Gregory R Steinberg

Summary

Affiliation: St. Vincent's Institute
Country: Australia

Publications

  1. ncbi request reprint Reduced glycogen availability is associated with increased AMPKalpha2 activity, nuclear AMPKalpha2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle
    Gregory R Steinberg
    Vincent s Institute and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    Appl Physiol Nutr Metab 31:302-12. 2006
  2. ncbi request reprint Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice
    Gregory R Steinberg
    St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    Endocrinology 147:3906-14. 2006
  3. ncbi request reprint The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans
    Gregory R Steinberg
    St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    J Clin Endocrinol Metab 91:3592-7. 2006
  4. ncbi request reprint Adiponectin: starving for attention
    Gregory R Steinberg
    St Vincent s Institute, Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Cell Metab 6:3-4. 2007
  5. ncbi request reprint Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling
    Gregory R Steinberg
    St Vincent s Institute and Department of Medicine, University of Melbourne, Fitzroy, Vic, 3065, Australia
    Cell Metab 4:465-74. 2006
  6. ncbi request reprint Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistance
    Gregory R Steinberg
    St Vincent s Institute, Fitzroy, Victoria, Australia
    Cell Cycle 6:888-94. 2007
  7. ncbi request reprint AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese females
    Gregory R Steinberg
    St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria, Australia 3065
    J Clin Endocrinol Metab 89:4575-80. 2004
  8. ncbi request reprint The AMP-activated protein kinase: role in regulation of skeletal muscle metabolism and insulin sensitivity
    Gregory R Steinberg
    St Vincent s Institute of Medical Research, Australia
    Mini Rev Med Chem 7:519-26. 2007
  9. pmc AMPK-independent pathways regulate skeletal muscle fatty acid oxidation
    Nicolas Dzamko
    St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    J Physiol 586:5819-31. 2008
  10. ncbi request reprint Cytokine Regulation of AMPK signalling
    Gregory R Steinberg
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia
    Front Biosci (Landmark Ed) 14:1902-16. 2009

Detail Information

Publications55

  1. ncbi request reprint Reduced glycogen availability is associated with increased AMPKalpha2 activity, nuclear AMPKalpha2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle
    Gregory R Steinberg
    Vincent s Institute and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    Appl Physiol Nutr Metab 31:302-12. 2006
    ..We suggest that increased activation of AMPK alpha2 under conditions of low muscle glycogen enhances AMPK alpha2 nuclear translocation and increases GLUT4 mRNA expression in response to exercise in human skeletal muscle...
  2. ncbi request reprint Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice
    Gregory R Steinberg
    St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    Endocrinology 147:3906-14. 2006
    ..A HFD blunted leptin but not CNTF effects on AMPK signaling in the ARC and PVN. In summary, these data demonstrate that CNTF(Ax15) bypasses diet-induced leptin resistance to reduce hypothalamic AMPK activity...
  3. ncbi request reprint The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans
    Gregory R Steinberg
    St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    J Clin Endocrinol Metab 91:3592-7. 2006
    ..Human obesity is associated with leptin resistance, and recent studies have demonstrated that hypothalamic expression of the suppressors of cytokine signaling 3 (SOCS3) regulates leptin sensitivity in rodents...
  4. ncbi request reprint Adiponectin: starving for attention
    Gregory R Steinberg
    St Vincent s Institute, Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Cell Metab 6:3-4. 2007
    ..A new study from the Kadowaki laboratory (Kubota et al., 2007) shows that the adipocyte-derived hormone adiponectin increases appetite and reduces energy expenditure by stimulating AMPK in the hypothalamus...
  5. ncbi request reprint Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling
    Gregory R Steinberg
    St Vincent s Institute and Department of Medicine, University of Melbourne, Fitzroy, Vic, 3065, Australia
    Cell Metab 4:465-74. 2006
    ..Our data demonstrate that AMPK is an important TNFalpha signaling target and is a contributing factor to the suppression of fatty-acid oxidation and the development of lipid-induced insulin resistance in obesity...
  6. ncbi request reprint Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistance
    Gregory R Steinberg
    St Vincent s Institute, Fitzroy, Victoria, Australia
    Cell Cycle 6:888-94. 2007
    ..1) These data identify a novel mechanism by which inflammation in obesity is a precursor to defects in skeletal muscle fatty acid oxidation that generates a vicious cycle exacerbating the development of insulin resistance...
