John W Scott

Summary

Affiliation: St. Vincent's Institute
Country: Australia

Publications

  1. ncbi request reprint Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling
    John W Scott
    Protein Chemistry and Metabolism, St Vincent s Institute of Medical Research, University of Melbourne, 41 Victoria Parade, Fitzroy VIC 3065, Australia Electronic address
    Chem Biol 21:619-27. 2014
  2. doi request reprint ATP sensitive bi-quinoline activator of the AMP-activated protein kinase
    John W Scott
    St Vincent s Institute and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy 3065, Victoria, Australia Electronic address
    Biochem Biophys Res Commun 443:435-40. 2014
  3. doi request reprint Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes
    John W Scott
    St Vincent s Institute and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy 3065, VIC Australia
    Chem Biol 15:1220-30. 2008
  4. ncbi request reprint AMPK/SNF1 structure: a menage a trois of energy-sensing
    John W Scott
    St Vincent s Institute and Dept of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Front Biosci (Landmark Ed) 14:596-610. 2009
  5. doi request reprint AMPK is a direct adenylate charge-regulated protein kinase
    Jonathan S Oakhill
    Department of Protein Chemistry and Metabolism, St Vincent s Institute of Medical Research, University of Melbourne, 41 Victoria Parade, Fitzroy 3065, Victoria, Australia
    Science 332:1433-5. 2011
  6. pmc β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)
    Jonathan S Oakhill
    Protein Chemistry and Metabolism, Saint Vincent s Institute of Medical Research, University of Melbourne, 41 Victoria Parade, Fitzroy 3065, Australia
    Proc Natl Acad Sci U S A 107:19237-41. 2010
  7. doi request reprint AMPK functions as an adenylate charge-regulated protein kinase
    Jonathan S Oakhill
    Protein Chemistry and Metabolism, St Vincent s Institute and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Trends Endocrinol Metab 23:125-32. 2012
  8. doi request reprint Mutant TDP-43 Deregulates AMPK activation by PP2A in ALS models
    Nirma D Perera
    Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Melbourne, Victoria, Australia Centre for Neuroscience, University of Melbourne, Parkville, Melbourne, Victoria, Australia
    PLoS ONE 9:e90449. 2014

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling
    John W Scott
    Protein Chemistry and Metabolism, St Vincent s Institute of Medical Research, University of Melbourne, 41 Victoria Parade, Fitzroy VIC 3065, Australia Electronic address
    Chem Biol 21:619-27. 2014
    ..These findings have important implications for development of AMPK-targeting therapeutics and point to possible combinatorial therapeutic strategies based on AMP and AMPK drugs. ..
  2. doi request reprint ATP sensitive bi-quinoline activator of the AMP-activated protein kinase
    John W Scott
    St Vincent s Institute and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy 3065, Victoria, Australia Electronic address
    Biochem Biophys Res Commun 443:435-40. 2014
    ..Our findings indicate that AMPK has multiple modes of allosteric activation that may be exploited to design isoform-specific activators as potential therapeutics for metabolic diseases. ..
  3. doi request reprint Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes
    John W Scott
    St Vincent s Institute and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy 3065, VIC Australia
    Chem Biol 15:1220-30. 2008
    ..Our findings highlight the regulatory role played by the beta subunit in modulating AMPK activity and the possibility of developing isoform specific therapeutic activators of this important metabolic regulator...
  4. ncbi request reprint AMPK/SNF1 structure: a menage a trois of energy-sensing
    John W Scott
    St Vincent s Institute and Dept of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Front Biosci (Landmark Ed) 14:596-610. 2009
    ..Together they provide an impressive insight into the molecular interactions involved in regulating kinase activity, heterotrimeric assembly, glycogen binding, and binding of the regulatory nucleotides AMP and ATP...
  5. doi request reprint AMPK is a direct adenylate charge-regulated protein kinase
    Jonathan S Oakhill
    Department of Protein Chemistry and Metabolism, St Vincent s Institute of Medical Research, University of Melbourne, 41 Victoria Parade, Fitzroy 3065, Victoria, Australia
    Science 332:1433-5. 2011
    ..However, in contrast to AMP, ADP did not directly activate phosphorylated AMPK. In this way, both ADP/ATP and AMP/ATP ratios contribute to AMPK regulation...
  6. pmc β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)
    Jonathan S Oakhill
    Protein Chemistry and Metabolism, Saint Vincent s Institute of Medical Research, University of Melbourne, 41 Victoria Parade, Fitzroy 3065, Australia
    Proc Natl Acad Sci U S A 107:19237-41. 2010
    ..Our results show that AMP regulates AMPK activation at the initial phosphorylation step, and that β-subunit myristoylation is important for transducing the metabolic stress signal...
  7. doi request reprint AMPK functions as an adenylate charge-regulated protein kinase
    Jonathan S Oakhill
    Protein Chemistry and Metabolism, St Vincent s Institute and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Trends Endocrinol Metab 23:125-32. 2012
    ..Here we discuss the current state of AMPK regulation by adenine nucleotides and we propose that AMPK functions as an adenylate charge-regulated protein kinase...
  8. doi request reprint Mutant TDP-43 Deregulates AMPK activation by PP2A in ALS models
    Nirma D Perera
    Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Melbourne, Victoria, Australia Centre for Neuroscience, University of Melbourne, Parkville, Melbourne, Victoria, Australia
    PLoS ONE 9:e90449. 2014
    ..While AMPK activation in motor neurons correlateswith progressionin mutant SOD1-mediated disease, AMPK inactivation mediated by PP2Ais associated withmutant TDP-43-linked ALS. ..