Harshal Nandurkar

Summary

Affiliation: St Vincent's Hospital
Country: Australia

Publications

  1. ncbi Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene
    Warren S Alexander
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 103:16442-7. 2006
  2. ncbi CGH and SNP array using DNA extracted from fixed cytogenetic preparations and long-term refrigerated bone marrow specimens
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital Melbourne, Fitzroy, Vic, Australia
    Mol Cytogenet 5:10. 2012
  3. ncbi Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP
    Harshal H Nandurkar
    St Vincent s Hospital, 3065 Melbourne, Australia
    Proc Natl Acad Sci U S A 100:8660-5. 2003
  4. ncbi The paradox of 20q11.21 amplification in a subset of cases of myeloid malignancy with chromosome 20 deletion
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital, Melbourne, Australia
    Genes Chromosomes Cancer 49:998-1013. 2010
  5. ncbi High incidence of Pneumocystis jirovecii pneumonia in patients receiving biweekly rituximab and cyclophosphamide, adriamycin, vincristine, and prednisone
    Sarah Kamel
    Hematology Department, St Vincent s Hospital, Melbourne, Victoria, Australia
    Leuk Lymphoma 51:797-801. 2010
  6. ncbi Protein kinase C-beta II expression in diffuse large B-cell lymphoma predicts for inferior outcome of anthracycline-based chemotherapy with and without rituximab
    Kritika Chaiwatanatorn
    Department of Haematology, St Vincent s Hospital, Melbourne, Australia
    Leuk Lymphoma 50:1666-75. 2009
  7. ncbi Glycosylation changes in hFUT1 transgenic mice increase TCR signaling and apoptosis resulting in thymocyte maturation arrest
    Gregory T C Moore
    Immunology Research Centre, St Vincent s Hospital Melbourne, 41 Victoria Parade, Fitzroy 3065, Australia
    Mol Immunol 45:2401-10. 2008
  8. ncbi The myotubularin family: novel phosphoinositide regulators
    Harshal H Nandurkar
    Department of Haematology, St Vincent s Hospital, Fitzroy, Victoria, Australia
    IUBMB Life 53:37-43. 2002
  9. ncbi Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane
    Anne M Kong
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Mol Cell Biol 26:6065-81. 2006
  10. ncbi The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation
    Lisa M Ooms
    Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia
    Mol Biol Cell 17:607-22. 2006

Research Grants

  1. A NOVEL APPROACH TO TARGET INFLAMMATION AND THROMBOSIS
    Harshal Nandurkar; Fiscal Year: 2007

Collaborators

Detail Information

Publications12

  1. ncbi Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene
    Warren S Alexander
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 103:16442-7. 2006
    ..The disease in plt1/plt1 mice suggests that, in addition to immune-mediated effects, intrinsic C1Gal-T1 deficiency in megakaryocytes and the kidney may contribute to pathology...
  2. ncbi CGH and SNP array using DNA extracted from fixed cytogenetic preparations and long-term refrigerated bone marrow specimens
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital Melbourne, Fitzroy, Vic, Australia
    Mol Cytogenet 5:10. 2012
    ..abstract:..
  3. ncbi Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP
    Harshal H Nandurkar
    St Vincent s Hospital, 3065 Melbourne, Australia
    Proc Natl Acad Sci U S A 100:8660-5. 2003
    ..Collectively these studies indicate 3-PAP functions as an "adapter" for myotubularin, regulating myotubularin intracellular location and thereby altering the phenotype resulting from myotubularin overexpression...
  4. ncbi The paradox of 20q11.21 amplification in a subset of cases of myeloid malignancy with chromosome 20 deletion
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital, Melbourne, Australia
    Genes Chromosomes Cancer 49:998-1013. 2010
    ..Chromosome sub-band 20q11.21 amplification may therefore prove to be a marker of a specific subset of AML/MDS with a significant erythroid component...
  5. ncbi High incidence of Pneumocystis jirovecii pneumonia in patients receiving biweekly rituximab and cyclophosphamide, adriamycin, vincristine, and prednisone
    Sarah Kamel
    Hematology Department, St Vincent s Hospital, Melbourne, Victoria, Australia
    Leuk Lymphoma 51:797-801. 2010
    ..None of these patients were HIV-positive or had additional risk factors for PCP. Our experience suggests that PCP prophylaxis should be considered in institutions using R-CHOP-14 for the treatment of patients with aggressive lymphomas...
  6. ncbi Protein kinase C-beta II expression in diffuse large B-cell lymphoma predicts for inferior outcome of anthracycline-based chemotherapy with and without rituximab
    Kritika Chaiwatanatorn
    Department of Haematology, St Vincent s Hospital, Melbourne, Australia
    Leuk Lymphoma 50:1666-75. 2009
    ..We now report that PKC-beta II expression has prognostic significance not only for CHOP therapy in low-risk IPI disease, but also for all patients receiving CHOP plus rituximab...
  7. ncbi Glycosylation changes in hFUT1 transgenic mice increase TCR signaling and apoptosis resulting in thymocyte maturation arrest
    Gregory T C Moore
    Immunology Research Centre, St Vincent s Hospital Melbourne, 41 Victoria Parade, Fitzroy 3065, Australia
    Mol Immunol 45:2401-10. 2008
    ..Our results therefore demonstrate that aberrant expression of a single glycosyltransferase can profoundly affect thymopoiesis, although the relative involvement of CD45-dependent and -independent mechanisms is yet to be determined...
  8. ncbi The myotubularin family: novel phosphoinositide regulators
    Harshal H Nandurkar
    Department of Haematology, St Vincent s Hospital, Fitzroy, Victoria, Australia
    IUBMB Life 53:37-43. 2002
    ..The present challenge is to understand how deregulation of phosphoinositide metabolism causes human disease...
  9. ncbi Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane
    Anne M Kong
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Mol Cell Biol 26:6065-81. 2006
    ..72-5ptase expression promoted GLUT4 trafficking via a Rab11-dependent pathway but not by Rab5-mediated endocytosis. Therefore, endogenous PtdIns(3)P at the plasma membrane promotes GLUT4 translocation...
  10. ncbi The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation
    Lisa M Ooms
    Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia
    Mol Biol Cell 17:607-22. 2006
    ..PIPP therefore inhibits PI3-kinase-dependent neurite elongation in PC12 cells, via regulation of the spatial distribution of phospho-Ser473-Akt and phospho-Ser9-GSK-3beta signaling...
  11. ncbi Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation
    Karen M Dwyer
    Immunology Research Center and Department of Medicine, St Vincent s Hospital, University of Melbourne, Victoria, Australia
    J Clin Invest 113:1440-6. 2004
    ....
  12. ncbi SHIP-2 forms a tetrameric complex with filamin, actin, and GPIb-IX-V: localization of SHIP-2 to the activated platelet actin cytoskeleton
    Jennifer M Dyson
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800, Australia
    Blood 102:940-8. 2003
    ..These studies demonstrate a functionally active complex between SHIP-2, filamin, actin, and GPIb-IX-V that may orchestrate the localized hydrolysis of PtdIns(3,4,5)P3 and thereby regulate cortical and submembraneous actin...

Research Grants3

  1. A NOVEL APPROACH TO TARGET INFLAMMATION AND THROMBOSIS
    Harshal Nandurkar; Fiscal Year: 2007
    ..The ability of CD39 expression to modify atherosclerosis, will be analyzed in the CD39 transgenic mice and CD39-null mice bred on a background of apolipoprotein E-null and low density lipoprotein receptor-null mice. ..