Research Topics
Genomes and Genes
| Gregory R SteinbergSummaryAffiliation: St. Vincent's Institute Country: Australia Publications
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Detail Information
Publications
Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistanceGregory R Steinberg
St Vincent s Institute, Fitzroy, Victoria, Australia
Cell Cycle 6:888-94. 2007..1) These data identify a novel mechanism by which inflammation in obesity is a precursor to defects in skeletal muscle fatty acid oxidation that generates a vicious cycle exacerbating the development of insulin resistance...
AMPK-independent pathways regulate skeletal muscle fatty acid oxidationNicolas Dzamko
St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
J Physiol 586:5819-31. 2008..These data demonstrate that AMPK is not essential for the regulation of fatty acid oxidation by AICAR or muscle contraction...- AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese femalesGregory R Steinberg
St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria, Australia 3065
J Clin Endocrinol Metab 89:4575-80. 2004.... - Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese miceGregory R Steinberg
St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
Endocrinology 147:3906-14. 2006..A HFD blunted leptin but not CNTF effects on AMPK signaling in the ARC and PVN. In summary, these data demonstrate that CNTF(Ax15) bypasses diet-induced leptin resistance to reduce hypothalamic AMPK activity... - Reduced glycogen availability is associated with increased AMPKalpha2 activity, nuclear AMPKalpha2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscleGregory R Steinberg
Vincent s Institute and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
Appl Physiol Nutr Metab 31:302-12. 2006..We suggest that increased activation of AMPK alpha2 under conditions of low muscle glycogen enhances AMPK alpha2 nuclear translocation and increases GLUT4 mRNA expression in response to exercise in human skeletal muscle... - The AMP-activated protein kinase: role in regulation of skeletal muscle metabolism and insulin sensitivityGregory R Steinberg
St Vincent s Institute of Medical Research, Australia
Mini Rev Med Chem 7:519-26. 2007.... - The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humansGregory R Steinberg
St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
J Clin Endocrinol Metab 91:3592-7. 2006..Human obesity is associated with leptin resistance, and recent studies have demonstrated that hypothalamic expression of the suppressors of cytokine signaling 3 (SOCS3) regulates leptin sensitivity in rodents... - Adiponectin: starving for attentionGregory R Steinberg
St Vincent s Institute, Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
Cell Metab 6:3-4. 2007..A new study from the Kadowaki laboratory (Kubota et al., 2007) shows that the adipocyte-derived hormone adiponectin increases appetite and reduces energy expenditure by stimulating AMPK in the hypothalamus... - Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signalingGregory R Steinberg
St Vincent s Institute and Department of Medicine, University of Melbourne, Fitzroy, Vic, 3065, Australia
Cell Metab 4:465-74. 2006..Our data demonstrate that AMPK is an important TNFalpha signaling target and is a contributing factor to the suppression of fatty-acid oxidation and the development of lipid-induced insulin resistance in obesity... - Cytokine Regulation of AMPK signallingGregory R Steinberg
St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia
Front Biosci 14:1902-16. 2009.... - AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistanceNicolas Dzamko
Department of Medicine, St Vincent s Institute of Medical Research, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
J Biol Chem 285:115-22. 2010..We demonstrate that the loss of beta1 reduces food intake and protects against the deleterious effects of an obesity-inducing diet... 
Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesityNirupa Sachithanandan
St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
Hepatology 52:1632-42. 2010..CONCLUSION: Deletion of SOCS3 in the liver increases liver insulin sensitivity in mice fed a control diet but paradoxically promotes lipogenesis, leading to the development of nonalcoholic fatty liver disease, inflammation, and obesity...- Ciliary neurotrophic factor stimulates muscle glucose uptake by a PI3-kinase-dependent pathway that is impaired with obesityGregory R Steinberg
St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Australia
Diabetes 58:829-39. 2009..CNTF also increases Akt signaling in neurons and adipocytes. Because both Akt and AMPK regulate glucose uptake, we investigated muscle glucose uptake in response to CNTF signaling in lean and obese mice... - Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissueMatthew J Watt
Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, PO Box 71, Bundoora 3083, Victoria, Australia
Am J Physiol Endocrinol Metab 290:E500-8. 2006..Taken together, these data indicate that HSL activity is maintained in the face of AMPK activation as a result of elevated HSL Ser(660) phosphorylation in adipose tissue but not skeletal muscle... - PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscleRobert J Southgate
Cellular and Molecular Metabolism Laboratory, RMIT University, Bundoora, Victoria, Australia
FASEB J 19:2072-4. 2005..We conclude that insulin decreases the expression of genes involved in oxidative metabolism in healthy but not insulin resistant muscle, due to a decrease in FoxO1 phosphorylation and nuclear exclusion secondary to reduced Akt activity... - Beta-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signalingMatthew J Watt
Skeletal Muscle Research Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology, Bundoora, Victoria, Australia
FASEB J 18:1445-6. 2004..However, the increased IMTG degradation in LG suggests factors other than HSL activity are important for IMTG degradation... - Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabeticsMichael B Chen
St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
J Clin Endocrinol Metab 90:3665-72. 2005..These data suggest that reduced activation of AMPK by gAD in obese and obese type 2 diabetic subjects is not caused by reduced adiponectin receptor expression but that aspects downstream of the receptor may inhibit AMPK signaling... - Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesitySandra Galic
St Vincent s Institute of Medical Research, University of Melbourne, Fitzroy, Victoria, Australia
J Clin Invest 121:4903-15. 2011..Thus, activation of AMPK β1 and increasing fatty acid oxidation in macrophages may represent a new therapeutic approach for the treatment of insulin resistance... - Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubesMatthew J Watt
Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, Victoria, Australia
J Physiol 574:139-47. 2006.... - Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in ratsAnna G Holmes
Diabetes and Metabolism Division, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
J Endocrinol 198:367-74. 2008..Our results do not support the notion that prolonged chronically elevated IL-6 impairs insulin action in vivo... - Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocationSebastian Beck Jørgensen
St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia
Am J Physiol Endocrinol Metab 297:E57-66. 2009..We conclude that resistin impairs insulin-stimulated glucose uptake by mechanisms involving reduced plasma membrane GLUT4 translocation but independent of the proximal insulin-signaling cascade, AMPK, and SOCS-3... - Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistanceNirupa Sachithanandan
St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
Diabetes 60:2023-31. 2011..In the current study, we investigated the physiological role of myeloid and lymphoid cell SOCS1 in regulating inflammation and insulin sensitivity... - Deficiency in interferon-gamma results in reduced body weight and better glucose tolerance in miceNicole Wong
University of Melbourne, Department of Medicine Austin Health and Northern Health, Heidelberg Repatriation Hospital, 300 Waterdale Road, Heidelberg Heights, Victoria 3081, Australia
Endocrinology 152:3690-9. 2011..Our findings demonstrate that IFNγ plays a critical role in the regulation of body weight and glucose metabolism... - AMP-activated protein kinase--the fat controller of the energy railroadGregory R Steinberg
St. Vincent's Institute, 41 Victoria Pd, Fitzroy, 3065 Victoria, Australia
