Donald Staines

Summary

Country: Australia

Publications

  1. pmc Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis
    Ekua W Brenu
    Population Health and Neuroimmunology Unit, Bond University, Robina, QLD, Australia
    J Transl Med 10:88. 2012
  2. pmc Vasoactive neuropeptides in clinical ophthalmology: An association with autoimmune retinopathy?
    Donald R Staines
    Queensland Health, Gold Coast Population Health Unit, Southport, Gold Coast, Queensland, Australia
    Clin Ophthalmol 3:259-61. 2009
  3. pmc Postulated vasoactive neuropeptide immunopathology affecting the blood-brain/blood-spinal barrier in certain neuropsychiatric fatigue-related conditions: A role for phosphodiesterase inhibitors in treatment?
    Donald R Staines
    Queensland Health, Gold Coast Population Health Unit, Southport, Gold Coast, Queensland, Australia
    Neuropsychiatr Dis Treat 5:81-9. 2009
  4. pmc Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
    Ekua W Brenu
    Population Health and Neuroimmunology Unit, Faculty of Health Science and Medicine, Bond University, Robina, Queensland, Australia
    J Transl Med 9:81. 2011
  5. pmc Immune and hemorheological changes in chronic fatigue syndrome
    Ekua W Brenu
    Faculty of Health Science and Medicine, Population Health and Neuroimmunology Unit, Bond University, Robina, Queensland, Australia
    J Transl Med 8:1. 2010
  6. pmc Postulated vasoactive neuropeptide autoimmunity in fatigue-related conditions: a brief review and hypothesis
    Donald R Staines
    Gold Coast Public Health Unit, 10 12 Young Street, Southport, QLD, 4215, Australia
    Clin Dev Immunol 13:25-39. 2006
  7. ncbi request reprint Does autoimmunity of endogenous vasoactive neuropeptides cause retinopathy in humans?
    Donald R Staines
    Gold Coast Population Health Unit, 10 12 Young Street, Southport 4215, QLD, Australia
    Med Hypotheses 70:137-40. 2008
  8. ncbi request reprint Is Parkinson's disease an autoimmune disorder of endogenous vasoactive neuropeptides?
    Donald R Staines
    Gold Coast Population Health Unit, 10 12 Young Street, Southport 4215, QLD, Australia
    Med Hypotheses 69:1208-11. 2007
  9. ncbi request reprint Are multiple sclerosis and amyotrophic lateral sclerosis autoimmune disorders of endogenous vasoactive neuropeptides?
    Donald R Staines
    Gold Coast Public Health Unit, 10 12, Young Street, Southport 4215, Queensland, Australia
    Med Hypotheses 70:413-8. 2008
  10. ncbi request reprint Does dysregulation of key epigenetic and biochemical pathways occur in postulated vasoactive neuropeptide autoimmune disorders?
    Donald R Staines
    Gold Coast Public Health Unit, 10 12 Young Street, Southport 4215, Queensland, Australia
    Med Hypotheses 65:1154-60. 2005

Collaborators

  • O K Baskurt
  • Ekua W Brenu
  • Sandra B Ramos
  • Kevin J Ashton
  • Sonya M Marshall-Gradisnik
  • Samantha Johnston
  • James Keane
  • Mieke L Van Driel
  • Sonya Marshall-Gradisnik
  • Lotti Tajouri
  • Daniel Peterson
  • Sharni L Hardcastle
  • Nancy G Klimas
  • Rhys M Christy

