Research Topics
| M MakridesSummaryAffiliation: South Australia Country: Australia Publications
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Publications
Marine oil, and other prostaglandin precursor, supplementation for pregnancy uncomplicated by pre-eclampsia or intrauterine growth restrictionM Makrides
Child Health Research Institute, Women s and Children s Hospital, 72 King William Road, North Adelaide, SA, Australia 5006
Cochrane Database Syst Rev 3:CD003402. 2006..It is suggested that the fatty acids of marine foods may be the underlying cause of these associations...- Outcomes for mothers and their babies: do n-3 long-chain polyunsaturated fatty acids and seafoods make a difference?Maria Makrides
Women s and Children s Health Research Institute, North Adelaide, SA, Australia
J Am Diet Assoc 108:1622-6. 2008 
Neurodevelopmental outcomes of preterm infants fed high-dose docosahexaenoic acid: a randomized controlled trialMaria Makrides
Child Nutrition Research Centre, Women s and Children s Health Research Institute, Women s and Children s Hospital, 72 King William Rd, North Adelaide SA 5006, Australia
JAMA 301:175-82. 2009..Uncertainty exists about the benefit of dietary docosahexaenoic acid (DHA) on the neurodevelopment of preterm infants...
Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants' allergies in first year of life: randomised controlled trialD J Palmer
Women s and Children s Health Research Institute, North Adelaide, South Australia, Australia
BMJ 344:e184. 2012..To determine whether dietary n-3 long chain polyunsaturated fatty acid (LCPUFA) supplementation of pregnant women with a fetus at high risk of allergic disease reduces immunoglobulin E associated eczema or food allergy at 1 year of age...- Transforming growth factor beta in human milk does not change in response to modest intakes of docosahexaenoic acidJ S Hawkes
Child Nutrition Research Centre, Flinders Medical Centre, Bedford Park, South Australia, Australia
Lipids 36:1179-81. 2001..The DHA increase in milk and plasma was proportional to dietary DHA. There was no relationship between milk DHA status and TGFbeta1 and TGFbeta2 levels... - Effect of maternal egg consumption on breast milk ovalbumin concentrationD J Palmer
Department of Paediatrics, Women s and Children s Health Research Institute, The University of Adelaide, Woman s and Children s Hospital, North Adelaide, SA, Australia
Clin Exp Allergy 38:1186-91. 2008..Maternal dietary avoidance of egg has been recommended to treat egg allergy in breastfed infants. However, only one of three randomized controlled trials have produced evidence in favour of this recommendation... - n-3 polyunsaturated fatty acid requirements of term infantsR A Gibson
Child Nutrition Research Centre, Child Health Research Institute, North Adelaide, Australia
Am J Clin Nutr 71:251S-5S. 2000..Therefore, there is a clear need to associate a measure of LCPUFA status with a specific functional outcome before any recommendations can be made for achieving optimal or maximal LCPUFA status... - Effect of two doses of docosahexaenoic acid (DHA) in the diet of preterm infants on infant fatty acid status: results from the DINO trialL G Smithers
Women s and Children s Health Research Institute, Children Youth and Women s Health Service, North Adelaide and Flinders Medical Centre, Flinders Drive, Bedford Park, Australia, Australia
Prostaglandins Leukot Essent Fatty Acids 79:141-6. 2008..2, p<0.0005). Feeding preterm infants human milk and formula with 1% DHA raises but does not saturate erythrocyte phospholipids with DHA. Milk exceeding 1% DHA may be required to increase DHA status to levels seen in term infants... - Randomized trials with polyunsaturated fatty acid interventions in preterm and term infants: functional and clinical outcomesR A Gibson
Child Health Research Institute at Flinders Centre and Women s and Children s Hospital, Adelaide, SA, Australia
Lipids 36:873-83. 2001..In summary, there appear to be few safety concerns relating to the use of LC-PUFA in infant nutrition. The potential medium- and long-term effects of including these compounds in the early diet of infants remain to be assessed... - Effect of long-chain polyunsaturated fatty acid supplementation of preterm infants on disease risk and neurodevelopment: a systematic review of randomized controlled trialsLisa G Smithers
Child Health Research Institute, Child, Youth and Women s Health Service, North Adelaide, Australia