Can J Physiol Pharmacol 84:655-65. 2006..As such, it can be considered to be the fat controller of the energy railroad. It is thought that AMPK may be a major mediator of the health benefits of exercise in mitigating the development of obesity and age-onset diseases... - Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesitySebastian Beck Jorgensen
St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
Diabetes 62:56-64. 2013..Therapies aimed at inhibiting SOCS3 in skeletal muscle may be effective in reversing obesity-related glucose intolerance and insulin resistance... - Low salt concentrations activate AMP-activated protein kinase in mouse macula densa cellsNatasha Cook
Dept of Nephrology, Austin Health, Studley Rd, Heidelberg 3084, Victoria, Australia
Am J Physiol Renal Physiol 296:F801-9. 2009..Phosphorylation of these substrates in vivo is predicted to increase intracellular chloride and so reduce the effect of salt restriction on tubuloglomerular feedback and renin secretion... - Adipose tissue as an endocrine organSandra Galic
St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia
Mol Cell Endocrinol 316:129-39. 2010.... - Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexesJohn W Scott
St Vincent s Institute and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy 3065, VIC Australia
Chem Biol 15:1220-30. 2008..Our findings highlight the regulatory role played by the beta subunit in modulating AMPK activity and the possibility of developing isoform specific therapeutic activators of this important metabolic regulator... - Skeletal muscle glucose uptake during contraction is regulated by nitric oxide and ROS independently of AMPKTroy L Merry
Dept of Physiology, Univ of Melbourne, Victoria, Australia
Am J Physiol Endocrinol Metab 298:E577-85. 2010..In conclusion, ROS and NO are involved in regulating skeletal muscle glucose uptake during contraction via an AMPK-independent mechanism... - Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPKPeter F Mount
Department of Nephrology, Austin Health, Heidelberg, Victoria, Australia
Atherosclerosis 200:28-36. 2008..The effect of BK on endothelial lipid metabolism represents a novel pathway for targeting fatty acid mediated endothelial cell dysfunction... - Socs1 deficiency enhances hepatic insulin signalingEmma Jamieson
St Vincent s Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
J Biol Chem 280:31516-21. 2005..Socs1 deficiency increases IRS-2 expression and enhances hepatic insulin sensitivity in vivo indicating that inhibition of SOCS1 may be a logical strategy in type 2 diabetes... - Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal womenKristy A Brown
Prince Henry s Institute, Monash Medical Centre, Clayton, Victoria, Australia
Cancer Res 69:5392-9. 2009..In conclusion, the regulation of aromatase by CRTC2, in response to the altered hormonal milieu associated with menopause and obesity, provides a critical link between obesity and breast cancer... - High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitusBrian G Drew
Baker IDI Heart and Diabetes Institute, Melbourne, Australia
Circulation 119:2103-11. 2009..We hypothesized that HDL modulates glucose metabolism via elevation of plasma insulin and through activation of the key metabolic regulatory enzyme, AMP-activated protein kinase, in skeletal muscle... - Adipocyte triglyceride lipase expression in human obesityGregory R Steinberg
St Vincent s Institute, Department of Medicine, The University of Melbourne, Fitzroy, Victoria, Australia
Am J Physiol Endocrinol Metab 293:E958-64. 2007.... - Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscleMatthew J Watt
Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT Univ, PO Box 71, Bundoora 3083, Victoria, Australia
Am J Physiol Endocrinol Metab 287:E120-7. 2004..These changes in IMTG degradation appear to disassociate, however, from the activity of the key enzymes responsible for synthesis and degradation of this substrate... - AMPK in Health and DiseaseGregory R Steinberg
Protein Chemistry and Metabolism, St Vincent s Institute of Medical Research, University of Melbourne, Fitzroy, Victoria, Australia
Physiol Rev 89:1025-78. 2009..Lastly, we review the possible role of AMPK in multiple common diseases and the role of the new age of drugs targeting AMPK signaling... - Impact of SOCS3 overexpression on human skeletal muscle development in vitroMarissa K Caldow
Molecular Nutrition Unit, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia
Cytokine 55:104-9. 2011..Thus SOCS3 influences myoblast differentiation and SOCS3 may be significant in regulating the activity of genes previously identified as transcriptionally regulated by STAT3... - Role of the AMP-activated protein kinase in regulating fatty acid metabolism during exerciseGregory R Steinberg
