Affiliation: South Australia
- Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1Olga Sukocheva
Signal Transduction Laboratory, Division of Human Immunology, Hanson Institute, Institute of Medical and Veterinary Science, Adelaide SA 5000, Australia
J Cell Biol 173:301-10. 2006..They also suggest a new signal transduction model across three individual ligand-receptor systems, i.e., "criss-cross" transactivation...
- An oncogenic role of sphingosine kinaseP Xia
Division of Human Immunology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science and University of Adelaide, Frome Road, SA 5000, Adelaide, Australia
Curr Biol 10:1527-30. 2000..The findings not only point to a new signalling pathway in transformation but also to the potential of SphK inhibitors in cancer therapy...
- Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymesS M Pitson
Hanson Centre for Cancer Research, Division of Human Immunology, Institute of Medical and Veterinary Science, Frome Road, Adelaide 5000, SA, Australia
Biochem J 350:429-41. 2000..In all cases, both the native and recombinant SKs displayed remarkably similar properties, indicating that post-translational modifications are not required for basal activity of human SK...
- Role of sphingolipids in the cytoplasmic signaling of estrogensO Sukocheva
Division of Human Immunology, Hanson Institute, Institute of Medical and Veterinary Science, Frome Road, Adelaide, SA 5000, Australia
Steroids 74:562-7. 2009..In the current review we mainly focus on the SphK pathway and discuss the potential role of SphK and sphingolipids in the cellular biology of estrogens...