Michael A McGuckin

Summary

Affiliation: South Brisbane
Country: Australia

Publications

  1. pmc Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins
    Indrajit Das
    Immunity, Infection and Inflammation Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland 4101, Australia
    J Exp Med 210:1201-16. 2013
  2. pmc An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity
    R D Eri
    Mater Medical Research Institute and The University of Queensland, Mater Health Services, South Brisbane, Queensland, Australia
    Mucosal Immunol 4:354-64. 2011
  3. pmc Mucin 1 (MUC1) is a novel partner for MAL2 in breast carcinoma cells
    Susan Fanayan
    Molecular Oncology Laboratory, Oncology Research Unit, The Children s Hospital at Westmead, Locked Bag 4001, Westmead, 2145 NSW, Australia
    BMC Cell Biol 10:7. 2009
  4. doi request reprint Mucin dynamics and enteric pathogens
    Michael A McGuckin
    Immunity, Infection and Inflammation Program, Mater Medical Research Institute and The University of Queensland School of Medicine, South Brisbane, Queensland 4101, Australia
    Nat Rev Microbiol 9:265-78. 2011
  5. doi request reprint Intestinal secretory cell ER stress and inflammation
    Michael A McGuckin
    Immunity, Infection and Inflammation Program, Mater Medical Research Institute and The University of Queensland, Mater Health Services, South Brisbane, QLD 4101, Australia
    Biochem Soc Trans 39:1081-5. 2011
  6. doi request reprint ER stress and the unfolded protein response in intestinal inflammation
    Michael A McGuckin
    Mucosal Diseases Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, QLD 4029, Australia
    Am J Physiol Gastrointest Liver Physiol 298:G820-32. 2010
  7. doi request reprint Intestinal barrier dysfunction in inflammatory bowel diseases
    Michael A McGuckin
    Mucosal Diseases Program, Mater Medical Research Institute, University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia
    Inflamm Bowel Dis 15:100-13. 2009
  8. pmc MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy
    Sara K Linden
    Mucosal Diseases Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland, Australia
    PLoS Pathog 5:e1000617. 2009
  9. doi request reprint Carbohydrate binding and gene expression by in vitro and in vivo propagated Campylobacter jejuni after immunomagnetic separation
    Rebecca M King
    Institute for Glycomics, Griffith University Gold Coast Campus, Queensland, Australia
    J Basic Microbiol 53:240-50. 2013
  10. doi request reprint IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells
    Sumaira Z Hasnain
    Immunity, Infection and Inflammation Program, Mater Medical Research Institute, Mater Health Services and the University of Queensland, South Brisbane, Queensland, Australia
    Gastroenterology 144:357-368.e9. 2013

