J C Paton

Summary

Affiliation: South Australia
Country: Australia

Publications

  1. pmc Molecular microbiological investigation of an outbreak of hemolytic-uremic syndrome caused by dry fermented sausage contaminated with Shiga-like toxin-producing Escherichia coli
    A W Paton
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, Australia
    J Clin Microbiol 34:1622-7. 1996
  2. pmc Translocated intimin receptors (Tir) of Shiga-toxigenic Escherichia coli isolates belonging to serogroups O26, O111, and O157 react with sera from patients with hemolytic-uremic syndrome and exhibit marked sequence heterogeneity
    A W Paton
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, South Australia 5006
    Infect Immun 66:5580-6. 1998
  3. pmc Pathogenesis and diagnosis of Shiga toxin-producing Escherichia coli infections
    J C Paton
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, Australia
    Clin Microbiol Rev 11:450-79. 1998
  4. pmc Molecular analysis of Shiga toxigenic Escherichia coli O111:H- proteins which react with sera from patients with hemolytic-uremic syndrome
    E Voss
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, South Australia
    Infect Immun 66:1467-72. 1998
  5. ncbi request reprint Nucleotide sequence analysis of genes essential for production of Streptococcus pneumoniae type 19F capsular polysaccharide
    A Guildolin
    Microbiology Dept, Women s and Children s Hospital, North Adelaide, S A, Australia
    Dev Biol Stand 85:267-71. 1995
  6. pmc Cloning and characterization of nanB, a second Streptococcus pneumoniae neuraminidase gene, and purification of the NanB enzyme from recombinant Escherichia coli
    A M Berry
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    J Bacteriol 178:4854-60. 1996
  7. pmc Isolation, characterization, and nucleotide sequence of IS1202, an insertion sequence of Streptococcus pneumoniae
    J K Morona
    Department of Microbiology, Women s and Children s Hospital, North Adelaide, Australia
    J Bacteriol 176:4437-43. 1994
  8. pmc Molecular characterization of the locus encoding biosynthesis of the lipopolysaccharide O antigen of Escherichia coli serotype O113
    A W Paton
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, S A 5006, Australia
    Infect Immun 67:5930-7. 1999
  9. ncbi request reprint Heterogeneity of the amino-acid sequences of Escherichia coli Shiga-like toxin type-I operons
    A W Paton
    Department of Microbiology, Women s and Children s Hospital, North Adelaide, Australia
    Gene 153:71-4. 1995
  10. ncbi request reprint Tyrosine phosphorylation of CpsD negatively regulates capsular polysaccharide biosynthesis in streptococcus pneumoniae
    J K Morona
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, South Australia 5006, Australia
    Mol Microbiol 35:1431-42. 2000

