A C W Zannettino

Summary

Affiliation: South Australia
Country: Australia

Publications

  1. ncbi request reprint An in vitro osteoclast-forming assay to measure myeloma cell-derived osteoclast-activating factors
    Andrew C W Zannettino
    Myeloma and Mesenchymal Research Laboratory, Institute of Medical and Veterinary Science, Adelaide, Australia
    Methods Mol Med 113:245-56. 2005
  2. ncbi request reprint Evidence for reduced bone formation surface relative to bone resorption surface in female femoral fragility fracture patients
    Helen Tsangari
    Bone and Joint Research Laboratory, Division of Tissue Pathology, Institute of Medical and Veterinary Science, Hanson Institute, and the University of Adelaide, Frome Road, Adelaide 5000, Australia
    Bone 39:1226-35. 2006
  3. ncbi request reprint The role of the chemokine CXCL12 in osteoclastogenesis
    Stan Gronthos
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute, Adelaide, South Australia, Australia
    Trends Endocrinol Metab 18:108-13. 2007
  4. pmc Pentosan polysulfate promotes proliferation and chondrogenic differentiation of adult human bone marrow-derived mesenchymal precursor cells
    Peter Ghosh
    Proteobioactives Pty Ltd, 27 9 Powells Road, Brookvale, New South Wales 2100, Australia
    Arthritis Res Ther 12:R28. 2010
  5. ncbi request reprint The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis
    A C Zannettino
    Hanson Centre for Cancer Research, Matthew Roberts Laboratory, Institute of Medical and Veterinary Science, Adelaide, Australia
    Blood 92:2613-28. 1998
  6. ncbi request reprint Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients
    Andrew C W Zannettino
    Myeloma and Mesenchymal Research Group, Matthew Roberts Foundation Laboratory and Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute, Adelaide, Australia
    Cancer Res 65:1700-9. 2005
  7. ncbi request reprint Osteoprotegerin (OPG) is localized to the Weibel-Palade bodies of human vascular endothelial cells and is physically associated with von Willebrand factor
    A C W Zannettino
    Myeloma and Mesenchymal Research Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, and Hanson Institute, Adelaide, South Australia, Australia
    J Cell Physiol 204:714-23. 2005
  8. ncbi request reprint Molecular cloning of the cell surface antigen identified by the osteoprogenitor-specific monoclonal antibody, HOP-26
    Andrew C W Zannettino
    Myeloma and Mesenchymal Research Laboratory, Hanson Centre for Cancer Research, I M V S, PO Box 14, Rundle Mall, Adelaide 5000, South Australia, Australia
    J Cell Biochem 89:56-66. 2003
  9. ncbi request reprint CD164
    A C Zannettino
    Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    J Biol Regul Homeost Agents 15:394-6. 2001
  10. doi request reprint Enrichment for STRO-1 expression enhances the cardiovascular paracrine activity of human bone marrow-derived mesenchymal cell populations
    P J Psaltis
    Centre for Stem Cell Research, Robinson Institute and Department of Medicine, University of Adelaide, South Australia, Australia
    J Cell Physiol 223:530-40. 2010

Collaborators

Detail Information

Publications48

  1. ncbi request reprint An in vitro osteoclast-forming assay to measure myeloma cell-derived osteoclast-activating factors
    Andrew C W Zannettino
    Myeloma and Mesenchymal Research Laboratory, Institute of Medical and Veterinary Science, Adelaide, Australia
    Methods Mol Med 113:245-56. 2005
    ..This chapter describes one such in vitro model system...
  2. ncbi request reprint Evidence for reduced bone formation surface relative to bone resorption surface in female femoral fragility fracture patients
    Helen Tsangari
    Bone and Joint Research Laboratory, Division of Tissue Pathology, Institute of Medical and Veterinary Science, Hanson Institute, and the University of Adelaide, Frome Road, Adelaide 5000, Australia
    Bone 39:1226-35. 2006
    ..These data suggest that perturbations in bone formation surface, relative to resorption surface, are potentially important in producing bone in the proximal femur with increased propensity to fracture...
  3. ncbi request reprint The role of the chemokine CXCL12 in osteoclastogenesis
    Stan Gronthos
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute, Adelaide, South Australia, Australia
    Trends Endocrinol Metab 18:108-13. 2007
    ..Recent studies have highlighted an emerging role for CXCL12 in the processes of physiological and pathological bone remodelling...