  7. ncbi request reprint AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese females
    Gregory R Steinberg
    St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria, Australia 3065
    J Clin Endocrinol Metab 89:4575-80. 2004
    ....
  8. ncbi request reprint The AMP-activated protein kinase: role in regulation of skeletal muscle metabolism and insulin sensitivity
    Gregory R Steinberg
    St Vincent s Institute of Medical Research, Australia
    Mini Rev Med Chem 7:519-26. 2007
    ....
  9. pmc AMPK-independent pathways regulate skeletal muscle fatty acid oxidation
    Nicolas Dzamko
    St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    J Physiol 586:5819-31. 2008
    ..These data demonstrate that AMPK is not essential for the regulation of fatty acid oxidation by AICAR or muscle contraction...
  10. ncbi request reprint Cytokine Regulation of AMPK signalling
    Gregory R Steinberg
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia
    Front Biosci (Landmark Ed) 14:1902-16. 2009
    ....
  11. pmc AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance
    Nicolas Dzamko
    Department of Medicine, St Vincent s Institute of Medical Research, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    J Biol Chem 285:115-22. 2010
    ..We demonstrate that the loss of beta1 reduces food intake and protects against the deleterious effects of an obesity-inducing diet...
  12. doi request reprint Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity
    Nirupa Sachithanandan
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    Hepatology 52:1632-42. 2010
    ..SOCS3 LKO mice fed an HFD also had elevated hypothalamic SOCS3 and fatty acid synthase expression and developed greater obesity due to increased food intake and reduced energy expenditure...
  13. ncbi request reprint Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue
    Matthew J Watt
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, PO Box 71, Bundoora 3083, Victoria, Australia
    Am J Physiol Endocrinol Metab 290:E500-8. 2006
    ..Taken together, these data indicate that HSL activity is maintained in the face of AMPK activation as a result of elevated HSL Ser(660) phosphorylation in adipose tissue but not skeletal muscle...
  14. pmc Ciliary neurotrophic factor stimulates muscle glucose uptake by a PI3-kinase-dependent pathway that is impaired with obesity
    Gregory R Steinberg
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Australia
    Diabetes 58:829-39. 2009
    ..CNTF also increases Akt signaling in neurons and adipocytes. Because both Akt and AMPK regulate glucose uptake, we investigated muscle glucose uptake in response to CNTF signaling in lean and obese mice...
  15. ncbi request reprint PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle
    Robert J Southgate
    Cellular and Molecular Metabolism Laboratory, RMIT University, Bundoora, Victoria, Australia
    FASEB J 19:2072-4. 2005
    ..We conclude that insulin decreases the expression of genes involved in oxidative metabolism in healthy but not insulin resistant muscle, due to a decrease in FoxO1 phosphorylation and nuclear exclusion secondary to reduced Akt activity...
  16. ncbi request reprint Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics
    Michael B Chen
    St Vincent s Institute, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    J Clin Endocrinol Metab 90:3665-72. 2005
    ..These data suggest that reduced activation of AMPK by gAD in obese and obese type 2 diabetic subjects is not caused by reduced adiponectin receptor expression but that aspects downstream of the receptor may inhibit AMPK signaling...
  17. ncbi request reprint Beta-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling
    Matthew J Watt
    Skeletal Muscle Research Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology, Bundoora, Victoria, Australia
    FASEB J 18:1445-6. 2004
    ..However, the increased IMTG degradation in LG suggests factors other than HSL activity are important for IMTG degradation...
  18. pmc Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity
    Sandra Galic
    St Vincent s Institute of Medical Research, University of Melbourne, Fitzroy, Victoria, Australia
    J Clin Invest 121:4903-15. 2011
    ..Thus, activation of AMPK β1 and increasing fatty acid oxidation in macrophages may represent a new therapeutic approach for the treatment of insulin resistance...
  19. ncbi request reprint Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation
    Sebastian Beck Jørgensen
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia
    Am J Physiol Endocrinol Metab 297:E57-66. 2009
    ..We conclude that resistin impairs insulin-stimulated glucose uptake by mechanisms involving reduced plasma membrane GLUT4 translocation but independent of the proximal insulin-signaling cascade, AMPK, and SOCS-3...
