J M Adams

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. ncbi Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
    Lin Chen
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville Victoria 3050, Australia
    Mol Cell 17:393-403. 2005
  2. pmc Endogenous bcl-2 is not required for the development of Emu-myc-induced B-cell lymphoma
    Priscilla N Kelly
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050 Victoria, Melbourne, Australia
    Blood 109:4907-13. 2007
  3. pmc Therapeutic potential of a peptide targeting BCL-2 cell guardians in cancer
    Jerry M Adams
    Walter and Eliza Hall Institute of Medical Research, Molecular Genetics of Cancer Division, Parkville, Victoria, Australia
    J Clin Invest 122:1965-7. 2012
  4. ncbi Apoptosomes: engines for caspase activation
    Jerry M Adams
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, 3050, Victoria, Australia
    Curr Opin Cell Biol 14:715-20. 2002
  5. ncbi Is tumor growth sustained by rare cancer stem cells or dominant clones?
    Jerry M Adams
    The Walter and Eliza Hall Institute of Medical Research Melbourne, Victoria, Australia
    Cancer Res 68:4018-21. 2008
  6. pmc The Bcl-2 apoptotic switch in cancer development and therapy
    J M Adams
    Department of Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Oncogene 26:1324-37. 2007
  7. ncbi Life-or-death decisions by the Bcl-2 protein family
    J M Adams
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, 3050, Melbourne, Australia
    Trends Biochem Sci 26:61-6. 2001
  8. pmc Bcl-2-regulated apoptosis: mechanism and therapeutic potential
    Jerry M Adams
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne 3050 Australia
    Curr Opin Immunol 19:488-96. 2007
  9. ncbi Ways of dying: multiple pathways to apoptosis
    Jerry M Adams
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Genes Dev 17:2481-95. 2003
  10. ncbi Hemopoietic lineage switch: v-raf oncogene converts Emu-myc transgenic B cells into macrophages
    S P Klinken
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Cell 53:857-67. 1988

Research Grants

  1. MECHANISMS IN THE REGULATION OF APOPTOSIS
    Jerry Adams; Fiscal Year: 1999
  2. MECHANISMS IN THE REGULATION OF APOPTOSIS
    Jerry Adams; Fiscal Year: 2000
  3. MECHANISMS IN THE REGULATION OF APOPTOSIS
    Jerry Adams; Fiscal Year: 2001
  4. MECHANISMS IN THE REGULATION OF APOPTOSIS
    Jerry Adams; Fiscal Year: 2002
  5. MECHANISMS IN THE REGULATION OF APOPTOSIS
    Jerry Adams; Fiscal Year: 2002
  6. MECHANISMS IN THE REGULATION OF APOPTOSIS
    Jerry Adams; Fiscal Year: 2003
  7. MECHANISMS IN THE REGULATION OF APOPTOSIS
    Jerry Adams; Fiscal Year: 2004
  8. MECHANISMS IN THE REGULATION OF APOPTOSIS
    Jerry Adams; Fiscal Year: 2005
  9. MECHANISMS IN THE REGULATION OF APOPTOSIS
    Jerry Adams; Fiscal Year: 2006

Collaborators

Detail Information

Publications73

  1. ncbi Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
    Lin Chen
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville Victoria 3050, Australia
    Mol Cell 17:393-403. 2005
    ..The results suggest that apoptosis relies on selective interactions between particular subsets of these proteins and that it should be feasible to discover BH3-mimetic drugs that inactivate specific prosurvival targets...
  2. pmc Endogenous bcl-2 is not required for the development of Emu-myc-induced B-cell lymphoma
    Priscilla N Kelly
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050 Victoria, Melbourne, Australia
    Blood 109:4907-13. 2007
    ..These results have implications for the treatment of hematopoietic tumors, particularly those that are not caused by Bcl-2 overexpression...
  3. pmc Therapeutic potential of a peptide targeting BCL-2 cell guardians in cancer
    Jerry M Adams
    Walter and Eliza Hall Institute of Medical Research, Molecular Genetics of Cancer Division, Parkville, Victoria, Australia
    J Clin Invest 122:1965-7. 2012
    ..The peptide killed cultured hematologic tumor cells and abated growth of a leukemia xenograft, without perturbing the hematopoietic compartment. Hence, such peptides might eventually provide a new way to treat refractory leukemias...