Collaborators

Detail Information

Publications26

  1. pmc Molecular microbiological investigation of an outbreak of hemolytic-uremic syndrome caused by dry fermented sausage contaminated with Shiga-like toxin-producing Escherichia coli
    A W Paton
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, Australia
    J Clin Microbiol 34:1622-7. 1996
    ..However, SLTEC strains of other serotypes, including O157:H-, were also isolated from some of the HUS patients...
  2. pmc Translocated intimin receptors (Tir) of Shiga-toxigenic Escherichia coli isolates belonging to serogroups O26, O111, and O157 react with sera from patients with hemolytic-uremic syndrome and exhibit marked sequence heterogeneity
    A W Paton
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, South Australia 5006
    Infect Immun 66:5580-6. 1998
    ..Covariation of exposed epitopes on both intimin and Tir may be a means whereby STEC avoid host immune responses without compromising adhesin-receptor interaction...
  3. pmc Pathogenesis and diagnosis of Shiga toxin-producing Escherichia coli infections
    J C Paton
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, Australia
    Clin Microbiol Rev 11:450-79. 1998
    ..This, in turn, has created a potential window of opportunity for future therapeutic intervention...
  4. pmc Molecular analysis of Shiga toxigenic Escherichia coli O111:H- proteins which react with sera from patients with hemolytic-uremic syndrome
    E Voss
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, South Australia
    Infect Immun 66:1467-72. 1998
    ..Sera from two of the other HUS patients also failed to react with intimin from this latter strain. However, intimin from O157:H- STEC did react with serum from a patient infected with both O111:H- and O157:H- STEC...
  5. ncbi request reprint Nucleotide sequence analysis of genes essential for production of Streptococcus pneumoniae type 19F capsular polysaccharide
    A Guildolin
    Microbiology Dept, Women s and Children s Hospital, North Adelaide, S A, Australia
    Dev Biol Stand 85:267-71. 1995
  6. pmc Cloning and characterization of nanB, a second Streptococcus pneumoniae neuraminidase gene, and purification of the NanB enzyme from recombinant Escherichia coli
    A M Berry
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    J Bacteriol 178:4854-60. 1996
    ..The discrepancy between this estimate and the size predicted from the nucleotide sequence is most likely a consequence of C-terminal processing or anomalous electrophoretic behavior...
  7. pmc Isolation, characterization, and nucleotide sequence of IS1202, an insertion sequence of Streptococcus pneumoniae
    J K Morona
    Department of Microbiology, Women s and Children s Hospital, North Adelaide, Australia
    J Bacteriol 176:4437-43. 1994
    ..One of the four IS1202 copies in the encapsulated strain SSZ is located 1,009 bp downstream of the dexB gene, and transformation studies reveal that it is also closely linked to the type 19F capsular polysaccharide synthesis (cps) locus...
  8. pmc Molecular characterization of the locus encoding biosynthesis of the lipopolysaccharide O antigen of Escherichia coli serotype O113
    A W Paton
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, S A 5006, Australia
    Infect Immun 67:5930-7. 1999
    ..Interestingly, expression of O113 O antigen by E. coli K-12 significantly increased in vitro adherence to both HEp-2 and Henle 407 cells...
  9. ncbi request reprint Heterogeneity of the amino-acid sequences of Escherichia coli Shiga-like toxin type-I operons
    A W Paton
    Department of Microbiology, Women s and Children s Hospital, North Adelaide, Australia
    Gene 153:71-4. 1995
    ..The greatest deviation in deduced amino acid (aa) sequence was observed in the SltI protein from the OX3:H8 strain, which differed from the phage 933J-encoded SltI by 9 aa in the A subunit and 3 aa in the B subunit...
  10. ncbi request reprint Tyrosine phosphorylation of CpsD negatively regulates capsular polysaccharide biosynthesis in streptococcus pneumoniae
    J K Morona
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, South Australia 5006, Australia
    Mol Microbiol 35:1431-42. 2000
    ..This has implications for the function of CpsC/CpsD homologues in both Gram-positive and Gram-negative bacteria and provides a mechanism to explain regulation of CPS production during pathogenesis...
  11. pmc Oral administration of formaldehyde-killed recombinant bacteria expressing a mimic of the Shiga toxin receptor protects mice from fatal challenge with Shiga-toxigenic Escherichia coli
    J C Paton
    Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, South Australia 5006
    Infect Immun 69:1389-93. 2001
    ..Thus, administration of this agent early in the course of human STEC disease may prevent progression to life-threatening complications...
  12. pmc Neutralization of Shiga toxins Stx1, Stx2c, and Stx2e by recombinant bacteria expressing mimics of globotriose and globotetraose
    A W Paton
    Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, South Australia 5006
    Infect Immun 69:1967-70. 2001
    ..4% of the cytotoxicity in lysates of E. coli JM109 expressing cloned stx2e. These data suggest that either globotriose- or globotetraose-expressing constructs may be suitable for treatment and/or prevention of edema disease in pigs...
  13. pmc Sequence heterogeneity of PsaA, a 37-kilodalton putative adhesin essential for virulence of Streptococcus pneumoniae
    A M Berry
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, S A, Australia
    Infect Immun 64:5255-62. 1996
