Ingrid G Winkler

Summary

Affiliation: South Brisbane
Country: Australia

Publications

  1. doi request reprint Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance
    Ingrid G Winkler
    Stem Cells and Cancer Group, Mater Medical Research Institute, South Brisbane, Queensland, Australia
    Nat Med 18:1651-7. 2012
  2. pmc Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization
    Ingrid G Winkler
    Haematopoietic Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia
    J Exp Med 201:1077-88. 2005
  3. doi request reprint Flow cytometry measurement of bone marrow perfusion in the mouse and sorting of progenitors and stems cells according to position relative to blood flow in vivo
    Valerie Barbier
    Stem Cell and Cancer Group, Mater Medical Research Institute, South Brisbane, QLD, Australia
    Methods Mol Biol 844:45-63. 2012
  4. doi request reprint Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches
    Ingrid G Winkler
    Biotherapy Program, Mater Medical Research Institute, South Brisbane, Australia
    Blood 116:375-85. 2010
  5. ncbi request reprint Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1 alpha and vascular endothelial growth factor A in bone marrow
    Jean Pierre Levesque
    Mater Medical Research Institute, Raymond Terrace, Aubigny Place, South Brisbane, QLD, Australia
    Stem Cells 25:1954-65. 2007
  6. doi request reprint Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs
    Ingrid G Winkler
    Haematopoietic Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, Australia
    Blood 116:4815-28. 2010
  7. doi request reprint Mobilization of hematopoietic stem cells by depleting bone marrow macrophages
    Valerie Barbier
    Mater Medical Research Institute, Aubigny Place, Raymond Terrace, South Brisbane, QLD, Australia
    Methods Mol Biol 904:117-38. 2012
  8. doi request reprint Flow cytometry analysis of cell cycling and proliferation in mouse hematopoietic stem and progenitor cells
    Valerie Barbier
    Stem Cell and Cancer Group, Mater Medical Research Institute, South Brisbane, QLD, Australia
    Methods Mol Biol 844:31-43. 2012
  9. doi request reprint Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation
    Catherine E Forristal
    Stem Cell Biology Group, Mater Medical Research Institute, South Brisbane, Australia
    Blood 121:759-69. 2013
  10. pmc B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2
    Ingrid G Winkler
    Mater Research at the Translational Research Institute, Woolloongabba, Queensland, Australia
    Haematologica 98:325-33. 2013

