Research Topics
| David St ClairSummaryCountry: Australia Publications
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Detail Information
Publications
The association between cannabis use and earlier age at onset of schizophrenia and other psychoses: meta-analysis of possible confounding factorsNicholas Myles
The Euroa Centre, The Prince of Wales Hospital, Barker Street, Randwick, NSW, Australia 2031
Curr Pharm Des 18:5055-69. 2012....
Self-enucleation: forget Freud and Oedipus, it's all about untreated psychosisMatthew Michael Large
School of Psychiatry, University of New South Wales, Sydney, Australia
Br J Ophthalmol 96:1056-7. 2012..Early treatment with antipsychotic medication in the case of unilateral or threatened self-enucleation might prevent some cases of blindness...
Meta-analysis of self-reported substance use compared with laboratory substance assay in general adult mental health settingsMatthew M Large
School of Psychiatry, University of New South Wales, Randwick, NSW, Australia
Int J Methods Psychiatr Res 21:134-48. 2012....
The validity and utility of risk assessment for inpatient suicideMatthew Large
Prince of Wales Hospital and School of Psychiatry, UNSW, Sydney, NSW, Australia
Australas Psychiatry 19:507-12. 2011..We aimed to examine the validity and utility of categorizing psychiatric patients to be at either high or low risk of committing suicide while in hospital...
Did the introduction of 'dangerousness' and 'risk of harm' criteria in mental health laws increase the incidence of suicide in the United States of America?Matthew M Large
Mental Health Services, St Vincent s Hospital, Darlinghurst NSW, Australia
Soc Psychiatry Psychiatr Epidemiol 44:614-21. 2009..In order to investigate whether or not suicide rates increased after the introduction of ODC, we examined suicide statistics from 48 states and the District of Columbia...
The epidemiology of homicide followed by suicide: a systematic and quantitative reviewMatthew Large
Mental Health Services, The Prince of Wales Hospital, Randwick, Sydney, NSW, Australia and the School of Psychiatry, University of New South Wales, Sydney, NSW, Australia
Suicide Life Threat Behav 39:294-306. 2009..Homicide-suicide appears to be closer in epidemiological terms to homicide than suicide in regions with high rates of homicide and measures to reduce homicide in these regions may also reduce homicide-suicide...
The associations between infant homicide, homicide, and suicide rates: an analysis of world health organization and centers for disease control statisticsMatthew Large
School of Psychiatry, University of New South Wales, Randwick, Australia
Suicide Life Threat Behav 40:87-97. 2010..The epidemiological evidence supports the clinical observation that infant homicides are due to a range of causes, including maternal mental illness, but are also related to the level of serious violence within a community...
Suicide in Australia: meta-analysis of rates and methods of suicide between 1988 and 2007Matthew M Large
School of Psychiatry, University of New South Wales, Sydney, NSW, Australia
Med J Aust 192:432-7. 2010..To examine the changes in rates of methods of suicide in Australian states and territories between 1988 and 2007...
The reliability of evidence about psychiatric diagnosis after serious crime: part II. Agreement between experts and treating practitionersMatthew Large
University of New South Wales, Australia
J Am Acad Psychiatry Law 38:524-30. 2010....
The predictive value of risk categorization in schizophreniaMatthew M Large
University of New South Wales, Prince of Wales Hospital, Sydney, Australia
Harv Rev Psychiatry 19:25-33. 2011..Risk assessment is increasingly used to inform decisions regarding the psychiatric treatment of patients with schizophrenia and other serious mental disorders...
Systematic review and meta-analysis of the clinical factors associated with the suicide of psychiatric in-patientsM Large
The Euroa Centre, Prince of Wales Hospital, Barker Street, Randwick, Sydney, NSW 2031, Australia
Acta Psychiatr Scand 124:18-29. 2011..To estimate the strength of the associations between the suicide of psychiatric in-patients and demographic, historical, symptomatic, diagnostic and treatment factors...
Cannabis use and earlier onset of psychosis: a systematic meta-analysisMatthew Large
Mental Health Service, Prince of Wales Hospital, Sydney, Australia
Arch Gen Psychiatry 68:555-61. 2011..A number of studies have found that the use of cannabis and other psychoactive substances is associated with an earlier onset of psychotic illness...