  20. pmc Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes
    Matthew J Watt
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, Victoria, Australia
    J Physiol 574:139-47. 2006
    ....
  21. ncbi request reprint Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in rats
    Anna G Holmes
    Diabetes and Metabolism Division, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Endocrinol 198:367-74. 2008
    ..Our results do not support the notion that prolonged chronically elevated IL-6 impairs insulin action in vivo...
  22. pmc Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance
    Nirupa Sachithanandan
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    Diabetes 60:2023-31. 2011
    ..In the current study, we investigated the physiological role of myeloid and lymphoid cell SOCS1 in regulating inflammation and insulin sensitivity...
  23. doi request reprint Deficiency in interferon-gamma results in reduced body weight and better glucose tolerance in mice
    Nicole Wong
    University of Melbourne, Department of Medicine Austin Health and Northern Health, Heidelberg Repatriation Hospital, 300 Waterdale Road, Heidelberg Heights, Victoria 3081, Australia
    Endocrinology 152:3690-9. 2011
    ..Our findings demonstrate that IFNγ plays a critical role in the regulation of body weight and glucose metabolism...
  24. doi request reprint AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity
    Hayley M O'Neill
    University of Melbourne, Department of Medicine, St Vincent s Institute of Medical Research, Melbourne, Victoria, Australia
    Mol Cell Endocrinol 366:135-51. 2013
    ....
  25. ncbi request reprint AMP-activated protein kinase--the fat controller of the energy railroad
    Gregory R Steinberg
    St Vincent s Institute, 41 Victoria Pd, Fitzroy, 3065 Victoria, Australia
    Can J Physiol Pharmacol 84:655-65. 2006
    ..As such, it can be considered to be the fat controller of the energy railroad. It is thought that AMPK may be a major mediator of the health benefits of exercise in mitigating the development of obesity and age-onset diseases...
  26. pmc Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity
    Sebastian Beck Jorgensen
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    Diabetes 62:56-64. 2013
    ..Therapies aimed at inhibiting SOCS3 in skeletal muscle may be effective in reversing obesity-related glucose intolerance and insulin resistance...
  27. doi request reprint Low salt concentrations activate AMP-activated protein kinase in mouse macula densa cells
    Natasha Cook
    Dept of Nephrology, Austin Health, Studley Rd, Heidelberg 3084, Victoria, Australia
    Am J Physiol Renal Physiol 296:F801-9. 2009
    ..Phosphorylation of these substrates in vivo is predicted to increase intracellular chloride and so reduce the effect of salt restriction on tubuloglomerular feedback and renin secretion...
  28. doi request reprint Adipose tissue as an endocrine organ
    Sandra Galic
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia
    Mol Cell Endocrinol 316:129-39. 2010
    ....
  29. doi request reprint Skeletal muscle glucose uptake during contraction is regulated by nitric oxide and ROS independently of AMPK
    Troy L Merry
    Dept of Physiology, Univ of Melbourne, Victoria, Australia
    Am J Physiol Endocrinol Metab 298:E577-85. 2010
    ..In conclusion, ROS and NO are involved in regulating skeletal muscle glucose uptake during contraction via an AMPK-independent mechanism...
  30. doi request reprint Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes
    John W Scott
    St Vincent s Institute and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy 3065, VIC Australia
    Chem Biol 15:1220-30. 2008
    ..Our findings highlight the regulatory role played by the beta subunit in modulating AMPK activity and the possibility of developing isoform specific therapeutic activators of this important metabolic regulator...
  31. ncbi request reprint Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK
    Peter F Mount
    Department of Nephrology, Austin Health, Heidelberg, Victoria, Australia
    Atherosclerosis 200:28-36. 2008
    ..The effect of BK on endothelial lipid metabolism represents a novel pathway for targeting fatty acid mediated endothelial cell dysfunction...
  32. ncbi request reprint Socs1 deficiency enhances hepatic insulin signaling
    Emma Jamieson
    St Vincent s Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    J Biol Chem 280:31516-21. 2005
    ..Socs1 deficiency increases IRS-2 expression and enhances hepatic insulin sensitivity in vivo indicating that inhibition of SOCS1 may be a logical strategy in type 2 diabetes...
