Affiliation: St Vincent's Hospital
- Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 geneWarren S Alexander
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Proc Natl Acad Sci U S A 103:16442-7. 2006..The disease in plt1/plt1 mice suggests that, in addition to immune-mediated effects, intrinsic C1Gal-T1 deficiency in megakaryocytes and the kidney may contribute to pathology...
- CGH and SNP array using DNA extracted from fixed cytogenetic preparations and long-term refrigerated bone marrow specimensRuth N MacKinnon
Victorian Cancer Cytogenetics Service, St Vincent s Hospital Melbourne, Fitzroy, Vic, Australia
Mol Cytogenet 5:10. 2012..abstract:..
- Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAPHarshal H Nandurkar
St Vincent s Hospital, 3065 Melbourne, Australia
Proc Natl Acad Sci U S A 100:8660-5. 2003..Collectively these studies indicate 3-PAP functions as an "adapter" for myotubularin, regulating myotubularin intracellular location and thereby altering the phenotype resulting from myotubularin overexpression...
- The paradox of 20q11.21 amplification in a subset of cases of myeloid malignancy with chromosome 20 deletionRuth N MacKinnon
Victorian Cancer Cytogenetics Service, St Vincent s Hospital, Melbourne, Australia
Genes Chromosomes Cancer 49:998-1013. 2010..Chromosome sub-band 20q11.21 amplification may therefore prove to be a marker of a specific subset of AML/MDS with a significant erythroid component...
- High incidence of Pneumocystis jirovecii pneumonia in patients receiving biweekly rituximab and cyclophosphamide, adriamycin, vincristine, and prednisoneSarah Kamel
Hematology Department, St Vincent s Hospital, Melbourne, Victoria, Australia
Leuk Lymphoma 51:797-801. 2010..None of these patients were HIV-positive or had additional risk factors for PCP. Our experience suggests that PCP prophylaxis should be considered in institutions using R-CHOP-14 for the treatment of patients with aggressive lymphomas...
- Protein kinase C-beta II expression in diffuse large B-cell lymphoma predicts for inferior outcome of anthracycline-based chemotherapy with and without rituximabKritika Chaiwatanatorn
Department of Haematology, St Vincent s Hospital, Melbourne, Australia
Leuk Lymphoma 50:1666-75. 2009..We now report that PKC-beta II expression has prognostic significance not only for CHOP therapy in low-risk IPI disease, but also for all patients receiving CHOP plus rituximab...
- Glycosylation changes in hFUT1 transgenic mice increase TCR signaling and apoptosis resulting in thymocyte maturation arrestGregory T C Moore
Immunology Research Centre, St Vincent s Hospital Melbourne, 41 Victoria Parade, Fitzroy 3065, Australia
Mol Immunol 45:2401-10. 2008..Our results therefore demonstrate that aberrant expression of a single glycosyltransferase can profoundly affect thymopoiesis, although the relative involvement of CD45-dependent and -independent mechanisms is yet to be determined...
- The myotubularin family: novel phosphoinositide regulatorsHarshal H Nandurkar
Department of Haematology, St Vincent s Hospital, Fitzroy, Victoria, Australia
IUBMB Life 53:37-43. 2002..The present challenge is to understand how deregulation of phosphoinositide metabolism causes human disease...
- Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membraneAnne M Kong
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
Mol Cell Biol 26:6065-81. 2006..72-5ptase expression promoted GLUT4 trafficking via a Rab11-dependent pathway but not by Rab5-mediated endocytosis. Therefore, endogenous PtdIns(3)P at the plasma membrane promotes GLUT4 translocation...
- The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongationLisa M Ooms
Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia
Mol Biol Cell 17:607-22. 2006..PIPP therefore inhibits PI3-kinase-dependent neurite elongation in PC12 cells, via regulation of the spatial distribution of phospho-Ser473-Akt and phospho-Ser9-GSK-3beta signaling...
- Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantationKaren M Dwyer
Immunology Research Center and Department of Medicine, St Vincent s Hospital, University of Melbourne, Victoria, Australia
J Clin Invest 113:1440-6. 2004....
- SHIP-2 forms a tetrameric complex with filamin, actin, and GPIb-IX-V: localization of SHIP-2 to the activated platelet actin cytoskeletonJennifer M Dyson
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800, Australia
Blood 102:940-8. 2003..These studies demonstrate a functionally active complex between SHIP-2, filamin, actin, and GPIb-IX-V that may orchestrate the localized hydrolysis of PtdIns(3,4,5)P3 and thereby regulate cortical and submembraneous actin...
- A NOVEL APPROACH TO TARGET INFLAMMATION AND THROMBOSISHarshal Nandurkar; Fiscal Year: 2007..The ability of CD39 expression to modify atherosclerosis, will be analyzed in the CD39 transgenic mice and CD39-null mice bred on a background of apolipoprotein E-null and low density lipoprotein receptor-null mice. ..