  4. ncbi Apoptosomes: engines for caspase activation
    Jerry M Adams
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, 3050, Victoria, Australia
    Curr Opin Cell Biol 14:715-20. 2002
    ..CED-4 is essential for apoptosis in the worm and Dark for many apoptotic responses in the fly, but the Apaf-1/caspase-9 system probably amplifies rather than initiates the mammalian caspase cascade...
  5. ncbi Is tumor growth sustained by rare cancer stem cells or dominant clones?
    Jerry M Adams
    The Walter and Eliza Hall Institute of Medical Research Melbourne, Victoria, Australia
    Cancer Res 68:4018-21. 2008
    ....
  6. pmc The Bcl-2 apoptotic switch in cancer development and therapy
    J M Adams
    Department of Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Oncogene 26:1324-37. 2007
    ..Better understanding of the Bcl-2 family is clarifying its role in cancer development, revealing how conventional therapy works and stimulating the search for "BH3 mimetics" as a novel class of anticancer drugs...
  7. ncbi Life-or-death decisions by the Bcl-2 protein family
    J M Adams
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, 3050, Melbourne, Australia
    Trends Biochem Sci 26:61-6. 2001
    ..Pro-apoptotic family members act as sentinels for cellular damage: cytotoxic signals induce their translocation to the organelles where they bind to their pro-survival relatives, promote organelle damage and trigger apoptosis...
  8. pmc Bcl-2-regulated apoptosis: mechanism and therapeutic potential
    Jerry M Adams
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne 3050 Australia
    Curr Opin Immunol 19:488-96. 2007
    ..The Bcl-2 family may also regulate autophagy and mitochondrial fission/fusion. Its pro-survival members are attractive therapeutic targets in cancer and perhaps autoimmunity and viral infections...
  9. ncbi Ways of dying: multiple pathways to apoptosis
    Jerry M Adams
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Genes Dev 17:2481-95. 2003
  10. ncbi Hemopoietic lineage switch: v-raf oncogene converts Emu-myc transgenic B cells into macrophages
    S P Klinken
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Cell 53:857-67. 1988
    ..The converted lines produced the myeloid growth factor GM-CSF, and most had karyotypic alterations. These results suggest that constitutive myc plus raf expression can provoke genetic reprogramming in lymphocytes...
  11. ncbi Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members
    S P Holmgreen
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital Victoria 3050, Australia
    Cell Death Differ 6:525-32. 1999
    ..The results may reflect critical threshold affinities but also suggest that certain pro-apoptotic proteins may also contribute to apoptosis by a mechanism independent of binding pro-survival proteins...
  12. ncbi Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria 3050, Melbourne, Australia
    Dev Cell 1:645-53. 2001
    ..These results demonstrate that Bim levels set the threshold for initiation of apoptosis in several tissues and suggest that degenerative diseases might be alleviated by blocking BH3-only proteins...
  13. ncbi Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Science 286:1735-8. 1999
    ..Thus, Bim is required for hematopoietic homeostasis and as a barrier to autoimmunity. Moreover, particular death stimuli appear to activate apoptosis through distinct BH3-only proteins...
  14. pmc Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival
    S Ogilvy
    The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 96:14943-8. 1999
    ..Thus, Bcl-2 has multiple effects on the hematopoietic system. These mice should help to further clarify the role of apoptosis in the development and homeostasis of this compartment...
  15. ncbi Subversion of the Bcl-2 life/death switch in cancer development and therapy
    J M Adams
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Cold Spring Harb Symp Quant Biol 70:469-77. 2005
    ..We find that, like Bad, ABT-737 kills cells efficiently only if Mcl-1 is absent or down-regulated. Thus, manipulation of apoptosis by targeting the Bcl-2 family has exciting potential for cancer treatment...
  16. pmc Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis
    E M Michalak
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Cell Death Differ 16:684-96. 2009
    ..They also indicate that additional BH3-only proteins probably also drive Myc-induced apoptosis and that non-apoptotic functions of p53 may contribute substantially to its tumour suppressor role...
  17. pmc The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4
    D C Huang
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    EMBO J 17:1029-39. 1998
    ..These results favour the hypothesis that the BH4 domain of pro-survival Bcl-2 family members allows them to sequester CED-4 relatives and thereby prevent apoptosis...
  18. ncbi Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector
    J M Adams
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Oncogene 18:5268-77. 1999
    ..This novel vector should aid studies on many aspects of hematopoiesis, including the modeling of leukemogenesis...
