Ruth N MacKinnon

Summary

Affiliation: St Vincent's Hospital
Country: Australia

Publications

  1. pmc The role of dicentric chromosome formation and secondary centromere deletion in the evolution of myeloid malignancy
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital Melbourne Ltd, P O Box 2900, Fitzroy, VIC 3065, Australia
    Genet Res Int 2011:643628. 2011
  2. pmc CGH and SNP array using DNA extracted from fixed cytogenetic preparations and long-term refrigerated bone marrow specimens
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital Melbourne, Fitzroy, Vic, Australia
    Mol Cytogenet 5:10. 2012
  3. doi request reprint A cryptic deletion in 5q31.2 provides further evidence for a minimally deleted region in myelodysplastic syndromes
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital Melbourne, Fitzroy, Vic, Australia
    Cancer Genet 204:187-94. 2011
  4. doi request reprint Unbalanced translocations of 20q in AML and MDS often involve interstitial rather than terminal deletions of 20q
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital, Melbourne, Victoria, Australia
    Cancer Genet 204:153-61. 2011
  5. doi request reprint The use of M-FISH and M-BAND to define chromosome abnormalities
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital Melbourne, Fitzroy, Vic, Australia
    Methods Mol Biol 730:203-18. 2011
  6. doi request reprint The paradox of 20q11.21 amplification in a subset of cases of myeloid malignancy with chromosome 20 deletion
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital, Melbourne, Australia
    Genes Chromosomes Cancer 49:998-1013. 2010
  7. doi request reprint Dicentric chromosomes and 20q11.2 amplification in MDS/AML with apparent monosomy 20
    R N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital, University of Melbourne, Melbourne, Australia
    Cytogenet Genome Res 119:211-20. 2007
  8. ncbi request reprint A FISH comparison of variant derivatives of the recurrent dic(17;20) of myelodysplastic syndromes and acute myeloid leukemia: Obligatory retention of genes on 17p and 20q may explain the formation of dicentric chromosomes
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital Melbourne, Australia
    Genes Chromosomes Cancer 46:27-36. 2007
  9. ncbi request reprint A comparison of two contrasting recurrent isochromosomes 20 found in myelodysplastic syndromes suggests that retention of proximal 20q is a significant factor in myeloid malignancies
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, Department of Medicine, St Vincent s Hospital Melbourne and University of Melbourne, Fitzroy Vic, Australia
    Cancer Genet Cytogenet 163:176-9. 2005
  10. ncbi request reprint Recurrent duplication of Xq27-qter in hematological malignancies revealed by multicolor fluorescence in situ hybridization and multicolor banding
    Ruth N MacKinnon
    University of Melbourne Department of Medicine, St Vincent s Hospital, Melbourne, Victoria, Australia
    Cancer Genet Cytogenet 161:125-9. 2005

Collaborators

Detail Information

Publications12

  1. pmc The role of dicentric chromosome formation and secondary centromere deletion in the evolution of myeloid malignancy
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital Melbourne Ltd, P O Box 2900, Fitzroy, VIC 3065, Australia
    Genet Res Int 2011:643628. 2011
    ..We present a model that predicts and explains a significant role for dicentric chromosomes in the formation of unbalanced translocations in malignancy...
  2. pmc CGH and SNP array using DNA extracted from fixed cytogenetic preparations and long-term refrigerated bone marrow specimens
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital Melbourne, Fitzroy, Vic, Australia
    Mol Cytogenet 5:10. 2012
    ..abstract:..
  3. doi request reprint A cryptic deletion in 5q31.2 provides further evidence for a minimally deleted region in myelodysplastic syndromes
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital Melbourne, Fitzroy, Vic, Australia
    Cancer Genet 204:187-94. 2011
    ..This case, together with previously published studies, suggests that the proximal boundary of the common deleted region may lie within the KDM3B gene...
  4. doi request reprint Unbalanced translocations of 20q in AML and MDS often involve interstitial rather than terminal deletions of 20q
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital, Melbourne, Victoria, Australia
    Cancer Genet 204:153-61. 2011
    ..This points to a more complex mechanism of translocation involving at least three breakpoints and two separate events, and raises questions about the order of these events and the significance of these abnormalities...
  5. doi request reprint The use of M-FISH and M-BAND to define chromosome abnormalities
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital Melbourne, Fitzroy, Vic, Australia
    Methods Mol Biol 730:203-18. 2011
    ..The single colour galleries - which show the hybridisation patterns of the individual fluorochromes - are useful to help interpret and confirm the false colour images produced by the software, including ambiguous signals...
  6. doi request reprint The paradox of 20q11.21 amplification in a subset of cases of myeloid malignancy with chromosome 20 deletion
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital, Melbourne, Australia
    Genes Chromosomes Cancer 49:998-1013. 2010
    ..Chromosome sub-band 20q11.21 amplification may therefore prove to be a marker of a specific subset of AML/MDS with a significant erythroid component...
  7. doi request reprint Dicentric chromosomes and 20q11.2 amplification in MDS/AML with apparent monosomy 20
    R N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital, University of Melbourne, Melbourne, Australia
    Cytogenet Genome Res 119:211-20. 2007
    ..The reported incidence of dicentric chromosomes is clearly an under-estimate but is increasing in myeloid disorders as more cases are studied with methods allowing their detection...
  8. ncbi request reprint A FISH comparison of variant derivatives of the recurrent dic(17;20) of myelodysplastic syndromes and acute myeloid leukemia: Obligatory retention of genes on 17p and 20q may explain the formation of dicentric chromosomes
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital Melbourne, Australia
    Genes Chromosomes Cancer 46:27-36. 2007
    ..This would explain the excess of dicentric chromosomes resulting from 17;20 translocation, and the apparent stabilization of the unstable derivatives by further rearrangements which preserve 17p and 20q material...
  9. ncbi request reprint A comparison of two contrasting recurrent isochromosomes 20 found in myelodysplastic syndromes suggests that retention of proximal 20q is a significant factor in myeloid malignancies
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, Department of Medicine, St Vincent s Hospital Melbourne and University of Melbourne, Fitzroy Vic, Australia
    Cancer Genet Cytogenet 163:176-9. 2005
    ..We speculate that a region of proximal 20q is preferentially retained during deletions of the critical region in MDS and acute myeloid leukemia...
  10. ncbi request reprint Recurrent duplication of Xq27-qter in hematological malignancies revealed by multicolor fluorescence in situ hybridization and multicolor banding
    Ruth N MacKinnon
    University of Melbourne Department of Medicine, St Vincent s Hospital, Melbourne, Victoria, Australia
    Cancer Genet Cytogenet 161:125-9. 2005
    ..e., in one third of male cases and one fifth of all cases). These preliminary results may point to the existence of a recurrent chromosome abnormality, either translocation at a specific Xq27 locus or duplication of Xq27-qter...
  11. doi request reprint Chromothripsis under the microscope: a cytogenetic perspective of two cases of AML with catastrophic chromosome rearrangement
    Ruth N MacKinnon
    Victorian Cancer Cytogenetics Service, St Vincent s Hospital Melbourne, Fitzroy, Australia
    Cancer Genet 206:238-51. 2013
    ..Understanding chromothripsis in the context of chromosome biology will help us identify its causes and consequences. ..