Am J Clin Nutr 87:912-20. 2008..Supplementation of preterm formulas with long-chain polyunsaturated fatty acids (LCPUFAs) is based on their effectiveness to increase blood status and improve visual outcomes. Dispute remains over their efficacy on global development... - Higher dose of docosahexaenoic acid in the neonatal period improves visual acuity of preterm infants: results of a randomized controlled trialLisa G Smithers
Women s and Children s Health Research Institute and the School of Agriculture, Food and Wine, University of Adelaide, Adelaide, SA, Australia
Am J Clin Nutr 88:1049-56. 2008..Preterm infants have improved visual outcomes when fed a formula containing 0.2-0.4% docosahexaenoic acid (DHA) compared with infants fed no DHA, but the optimal DHA dose is unknown... - Long-chain polyunsaturated fatty acid requirements during pregnancy and lactationM Makrides
Department of Obstetrics and Gynaecology, University of Adelaide, Women s and Children s Hospital, 72 King William Road, North Adelaide, SA 5006, Australia
Am J Clin Nutr 71:307S-11S. 2000..Careful attention should be paid to study design, measurement of appropriate health outcomes, and defining minimum and maximum plasma n-3 LCPUFA concentrations that are optimal for both mothers and infants... - Effect of iron supplementation during pregnancy on the intelligence quotient and behavior of children at 4 y of age: long-term follow-up of a randomized controlled trialShao J Zhou
Child Nutrition Research Centre and the Department of Pediatrics, Women's and Children's Hospital, University of Adelaide, North Adelaide, Australia
Am J Clin Nutr 83:1112-7. 2006..CONCLUSIONS: Prenatal iron supplementation that reduces the incidence of iron deficiency anemia from 11% to 1% has no effect on the IQ of the offspring at 4 y of age... - Effect of iron supplementation during pregnancy on the behaviour of children at early school age: long-term follow-up of a randomised controlled trialAnnie G Parsons
Child Nutrition Research Centre, Flinders Medical Centre and Women s and Children s Hospital, Child Health Research Institute, North Adelaide, SA, Australia
Br J Nutr 99:1133-9. 2008..026). We conclude that prenatal Fe supplementation had no consistent effect on child behaviour at early school age in this study population. Further investigation regarding the long-term effects of this common practice is warranted... - Long-chain polyunsaturated fatty acids in breast milk: are they essential?R A Gibson
Child Nutrition Research Centre, Child Health Research Institute, Flinders Medical Centre, Adelaide, SA, Australia
Adv Exp Med Biol 501:375-83. 2001..However, only tissue DHA levels have consistently correlated with outcomes... - Supplementation of infant formula with long-chain polyunsaturated fatty acids does not influence the growth of term infantsMaria Makrides
Applied Nutrition Group, Child Health Research Institute, Women s and Children s Hospital, North Adelaide, SA, Australia
Am J Clin Nutr 81:1094-101. 2005..Adequate growth is an important indicator of health and well-being in infants... - Efficacy and tolerability of low-dose iron supplements during pregnancy: a randomized controlled trialMaria Makrides
Child Nutrition Research Centre, Child Health Research Institute, and Department of Paediatrics, University of Adelaide, Women s and Children s Hospital, North Adelaide, SA, Australia
Am J Clin Nutr 78:145-53. 2003..Iron deficiency anemia (IDA) is common in pregnant women, but previous trials aimed at preventing IDA used high-dose iron supplements that are known to cause gastrointestinal side effects... - Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trialMaria Makrides
Child Nutrition Research Centre, Women s and Children s Health Research Institute, Women s and Children s Hospital, 72 King William Rd, North Adelaide SA 5006, Australia
JAMA 304:1675-83. 2010..Uncertainty about the benefits of dietary docosahexaenoic acid (DHA) for pregnant women and their children exists, despite international recommendations that pregnant women increase their DHA intakes... - Impact of fatty acid status on growth and neurobehavioural development in humansMaria Makrides
Child Nutrition Research Centre, Women s and Children s Health Research Institute, Flinders Medical Centre, 72 King William Road, Bedford Park, SA 5006, Australia
Matern Child Nutr 7:80-8. 2011..Further work is required to determine whether dietary n-3 LCPUFA is neuroprotective for children from disadvantaged or low-income backgrounds... - Is there a dietary requirement for DHA in pregnancy?Maria Makrides
Women s and Children s Health Research Institute, Level 7, Clarence Rieger Building, Women s and Children s Hospital, 72 King William Road, North Adelaide, SA 5006, Australia