Collaborators

Detail Information

Publications31

  1. pmc Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins
    Indrajit Das
    Immunity, Infection and Inflammation Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland 4101, Australia
    J Exp Med 210:1201-16. 2013
    ..In IBD, glucocorticoids are likely to ameliorate ER stress by promoting correct folding of secreted proteins and enhancing removal of misfolded proteins from the ER...
  2. pmc An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity
    R D Eri
    Mater Medical Research Institute and The University of Queensland, Mater Health Services, South Brisbane, Queensland, Australia
    Mucosal Immunol 4:354-64. 2011
    ..Thus, the Winnie primary epithelial defect results in complex multicytokine-mediated colitis involving both innate and adaptive immune components with a prominent IL-23/T(H)17 response, similar to that of human ulcerative colitis...
  3. pmc Mucin 1 (MUC1) is a novel partner for MAL2 in breast carcinoma cells
    Susan Fanayan
    Molecular Oncology Laboratory, Oncology Research Unit, The Children s Hospital at Westmead, Locked Bag 4001, Westmead, 2145 NSW, Australia
    BMC Cell Biol 10:7. 2009
    ..MAL-like proteins have trafficking functions, but their molecular roles are largely obscure, partly due to a lack of known binding partners...
  4. doi request reprint Mucin dynamics and enteric pathogens
    Michael A McGuckin
    Immunity, Infection and Inflammation Program, Mater Medical Research Institute and The University of Queensland School of Medicine, South Brisbane, Queensland 4101, Australia
    Nat Rev Microbiol 9:265-78. 2011
    ..In addition, we describe dynamic alterations in the mucin barrier that are driven by host innate and adaptive immune responses to infection...
  5. doi request reprint Intestinal secretory cell ER stress and inflammation
    Michael A McGuckin
    Immunity, Infection and Inflammation Program, Mater Medical Research Institute and The University of Queensland, Mater Health Services, South Brisbane, QLD 4101, Australia
    Biochem Soc Trans 39:1081-5. 2011
    ....
  6. doi request reprint ER stress and the unfolded protein response in intestinal inflammation
    Michael A McGuckin
    Mucosal Diseases Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, QLD 4029, Australia
    Am J Physiol Gastrointest Liver Physiol 298:G820-32. 2010
    ..Evidence is reviewed from mouse models and human inflammatory bowel diseases that ties ER stress and activation of the UPR with intestinal inflammation, and possible therapeutic approaches to ameliorate ER stress are discussed...
  7. doi request reprint Intestinal barrier dysfunction in inflammatory bowel diseases
    Michael A McGuckin
    Mucosal Diseases Program, Mater Medical Research Institute, University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia
    Inflamm Bowel Dis 15:100-13. 2009
    ....
  8. pmc MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy
    Sara K Linden
    Mucosal Diseases Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland, Australia
    PLoS Pathog 5:e1000617. 2009
    ..pylori infected mice. Thus, MUC1 protects the epithelium from non-MUC1 binding bacteria by inhibiting adhesion to the cell surface by steric hindrance, and from MUC1-binding bacteria by acting as a releasable decoy...
  9. doi request reprint Carbohydrate binding and gene expression by in vitro and in vivo propagated Campylobacter jejuni after immunomagnetic separation
    Rebecca M King
    Institute for Glycomics, Griffith University Gold Coast Campus, Queensland, Australia
    J Basic Microbiol 53:240-50. 2013
    ..The optimised Campylobacter IMS technique described in this study allowed isolation directly from an animal host. Changes in gene expression and glycan binding at an in vivo level can also be identified by using this method...
  10. doi request reprint IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells
    Sumaira Z Hasnain
    Immunity, Infection and Inflammation Program, Mater Medical Research Institute, Mater Health Services and the University of Queensland, South Brisbane, Queensland, Australia
    Gastroenterology 144:357-368.e9. 2013
    ..However, it is not clear how immune factors affect ER stress and therefore disease symptoms...
  11. doi request reprint The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis
    Yong H Sheng
    Immunity, Infection and Inflammation Program, Mater Medical Research Institute and The University of Queensland, Mater Health Services, South Brisbane, Queensland, Australia
    Gut 60:1661-70. 2011
    ..This study aimed to explore whether MUC13 modulates intestinal inflammation...
  12. pmc Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
    Chad K Heazlewood
    Mucin and IBD Research Teams, Mucosal Diseases Program, Mater Medical Research Institute, and The University of Queensland, Aubigny Place, Mater Health Services, South Brisbane, Queensland, Australia
    PLoS Med 5:e54. 2008
    ..In this study we used random mutagenesis to produce two murine models of inflammatory bowel disease, characterised the basis and nature of the inflammation in these mice, and compared the pathology with human ulcerative colitis...
  13. doi request reprint Mucins in inflammatory bowel diseases and colorectal cancer
    Yong H Sheng
    Immunity, Infection and Inflammation Program, Mater Medical Research Institute, South Brisbane, Queensland, Australia
    J Gastroenterol Hepatol 27:28-38. 2012
    ..Data from animal models of intestinal inflammation, which support the importance of mucins in IBD and cancer development, are also discussed...
  14. ncbi request reprint Listeria monocytogenes internalins bind to the human intestinal mucin MUC2
    Sara K Linden
    Mucosal Diseases Program, Mater Medical Research Institute, Level 3 Aubigny Place, Raymond Terrace, South Brisbane, QLD, 4101, Australia
    Arch Microbiol 190:101-4. 2008
    ..We report here that the internalin domain of the InlJ protein also bound MUC2, suggesting that an internalin domain is sufficient to bind to MUC2...
  15. ncbi request reprint Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis
    Michael A McGuckin
    Mucosal Diseases Program, Mater Medical Research Institute and University of Queensland, Mater Misericordiae Hospitals, Brisbane, Australia
    Gastroenterology 133:1210-8. 2007
    ..We have evaluated the impact of Muc1 expression on the colonization and pathogenesis of gastric Helicobacter infections...
  16. doi request reprint Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria
    Chin Wen Png
    Mater Medical Research Institute and Department of Medicine, University of Queensland, Mater Health Services, South Brisbane, Queensland, Australia