  4. pmc Pentosan polysulfate promotes proliferation and chondrogenic differentiation of adult human bone marrow-derived mesenchymal precursor cells
    Peter Ghosh
    Proteobioactives Pty Ltd, 27 9 Powells Road, Brookvale, New South Wales 2100, Australia
    Arthritis Res Ther 12:R28. 2010
    ..This study was undertaken to determine whether the anti-osteoarthritis drug pentosan polysulfate (PPS) influenced mesenchymal precursor cell (MPC) proliferation and differentiation...
  5. ncbi request reprint The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis
    A C Zannettino
    Hanson Centre for Cancer Research, Matthew Roberts Laboratory, Institute of Medical and Veterinary Science, Adelaide, Australia
    Blood 92:2613-28. 1998
    ....
  6. ncbi request reprint Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients
    Andrew C W Zannettino
    Myeloma and Mesenchymal Research Group, Matthew Roberts Foundation Laboratory and Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute, Adelaide, Australia
    Cancer Res 65:1700-9. 2005
    ..Therefore, we propose that inhibition of the CXCR4-SDF-1alpha axis may provide an effective means of treatment for MM-induced osteolysis...
  7. ncbi request reprint Osteoprotegerin (OPG) is localized to the Weibel-Palade bodies of human vascular endothelial cells and is physically associated with von Willebrand factor
    A C W Zannettino
    Myeloma and Mesenchymal Research Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, and Hanson Institute, Adelaide, South Australia, Australia
    J Cell Physiol 204:714-23. 2005
    ....
  8. ncbi request reprint Molecular cloning of the cell surface antigen identified by the osteoprogenitor-specific monoclonal antibody, HOP-26
    Andrew C W Zannettino
    Myeloma and Mesenchymal Research Laboratory, Hanson Centre for Cancer Research, I M V S, PO Box 14, Rundle Mall, Adelaide 5000, South Australia, Australia
    J Cell Biochem 89:56-66. 2003
    ..Western blot analysis of human bone marrow stromal cells (HBMSC) has revealed that like a well defined CD63 mAb 12F12, HOP-26 interacts with a heavily glycosylated cell surface protein with an apparent molecular weight of 50-60 kD...
  9. ncbi request reprint CD164
    A C Zannettino
    Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    J Biol Regul Homeost Agents 15:394-6. 2001
  10. doi request reprint Enrichment for STRO-1 expression enhances the cardiovascular paracrine activity of human bone marrow-derived mesenchymal cell populations
    P J Psaltis
    Centre for Stem Cell Research, Robinson Institute and Department of Medicine, University of Adelaide, South Australia, Australia
    J Cell Physiol 223:530-40. 2010
    ..Immunoselection thus provides a strategy for improving the cardiovascular reparative potential of mesenchymal cells...
  11. ncbi request reprint Human trabecular bone-derived osteoblasts support human osteoclast formation in vitro in a defined, serum-free medium
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, and the Hanson Institute, Adelaide, South Australia, Australia
    J Cell Physiol 203:573-82. 2005
    ..This study demonstrates that under the appropriate conditions, adult human primary osteoblasts can support de novo osteoclast formation, and this model will enable the detailed study of the role of both cell types in this process...
  12. ncbi request reprint Human osteoblasts are resistant to Apo2L/TRAIL-mediated apoptosis
    G J Atkins
    Department of Orthopaedics and Trauma, Adelaide University and Royal Adelaide Hospital, Adelaide, SA, Australia
    Bone 31:448-56. 2002
    ..In addition, they predict that therapeutic use of recombinant Apo2L/TRAIL, in combination with chemotherapeutic agents to treat skeletal malignancies, would have limited toxic effects on normal osteoblastic cells...
  13. ncbi request reprint Multipotential human adipose-derived stromal stem cells exhibit a perivascular phenotype in vitro and in vivo
    A C W Zannettino
    Myeloma Research Program, Bone and Cancer Laboratories, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute and University of Adelaide, Adelaide, Australia
    J Cell Physiol 214:413-21. 2008
    ..The findings presented here, describe a multipotential stem cell population within adult human adipose tissue, which appear to be intimately associated with perivascular cells surrounding the blood vessels...
  14. ncbi request reprint Imatinib as a potential antiresorptive therapy for bone disease
    Andrea L Dewar
    Division of Haematology, Institute of Medical and Veterinary Science, Frome Rd, Adelaide 5000, Australia
    Blood 107:4334-7. 2006
    ..These results suggest that imatinib may have therapeutic value as an antiosteolytic agent in diseases such as osteoporosis, metastatic bone disease, and multiple myeloma...