Collaborators

Detail Information

Publications22

  1. doi request reprint Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance
    Ingrid G Winkler
    Stem Cells and Cancer Group, Mater Medical Research Institute, South Brisbane, Queensland, Australia
    Nat Med 18:1651-7. 2012
    ..As bone marrow suppression is a severe side effect of high-dose chemotherapy, transient blockade of E-selectin is potentially a promising treatment for the protection of HSCs during chemotherapy or irradiation...
  2. pmc Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization
    Ingrid G Winkler
    Haematopoietic Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia
    J Exp Med 201:1077-88. 2005
    ..These data suggest an unexpected role for serpina1 and serpina3 in regulating the bone marrow hematopoietic microenvironment as well as influencing the migratory behavior of hematopoietic precursors...
  3. doi request reprint Flow cytometry measurement of bone marrow perfusion in the mouse and sorting of progenitors and stems cells according to position relative to blood flow in vivo
    Valerie Barbier
    Stem Cell and Cancer Group, Mater Medical Research Institute, South Brisbane, QLD, Australia
    Methods Mol Biol 844:45-63. 2012
    ..This technique enables prospective isolation of HSCs based on the in vivo perfusion of the niches in which they reside...
  4. doi request reprint Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches
    Ingrid G Winkler
    Biotherapy Program, Mater Medical Research Institute, South Brisbane, Australia
    Blood 116:375-85. 2010
    ..This technique enables prospective isolation of serially reconstituting HSCs distinct from other less potent HSCs of the same phenotype, based on the in vivo niche in which they reside...
  5. ncbi request reprint Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1 alpha and vascular endothelial growth factor A in bone marrow
    Jean Pierre Levesque
    Mater Medical Research Institute, Raymond Terrace, Aubigny Place, South Brisbane, QLD, Australia
    Stem Cells 25:1954-65. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  6. doi request reprint Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs
    Ingrid G Winkler
    Haematopoietic Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, Australia
    Blood 116:4815-28. 2010
    ..Together, these results establish that bone marrow macrophages are pivotal to maintain the endosteal HSC niche and that the loss of such macrophages leads to the egress of HSCs into the blood...
  7. doi request reprint Mobilization of hematopoietic stem cells by depleting bone marrow macrophages
    Valerie Barbier
    Mater Medical Research Institute, Aubigny Place, Raymond Terrace, South Brisbane, QLD, Australia
    Methods Mol Biol 904:117-38. 2012
    ..Detailed methods to analyze mobilization of phenotypic and functional reconstituting HSC are described with examples...
  8. doi request reprint Flow cytometry analysis of cell cycling and proliferation in mouse hematopoietic stem and progenitor cells
    Valerie Barbier
    Stem Cell and Cancer Group, Mater Medical Research Institute, South Brisbane, QLD, Australia
    Methods Mol Biol 844:31-43. 2012
    ....
  9. doi request reprint Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation
    Catherine E Forristal
    Stem Cell Biology Group, Mater Medical Research Institute, South Brisbane, Australia
    Blood 121:759-69. 2013
    ..The results of the present study demonstrate that the levels of HIF-1α protein can be manipulated pharmacologically in vivo to increase HSC quiescence and recovery from irradiation...
  10. pmc B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2
    Ingrid G Winkler
    Mater Research at the Translational Research Institute, Woolloongabba, Queensland, Australia
    Haematologica 98:325-33. 2013
    ..These results suggest that blood mobilized with these three agents may have distinct immune properties...
  11. ncbi request reprint Mechanisms of hematopoietic stem cell mobilization: when innate immunity assails the cells that make blood and bone
    Ingrid G Winkler
    Haematopoietic Stem Cell Laboratory, Cancer Biotherapies Program, Mater Medical Research Institute, University of Queensland, South Brisbane, Queensland, Australia
    Exp Hematol 34:996-1009. 2006
    ....
  12. doi request reprint 38th Annual Meeting of the International Society of Experimental Hematology
    Jean Pierre Levesque
    Haematopoietic Stem Cell Laboratory, Mater Medical Research Institute, Aubigny Place, Raymond Terrace, South Brisbane, QLD 4101, Australia
    Expert Rev Hematol 2:645-7. 2009
    ..Owing to the large number of keynote speakers, this report focuses on the most novel, unpublished data presented during the meeting...
  13. pmc Tissue inhibitor of metalloproteinase-3 (TIMP-3) regulates hematopoiesis and bone formation in vivo
    Yi Shen
    Hematopoietic Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, Queensland, Australia
    PLoS ONE 5:. 2010
    ..TIMP-3 is associated with the extracellular matrix and is expressed in highly remodeling tissues. TIMP-3 function in the hematopoietic system is unknown...
  14. doi request reprint Mobilization of hematopoietic stem cells: state of the art
    Jean Pierre Levesque
    Mater Medical Research Institute, South Brisbane, Queensland, Australia
    Curr Opin Organ Transplant 13:53-8. 2008
    ..This article reviews recent advances in understanding the molecular mechanisms responsible for the retention of HSCs in the bone marrow, which are perturbed during HSC mobilization, and the clinical application of these findings...
  15. doi request reprint Hierarchy of immature hematopoietic cells related to blood flow and niche
    Jean Pierre Levesque
    Biological Therapies Program, Mater Medical Research Institute, South Brisbane, Australia
    Curr Opin Hematol 18:220-5. 2011
    ..Extrinsic instructions provided by unique microenvironments (niches) regulate the fate of individual HSCs and progenitors. This review discusses the latest findings in respect to the organization and function of these niches...
  16. doi request reprint Nichotherapy for stem cells: there goes the neighborhood
    Jean Pierre Levesque
    Stem Cell Biology Group, Biological Therapies Program, Mater Medical Research Institute, South Brisbane, Australia
    Bioessays 35:183-90. 2013
    ..Some have been employed for decades, such as hematopoietic stem cell mobilization, whereas others are emerging, such as chemosensitization of leukemia stem cells by targeting their niche...
  17. doi request reprint A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity
    Iulia Oancea
    IBD Team, Immunology Infection Inflammation Program, Mater Medical Research Institute, South Brisbane, Queensland, Australia
    Gut 62:594-605. 2013
    ..Understanding of SOS has been hindered by inability to ethically perform serial liver biopsies on patients and the lack of an animal model...
  18. ncbi request reprint Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells
    Jean Pierre Levesque
    Stem Cell Laboratory, Peter MacCallum Cancer Institute, Locked Bag 1, A Beckett Street, Melbourne, Victoria 3000, Australia
    Exp Hematol 31:109-17. 2003
    ..We sought to determine the mechanisms responsible for the reduced expression of c-KIT on mobilized hematopoietic progenitor cells...
  19. ncbi request reprint Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment
    Jean Pierre Levesque
    Stem Cell Biology Laboratory, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
    Exp Hematol 30:440-9. 2002
    ..We sought to determine whether mobilization induced by G-CSF or chemotherapy was triggered by common or distinct mechanisms...
  20. ncbi request reprint Granulocyte colony-stimulating factor and an RARalpha specific agonist, VTP195183, synergize to enhance the mobilization of hematopoietic progenitor cells
    Kirsten E Herbert
    Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Transplantation 83:375-84. 2007
    ....
  21. ncbi request reprint Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1
    Ingrid G Winkler
    Adhesive Interactions and Cell Trafficking Laboratory, Peter MacCallum Cancer Centre, Melbourne, Vic, Australia
    Blood 103:1685-92. 2004
    ..These data demonstrate that an E-selectin ligand(s) other than PSGL-1 transduces growth inhibitory and proapoptotic signals and requires posttranslational fucosylation to be functional...
  22. ncbi request reprint Detection of antiviral antibodies using enzyme-linked immunosorbent assay
    Ingrid G Winkler
    Methods Mol Biol 304:257-71. 2005
    ..The second uses fixed "virus-infected" cultured cells and can be used either as a second confirmatory assay or initially in a small-scale screening to identify potentially infected individuals for further study...