Prostaglandins Leukot Essent Fatty Acids 81:171-4. 2009..On the other hand, large-scale trials assessing marine oil supplementation with large doses indicate that DHA supplementation in pregnancy is safe... - Perinatal characteristics may influence the outcome of visual acuityM Makrides
Child Nutrition Research Centre, Child Health Research Institute and Women's and Children's Hospital, North Adelaide, SA 5006, Australia
Lipids 36:897-900. 2001..It is possible that a combination of perinatal factors could accumulate to either mask or enhance effects of diet on VEP acuity, given the relatively modest effects of long-chain PUFA on visual outcome... - Should we lower the dose of iron when treating anaemia in pregnancy? A randomized dose-response trialS J Zhou
Child Nutrition Research Centre, Flinders Medical Centre and Women s and Children s Hospital, Child Health Research Institute, North Adelaide, SA, Australia
Eur J Clin Nutr 63:183-90. 2009..To compare the efficacy and side effects of low-dose vs high-dose iron supplements to correct anaemia in pregnancy... - Safety of supplementing infant formula with long-chain polyunsaturated fatty acids and Bifidobacterium lactis in term infants: a randomised controlled trialRobert A Gibson
Women s and Children s Health Research Institute, Children, Youth and Women s Health Service, North Adelaide, Australia
Br J Nutr 101:1706-13. 2009..No influence of the supplements on the response to vaccines was observed. Growth characteristics of term infants fed the starter formula containing a probiotic and LC-PUFA were similar to standard formula-fed infants... - Nutritional effect of including egg yolk in the weaning diet of breast-fed and formula-fed infants: a randomized controlled trialMaria Makrides
Child Nutrition Research Centre, Child Health Research Institute, Women's and Children's Hospital, North Adelaide, Australia
Am J Clin Nutr 75:1084-92. 2002..Egg yolks may also be a useful source of iron during the weaning period and can be safely included in the weaning diet with no perturbations in plasma cholesterol... - Evaluation of an iron specific checklist for the assessment of dietary iron intake in pregnant and postpartum womenShao J Zhou
Child Nutrition Research Centre, Child Health Research Institute and Department of Paediatrics, University of Adelaide, Women's and Children's Hospital, North Adelaide, South Australia, Australia
Nutrition 21:908-13. 2005..CONCLUSION: This simple iron checklist is a useful tool in describing iron intake of population samples of pregnant women but has limited ability to predict iron status... - Polyunsaturated fatty acids and infant visual development: a critical appraisal of randomized clinical trialsR A Gibson
Child Nutrition Research Centre, Flinders Medical Centre, Bedford Park Adelaide, SA, Australia
Lipids 34:179-84. 1999..Our evaluation of the trials to date suggests that the definitive answer to the degree to which dietary long-chain PUFA is likely to influence visual development may only be resolved with impeccably conducted RCT... - Routine iron supplementation in pregnancy has no effect on iron status of children at six months and four years of ageShao J Zhou
Child Nutrition Research Centre, Flinders Medical Centre and Women s and Children s Hospital, Child Health Research Institute, North Adelaide, Australia
J Pediatr 151:438-40. 2007..The iron status at 6 months and 4 years of children born to women who were randomly allocated to receive 20 mg of iron daily in the second half of pregnancy did not differ from children of mothers in the control group... - A randomized trial of supplementation with docosahexaenoic acid-rich tuna oil and its effects on the human milk cytokines interleukin 1 beta, interleukin 6, and tumor necrosis factor alphaJoanna S Hawkes
Child Nutrition Research Centre, Flinders Medical Centre, Bedford Park, SA, Australia
Am J Clin Nutr 75:754-60. 2002..CONCLUSIONS: Consumption of < or = 600 mg DHA and 140 mg EPA/d for 4 wk increased n-3 PUFA concentrations in relevant tissues but did not cause perturbations in cytokine concentrations in human milk... - Essential role of fats throughout the lifecycle: summary and recommendationsRobert A Gibson
Child Nutrition Research Centre, Child Health Research Institute, Women's and Children's Hospital, Flinders Medical Centre, Adelaide, SA 5042, Australia
Med J Aust 176:S107-9. 2002 - The role of fats in the lifecycle stages: pregnancy and the first year of lifeMaria Makrides
Child Nutrition Research Centre, Child Health Research Institute, Women's and Children's Hospital, Flinders Medical Centre, Adelaide, SA 5042, Australia