  15. doi request reprint The tyrosine kinase inhibitor dasatinib dysregulates bone remodeling through inhibition of osteoclasts in vivo
    Kate Vandyke
    Myeloma Research Laboratory, Department of Haematology, Centre for Cancer Biology, Institute of Medical and Veterinary Science, Adelaide, Australia
    J Bone Miner Res 25:1759-70. 2010
    ..These studies show that dasatinib increases trabecular bone volume at least in part by inhibiting osteoclast activity, suggesting that dasatinib therapy may result in dysregulated bone remodeling...
  16. ncbi request reprint RANK Expression as a cell surface marker of human osteoclast precursors in peripheral blood, bone marrow, and giant cell tumors of bone
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia, Australia
    J Bone Miner Res 21:1339-49. 2006
    ..We describe the lineages that express RANK in bone marrow, peripheral blood, and GCTs. We show that CD14(+)RANK(high) cells constitute a circulating pre-osteoclast pool...
  17. doi request reprint The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma
    S K Martin
    Division of Haematology, Centre for Cancer Biology, SA Pathology, CSCR, University of Adelaide, Adelaide, South Australia
    Leukemia 25:1533-42. 2011
    ..The need for current and future therapeutic interventions to target HIF-1 and HIF-2 in myeloma will also be discussed...
  18. doi request reprint Chronic myeloid leukemia CD34+ cells have reduced uptake of imatinib due to low OCT-1 activity
    J R Engler
    Department of Haematology, SA Pathology RAH Campus, Adelaide, South Australia, Australia
    Leukemia 24:765-70. 2010
    ..These results indicate that low imatinib accumulation in primitive CML cells, mediated through reduced OCT-1 Activity may be a critical determinant of long-term disease persistence...
  19. doi request reprint Methods for the purification and characterization of human adipose-derived stem cells
    Stan Gronthos
    Mesenchymal Stem Cell Group, Department of Haematology, Institute of Medical and Veterinary Science Hanson Institute and Centre for Stem Cell Research, University of Adelaide, Adelaide, SA, Australia
    Methods Mol Biol 702:109-20. 2011
    ....
  20. doi request reprint Concise review: mesenchymal stromal cells: potential for cardiovascular repair
    Peter J Psaltis
    Cardiovascular Research Centre, Royal Adelaide Hospital and Department of Medicine, University of Adelaide, Adelaide, South Australia 5000, Australia
    Stem Cells 26:2201-10. 2008
    ....
  21. doi request reprint Dysregulation of bone remodeling by imatinib mesylate
    Kate Vandyke
    Myeloma and Mesenchymal Research Laboratory, Division of Haematology, Centre for Cancer Biology, Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, Australia
    Blood 115:766-74. 2010
    ..The potential application of imatinib in the treatment of cancer-induced osteolysis will also be discussed...
  22. ncbi request reprint A novel monoclonal antibody (STRO-3) identifies an isoform of tissue nonspecific alkaline phosphatase expressed by multipotent bone marrow stromal stem cells
    Stan Gronthos
    Mesenchymal Research Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute and University of Adelaide, Australia 5000
    Stem Cells Dev 16:953-63. 2007
    ..Finally, these studies suggest that antibodies to TNSALP may be used as an effective single marker of enrichment of BMSSCs from various tissues...
  23. doi request reprint Genomic profiling of mesenchymal stem cells
    Danijela Menicanin
    Mesenchymal Stem Cell Group, Bone and Cancer Laboratories, Division of Haematology, Institute of Medical and Veterinary Science Hanson Institute and CSCR, University of Adelaide, SA, Australia
    Stem Cell Rev 5:36-50. 2009
    ..The present review summarizes studies characterizing the gene expression profile of MSCs...
  24. ncbi request reprint Macrophage colony-stimulating factor receptor c-fms is a novel target of imatinib
    Andrea L Dewar
    Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    Blood 105:3127-32. 2005
    ..Imatinib should now be assessed for activity in diseases where c-fms activation is implicated, including breast and ovarian cancer and inflammatory conditions...
  25. ncbi request reprint OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib
    Deborah L White
    Division of Hematology, Institute of Medical and Veterinary Science IMVS and Hanson Institute, Adelaide, South Australia
    Blood 108:697-704. 2006
    ..Determining interpatient and interdrug differences in cellular uptake and retention could allow individual optimization of kinase inhibitor therapy...
