Mouse models of diseases of megakaryocyte and platelet homeostasis
    Catherine L Carmichael
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Mamm Genome 22:449-65. 2011
    ....
  61. ncbi request reprint Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling
    Christopher J Greenhalgh
    Walter and Eliza Hall Institute of Medical Research and the Cooperative Research for Cellular Growth Factors, PO Royal Melbourne Hospital, VIC 3050, Australia
    J Biol Chem 277:40181-4. 2002
    ..Together, the data implicate SOCS-2 as having dual effects on GH signaling in vivo...
  62. ncbi request reprint The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response
    Warren S Alexander
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Center for Cellular Growth Factors, Parkville, 3052 Victoria, Australia
    Annu Rev Immunol 22:503-29. 2004
    ....
  63. ncbi request reprint The lack of suppressor of cytokine signalling-1 (SOCS1) protects mice from the development of cerebral malaria caused by Plasmodium berghei ANKA
    Denise V R Bullen
    The Walter and Eliza Hall Institute of Medical Research and Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Victoria 3050, Australia
    Parasite Immunol 25:113-8. 2003
    ..Understanding the mechanism by which SOCS1 deficiency protects mice from cerebral malaria may allow the manipulation of its activity and alleviate pathology...
  64. pmc Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)
    Donald Metcalf
    The Walter and Eliza Hall Institute of Medical Research, and The Cooperative Research Centre for Cellular Growth Factors, Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 99:943-8. 2002
    ..The chronic infections and granulomas of SOCS-1(-/-) IFN-gamma(-/-) mice may be based on autoaggression of SOCS-1(-/-) T lymphoid and related cells or a functional deficiency of these cells when lacking SOCS-1...
  65. pmc An ethyl-nitrosourea-induced point mutation in phex causes exon skipping, x-linked hypophosphatemia, and rickets
    Marina R Carpinelli
    Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    Am J Pathol 161:1925-33. 2002
    ....
  66. ncbi request reprint Thrombopoietin bioassay
    Warren S Alexander
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hosital, Victoria, Australia
    Methods Mol Biol 272:347-59. 2004
  67. pmc Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
    Stefan P Glaser
    The Walter and Eliza Hall Institute, Parkville, Melbourne, Victoria 3052, Australia
    Genes Dev 26:120-5. 2012
    ..Thus, targeting of Mcl-1 or regulators of its expression may be a useful strategy for the treatment of AML...
  68. ncbi request reprint Tyrosine residues of the granulocyte colony-stimulating factor receptor transmit proliferation and differentiation signals in murine bone marrow cells
    Shiva Akbarzadeh
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Blood 99:879-87. 2002
    ..These observations have suggested novel roles for the G-CSF-R tyrosine residues in primary cells that were not observed previously in studies in cell lines...
  69. pmc Differential regulation of SOCS genes in normal and transformed erythroid cells
    Mohinder K Sarna
    Laboratory for Cancer Medicine, Western Australian Institute for Medical Research, Royal Perth Hospital and Centre for Medical Research, The University of Western Australia, Perth, Australia
    Oncogene 22:3221-30. 2003
    ..These observations indicate complex, stage-specific regulation of SOCS genes during normal erythroid maturation and in erythroleukemic cells...
  70. ncbi request reprint Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors
    Jennifer Antonchuk
    Cancer and Haematology Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Blood 104:1306-13. 2004
    ..Thus, c-Mpl(-/-) Kit(Wv/Wv) mice reveal nonredundant and synergistic effects of Tpo and SF on primitive hematopoietic cells...
  71. ncbi request reprint Thrombopoietin signalling in physiology and disease
    Brooke Fishley
    The Walter and Eliza Hall Institute for Medical Research, IG Royal Parade, Parkville, VIC 3050, Australia
    Growth Factors 22:151-5. 2004
    ....
  72. ncbi request reprint Socs2 and elf5 mediate prolactin-induced mammary gland development
    Jessica Harris
    Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, New South Wales 2010, Australia
    Mol Endocrinol 20:1177-87. 2006
    ..Thus, Socs2 and Elf5 are key members of the set of prolactin-regulated genes that mediate prolactin-driven mammary development...
  73. ncbi request reprint Reduced bone mineral density in SOCS-2-deficient mice
    Mattias Lorentzon
    Center for Bone Research at the Sahlgrenska Academy, Division of Endocrinology, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg University, 41345 Gothenburg, Sweden
    Pediatr Res 57:223-6. 2005
    ..These effects are not consistent with an augmented GH/IGF-I signaling and, therefore, the mechanism behind the reduced BMD remains to be elucidated...
  74. ncbi request reprint Suppressor of cytokine signaling-1 in T cells and macrophages is critical for preventing lethal inflammation
    Mark M W Chong
    St Vincent s Institute, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Blood 106:1668-75. 2005
    ..A dysregulated cytokine network between T cells and macrophages is thus associated with this inflammatory disease. These findings indicate that SOCS-1 is critical in both T cells and macrophages for preventing uncontrolled inflammation...
  75. ncbi request reprint Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity
    Jennifer E Fenner
    Centre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Monash University, Clayton 3168, Australia
    Nat Immunol 7:33-9. 2006
    ..Thus, SOCS1 is an important in vivo inhibitor of type I interferon signaling and contributes to balancing its beneficial antiviral versus detrimental proinflammatory effects on innate immunity...
  76. pmc Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination
    Ben Emery
    Department of Neurobiology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:7859-64. 2006
    ..These results indicate that modulation of SOCS3 expression could facilitate the endogenous response to CNS injury...
  77. ncbi request reprint Suppressor of cytokine signaling-2 deficiency induces molecular and metabolic changes that partially overlap with growth hormone-dependent effects
    Elizabeth Rico-Bautista
    Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Mol Endocrinol 19:781-93. 2005
    ..Our data indicate that SOCS2 deficiency partially mimics a state of increased GH activity, but also results in changes that cannot be related to known GH effects...
  78. ncbi request reprint Mice rendered severely deficient in megakaryocytes through targeted gene deletion of the thrombopoietin receptor c-Mpl have a normal skeletal phenotype
    Mark J Perry
    Anatomy and Clinical Sciences North Bristol, University of Bristol, Southwell Street, Bristol, BS2 8EJ, UK
    Calcif Tissue Int 81:224-31. 2007
    ..These results represent the first in vivo evidence that severe megakaryocyte deficiency does not affect bone formation, suggesting that this process is not dependent on normal megakaryocyte number...
  79. doi request reprint Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3
    Hayley A Croom
    Signal Transduction Laboratory, St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    Mol Immunol 45:2888-96. 2008
    ..This is the first demonstration of functional redundancy within the SOCS family, and has uncovered a vital role for SOCS1 and SOCS3 during two important checkpoints in early T cell development...
  80. doi request reprint Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells
    Hong Qian
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, 221 84, Sweden
    Cell Stem Cell 1:671-84. 2007
    ..Thus, THPO regulates posttransplantation HSC expansion as well as the maintenance of adult quiescent HSCs, of critical importance to avoid postnatal HSC exhaustion...