Med J Aust 176:S111-2. 2002..Debate continues about the importance of DHA supplementation for term infants; the current consensus is that the benefits of DHA supplementation in term infants are smaller than for preterm infants... - Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissuesL R Kartikasari
Foodplus Research Centre, School of Agriculture, Food and Wine, University of Adelaide, Adelaide, SA, Australia
Prostaglandins Leukot Essent Fatty Acids 87:103-9. 2012..In contrast, arachidonic acid (AA) was reduced in response to increasing dietary ALA... - Effect of dietary nucleotide supplementation on growth and immune function in term infants: a randomized controlled trialJ S Hawkes
Child Health Research Institute, Flinders Medical Centre and Flinders University, Bedford Park, SA, Australia
Eur J Clin Nutr 60:254-64. 2006.... - Effect of cooked and raw egg consumption on ovalbumin content of human milk: a randomized, double-blind, cross-over trialD J Palmer
Child Health Research Institute, Women's and Children's Hospital, North Adelaide, SA, Australia
Clin Exp Allergy 35:173-8. 2005..A dose-response correlation was indicated. As excretion of OVA in human milk appears to be a normal phenomenon, further studies need to determine the threshold of OVA excretion that leads to symptoms in egg-allergic breastfed infants... - Dietary nucleotides do not alter erythrocyte long-chain polyunsaturated fatty acids in formula-fed term infantsRobert A Gibson
Child Health Research Institute, Flinders Medical Centre and Flinders University, Bedford Park, South Australia 5042, Australia
Lipids 40:631-4. 2005..We conclude that there is no induction of LCPUFA accumulation in erythrocyte phospholipids of term, formula-fed infants following 7 mon of NT supplementation... - Carbohydrate intake is the main determinant of growth in infants born <33 weeks' gestation when protein intake is adequateCarmel T Collins
Child Health Research Institute, Women s and Children s Hospital, North Adelaide and Flinders Medical Centre, Bedford Park, South Australia, Australia
Nutrition 24:451-7. 2008..We investigated the relative contribution of macronutrients to postnatal growth in preterm infants born <33 wk of gestation... - Higher protein and energy intake is associated with increased weight gain in pre-term infantsCarmel T Collins
Child Nutrition Research Centre, Women s and Children s Hospital, Flinders Medical Centre and Women s and Children s Health Research Institute, Adelaide, Australia
J Paediatr Child Health 46:96-102. 2010..To characterise and compare the nutritional management and growth in infants <33 weeks' gestation in two tertiary centres... - Diet of lactating women and allergic reactions in their infantsDebra Jane Palmer
Child Health Research Institute, and Department of Paediatrics, The University of Adelaide, Women's and Children's Hospital, North Adelaide, South Australia, Australia
Curr Opin Clin Nutr Metab Care 9:284-8. 2006..Controlled trials are required to evaluate the efficacy of maternal dietary n-3 fatty acid interventions in preventing allergic disease in at-risk infants... - Selenium status of term infants fed selenium-supplemented formula in a randomized dose-response trialLynne Daniels
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
Am J Clin Nutr 88:70-6. 2008..The optimal form and dose of selenium supplementation required to achieve indicators of selenium status equivalent to those in breastfed infants are unclear... - The effect of alpha-linolenic acid and linoleic acid on the growth and development of formula-fed infants: a systematic review and meta-analysis of randomized controlled trialsTuesday Udell
Department of Paediatrics and Child Health, Flinders University, Bedford Park, South Australia, Australia
Lipids 40:1-11. 2005..The findings suggest that ALA-supplemented diets improve the DHA status of infants. Further studies are needed to provide convincing evidence regarding the effects of ALA supplementation of formula on infant growth and development... - The importance of early complementary feeding in the development of oral tolerance: concerns and controversiesSusan L Prescott
School of Paediatrics and Child Health Research, University of Western Australia, Perth, WA, Australia
Pediatr Allergy Immunol 19:375-80. 2008..It will also examine the growing case for introducing complementary foods from around 4 months of age and maintaining breastfeeding during this early feeding period, for at least 6 months if possible... - Plasma phospholipid fatty acid composition as a biomarker of habitual dietary fat intake in an ethnically diverse cohortAllison M Hodge
Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia
Nutr Metab Cardiovasc Dis 17:415-26. 2007....