D J Torpy

Summary

Affiliation: South Australia
Country: Australia

Publications

  1. ncbi request reprint Glucocorticoid receptor polymorphisms and post-traumatic stress disorder
    Anthony W Bachmann
    Department of Medicine, University of Queensland, Greenslopes Private Hospital, Brisbane, QLD 4120, Australia
    Psychoneuroendocrinology 30:297-306. 2005
  2. ncbi request reprint Value of free cortisol measurement in systemic infection
    D J Torpy
    Endocrine and Metabolic Unit, Royal Adelaide Hospital, North Terrace, Adelaide SA Australia
    Horm Metab Res 39:439-44. 2007
  3. ncbi request reprint Corticosteroid-binding globulin gene polymorphisms: clinical implications and links to idiopathic chronic fatigue disorders
    D J Torpy
    Endocrine and Metabolic Unit, and the Hanson Institute, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Clin Endocrinol (Oxf) 67:161-7. 2007
  4. ncbi request reprint Association between chronic fatigue syndrome and the corticosteroid-binding globulin gene ALA SER224 polymorphism
    David J Torpy
    University of Queensland Department of Medicine, Greenslopes Hospital, Brisbane, Queensland, Australia
    Endocr Res 30:417-29. 2004
  5. ncbi request reprint Early rise in blood pressure following administration of adrenocorticotropic hormone-[1-24] in humans
    R V Jackson
    Neuroendocrine Research Unit, Department of Medicine, University of Queensland, Greenslopes Private Hospital, Brisbane, Queensland 4120, Australia
    Clin Exp Pharmacol Physiol 28:773-5. 2001
  6. ncbi request reprint The insulin hypoglycemia test: hypoglycemic criteria and reproducibility
    E J Nye
    Neuroendocrine Research Unit, Department of Medicine, Brisbane, The University of Queensland, Queensland, Australia
    J Neuroendocrinol 13:524-30. 2001
  7. ncbi request reprint Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension
    D J Torpy
    Department of Medicine, University of Queensland, Greenslopes Private Hospital, Brisbane, Queensland 4120, Australia
    J Clin Endocrinol Metab 86:3692-700. 2001
  8. doi request reprint Characteristics of plasma NOx levels in severe sepsis: high interindividual variability and correlation with illness severity, but lack of correlation with cortisol levels
    J T Ho
    Hanson Institute, Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia
    Clin Endocrinol (Oxf) 73:413-20. 2010
  9. ncbi request reprint Moderate weight loss reduces renin and aldosterone but does not influence basal or stimulated pituitary-adrenal axis function
    J T Ho
    Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Horm Metab Res 39:694-9. 2007
  10. ncbi request reprint Septic shock and sepsis: a comparison of total and free plasma cortisol levels
    J T Ho
    Hanson Institute, The University of Adelaide, Adelaide, Australia
    J Clin Endocrinol Metab 91:105-14. 2006