  26. ncbi request reprint Inhibition of c-fms by imatinib: expanding the spectrum of treatment
    Andrea L Dewar
    Division of Haematology, Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Cell Cycle 4:851-3. 2005
    ..We also speculate that imatinib may be used in diseases where bone destruction occurs due to excessive osteoclast activity, such as in the haematologic malignancy, multiple myeloma...
  27. ncbi request reprint Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow
    Stan Gronthos
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    J Cell Sci 116:1827-35. 2003
    ..Our novel selection protocol provides a means to generate purified populations of BMSSCs for use in a range of different tissue engineering and gene therapy strategies...
  28. ncbi request reprint TWIST family of basic helix-loop-helix transcription factors mediate human mesenchymal stem cell growth and commitment
    Sandra Isenmann
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science Hanson Institute CSCR, University of Adelaide, SA, Australia
    Stem Cells 27:2457-68. 2009
    ..These findings implicate the TWIST gene family members as potential mediators of MSC self-renewal and lineage commitment in postnatal skeletal tissues by exerting their effects on genes involved in the early stages of bone development...
  29. ncbi request reprint Long-term imatinib therapy promotes bone formation in CML patients
    Stephen Fitter
    Bone and Cancer Research Laboratories, and Division of Haematology, Institute of Medical and Veterinary Science IMVS, The Hanson Institute, Adelaide, SA 5000, Australia
    Blood 111:2538-47. 2008
    ..Further investigation is required to determine whether the increase in TBV associated with imatinib therapy may represent a novel therapeutic avenue for the treatment of diseases that are characterized by generalized bone loss...
  30. doi request reprint Apo2L/TRAIL inhibits tumor growth and bone destruction in a murine model of multiple myeloma
    Agatha Labrinidis
    Discipline of Orthopaedics and Trauma, The University of Adelaide, Royal Adelaide Hospital, and Hanson Institute, South Australia, Australia
    Clin Cancer Res 15:1998-2009. 2009
    ..Here, we report on the efficacy of recombinant soluble Apo2L/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to inhibit tumor progression and bone destruction in a xenogeneic model of human multiple myeloma...
  31. ncbi request reprint Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo
    Amanda N Farrugia
    Myeloma and Mesenchymal Research Group, Matthew Roberts Foundation Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Cancer Res 63:5438-45. 2003
    ....
  32. ncbi request reprint RANKL expression is related to the differentiation state of human osteoblasts
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia, Australia
    J Bone Miner Res 18:1088-98. 2003
    ..Additionally, the dual roles of osteoblasts, in supporting osteoclastogenesis or forming bone, may be performed by the same lineage of cells at different stages of their maturation...
  33. ncbi request reprint Tumor angiogenesis is associated with plasma levels of stromal-derived factor-1alpha in patients with multiple myeloma
    Sally K Martin
    Myeloma and Mesenchymal Research Group, Matthew Roberts Foundation Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, University of Adelaide, Australia
    Clin Cancer Res 12:6973-7. 2006
    ..We have now examined whether SDF-1alpha levels also correlate with angiogenesis...
  34. doi request reprint Plasma adiponectin levels are markedly elevated in imatinib-treated chronic myeloid leukemia (CML) patients: a mechanism for improved insulin sensitivity in type 2 diabetic CML patients?
    Stephen Fitter
    Myeloma Research Laboratory, Department of Hematology, Centre for Cancer Biology, Institute of Medical and Veterinary Science, G P O Box 14, Adelaide, South Australia 5000, Australia
    J Clin Endocrinol Metab 95:3763-7. 2010
    ..The mechanism(s) by which imatinib improves glycemic control in chronic myeloid leukemia (CML) patients with type 2 diabetes remains unclear...
  35. ncbi request reprint Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of myeloma-associated bone loss
    Peter Diamond
    Myeloma Research Program, Bone and Cancer Laboratories, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute and the Department of Medicine, University of Adelaide, Adelaide, Australia
    J Bone Miner Res 24:1150-61. 2009
    ..These findings confirm our hypothesis that MM PC-derived CXCL12 stimulates the recruitment and activity of OC, thereby contributing to the formation of MM osteolytic lesions...