Measurement and reporting of the duration of untreated psychosisMatthew Large
Clinical Research Unit for Anxiety Disorders, School of Psychiatry, University of New South Wales at St Vincent s Hospital, Darlinghurst, New South Wales, Australia
Early Interv Psychiatry 2:201-11. 2008..The aim of this study was to investigate the demographic, illness and methodological factors associated with mean and median duration of untreated psychosis (DUP)...
Risk factors for suicide within a year of discharge from psychiatric hospital: a systematic meta-analysisMatthew Large
The Euroa Centre, The Prince of Wales Hospital, Barker Street, Randwick, Sydney, New South Wales 2031, Australia
Aust N Z J Psychiatry 45:619-28. 2011....
Factors associated with agreement between experts in evidence about psychiatric injuryMatthew M Large
Private Practice, Sydney, Australia
J Am Acad Psychiatry Law 36:515-21. 2008..Experts were more likely to agree about the presence of a mental disorder if the plaintiff was involved in a fatal accident. The agreement of treating doctors and experts was similar to that of pairs of experts...
The danger of dangerousness: why we must remove the dangerousness criterion from our mental health actsM M Large
Mental Health Service, St Vincent s Hospitai, Darlinghurst, NSW, Australia
J Med Ethics 34:877-81. 2008..This paper argues that the dangerousness criterion is unnecessary, unethical and, in the case of the ODC, potentially harmful to mentally ill people and to the rest of the community...
Major self-mutilation in the first episode of psychosisMatthew Large
Schizophr Bull 35:1012-21. 2009..Acute psychosis, in particular first-episode schizophrenia, appears to be the major cause of MSM. Although MSM is extremely uncommon, earlier treatment of psychotic illness may reduce the incidence of MSM...
The Penrose hypothesis in 2004: patient and prisoner numbers are positively correlated in low-and-middle income countries but are unrelated in high-income countriesMatthew M Large
Private Practice, Sydney, New South Wales, Australia
Psychol Psychother 82:113-9. 2009..To examine the relationship between the numbers of psychiatric hospital beds and prisoners using recent statistics...
Mental health laws that require dangerousness for involuntary admission may delay the initial treatment of schizophreniaMatthew M Large
Soc Psychiatry Psychiatr Epidemiol 43:251-6. 2008..Mental health laws that require patients to be dangerous to themselves or to others before they can receive involuntary psychiatric treatment may make it more difficult to treat patients in their first episode of psychosis...
Homicide due to mental disorder in England and Wales over 50 yearsMatthew Large
Northern Sydney Central Coast Area Health Service, Macquarie Hospital, North Ryde, Australia
Br J Psychiatry 193:130-3. 2008..It has been stated that rates of homicide due to mental disorder are constant over time...
Relationship between gross domestic product and duration of untreated psychosis in low- and middle-income countriesMatthew Large
PO Box 110, Double Bay 1360, NSW, Australia
Br J Psychiatry 193:272-8. 2008..The duration of untreated psychosis (DUP), the period between the first onset of psychotic symptoms and treatment, has an important influence on the outcome of schizophrenia...
Evidence for a relationship between the duration of untreated psychosis and the proportion of psychotic homicides prior to treatmentMatthew Large
Soc Psychiatry Psychiatr Epidemiol 43:37-44. 2008..We aimed to establish whether there was an association between the average duration of untreated psychosis and the proportion of homicides committed during the first episode of psychosis in the same countries...
Copy number variation and schizophreniaDavid St Clair
University of Aberdeen, Institute of Medical Science, Aberdeen, AB25 2ZD
Schizophr Bull 35:9-12. 2009..A major focus of research will be to identify the key, the genetic and environmental determinants of schizophrenia risk in carriers of these copy number variants, and to discover whether their rates of mutation are unstable or fixed...
Self-inflicted eye injuries in first-episode and previously treated psychosisMatthew Large
Aust N Z J Psychiatry 42:183-91. 2008..Serious self-inflicted eye injuries are rare, but the risk appears to be greatest during FEP. Earlier treatment of emerging psychosis and close attention to patients who attempt to injure their eyes may occasionally prevent blindness...
The reliability of evidence about psychiatric diagnosis after serious crime: Part I. Agreement between expertsOlav Nielssen
University of New South Wales, Australia
J Am Acad Psychiatry Law 38:516-23. 2010..Concern about bias in expert psychiatric opinion in criminal cases appears to have been overstated. There was little evidence to suggest that experts' adversarial roles influenced their opinions on psychiatric diagnosis...