Detail Information

Publications23

  1. pmc Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis
    Ekua W Brenu
    Population Health and Neuroimmunology Unit, Bond University, Robina, QLD, Australia
    J Transl Med 10:88. 2012
    ..This study investigates Natural Killer (NK) cell cytotoxic activity, NK cell subsets (CD56brightCD16- and CD56dimCD16+) and cytokines, over the course of a12 month period in patients with CFS/ME...
  2. pmc Vasoactive neuropeptides in clinical ophthalmology: An association with autoimmune retinopathy?
    Donald R Staines
    Queensland Health, Gold Coast Population Health Unit, Southport, Gold Coast, Queensland, Australia
    Clin Ophthalmol 3:259-61. 2009
    ..Phosphodiesterase inhibitors and purinergic modulators may have a role in the treatment of postulated VN autoimmune retinopathy...
  3. pmc Postulated vasoactive neuropeptide immunopathology affecting the blood-brain/blood-spinal barrier in certain neuropsychiatric fatigue-related conditions: A role for phosphodiesterase inhibitors in treatment?
    Donald R Staines
    Queensland Health, Gold Coast Population Health Unit, Southport, Gold Coast, Queensland, Australia
    Neuropsychiatr Dis Treat 5:81-9. 2009
    ..Therefore PDEIs may have a role in therapy for certain neuropsychiatric fatigue-related conditions...
  4. pmc Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
    Ekua W Brenu
    Population Health and Neuroimmunology Unit, Faculty of Health Science and Medicine, Bond University, Robina, Queensland, Australia
    J Transl Med 9:81. 2011
    ..Studies have identified abnormalities in immune function but these data are inconsistent. We investigated the profile of markers of immune function (including novel markers) in CFS/ME patients...
  5. pmc Immune and hemorheological changes in chronic fatigue syndrome
    Ekua W Brenu
    Faculty of Health Science and Medicine, Population Health and Neuroimmunology Unit, Bond University, Robina, Queensland, Australia
    J Transl Med 8:1. 2010
    ..Additionally the role of erythrocyte rheological characteristics in CFS has not been fully expounded. The objective of this present study was to determine deficiencies in lymphocyte function and erythrocyte rheology in CFS patients...
  6. pmc Postulated vasoactive neuropeptide autoimmunity in fatigue-related conditions: a brief review and hypothesis
    Donald R Staines
    Gold Coast Public Health Unit, 10 12 Young Street, Southport, QLD, 4215, Australia
    Clin Dev Immunol 13:25-39. 2006
    ..Possible treatment and prevention options are considered...
  7. ncbi request reprint Does autoimmunity of endogenous vasoactive neuropeptides cause retinopathy in humans?
    Donald R Staines
    Gold Coast Population Health Unit, 10 12 Young Street, Southport 4215, QLD, Australia
    Med Hypotheses 70:137-40. 2008
    ..A compelling case may exist to undertake a therapeutic trial of VN replacement, PDE inhibitors and other agents in autoimmune retinopathies resulting from possible VN autoimmunity...
  8. ncbi request reprint Is Parkinson's disease an autoimmune disorder of endogenous vasoactive neuropeptides?
    Donald R Staines
    Gold Coast Population Health Unit, 10 12 Young Street, Southport 4215, QLD, Australia
    Med Hypotheses 69:1208-11. 2007
    ..Possibly unusual or anatomically specific receptors for these VNs may be involved. If proven, this hypothesis would have significant implications for immunological and pharmacological treatment and prevention of PD...
  9. ncbi request reprint Are multiple sclerosis and amyotrophic lateral sclerosis autoimmune disorders of endogenous vasoactive neuropeptides?
    Donald R Staines
    Gold Coast Public Health Unit, 10 12, Young Street, Southport 4215, Queensland, Australia
    Med Hypotheses 70:413-8. 2008
    ..This hypothesis, if proven, may have implications for the development of treatment and preventive strategies...
  10. ncbi request reprint Does dysregulation of key epigenetic and biochemical pathways occur in postulated vasoactive neuropeptide autoimmune disorders?
    Donald R Staines
    Gold Coast Public Health Unit, 10 12 Young Street, Southport 4215, Queensland, Australia
    Med Hypotheses 65:1154-60. 2005
    ..VN autoimmune processes have implications for military medicine where radiological, chemical and biological agents may play an important role in pathogenesis...
  11. ncbi request reprint Do vasoactive neuropeptide autoimmune disorders explain pyridostigmine's association with Gulf War syndrome?
    Donald Staines
    Gold Coast Public Health Unit, 10 12 Young Street, Southport 4215, Queensland, Australia
    Med Hypotheses 65:591-4. 2005