  19. doi Role of "cancer stem cells" and cell survival in tumor development and maintenance
    J M Adams
    Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Cold Spring Harb Symp Quant Biol 73:451-9. 2008
    ..This suggests that these tumors originate in an earlier cell type, such as the pro-B or pre-B cell, and that the nascent neoplastic clones do not require Bcl-2 but may instead be protected by a Bcl-2 relative...
  20. pmc Bcl-2 retards cell cycle entry through p27(Kip1), pRB relative p130, and altered E2F regulation
    G Vairo
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Mol Cell Biol 20:4745-53. 2000
    ..Hence, Bcl-2 appears to retard cell cycle entry by increasing p27 and p130 levels and maintaining repressive complexes of p130 with E2F4, perhaps to delay E2F1 expression...
  21. pmc Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development
    P N Kelly
    The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050, Australia
    Cell Death Differ 17:1655-64. 2010
    ..Collectively, these results show that Bim and Bad can cooperate in the apoptosis of thymocytes and activated B lymphocytes and in the suppression of thymic lymphoma development...
  22. pmc Bim: a novel member of the Bcl-2 family that promotes apoptosis
    L O'Connor
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    EMBO J 17:384-95. 1998
    ..Hence, Bim appears to act as a 'death ligand' which can only neutralize certain members of the pro-survival Bcl-2 sub-family...
  23. ncbi Immunoglobulin JH rearrangement in a T-cell line reflects fusion to the DH locus at a sequence lacking the nonamer recognition signal
    S Gerondakis
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Immunogenetics 28:255-9. 1988
    ..This result suggests that the heptamer may be the primary determinant of the specificity in V-gene assembly and that the DH locus as a whole may be preferred target for recombination...
  24. ncbi Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    Mamm Genome 12:163-8. 2001
    ..These findings should help to clarify the regulation of Bim expression and to assess whether mutations involving Bim contribute to neoplastic and other diseases...
  25. pmc In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute
    E M Michalak
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Cell Death Differ 15:1019-29. 2008
    ..The absence of tumours in the mice suggests that tumour suppression by p53 requires functions in addition to induction of apoptosis...
  26. ncbi Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenes
    T Metz
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital Victoria, Australia
    Cell 82:29-36. 1995
    ..These findings imply that p53 loss contributes directly to immortalization and tumorigenesis, probably by abrogating an intrinsic senescence program...
  27. pmc The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells
    A W Harris
    Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    J Exp Med 167:353-71. 1988
    ..A transient leukocytosis identified in young E mu-myc mice was developed into a rapid assay for inheritance of the transgene...
  28. ncbi bcl-w, a novel member of the bcl-2 family, promotes cell survival
    L Gibson
    Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Oncogene 13:665-75. 1996
    ..These findings suggest that bcl-w participates in the control of apoptosis in multiple cell types. Its functional similarity to bcl-2 also makes it an attractive candidate proto-oncogene...
  29. ncbi Transcriptional regulation of vav, a gene expressed throughout the hematopoietic compartment
    S Ogilvy
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Blood 91:419-30. 1998
    ..Maintaining pan-hematopoietic expression may require additional vav elements or an alternative reporter...
  30. pmc Prophylactic treatment with the BH3 mimetic ABT-737 impedes Myc-driven lymphomagenesis in mice
    P N Kelly
    Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Cell Death Differ 20:57-63. 2013
    ..Moreover, such treatment may help in the management of patients with hereditary cancer syndromes and perhaps also in the prevention of tumour relapses...
  31. pmc Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant
    C G Print
    The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 95:12424-31. 1998
    ..The bcl-w-/- mouse provides a unique model of failed spermatogenesis in the adult that may be relevant to some cases of human male sterility...
  32. ncbi Matters of life and death: programmed cell death at Cold Spring Harbor
    S Cory
    Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
    Biochim Biophys Acta 1377:R25-44. 1998
  33. pmc An E mu-v-abl transgene elicits plasmacytomas in concert with an activated myc gene
    H Rosenbaum
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    EMBO J 9:897-905. 1990
    ..Moreover, progeny of a cross with analogous E mu-myc mice rapidly developed oligoclonal plasmacytomas. Thus, the collusion of v-abl with c-myc is stage specific, efficiently transforming plasma cells but not pre-B cells or B cells...
