S I Mannering
Affiliation: St. Vincent's Institute
- The A-chain of insulin is a hot-spot for CD4+ T cell epitopes in human type 1 diabetesS I Mannering
Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Australia
Clin Exp Immunol 156:226-31. 2009..The finding of a further CD4(+) T cell epitope in the N-terminal A-chain region of human insulin underscores the importance of this region as a target of CD4(+) T cell responses in human T1D...
- Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetesS I Mannering
St Vincent s Institute, The University of Melbourne, Department of Medicine, St Vincent s Hospital, Fitzroy, Vic, Australia
Clin Exp Immunol 162:197-209. 2010..Here we describe some of the assays used currently to detect autoreactive T cells in human blood and review critically their strengths and weaknesses. The challenges and future prospects for the T cell assays are discussed...
- Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulinL Chang
Department of Microbiology and Immunology and ImmunoID, University of Melbourne, Vic, Australia
Tissue Antigens 62:408-17. 2003..Peptides from the library were used to initiate assembly of recombinant HLA-B8, HLA-B15 and HLA-A2, facilitating the identification of candidate T-cell epitopes from preproinsulin...
- Ara h 1 CD4+ T cell epitope-based peptides: candidates for a peanut allergy therapeuticS R Prickett
Department of Immunology, Monash University, Melbourne, Vic, Australia
Clin Exp Allergy 43:684-97. 2013..Peanut allergy is a life-threatening condition; there is currently no cure. While whole allergen extracts are used for specific immunotherapy for many allergies, they can cause severe reactions and even fatalities in peanut allergy...