    ..Paradoxically pyridostigmine may prove to have a role in therapy although VN treatment/replacement may be associated with tachyphylaxis...
  12. ncbi request reprint Is chronic fatigue syndrome an autoimmune disorder of endogenous neuropeptides, exogenous infection and molecular mimicry?
    Donald R Staines
    Gold Coast Public Health Unit, 10 12 Young Street, Southport 4215, QLD, Australia
    Med Hypotheses 62:646-52. 2004
    ..A biologically plausible theory of CFS causation associated with vasoactive neuropeptide dysfunction would promote a coherent and systematic approach to research into this and other possibly associated disabling conditions...
  13. ncbi request reprint Is sudden infant death syndrome (SIDS) an autoimmune disorder of endogenous vasoactive neuropeptides?
    Donald R Staines
    Gold Coast Public Health Unit, 10 12 Young Street, Southport 4215, QLD, Australia
    Med Hypotheses 62:653-7. 2004
    ..This paper discusses the potential role of certain vasoactive neuropeptides in causing autoimmune responses in susceptible infants predisposing them to SIDS...
  14. ncbi request reprint Is Gulf War Syndrome an autoimmune disorder of endogenous neuropeptides, exogenous sandfly maxadilan and molecular mimicry?
    Donald R Staines
    Gold Coast Public Health Unit, 10 12 Young Street, Southport, QLD 4215, Australia
    Med Hypotheses 62:658-64. 2004
    ....
  15. ncbi request reprint Is fibromyalgia an autoimmune disorder of endogenous vasoactive neuropeptides?
    Donald R Staines
    Gold Coast Public Health Unit, 10 12 Young Street, Southport, QLD 4215, Australia
    Med Hypotheses 62:665-9. 2004
    ..The condition may potentially arise de novo perhaps in genetically susceptible individuals. FM is postulated to be an autoimmune disorder and may include dysfunction of purine nucleotide metabolism and nociception...
  16. ncbi request reprint Is osteoporosis linked to vaccinations and Gulf War Syndrome?
    Donald R Staines
    Gold Coast Public Health Unit, 10 12 Young Street, Southport 4215, Queensland, Australia
    Med Hypotheses 62:670-3. 2004
    ....
  17. ncbi request reprint Do vasoactive neuropeptides and heat shock proteins mediate fatigue-related autoimmune disorders?
    Donald R Staines
    Gold Coast Public Health Unit, 10 12 Young Street, Southport 4215, QLD, Australia
    Med Hypotheses 64:539-42. 2005
    ..While peptide-HSP complexes are a relatively new area for research, this paper asserts that attention could be focused on these substances and complexes in an effort to elucidate a number of perplexing fatigue-associated disorders...
  18. ncbi request reprint Are vasoactive neuropeptide autoimmune fatigue-related disorders mediated via G protein-coupled receptors?
    Donald Staines
    Gold Coast Public Health Unit, 10 12 Young Street, Southport 4215, QLD, Australia
    Med Hypotheses 65:29-31. 2005
    ....
  19. ncbi request reprint Do cytosine guanine dinucleotide (CpG) fragments induce vasoactive neuropeptide mediated fatigue-related autoimmune disorders?
    Donald R Staines
    Gold Coast Public Health Unit, 10 12 Young Street, Southport 4215, QLD, Australia
    Med Hypotheses 65:370-3. 2005
    ..Interactions between CpG fragments, heat shock proteins and vasoactive neuropeptides may be associated with fatigue-related autoimmune conditions...
  20. ncbi request reprint Therapeutic and preventive interventions for postulated vasoactive neuropeptide autoimmune fatigue-related disorders
    Donald R Staines
    Gold Coast Public Health Unit, 10 12 Young Street, Southport 4215, Queensland, Australia
    Med Hypotheses 65:797-803. 2005
    ..Prevention and treatment of possible VN autoimmune fatigue-related disorders may prove to be important areas for future research and development...
  21. ncbi request reprint Overview of an autoimmune theory of endogenous vasoactive neuropeptides in the aetiology of certain conditions
    Donald R Staines
    Public Health Physician, Gold Coast Public Health Unit, 10 12 Young Street, Southport 4215, Queensland, Australia
    Med Hypotheses 62:643-5. 2004
  22. pmc The prevalence of chronic fatigue syndrome/ myalgic encephalomyelitis: a meta-analysis
    Samantha Johnston
    Griffith Health Institute, School of Medical Sciences, National Centre for Neuroimmunology and Emerging Diseases, Griffith University, Parklands, QLD, Australia
    Clin Epidemiol 5:105-10. 2013
    ..To perform a meta-analysis to examine variability among prevalence estimates for CFS/ME, according to the method of assessment used...
  23. ncbi request reprint Phosphodiesterase inhibitors may be indicated in the treatment of postulated vasoactive neuropeptide autoimmune fatigue-related disorders
    Donald R Staines
    Med Hypotheses 66:203-4. 2006