Affiliation: Sullivan Nicolaides Pathology
- Significance of minute focus of adenocarcinoma on prostate needle biopsyHemamali Samaratunga
Sullivan Nicolaides Pathology, Brisbane, Queensland, Australia
Urology 70:299-302. 2007..To assess the radical prostatectomy findings in patients with a minute focus of adenocarcinoma on prostate needle biopsy in current practice in Australia...
- What is the molecular pathology of low-risk prostate cancer?Hemamali Samaratunga
Department of Anatomical Pathology, Sullivan Nicolaides Pathology, 134 Whitmore Street, Taringa, Brisbane, QLD, 4068, Australia
World J Urol 26:431-6. 2008..This review was to evaluate which of these changes may be useful to distinguish the group of patients likely to have significant carcinoma within the low risk category...
- Ductal adenocarcinoma of the prostate: current opinion and controversiesHemamali Samaratunga
Sullivan Nicolaides Pathology, Brisbane, Australia
Anal Quant Cytol Histol 30:237-46. 2008..To evaluate the morphologic spectrum and clinical significance of ductal adenocarcinoma of the prostate (DAP)...
- Micropapillary variant of urothelial carcinoma of the urinary bladder; a clinicopathological and immunohistochemical studyH Samaratunga
Sullivan Nicolaides Pathology, Brisbane, Queensland, Australia
Histopathology 45:55-64. 2004..To investigate whether prognosis in micropapillary urothelial carcinoma is related to the proportion of the micropapillary component (MPC), and to identify the immunohistochemical features of MPC...
- Prostatic ductal adenocarcinoma presenting as a urethral polyp: a clinicopathological study of eight cases of a lesion with the potential to be misdiagnosed as a benign prostatic urethral polypHemamali Samaratunga
Sullivan Nicolaides Pathology, 134 Whitmore Street, Taringa, Brisbane, Queensland 4068, Australia
Pathology 39:476-81. 2007..Centrally located prostatic ductal adenocarcinoma can present as a single urethral polyp mimicking a benign polyp. Such lesions have not been formally studied...
- Atypical prostatic glandular proliferations on needle biopsy: Diagnostic implications, use of immunohistochemistry, and clinical significanceHemamali Samaratunga
Department of Anatomical Pathology, Sullivan Nicolaides Pathology, Royal Brisbane Hospital, University of Queensland, Brisbane, Queensland, Australia
Anal Quant Cytol Histol 28:104-10. 2006..Patients with atypical glands on prostate needle biopsy have a high risk for harboring cancer and therefore have an increased risk for having cancer detected in subsequent biopsies...
- Use of multiple biomarkers for a molecular diagnosis of prostate cancerKelly A Landers
Department of Surgery, Central Clinical Division, School of Medicine, University of Queensland, Herston, Queensland 4072, Australia
Int J Cancer 114:950-6. 2005..Supplemental material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html.)..
- Atypical presentation of herpes simplex (chronic hypertrophic herpes) in a patient with HIV infectionH Samaratunga
Anatomical Pathology, Royal Brisbane Hospital, QLD, Australia
Pathology 33:532-5. 2001..Viral culture or PCR may need to be performed for a definite diagnosis to alleviate prolonged discomfort and avoid unnecessary radical surgery...
- Phyllodes tumors of the breast: correlation of nucleolar organizer regions with histopathological malignancy grading, flow cytometric DNA analysis and clinical outcomeH Samaratunga
Department of Anatomical Pathology, Royal Brisbane Hospital, Queensland, Australia
Pathol Int 51:866-73. 2001..Ag-NOR counts are significant in predicting survival in the presence of histopathological features of malignancy...
- Any proportion of ductal adenocarcinoma in radical prostatectomy specimens predicts extraprostatic extensionHemamali Samaratunga
Aquesta Pathology, Brisbane, Queensland, 4064 Australia
Hum Pathol 41:281-5. 2010..In view of the significant association with extraprostatic extension we would recommend that in both core biopsies and radical prostatectomy specimens any proportion of ductal adenocarcinoma of the prostate should be reported...
- Significance of stromal reaction patterns in invasive urothelial carcinomaHemamali Samaratunga
Department of Surgical Pathology, Sullivan Nicolaides, Pathology, Brisbane, Australia
Am J Clin Pathol 123:851-7. 2005..Stromal reaction patterns seem to have some prognostic usefulness. Cases with stromal edema might benefit from closer follow-up. Awareness of the different types of stromal reactions also is useful for diagnosing invasion...
- Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaPDaniel R McCulloch
Hormone-Dependent Cancer Program, School of Life Sciences, Queensland University of Technology, Brisbane, Queensland, Australia
Clin Cancer Res 10:314-23. 2004..The regulation and membrane localization of ADAM-10 support our hypothesis that ADAM-10 has a role in extracellular matrix maintenance and cell invasion, although the potential role of nuclear ADAM-10 is not yet known...
- A novel transcript from the KLKP1 gene is androgen regulated, down-regulated during prostate cancer progression and encodes the first non-serine protease identified from the human kallikrein gene locusAneel Kaushal
Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Australia
Prostate 68:381-99. 2008..Other members of the KLK family are also emerging as potential adjunct biomarkers for this disease. Our aim was to identify and characterize novel KLK-related genes with potential as PCa bio-markers...
- Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progressionAndrew J Ramsay
Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Corner Musk Ave and Blamey St, Kelvin Grove, Queensland 4059, Australia
J Biol Chem 283:12293-304. 2008..These data provide insight into KLK4-mediated cell signaling and suggest that signals induced by this enzyme via PARs may be important in prostate cancer...
- Prostatic trypsin-like kallikrein-related peptidases (KLKs) and other prostate-expressed tryptic proteinases as regulators of signalling via proteinase-activated receptors (PARs)Andrew J Ramsay
Institute of Health and Biomedical Innovation, Queensland University of Technology, 6 Musk Avenue, Kelvin Grove, Queensland 4059, Australia
Biol Chem 389:653-68. 2008....