  34. ncbi The role of bim, a proapoptotic BH3-only member of the Bcl-2 family in cell-death control
    A Strasser
    Walter and Eliza Hall Institute, Post Office Royal Melbourne Hospital, 3050 Vic, Melbourne, Australia
    Ann N Y Acad Sci 917:541-8. 2000
    ..Unleashed BH3-only proteins neutralize the prosurvival function of Bcl-2-like molecules, and this is thought to liberate Apaf-l-like adapters to activate caspase zymogens, which then initiate cell degradation...
  35. pmc Apoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases
    M F van Delft
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Cell Death Differ 17:821-32. 2010
    ..Thus, caspases appear dispensable for some essential biological functions of apoptosis...
  36. pmc Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene
    S E Bodrug
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria 3050, Australia
    EMBO J 13:2124-30. 1994
    ..These findings indicate that this G1 cyclin can modulate differentiation and collaborate with myc-like genes in oncogenesis...
  37. ncbi Bfk: a novel weakly proapoptotic member of the Bcl-2 protein family with a BH3 and a BH2 region
    L Coultas
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Cell Death Differ 10:185-92. 2003
    ..Low amounts of Bfk were found in stomach, ovary, bone marrow and spleen, but its level in the mammary gland rose markedly during pregnancy, suggesting that Bfk may play a role in mammary development...
  38. ncbi Hlx homeo box gene is essential for an inductive tissue interaction that drives expansion of embryonic liver and gut
    B Hentsch
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Genes Dev 10:70-9. 1996
    ..Moreover, because mutation of Hlx blocked liver growth but not its specification, early morphogenesis, or differentiation, development of this organ appears to occur by step-wise inductive interactions under separate genetic control...
  39. pmc Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 88:8661-5. 1991
    ..Thus E mu-bcl-2-22 mice constitute a transgenic model for a systemic autoimmune disease resembling the human disorder systemic lupus erythematosus...
  40. pmc Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages
    K Kongsuwan
    Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia
    EMBO J 7:2131-8. 1988
    ..In one myeloid leukaemia, DNA rearrangement has perturbed expression. These findings suggest that homeobox genes may influence developmental decisions within the haemopoietic system...
  41. pmc Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity
    Julie Wilson-Annan
    Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
    J Cell Biol 162:877-87. 2003
    ..These results suggest that ligation of a proapoptotic BH3-only protein alters the conformation of Bcl-w, enhances membrane association, and neutralizes its survival function...
  42. ncbi Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
    Vanessa S Marsden
    The Walter and Eliza Hall Institute, Melbourne, 3050, Australia
    Nature 419:634-7. 2002
    ..We conclude that Bcl-2 regulates a caspase activation programme independently of the cytochrome c/Apaf-1/caspase-9 'apoptosome', which seems to amplify rather than initiate the caspase cascade...
  43. ncbi The Bcl-2 family: roles in cell survival and oncogenesis
    Suzanne Cory
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Oncogene 22:8590-607. 2003
    ..Finally, it discusses the promise of novel anticancer therapeutics that target these vital regulators...
  44. pmc The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins
    Delphine Merino
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia
    J Cell Biol 186:355-62. 2009
    ..Thus, initiation of apoptosis in vivo appears to require features of both models...
  45. pmc The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
    Mark F van Delft
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Cancer Cell 10:389-99. 2006
    ..Hence, ABT-737 should prove efficacious in tumors with low Mcl-1 levels, or when combined with agents that inactivate Mcl-1, even to treat those tumors that overexpress Bcl-2...
  46. ncbi BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
    Philippe Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, P O The Royal Melbourne Hospital, Victoria 3050, Australia
    Nature 415:922-6. 2002
    ..TCR ligation upregulated Bim expression and promoted interaction of Bim with Bcl-XL, inhibiting its survival function. These findings identify Bim as an essential initiator of apoptosis in thymocyte-negative selection...
  47. pmc Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis
    Leigh Coultas
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    EMBO J 24:3963-73. 2005
    ..Thus, Bik and Bim share, upstream of Bax, the role of eliminating supernumerary germ cells during the first wave of spermatogenesis, a process vital for normal testicular development...
  48. ncbi Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
    Simon N Willis
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Science 315:856-9. 2007
    ..Our results indicate that BH3-only proteins induce apoptosis at least primarily by engaging the multiple pro-survival relatives guarding Bax and Bak...
  49. ncbi Loss of pro-apoptotic BH3-only Bcl-2 family member Bim does not protect mutant Lurcher mice from neurodegeneration
    Philippe Bouillet
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    J Neurosci Res 74:777-81. 2003
    ..Our studies show that Bim deficiency does not modify the Lurcher phenotype, ruling out an indispensable role for Bim in this neurodegenerative disease...