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Glucocorticoid receptor polymorphisms and post-traumatic stress disorder
    Anthony W Bachmann
    Department of Medicine, University of Queensland, Greenslopes Private Hospital, Brisbane, QLD 4120, Australia
    Psychoneuroendocrinology 30:297-306. 2005
    ..Our PTSD group did not display GC hypersensitivity, as measured by the LD-DST and DVVA. In a subset of PTSD patients with the BclI GG genotype, CAPS scores and basal cortisol levels were negatively correlated...
  2. ncbi request reprint Value of free cortisol measurement in systemic infection
    D J Torpy
    Endocrine and Metabolic Unit, Royal Adelaide Hospital, North Terrace, Adelaide SA Australia
    Horm Metab Res 39:439-44. 2007
    ..Studies directed at determining if free cortisol is a better guide than total cortisol to the need for hydrocortisone supplementation may be of value...
  3. ncbi request reprint Corticosteroid-binding globulin gene polymorphisms: clinical implications and links to idiopathic chronic fatigue disorders
    D J Torpy
    Endocrine and Metabolic Unit, and the Hanson Institute, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Clin Endocrinol (Oxf) 67:161-7. 2007
    ..A mechanism for the effect of CBG mutations on fatigue is not readily apparent because free cortisol levels are normal, although we speculate that CBG may have an effect on cortisol-brain transport...
  4. ncbi request reprint Association between chronic fatigue syndrome and the corticosteroid-binding globulin gene ALA SER224 polymorphism
    David J Torpy
    University of Queensland Department of Medicine, Greenslopes Hospital, Brisbane, Queensland, Australia
    Endocr Res 30:417-29. 2004
    ..Homozygosity for the serine allele of the CBG gene may predispose to CFS, perhaps due to an effect on hypothalamic-pituitary-adrenal axis function related to altered CBG-cortisol transport function or immune-cortisol interactions...
  5. ncbi request reprint Early rise in blood pressure following administration of adrenocorticotropic hormone-[1-24] in humans
    R V Jackson
    Neuroendocrine Research Unit, Department of Medicine, University of Queensland, Greenslopes Private Hospital, Brisbane, Queensland 4120, Australia
    Clin Exp Pharmacol Physiol 28:773-5. 2001
    ..5. The cardiovascular consequences of therapeutic use of ACTH are well recognized. This results of the present study suggest that even diagnostic administration of ACTH, delivered over a few hours, may raise blood pressure...
  6. ncbi request reprint The insulin hypoglycemia test: hypoglycemic criteria and reproducibility
    E J Nye
    Neuroendocrine Research Unit, Department of Medicine, Brisbane, The University of Queensland, Queensland, Australia
    J Neuroendocrinol 13:524-30. 2001
    ..Overall, the cortisol response to hypoglycemia is more reproducible than the ACTH response but, in an individual subject, the difference in peak cortisol between two IHTs may exceed 100 nmol/l...
  7. ncbi request reprint Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension
    D J Torpy
    Department of Medicine, University of Queensland, Greenslopes Private Hospital, Brisbane, Queensland 4120, Australia
    J Clin Endocrinol Metab 86:3692-700. 2001
    ..As idiopathic fatigue disorders are associated with relatively low plasma cortisol, abnormalities of corticosteroid-binding globulin may be pathogenic...
  8. doi request reprint Characteristics of plasma NOx levels in severe sepsis: high interindividual variability and correlation with illness severity, but lack of correlation with cortisol levels
    J T Ho
    Hanson Institute, Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia
    Clin Endocrinol (Oxf) 73:413-20. 2010
    ..NOx levels were not suppressed reproducibly by hydrocortisone. High interindividual variability of NOx levels suggests that absolute NOx levels may not be a suitable target for individualized hydrocortisone therapy...
  9. ncbi request reprint Moderate weight loss reduces renin and aldosterone but does not influence basal or stimulated pituitary-adrenal axis function
    J T Ho
    Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Horm Metab Res 39:694-9. 2007
    ..There may be a threshold effect of weight loss/energy restriction required to alter HPA axis function, or moderate weight loss may lead to a counterbalanced effect of stimulatory and inhibitory influences on HPA axis function...
  10. ncbi request reprint Septic shock and sepsis: a comparison of total and free plasma cortisol levels
    J T Ho
    Hanson Institute, The University of Adelaide, Adelaide, Australia
    J Clin Endocrinol Metab 91:105-14. 2006
    ....
  11. doi request reprint CBG Santiago: a novel CBG mutation
    D J Torpy
    Endocrine and Metabolic Unit, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia
    J Clin Endocrinol Metab 97:E151-5. 2012
    ..Corticosteroid-binding globulin (CBG; SERPIN A6) gene mutations are rare; only four mutations have been described, often in association with fatigue and chronic pain, albeit with incomplete penetrance...
  12. ncbi request reprint Adrenocorticotropin stimulation tests in patients with hypothalamic-pituitary disease: low dose, standard high dose and 8-h infusion tests
    E J Nye
    Department of Medicine, The University of Queensland, Brisbane, Australia
    Clin Endocrinol (Oxf) 55:625-33. 2001
    ..1 microg) or a high dose prolonged infusion does not greatly improve the sensitivity of ACTH [1-24] testing. Dynamic tests that provide a central stimulus remain preferable in the assessment of patients with suspected ACTH deficiency...
  13. doi request reprint Corticosteroid-binding globulin: the clinical significance of altered levels and heritable mutations
    Lucia Gagliardi
    School of Medicine, University of Adelaide, Adelaide, SA 5005, Australia
    Mol Cell Endocrinol 316:24-34. 2010
    ..Further studies may clarify the functions of CBG, and clinical observations may validate and/or extend the phenotypic features of various CBG mutations...
  14. doi request reprint Familial vasopressin-sensitive ACTH-independent macronodular adrenal hyperplasia (VPs-AIMAH): clinical studies of three kindreds
    Lucia Gagliardi
    Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
    Clin Endocrinol (Oxf) 70:883-91. 2009
    ....
  15. ncbi request reprint Reduced maternal corticosteroid-binding globulin and cortisol levels in pre-eclampsia and gamete recipient pregnancies
    Jui T Ho
    Hanson Institute, University of Adelaide, and Endocrine and Metabolic Unit of the Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Clin Endocrinol (Oxf) 66:869-77. 2007
    ..To measure and contrast maternal cortisol and corticosteroid-binding globulin (CBG) levels in pregnancies with normal outcomes, pre-eclampsia, intrauterine growth restriction (IUGR) and in gamete recipients...
  16. ncbi request reprint Pregnancy-associated corticosteroid-binding globulin: high resolution separation of glycan isoforms
    E Mitchell
    The Hanson Institute, Frome Road, Adelaide, SA 5000, Australia
    Horm Metab Res 36:357-9. 2004
    ..The pregnancy-specific CBG previously defined probably represents a subset of the acidic and high molecular weight glycoforms we have resolved by two-dimensional electrophoresis and now describe as pregnancy-associated CBG...
  17. doi request reprint Screening for subclinical Cushing's syndrome in type 2 diabetes mellitus: low false-positive rates with nocturnal salivary cortisol
    L Gagliardi
    School of Medicine, University of Adelaide, Adelaide, South Australia, Australia
    Horm Metab Res 42:280-4. 2010
    ..The NSC and DST should be compared directly in metabolic disorder patients; although our data suggest the patient group will need to be substantially larger to definitively determine the optimal screening test...
  18. ncbi request reprint Association of hypertension and hypokalemia with Cushing's syndrome caused by ectopic ACTH secretion: a series of 58 cases
    David J Torpy
    University of Queensland, Department of Medicine, Greenslopes Hospital, Newdegate Street, Brisbane, Queensland 4120, Australia
    Ann N Y Acad Sci 970:134-44. 2002
    ....
  19. ncbi request reprint Plasma free cortisol fraction reflects levels of functioning corticosteroid-binding globulin
    John G Lewis
    Steroid and Immunobiochemistry Laboratory, Canterbury Health Laboratories, PO Box 151 Christchurch, New Zealand
    Clin Chim Acta 359:189-94. 2005
    ..However little is known about the distribution of free cortisol in plasma where CBG is inactivated or in congenital CBG deficiency...