  33. ncbi request reprint Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling
    John W Scott
    Protein Chemistry and Metabolism, St Vincent s Institute of Medical Research, University of Melbourne, 41 Victoria Parade, Fitzroy VIC 3065, Australia Electronic address
    Chem Biol 21:619-27. 2014
    ..These findings have important implications for development of AMPK-targeting therapeutics and point to possible combinatorial therapeutic strategies based on AMP and AMPK drugs. ..
  34. ncbi request reprint Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal women
    Kristy A Brown
    Prince Henry s Institute, Monash Medical Centre, Clayton, Victoria, Australia
    Cancer Res 69:5392-9. 2009
    ..In conclusion, the regulation of aromatase by CRTC2, in response to the altered hormonal milieu associated with menopause and obesity, provides a critical link between obesity and breast cancer...
  35. ncbi request reprint Adipocyte triglyceride lipase expression in human obesity
    Gregory R Steinberg
    St Vincent s Institute, Department of Medicine, The University of Melbourne, Fitzroy, Victoria, Australia
    Am J Physiol Endocrinol Metab 293:E958-64. 2007
    ....
  36. doi request reprint High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus
    Brian G Drew
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Circulation 119:2103-11. 2009
    ..We hypothesized that HDL modulates glucose metabolism via elevation of plasma insulin and through activation of the key metabolic regulatory enzyme, AMP-activated protein kinase, in skeletal muscle...
  37. ncbi request reprint Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress
    Sean L McGee
    Metabolic Remodelling Laboratory, Metabolic Research Unit, School of Medicine, Deakin University, Waurn Ponds, Victoria, Australia Division of Cell Signalling and Metabolism, Baker International Diabetes Institute Heart and Diabetes Institute, Melbourne, Victoria, Australia
    FASEB J 28:3384-95. 2014
    ..Gaur, V., Campbell, D. E., Jorgensen, S. B., Kemp, B. E., Baar, K., Steinberg, G. R., Hargreaves, M. Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress. ..
  38. ncbi request reprint Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity
    Sandra Galic
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, VIC 3065, Australia
    Biochem J 461:177-88. 2014
    ..Lastly, we discuss the important findings from SOCS whole-body and tissue-specific null mice, which implicate an important role for these proteins in controlling insulin action and glucose homoeostasis in obesity...
  39. doi request reprint Impact of SOCS3 overexpression on human skeletal muscle development in vitro
    Marissa K Caldow
    Molecular Nutrition Unit, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia
    Cytokine 55:104-9. 2011
    ..Thus SOCS3 influences myoblast differentiation and SOCS3 may be significant in regulating the activity of genes previously identified as transcriptionally regulated by STAT3...
  40. ncbi request reprint Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscle
    Matthew J Watt
    Skeletal Muscle Research Laboratory, School of Medical Sciences, RMIT Univ, PO Box 71, Bundoora 3083, Victoria, Australia
    Am J Physiol Endocrinol Metab 287:E120-7. 2004
    ..These changes in IMTG degradation appear to disassociate, however, from the activity of the key enzymes responsible for synthesis and degradation of this substrate...
  41. doi request reprint AMPK in Health and Disease
    Gregory R Steinberg
    Protein Chemistry and Metabolism, St Vincent s Institute of Medical Research, University of Melbourne, Fitzroy, Victoria, Australia
    Physiol Rev 89:1025-78. 2009
    ..Lastly, we review the possible role of AMPK in multiple common diseases and the role of the new age of drugs targeting AMPK signaling...
  42. doi request reprint Role of the AMP-activated protein kinase in regulating fatty acid metabolism during exercise
    Gregory R Steinberg
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria 3065, Australia
    Appl Physiol Nutr Metab 34:315-22. 2009
    ....
  43. pmc Hepatic Glucose Intolerance Precedes Hepatic Steatosis in the Male Aromatase Knockout (ArKO) Mouse
    Michelle L Van Sinderen
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
    PLoS ONE 9:e87230. 2014
    ..Therefore, we conclude that male ArKO mice develop hepatic glucose intolerance by the age of 3 months which precedes the sex-specific development of hepatic steatosis. This can be reversed upon the administration of exogenous E2. ..