    Am J Gastroenterol 105:2420-8. 2010
    ..We hypothesized that mucolytic bacteria are increased in IBD, providing increased substrate to sustain nonmucolytic mucosa-associated bacteria...
  17. doi request reprint Techniques for assessment of interactions of mucins with microbes and parasites in vitro and in vivo
    Yong H Sheng
    Immunity, Infection and Inflammation Program, Mater Medical Research Institute, South Brisbane, QLD, Australia
    Methods Mol Biol 842:297-312. 2012
    ....
  18. doi request reprint KCNN4 gene variant is associated with ileal Crohn's Disease in the Australian and New Zealand population
    Lisa A Simms
    Royal Brisbane and Women s Research Foundation, Brisbane, Queensland, Australia
    Am J Gastroenterol 105:2209-17. 2010
    ..Our aim was to determine whether a gene in the IBD linkage region on chromosome 19q13, with a role in Paneth cell secretion and T-cell activation, conferred genetic susceptibility to the development of CD...
  19. doi request reprint A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity
    Iulia Oancea
    IBD Team, Immunology Infection Inflammation Program, Mater Medical Research Institute, South Brisbane, Queensland, Australia
    Gut 62:594-605. 2013
    ..Understanding of SOS has been hindered by inability to ethically perform serial liver biopsies on patients and the lack of an animal model...
  20. doi request reprint The interplay between endoplasmic reticulum stress and inflammation
    Sumaira Z Hasnain
    Immunity, Infection and Inflammation Program, Mater Medical Research Institute, Mater Hospitals, South Brisbane, Queensland, Australia
    Immunol Cell Biol 90:260-70. 2012
    ..Finally, recommendations are made for future research with respect to the interaction of ER stress and inflammation...
  21. pmc Mucin dynamics in intestinal bacterial infection
    Sara K Linden
    Mucosal Diseases Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland, Australia
    PLoS ONE 3:e3952. 2008
    ..coli. Mucin glycoproteins are the main component of the first barrier that bacteria encounter in the intestinal tract...
  22. pmc MUC1 cell surface mucin is a critical element of the mucosal barrier to infection
    Julie L McAuley
    Mucosal Diseases Program, Mater Medical Research Institute and The University of Queensland, South Brisbane, Queensland, Australia
    J Clin Invest 117:2313-24. 2007
    ....
  23. ncbi request reprint Improved in vitro model systems for gastrointestinal infection by choice of cell line, pH, microaerobic conditions, and optimization of culture conditions
    Sara K Linden
    Mucosal Diseases Program, Mater Medical Research Institute, Mater Health Services, Aubigny Place, South Brisbane, Queensland 4101, Australia
    Helicobacter 12:341-53. 2007
    ..To make in vitro studies more applicable to human disease, we have developed coculture methods taking these factors into account...
  24. pmc Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier
    Sumaira Z Hasnain
    Immunity, Infection and Inflammation, Mater Medical Research Institute, Brisbane, Australia
    PLoS Negl Trop Dis 6:e1856. 2012
    ..However, during a T(H)2-mediated worm expulsion response, serpins, Muc5ac and increased levels of Muc2 protect the barrier from degradation by the nematode secreted protease(s)...
  25. ncbi request reprint A novel microbiota stratification system predicts future exacerbations in bronchiectasis
    Geraint B Rogers
    1 Immunity, Infection, and Inflammation Program, Mater Research Institute, University of Queensland, and Translational Research Institute, Woolloongabba, Queensland, Australia
    Ann Am Thorac Soc 11:496-503. 2014
    ..A system enabling microbiota data to be applied clinically would represent a substantial translational advance...
  26. doi request reprint T cell transfer model of colitis: a great tool to assess the contribution of T cells in chronic intestinal inflammation
    Rajaraman Eri
    Mater Medical Research Institute, South Brisbane, QLD, Australia
    Methods Mol Biol 844:261-75. 2012
    ..A special focus is paid to the utilisation of the T cell transfer model in delineating the immunopathology in a primary epithelial defect model of colitis, namely Winnie...
  27. ncbi request reprint IgG antibodies against common gut bacteria are more diagnostic for Crohn's disease than IgG against mannan or flagellin
    Rachel J Adams
    IBD Team, Mucosal Diseases Program, Mater Medical Research Institute, South Brisbane, Australia
    Am J Gastroenterol 103:386-96. 2008
    ..We hypothesized that reactivity with these antigens is a surrogate marker for a generalized increased IgG response against intestinal microbiota in Crohn's disease...
  28. pmc Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment
    Ying Dong
    Cancer Program, Institute of Health and Biomedical Innovation and Faculty of Sciences and Technology, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    PLoS ONE 8:e57056. 2013
    ..Nonetheless, these data suggest that KLK4 inhibition, in conjunction with paclitaxel, may improve the outcome for women with serous epithelial ovarian cancer and high KLK4 levels in their tumors...
  29. doi request reprint Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial
    David J Serisier
    Department of Respiratory Medicine, Level 9, Mater Adult Hospital, Raymond Terr, South Brisbane, Queensland 4101, Australia
    JAMA 309:1260-7. 2013
    ..Macrolide antibiotics such as erythromycin may improve clinical outcomes in non-cystic fibrosis (CF) bronchiectasis, although associated risks of macrolide resistance are poorly defined...
  30. pmc Endocrine impact of Helicobacter pylori: Focus on ghrelin and ghrelin o-acyltransferase
    Penny L Jeffery
    Penny L Jeffery, Michael A McGuckin, Mucosal Diseases Program, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queensland, 4101, Australia
    World J Gastroenterol 17:1249-60. 2011
    ..GOAT is essential for the production of biologically-active, acyl ghrelin and the impact of H. pylori on GOAT expression and activity will be highly informative in the future...
  31. ncbi request reprint Expression of the cell surface mucin gene family in adenocarcinomas
    Leisl M Packer
    Epithelial Cancer and Mucosal Biology Laboratory, Mater Medical Research Institute, Mater Health Services, South Brisbane, Queenslands 4101, Australia
    Int J Oncol 25:1119-26. 2004
    ..The reported expression profiles of the cell surface mucin gene family will help direct biological and clinical studies of these molecules in mucosal biology, and in malignant and inflammatory diseases of epithelial tissues...