St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria 3065, Australia
Appl Physiol Nutr Metab 34:315-22. 2009.... - AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesityHayley M O'Neill
University of Melbourne, Department of Medicine, St Vincent s Institute of Medical Research, Melbourne, Victoria, Australia
Mol Cell Endocrinol 366:135-51. 2013.... - AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatmentGregory R Steinberg
Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
Am J Physiol Endocrinol Metab 284:E648-54. 2003..However, taken as a whole, our data support recent evidence in rodent muscle that leptin stimulates FA oxidation through stimulation of AMPK and a subsequent downregulation of ACC activity... - Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistanceGregory R Steinberg
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
Am J Physiol Endocrinol Metab 283:E187-92. 2002..This study provides the first evidence that leptin increases FA oxidation in skeletal muscle of lean, but not obese humans, thus demonstrating the development of leptin resistance in obese human skeletal muscle... - Fatty acid oxidation and triacylglycerol hydrolysis are enhanced after chronic leptin treatment in ratsGregory R Steinberg
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1
Am J Physiol Endocrinol Metab 282:E593-600. 2002..e., carnitine palmitoyltransferase I regulation) or electron transport uncoupling (i.e., uncoupling protein-3 expression)... - Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acidMatthew J Watt
School of Medical Sciences, Royal Melbourne Institute of Technology, PO Box 71, Bundoora, Victoria 3083, Australia
Am J Physiol Endocrinol Metab 285:E412-9. 2003..It is possible that more powerful signals or a higher [Ca2+] may override the lipid-storage effect of the CPA-mediated effects during muscular contractions... - Endurance training partially reverses dietary-induced leptin resistance in rodent skeletal muscleGregory R Steinberg
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
Am J Physiol Endocrinol Metab 286:E57-63. 2004..Future studies should examine changes in the actual protein content of SOCS3 in muscle and establish whether aerobic exercise is also effective in treating leptin resistance in humans... - Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36Arend Bonen
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
FASEB J 18:1144-6. 2004.... - Chronic leptin administration decreases fatty acid uptake and fatty acid transporters in rat skeletal muscleGregory R Steinberg
Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario N1G 2W1, Canada
J Biol Chem 277:8854-60. 2002..88, p < 0.01) and plasma membrane FABPpm protein (r = 0.94, p < 0.01). These studies provide the first evidence that protein-mediated long chain fatty acid transport is subject to long term regulation by leptin... - CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPKMatthew J Watt
Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology, PO Box 71, Bundoora, 3083, Australia
Nat Med 12:541-8. 2006.... - Regulation and function of triacylglycerol lipases in cellular metabolismMatthew J Watt
Department of Physiology, Monash University, Clayton, VIC 3800, Australia
Biochem J 414:313-25. 2008..In the present review, we discuss the metabolic regulation and function of TAG lipases with a focus on HSL (hormone-sensitive lipase), ATGL (adipose triacylglycerol lipase) and newly identified members of the lipolytic proteome... - Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exerciseJason L Talanian
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
Am J Physiol Regul Integr Comp Physiol 291:R1094-9. 2006..This adrenergic stimulation contributes to the increase in HSL activity that occurs in human skeletal muscle in the first minute of exercise at 65% and 90% VO2 peak... - Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinaseAndrew L Carey
Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology RMIT University, Australia
Diabetes 55:2688-97. 2006..Our results demonstrate that acute IL-6 treatment enhances insulin-stimulated glucose disposal in humans in vivo, while the effects of IL-6 on glucose and fatty acid metabolism in vitro appear to be mediated by AMPK... - Differential regulation of adiponectin receptor gene expression by adiponectin and leptin in myotubes derived from obese and diabetic individualsAndrew J McAinch
School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia
Obesity (Silver Spring) 14:1898-904. 2006..The incapacity of skeletal muscle of obese and diabetic individuals to respond to exogenous adiponectin and leptin may be further suppressed as a result of impaired regulation of the AdipoR1 gene...