Rates of homicide during the first episode of psychosis and after treatment: a systematic review and meta-analysisOlav Nielssen
Clinical Research Unit for Anxiety Disorders, School of Psychiatry, UNSW at St Vincent s Hospital, 299 Forbes Street, Darlinghurst, NSW, 2010, Australia
Schizophr Bull 36:702-12. 2010..Earlier treatment of first-episode psychosis might prevent some homicides...
Reliability of psychiatric evidence in serious criminal matters: fitness to stand trial and the defence of mental illnessMatthew Large
Prince of Wales Hospital, Randwick, New South Wales, Australia
Aust N Z J Psychiatry 43:446-52. 2009..The aim of the present study was to assess the level of agreement between experts about these legal issues using a consecutive series of serious criminal matters in New South Wales...
The relationship between the rate of homicide by those with schizophrenia and the overall homicide rate: a systematic review and meta-analysisMatthew Large
Mental Health Services, Sydney South Eastern and Illawarra Area Health Service, Prince of Wales Hospital, Sydney, Australia
Schizophr Res 112:123-9. 2009..It is widely believed that the rate of homicide by the mentally ill is fixed, differs little between regions and is unrelated to the total homicide rate...
Simple viewing tests can detect eye movement abnormalities that distinguish schizophrenia cases from controls with exceptional accuracyPhilip J Benson
School of Psychology, King s College, University of Aberdeen, Aberdeen, United Kingdom
Biol Psychiatry 72:716-24. 2012..We have investigated which eye-movement tests alone and combined can best discriminate schizophrenia cases from control subjects and their predictive validity...
Child pornography offenders detected by surveillance of the Internet and by other methodsOlav Nielssen
Clinical Research Unit for Anxiety and Depression, St Vincent s Hospital, Sydney, Australia
Crim Behav Ment Health 21:215-24. 2011..It has been noted that many people charged with offences relating to this had not previously been identified as sexual offenders against children...
Prevalence of psychoses on reception to male prisons in New South WalesOlav Nielssen
Division of Psychiatry, St Vincents Hospital, Sydney, Australia
Aust N Z J Psychiatry 39:453-9. 2005..The study also sought to estimate the sensitivity and specificity of the psychosis screener in the Composite International Diagnostic Interview (CIDI-Auto)...
Clinical decisions in psychiatry should not be based on risk assessmentChristopher Ryan
Discipline of Psychiatry and the Centre for Values, Ethics and the Law in Medicine, University of Sydney and Westmead Hospital, Westmead, NSW, Australia
Australas Psychiatry 18:398-403. 2010..This paper examines the effects of categorization based on the results of a risk assessment...
Increasing rates of psychiatric publication from low- and middle-income countriesMatthew Large
Mental Health Services, Prince of Wales Hospital, Randwick, Australia
Int J Soc Psychiatry 56:497-506. 2010..The aim of this study was to establish if the worldwide increase in research publication during the last decade included an increase in publication about mental disorders from LAMI countries...
Global visual scanning abnormalities in schizophrenia and bipolar disorderPatricia E G Bestelmeyer
School of Psychology, William Guild Building, University of Aberdeen, Aberdeen, AB24 2UB, UK
Schizophr Res 87:212-22. 2006..Spatial scanning characteristics but not temporal ones may serve as biomarkers in the functional psychoses...
Homicide of strangers by people with a psychotic illnessOlav Nielssen
Clinical Research Unit for Anxiety and Depression, St Vincent s Hospital, Sydney, NSW, Australia
Schizophr Bull 37:572-9. 2011....
Violence in first-episode psychosis: a systematic review and meta-analysisMatthew M Large
The Prince of Wales Hospital, Randwick, School of Psychiatry, University of New South Wales, Sydney, Australia
Schizophr Res 125:209-20. 2011..Violence towards others is a recognised complication of first-episode psychosis...
Gender differences in the duration of untreated psychosisMatthew M Large
J Nerv Ment Dis 196:171-2; author reply 172. 2008
Violence and commitment to treatmentMatthew M Large
Psychiatr Serv 59:575; discussion 576. 2008
Treating the first episode of schizophrenia earlier will save livesMatthew Large
Schizophr Res 92:276-7. 2007