    ..pneumoniae R36A. The deduced amino acid sequences of mature PsaA from the two strains had only 81% homology, with the bulk of the variation occurring in the amino-terminal portion...
  14. pmc Comparative toxicity and virulence of Escherichia coli clones expressing variant and chimeric Shiga-like toxin type II operons
    A W Paton
    Department of Microbiology, Women s and Children s Hospital, North Adelaide, South Australia
    Infect Immun 63:2450-8. 1995
    ..These findings raise the possibility that naturally occurring SLT-II sequence variations may impact directly on the capacity of a given SLT-producing E. coli strain to cause disease...
  15. pmc Cloning and nucleotide sequence of the Streptococcus pneumoniae hyaluronidase gene and purification of the enzyme from recombinant Escherichia coli
    A M Berry
    Department of Microbiology, Women s and Children s Hospital, North Adelaide, Australia
    Infect Immun 62:1101-8. 1994
    ..This antiserum labelled a 107-kDa protein in partially purified hyaluronidase preparations from S. pneumoniae. The hyaluronidase activity in this pneumococcal extract was also neutralized by the antiserum...
  16. pmc Nucleotide sequence analysis of genes essential for capsular polysaccharide biosynthesis in Streptococcus pneumoniae type 19F
    A Guidolin
    Department of Microbiology, Women s and Children s Hospital, North Adelaide, Australia
    Infect Immun 62:5384-96. 1994
    ..Southern hybridization studies reveal that cps19fA and cps19fB are conserved among all 12 pneumococcal serotypes tested, whereas genes downstream of cps19fB are conserved among some, but not all, of the serotypes tested...
  17. ncbi request reprint Characterization of IS1203, an insertion sequence in Escherichia coli O111:H-
    A W Paton
    Department of Microbiology, Women s and Children s Hospital, North Adelaide, Australia
    Gene 150:67-70. 1994
    ..7 and 33.7 kDa, the latter being the putative transposase. IS1203 is closely related to IS629 of Shigella sonnei and IS3411 of E. coli. At least twelve copies of IS1203 were found in the genome of E. coli O111:H- strain PH...
  18. pmc Emergence of vancomycin-resistant enterococci in Australia: phenotypic and genotypic characteristics of isolates
    J M Bell
    National Antimicrobial Resistance Surveillance Program, Women s and Children s Hospital, North Adelaide, Australia
    J Clin Microbiol 36:2187-90. 1998
    ..Rapid and accurate methods are essential, because laboratory-based surveillance is critical in programs for the detection, control, and prevention of the transmission of glycopeptide-resistant enterococci...
  19. ncbi request reprint The crystal structure of pneumococcal surface antigen PsaA reveals a metal-binding site and a novel structure for a putative ABC-type binding protein
    M C Lawrence
    Biomolecular Research Institute 343 Royal Parade Parkville Victoria 3052 Australia
    Structure 6:1553-61. 1998
    ..PsaA is a putative ATP-binding cassette-type (ABC-type) binding protein involved in the uptake of Mn2+ and possibly Zn2+ and is considered to be both a potential drug target and and a candidate vaccine component...
  20. ncbi request reprint Expression, purification and preliminary X-ray crystallographic analysis of PsaA, a putative metal-transporter protein of Streptococcus pneumoniae
    P A Pilling
    Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria 3052, Australia
    Acta Crystallogr D Biol Crystallogr 54:1464-6. 1998
    ..The crystals are rectangular rods and diffract to beyond 2.7 A resolution. The crystal space group is P212121 with unit-cell dimensions a = 59.9, b = 66.5 and c = 69.9 A...
  21. pmc Protection against Streptococcus pneumoniae elicited by immunization with pneumolysin and CbpA
    A D Ogunniyi
    Department of Molecular Biosciences, Adelaide University, Adelaide, South Australia 5005, Australia
    Infect Immun 69:5997-6003. 2001
    ..Mice immunized with PdB in MPL plus AlPO4 were also significantly better protected than mice that received PdB in AlPO4 alone...
  22. ncbi request reprint The NADH oxidase of Streptococcus pneumoniae: its involvement in competence and virulence
    I Auzat
    Laboratoire d Enzymologie et de Biochimie structurale du Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    Mol Microbiol 34:1018-28. 1999
    ..This work establishes, for the first time, the role of O2 in the regulation of pneumococcal transformability and virulence...
  23. pmc Comparison of pneumolysin genes and proteins from Streptococcus pneumoniae types 1 and 2
    T J Mitchell
    Department of Microbiology, University of Leicester, UK
    Nucleic Acids Res 18:4010. 1990
  24. ncbi request reprint Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae
    T J Coffey
    Molecular Microbiology Group, School of Biological Sciences, University of Sussex, Brighton, UK
    Mol Microbiol 27:73-83. 1998
    ....
  25. ncbi request reprint Sequence of a variant Shiga-like toxin type-I operon of Escherichia coli O111:H-
    A W Paton
    Department of Microbiology, Adelaide Children s Hospital, Australia
    Gene 129:87-92. 1993
    ..The region of DNA upstream from the SLT-I of E. coli O111:H- contained an IS element, as well as a region with strong homology to a portion of the genome of bacteriophage lambda...
  26. pmc Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection
    J S Brown
    Centre for Molecular Microbiology and Infection, Imperial College School of Medicine, London SW7 2AZ, United Kingdom. jerry.brown.ic.ac.uk
    Infect Immun 69:6702-6. 2001
    ..pneumoniae. PiuA and PiaA are therefore promising additional candidates for a novel S. pneumoniae vaccine using protein antigens...