John T Price

Summary

Affiliation: St. Vincent's Institute
Country: Australia

Publications

  1. ncbi request reprint The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line
    John T Price
    Tumour Cell Migration and Metastasis Laboratory, St Vincent s Institute, Melbourne, Vistoria, Australia
    Cancer Res 65:4929-38. 2005
  2. ncbi request reprint Osteoclast inhibitory lectin (OCIL) inhibits osteoblast differentiation and function in vitro
    Akira Nakamura
    St Vincent s Institute, 9, Princes Street, Fitzroy, Victoria, Australia
    Bone 40:305-15. 2007
  3. ncbi request reprint Influenza A virus facilitates Streptococcus pneumoniae transmission and disease
    Dimitri A Diavatopoulos
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    FASEB J 24:1789-98. 2010
  4. ncbi request reprint Mechanisms of tumour invasion and metastasis: emerging targets for therapy
    John T Price
    Bone Metastasis and Cell Migration Laboratory, St Vincent s Institute of Medical Research, Department of Surgery, University of Melbourne, St Vincent s Hospital, Fitzroy, Melbourne, VIC 3065, Australia
    Expert Opin Ther Targets 6:217-33. 2002
  5. ncbi request reprint The type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by alphaVbeta3 integrin in human breast cancer cells
    Kulrut Borrirukwanit
    University of Melbourne, Department of Surgery, St Vincent s Hospital, Fitzroy, Victoria, 3065, Australia
    Matrix Biol 26:291-305. 2007
  6. ncbi request reprint Bimolecular interaction of insulin-like growth factor (IGF) binding protein-2 with alphavbeta3 negatively modulates IGF-I-mediated migration and tumor growth
    Joseph J Pereira
    Breast Bone Metastasis Cell Migration Laboratory, St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    Cancer Res 64:977-84. 2004
  7. ncbi request reprint STI-571 inhibits in vitro angiogenesis
    Andrew Dudley
    Department of Medicine, St Vincent s Hospital, University of Melbourne, Australia
    Biochem Biophys Res Commun 310:135-42. 2003
  8. ncbi request reprint A role for alphaV integrin subunit in TGF-beta-stimulated osteoclastogenesis
    Synn Lynn Chin
    University of Melbourne, Department of Medicine, St Vincent s Hospital, 4th Floor Clinical Sciences Building, 3065 Fitzroy, Vic, Australia
    Biochem Biophys Res Commun 307:1051-8. 2003
  9. ncbi request reprint Epidermal growth factor-induced epithelio-mesenchymal transition in human breast carcinoma cells
    Margaret L Ackland
    Deakin University, Burwood, Australia
    Lab Invest 83:435-48. 2003
  10. ncbi request reprint Doxycycline-inducible expression of SPARC/Osteonectin/BM40 in MDA-MB-231 human breast cancer cells results in growth inhibition
    Nirada Dhanesuan
    VBCRC Breast Cancer Invasion and Metastasis Unit, St Vincent s Institute of Medical Research Melbourne, Australia
    Breast Cancer Res Treat 75:73-85. 2002