  36. ncbi request reprint The nitrogen-containing bisphosphonate, zoledronic acid, increases mineralisation of human bone-derived cells in vitro
    Beiqing Pan
    Myeloma and Mesenchymal Research Group, Matthew Roberts Foundation Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide 5000, Australia
    Bone 34:112-23. 2004
    ..These results show that, in addition to its direct effects on OCs, ZOL also directly affects the proliferation and differentiation of human OB-like cells in vitro and may enhance bone formation in vivo...
  37. doi request reprint A method to isolate and purify human bone marrow stromal stem cells
    Stan Gronthos
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute, University of Adelaide, SA, Australia
    Methods Mol Biol 449:45-57. 2008
    ....
  38. ncbi request reprint Human mulipotential mesenchymal/stromal stem cells are derived from a discrete subpopulation of STRO-1bright/CD34 /CD45(-)/glycophorin-A-bone marrow cells
    Andrew C W Zannettino
    Multiple Myeloma Research Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute and University of Adelaide, Australia
    Haematologica 92:1707-8. 2007
    ..These studies support the view that these are two distinct stem cell compartments in adult bone marrow...
  39. ncbi request reprint Cardiac magnetic resonance, transthoracic and transoesophageal echocardiography: a comparison of in vivo assessment of ventricular function in rats
    J D Richardson
    Cardiovascular Research Centre, Royal Adelaide Hospital and Department of Medicine, University of Adelaide, South Australia, Australia
    Lab Anim 47:291-300. 2013
    ..87 and 0.84). Each modality is a viable option for evaluating ventricular function in rats, however the high image quality and excellent reproducibility of CMR offers distinct advantages even at 1.5 T with conventional coils and software...
  40. doi request reprint Home is where the heart is: via the FROUNT
    Andrew C W Zannettino
    Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    Cell Stem Cell 2:513-4. 2008
    ..This process is dependent on the intracellular adaptor molecule FROUNT, which interacts with the chemokine receptor CCR2...
  41. ncbi request reprint Apomab, a fully human agonistic antibody to DR5, exhibits potent antitumor activity against primary and metastatic breast cancer
    Irene Zinonos
    Discipline of Orthopaedics and Trauma Level 4, Bice Building, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia
    Mol Cancer Ther 8:2969-80. 2009
    ..Apomab represents a potent immunotherapeutic agent with strong activity against the development and progression of breast cancer and should be evaluated in patients with primary and metastatic disease...
  42. ncbi request reprint CD36/fatty acid translocase in rats: distribution, isolation from hepatocytes, and comparison with the scavenger receptor SR-B1
    Xingqi Zhang
    The Arthritis Research Laboratory, Hanson Centre for Cancer Research, Adelaide, South Australia, Australia
    Lab Invest 83:317-32. 2003
    ..We suggest that CD36/FAT might function in the liver as a sex-regulated accessory molecule, either in reverse cholesterol transport and/or in fatty acid uptake...
  43. pmc Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration
    Andrew C W Zannettino
    Myeloma and Mesenchymal Research Group, Matthew Roberts Laboratory, Hanson Centre for Cancer Research, I M V S, Adelaide 5000, Australia
    Biochem J 370:537-49. 2003
    ..These observations will be instrumental in determining the mechanisms whereby PZR isoforms regulate cell motility...
  44. ncbi request reprint The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE)
    Beiqing Pan
    Myeloma and Mesenchymal Research Group, Matthew Robert Foundation Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    J Bone Miner Res 19:147-54. 2004
    ..The decreased transmembrane RANKL expression seems to be related to the upregulation of the RANKL sheddase, TACE...
  45. ncbi request reprint Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia 5000, Australia
    Bone 40:1517-28. 2007
    ..Our results are therefore consistent with the reported benefits of maintaining a healthy vitamin D status in the elderly to reduce the risk of fractures...
  46. ncbi request reprint The proliferation and phenotypic expression of human osteoblasts on tantalum metal
    David M Findlay
    Department of Orthopaedics and Trauma, University of Adelaide, South Australia
    Biomaterials 25:2215-27. 2004
    ..No substrate-dependent differences were seen in the extent of in vitro mineralisation by NHBC. These results indicate that Ta is a good substrate for the attachment, growth and differentiated function of human osteoblasts...
  47. ncbi request reprint Does Apo2L/TRAIL play any physiologic role in osteoclastogenesis?
    Agatha Labrinidis
    Blood 111:5411-2; autor reply 5413. 2008
  48. ncbi request reprint Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts
    Yun Shan Hu
    Bone, Joint, and Cancer Unit, St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    J Bone Miner Res 19:89-99. 2004
    ..OCIL shows promise as a new antiresorptive...