  44. ncbi request reprint Differential regulation of adiponectin receptor gene expression by adiponectin and leptin in myotubes derived from obese and diabetic individuals
    Andrew J McAinch
    School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia
    Obesity (Silver Spring) 14:1898-904. 2006
    ..This study aimed to investigate the regulation of adiponectin receptors 1 (AdipoR1) and 2 (AdipoR2) gene expression in primary skeletal muscle myotubes, derived from human donors, after exposure to globular adiponectin (gAd) and leptin...
  45. ncbi request reprint CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK
    Matthew J Watt
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology, PO Box 71, Bundoora, 3083, Australia
    Nat Med 12:541-8. 2006
    ....
  46. ncbi request reprint Chronic leptin administration decreases fatty acid uptake and fatty acid transporters in rat skeletal muscle
    Gregory R Steinberg
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario N1G 2W1, Canada
    J Biol Chem 277:8854-60. 2002
    ..88, p < 0.01) and plasma membrane FABPpm protein (r = 0.94, p < 0.01). These studies provide the first evidence that protein-mediated long chain fatty acid transport is subject to long term regulation by leptin...
  47. ncbi request reprint Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36
    Arend Bonen
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    FASEB J 18:1144-6. 2004
    ....
  48. ncbi request reprint Endurance training partially reverses dietary-induced leptin resistance in rodent skeletal muscle
    Gregory R Steinberg
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Physiol Endocrinol Metab 286:E57-63. 2004
    ..Future studies should examine changes in the actual protein content of SOCS3 in muscle and establish whether aerobic exercise is also effective in treating leptin resistance in humans...
  49. ncbi request reprint Regulation and function of triacylglycerol lipases in cellular metabolism
    Matthew J Watt
    Department of Physiology, Monash University, Clayton, VIC 3800, Australia
    Biochem J 414:313-25. 2008
    ..In the present review, we discuss the metabolic regulation and function of TAG lipases with a focus on HSL (hormone-sensitive lipase), ATGL (adipose triacylglycerol lipase) and newly identified members of the lipolytic proteome...
  50. ncbi request reprint Fatty acid oxidation and triacylglycerol hydrolysis are enhanced after chronic leptin treatment in rats
    Gregory R Steinberg
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1
    Am J Physiol Endocrinol Metab 282:E593-600. 2002
    ..e., carnitine palmitoyltransferase I regulation) or electron transport uncoupling (i.e., uncoupling protein-3 expression)...
  51. ncbi request reprint Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acid
    Matthew J Watt
    School of Medical Sciences, Royal Melbourne Institute of Technology, PO Box 71, Bundoora, Victoria 3083, Australia
    Am J Physiol Endocrinol Metab 285:E412-9. 2003
    ..It is possible that more powerful signals or a higher [Ca2+] may override the lipid-storage effect of the CPA-mediated effects during muscular contractions...
  52. ncbi request reprint Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance
    Gregory R Steinberg
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Physiol Endocrinol Metab 283:E187-92. 2002
    ..This study provides the first evidence that leptin increases FA oxidation in skeletal muscle of lean, but not obese humans, thus demonstrating the development of leptin resistance in obese human skeletal muscle...
  53. ncbi request reprint Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase
    Andrew L Carey
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology RMIT University, Australia
    Diabetes 55:2688-97. 2006
    ..Our results demonstrate that acute IL-6 treatment enhances insulin-stimulated glucose disposal in humans in vivo, while the effects of IL-6 on glucose and fatty acid metabolism in vitro appear to be mediated by AMPK...
  54. ncbi request reprint AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment
    Gregory R Steinberg
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    Am J Physiol Endocrinol Metab 284:E648-54. 2003
    ..However, taken as a whole, our data support recent evidence in rodent muscle that leptin stimulates FA oxidation through stimulation of AMPK and a subsequent downregulation of ACC activity...
  55. ncbi request reprint Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise
    Jason L Talanian
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Physiol Regul Integr Comp Physiol 291:R1094-9. 2006
    ..This adrenergic stimulation contributes to the increase in HSL activity that occurs in human skeletal muscle in the first minute of exercise at 65% and 90% VO2 peak...