Research Grants

Collaborators

Detail Information

Publications11

  1. ncbi request reprint The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line
    John T Price
    Tumour Cell Migration and Metastasis Laboratory, St Vincent s Institute, Melbourne, Vistoria, Australia
    Cancer Res 65:4929-38. 2005
    ..These data suggest an important contraindication to the Hsp90 targeted cancer therapy currently undergoing clinical trial...
  2. ncbi request reprint Osteoclast inhibitory lectin (OCIL) inhibits osteoblast differentiation and function in vitro
    Akira Nakamura
    St Vincent s Institute, 9, Princes Street, Fitzroy, Victoria, Australia
    Bone 40:305-15. 2007
    ..In addition, the reduction of adipocyte formation in KUSA O cells by OCIL indicates that OCIL may have wider effects on the mesenchymal lineage that may be important for both bone metabolism and other connective tissue functions...
  3. ncbi request reprint Influenza A virus facilitates Streptococcus pneumoniae transmission and disease
    Dimitri A Diavatopoulos
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    FASEB J 24:1789-98. 2010
    ..Together, these data provide novel insights into pneumococcal-influenza synergism and may indicate a previously unappreciated role of IAV in the spread of S. pneumoniae...
  4. ncbi request reprint Mechanisms of tumour invasion and metastasis: emerging targets for therapy
    John T Price
    Bone Metastasis and Cell Migration Laboratory, St Vincent s Institute of Medical Research, Department of Surgery, University of Melbourne, St Vincent s Hospital, Fitzroy, Melbourne, VIC 3065, Australia
    Expert Opin Ther Targets 6:217-33. 2002
    ..The review focuses on representative key targets in each of these processes and summarises the state of play in each case...
  5. ncbi request reprint The type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by alphaVbeta3 integrin in human breast cancer cells
    Kulrut Borrirukwanit
    University of Melbourne, Department of Surgery, St Vincent s Hospital, Fitzroy, Victoria, 3065, Australia
    Matrix Biol 26:291-305. 2007
    ....
  6. ncbi request reprint Bimolecular interaction of insulin-like growth factor (IGF) binding protein-2 with alphavbeta3 negatively modulates IGF-I-mediated migration and tumor growth
    Joseph J Pereira
    Breast Bone Metastasis Cell Migration Laboratory, St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    Cancer Res 64:977-84. 2004
    ..Collectively, these results indicate that alpha v beta 3 and IGFBP-2 act cooperatively in a negative regulatory manner to reduce tumor growth and the migratory potential of breast cancer cells...
  7. ncbi request reprint STI-571 inhibits in vitro angiogenesis
    Andrew Dudley
    Department of Medicine, St Vincent s Hospital, University of Melbourne, Australia
    Biochem Biophys Res Commun 310:135-42. 2003
    ..These data suggest that STI-571, in addition to its efficacy in the treatment of certain cancers, may also prove to be clinically useful in diseases characterized by unregulated angiogenesis...
  8. ncbi request reprint A role for alphaV integrin subunit in TGF-beta-stimulated osteoclastogenesis
    Synn Lynn Chin
    University of Melbourne, Department of Medicine, St Vincent s Hospital, 4th Floor Clinical Sciences Building, 3065 Fitzroy, Vic, Australia
    Biochem Biophys Res Commun 307:1051-8. 2003
    ..These data suggest that TGF-beta potentiates RANKL-induced osteoclast formation, in part by increased expression of the alphaV integrin subunit, which may contribute to cell fusion...
  9. ncbi request reprint Epidermal growth factor-induced epithelio-mesenchymal transition in human breast carcinoma cells
    Margaret L Ackland
    Deakin University, Burwood, Australia
    Lab Invest 83:435-48. 2003
    ..N- and E-cadherin are not usually coexpressed in human carcinoma cell lines but can be coexpressed in embryonic tissues, and this may signify an epithelial cell population prone to epithelio-mesenchymal-like responses...
  10. ncbi request reprint Doxycycline-inducible expression of SPARC/Osteonectin/BM40 in MDA-MB-231 human breast cancer cells results in growth inhibition
    Nirada Dhanesuan
    VBCRC Breast Cancer Invasion and Metastasis Unit, St Vincent s Institute of Medical Research Melbourne, Australia
    Breast Cancer Res Treat 75:73-85. 2002
    ..Similar growth repression by SPARC has been reported for ovarian cancer cells, and this may be a common feature among carcinomas...
  11. ncbi request reprint Myoepithelial molecular markers in human breast carcinoma PMC42-LA cells are induced by extracellular matrix and stromal cells
    Stephanie C Lebret
    Deakin University, Burwood, Melbourne 3125, Australia
    In Vitro Cell Dev Biol Anim 42:298-307. 2006
    ..Our results demonstrate a key role for the breast microenvironment in the regulation of breast lineage development...

Research Grants1

  1. Molecular Modulators of Breast-Bone Metastasis
    John Price; Fiscal Year: 2004
    ..This proposal represents a unique opportunity to identify novel modulators of breast-bone metastasis. ..