  50. ncbi Killing cancer cells by flipping the Bcl-2/Bax switch
    Suzanne Cory
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Cancer Cell 8:5-6. 2005
    ..Hence, this work validates Bcl-2-like proteins as important new targets in cancer therapy...
  51. ncbi The Bcl2 family: regulators of the cellular life-or-death switch
    Suzanne Cory
    The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia
    Nat Rev Cancer 2:647-56. 2002
    ..Apoptosis is often impaired in cancer and can limit conventional therapy. A better understanding of how the Bcl2 family controls caspase activation should result in new, more effective therapeutic approaches...
  52. pmc Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death
    Leigh Coultas
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Mol Cell Biol 24:1570-81. 2004
    ..These results indicate that any function of Bik in programmed cell death and stress-induced apoptosis must overlap that of other BH3-only proteins...
  53. ncbi Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death
    Vanessa S Marsden
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Blood 107:1872-7. 2006
    ..However, although Apaf-1 and caspase-9 are essential for mast cell apoptosis, neither is required for the functional or clonogenic death of the cells, which may be due to mitochondrial dysfunction...
  54. pmc Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak
    Rachel T Uren
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    J Cell Biol 177:277-87. 2007
    ....
  55. ncbi Differential expression of the LYL, SCL and E2A helix-loop-helix genes within the hemopoietic system
    J Visvader
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Oncogene 6:187-94. 1991
    ....
  56. pmc Expression of Hox-2.4 homeobox gene directed by proviral insertion in a myeloid leukemia
    K Kongsuwan
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Nucleic Acids Res 17:1881-92. 1989
    ..4 and Hox-3.1, which reside on different chromosomes, supports the notion that an ancient homeobox gene cluster has been duplicated and dispersed early in vertebrate evolution...
  57. pmc Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
    Simon N Willis
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Genes Dev 19:1294-305. 2005
    ..The finding that different prosurvival proteins have selective roles has notable implications for the design of anti-cancer drugs that target the Bcl-2 family...
  58. pmc Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis
    Leigh Coultas
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Cell Sci 120:2044-52. 2007
    ..These results demonstrate that HRK contributes to apoptosis signalling elicited by trophic factor withdrawal in certain neuronal populations but is dispensable for apoptosis of haematopoietic cells...
  59. doi To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions
    Grant Dewson
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, Victoria 3050, Australia
    Mol Cell 30:369-80. 2008
    ..We conclude that this BH3:groove interaction is essential to nucleate Bak oligomerization, which in turn is required for its proapoptotic function...
  60. ncbi Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice
    Y Haupt
    Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, Victoria, Australia
    Cell 65:753-63. 1991
    ..Thus, myc-induced lymphomagenesis can entail the concerted action of several genes, including the presumptive nuclear regulator bmi-1...
  61. ncbi p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
    Andreas Villunger
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Science 302:1036-8. 2003
    ..Hence, Puma and Noxa are critical mediators of the apoptotic responses induced by p53 and other agents...
  62. pmc Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax
    Jamie I Fletcher
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 105:18081-7. 2008
    ....
  63. pmc Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9
    Vanessa S Marsden
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Cell Biol 165:775-80. 2004
    ..These findings suggest that caspases other than caspases 2 and 9 can promote cytochrome c release and initiate Bcl-2-regulated apoptosis...
  64. pmc Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa
    Edwina Naik
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    J Cell Biol 176:415-24. 2007
    ..Collectively, these results demonstrate that UVR activates the Bcl-2-regulated apoptotic pathway predominantly through activation of Noxa and, depending on cellular context, Puma...
  65. pmc Life in the balance: how BH3-only proteins induce apoptosis
    Simon N Willis
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Curr Opin Cell Biol 17:617-25. 2005
    ..Hence, multiple pro-survival proteins must be inactivated to unleash Bax and Bak, which drive apoptosis. Whether certain BH3-only proteins also directly activate Bax/Bak remains controversial...
  66. ncbi The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization
    J M Adams
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Oncogene 7:611-8. 1992
    ..Thus, like Dbl in other cell types, Vav may function throughout the hematopoietic compartment to govern a Ras-like signal transduction pathway...
  67. ncbi PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain
    Wendy D Cook
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Blood 104:3437-44. 2004
    ..1 normally suppresses development of myeloid leukemia by promoting differentiation and that the combination of gene deletion and a point mutation that impairs its ability to bind DNA is particularly leukemogenic...
  68. pmc Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death
    Ewa M Michalak
    The Walter and Eliza Hall Institute of Medical Research, Parkville VIC 3050, Australia
    Genes Dev 24:1608-13. 2010
    ..Our demonstration that cycles of cell attrition and repopulation by stem/progenitor cells can drive tumorigenesis has parallels in human cancers, such as therapy-induced malignancies...
  69. pmc BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo
    Miriam Erlacher
    Division of Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Blood 106:4131-8. 2005
    ..Our results thus establish that Puma and Bim are key initiators of gamma-radiation- and glucocorticoid-induced apoptosis in lymphoid cells in vivo...
  70. ncbi Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma
    Wen Shu Wu
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 123:641-53. 2005
    ..Thus, Slug functions downstream of p53 in developing blood cells as a critical switch that prevents their apoptosis by antagonizing the trans-activation of puma by p53...
  71. ncbi Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy
    Ting Ting Tan
    Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, USA
    Cancer Cell 7:227-38. 2005
    ....
  72. ncbi Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate
    Caryn Navarro
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute and Howard Hughes Medical Institute, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Nat Cell Biol 6:427-35. 2004
    ..Our data provide a direct link between a molecule necessary for oocyte specification and the microtubule motor complex, and supports the hypothesis that microtubule-mediated transport is important for preserving oocyte fate...
  73. ncbi Tumor growth need not be driven by rare cancer stem cells
    Priscilla N Kelly
    Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Science 317:337. 2007
    ..We suggest that the low frequency of tumor-sustaining cells observed in xenotransplantation studies may reflect the limited ability of human tumor cells to adapt to growth in a foreign (mouse) milieu...

Research Grants9

  1. MECHANISMS IN THE REGULATION OF APOPTOSIS
    Jerry Adams; Fiscal Year: 1999
    ..As the proposal addresses central issues about the regulation, builds on productive research, and exploits novel findings and special resources, it should significantly advance the molecular dissection of apoptosis. ..
  2. MECHANISMS IN THE REGULATION OF APOPTOSIS
    Jerry Adams; Fiscal Year: 2000
    ..As the proposal addresses central issues about the regulation, builds on productive research, and exploits novel findings and special resources, it should significantly advance the molecular dissection of apoptosis. ..
  3. MECHANISMS IN THE REGULATION OF APOPTOSIS
    Jerry Adams; Fiscal Year: 2001
    ..As the proposal addresses central issues about the regulation, builds on productive research, and exploits novel findings and special resources, it should significantly advance the molecular dissection of apoptosis. ..
  4. MECHANISMS IN THE REGULATION OF APOPTOSIS
    Jerry Adams; Fiscal Year: 2002
    ..Justification: As the proposal addresses central issues about the regulation of apoptosis, builds onproductive research, and exploits novel findings, it should significantly advance the molecular dissection of apoptosis. ..
  5. MECHANISMS IN THE REGULATION OF APOPTOSIS
    Jerry Adams; Fiscal Year: 2002
    ..As the proposal addresses central issues about the regulation, builds on productive research, and exploits novel findings and special resources, it should significantly advance the molecular dissection of apoptosis. ..
  6. MECHANISMS IN THE REGULATION OF APOPTOSIS
    Jerry Adams; Fiscal Year: 2003
    ..Justification: As the proposal addresses central issues about the regulation of apoptosis, builds onproductive research, and exploits novel findings, it should significantly advance the molecular dissection of apoptosis. ..
  7. MECHANISMS IN THE REGULATION OF APOPTOSIS
    Jerry Adams; Fiscal Year: 2004
    ..Justification: As the proposal addresses central issues about the regulation of apoptosis, builds onproductive research, and exploits novel findings, it should significantly advance the molecular dissection of apoptosis. ..
  8. MECHANISMS IN THE REGULATION OF APOPTOSIS
    Jerry Adams; Fiscal Year: 2005
    ..Justification: As the proposal addresses central issues about the regulation of apoptosis, builds onproductive research, and exploits novel findings, it should significantly advance the molecular dissection of apoptosis. ..
  9. MECHANISMS IN THE REGULATION OF APOPTOSIS
    Jerry Adams; Fiscal Year: 2006
    ..Justification: As the proposal addresses central issues about the regulation of apoptosis, builds onproductive research, and exploits novel findings, it should significantly advance the molecular dissection of apoptosis. ..