Jean-Pierre Levesque

Summary

Affiliation: Mater Medical Research Institute
Location: South Brisbane, Australia

Publications

  1. ncbi G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow
    Craig L Semerad
    Division of Oncology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8007, St Louis, MO 63110, USA
    Blood 106:3020-7. 2005
  2. ncbi Characterization of hematopoietic progenitor mobilization in protease-deficient mice
    Jean Pierre Levesque
    Stem Cell Biology Laboratory, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
    Blood 104:65-72. 2004
  3. ncbi Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches
    Ingrid G Winkler
    Biotherapy Program, Mater Medical Research Institute, South Brisbane, Australia
    Blood 116:375-85. 2010
  4. ncbi Hierarchy of immature hematopoietic cells related to blood flow and niche
    Jean Pierre Levesque
    Biological Therapies Program, Mater Medical Research Institute, South Brisbane, Australia
    Curr Opin Hematol 18:220-5. 2011
  5. ncbi Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1
    Ingrid G Winkler
    Adhesive Interactions and Cell Trafficking Laboratory, Peter MacCallum Cancer Centre, Melbourne, Vic, Australia
    Blood 103:1685-92. 2004
  6. ncbi Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells
    Jean Pierre Levesque
    Stem Cell Laboratory, Peter MacCallum Cancer Institute, Locked Bag 1, A Beckett Street, Melbourne, Victoria 3000, Australia
    Exp Hematol 31:109-17. 2003
  7. ncbi Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide
    Jean Pierre Levesque
    Stem Cell Biology Laboratory, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
    J Clin Invest 111:187-96. 2003
  8. ncbi A novel monoclonal antibody recognizing a cation-dependent epitope within the regulatory loop of human beta(1) integrin (CD29)
    Jean Pierre Levesque
    The Peter MacCallum Cancer Institute, Stem Cell Biology Laboratory, East Melbourne, Australia
    Hybrid Hybridomics 21:253-60. 2002
  9. ncbi Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment
    Jean Pierre Levesque
    Stem Cell Biology Laboratory, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
    Exp Hematol 30:440-9. 2002
  10. ncbi Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor
    J P Levesque
    Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
    Blood 98:1289-97. 2001

Collaborators

Detail Information

Publications62

  1. ncbi G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow
    Craig L Semerad
    Division of Oncology, Department of Medicine, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8007, St Louis, MO 63110, USA
    Blood 106:3020-7. 2005
    ..The consequent attenuation of CXCR4 signaling ultimately leads to HPC mobilization...
  2. ncbi Characterization of hematopoietic progenitor mobilization in protease-deficient mice
    Jean Pierre Levesque
    Stem Cell Biology Laboratory, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
    Blood 104:65-72. 2004
    ..Collectively, these data suggest a complex model in which both protease-dependent and -independent pathways may contribute to HPC mobilization...
  3. ncbi Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches
    Ingrid G Winkler
    Biotherapy Program, Mater Medical Research Institute, South Brisbane, Australia
    Blood 116:375-85. 2010
    ..This technique enables prospective isolation of serially reconstituting HSCs distinct from other less potent HSCs of the same phenotype, based on the in vivo niche in which they reside...
  4. ncbi Hierarchy of immature hematopoietic cells related to blood flow and niche
    Jean Pierre Levesque
    Biological Therapies Program, Mater Medical Research Institute, South Brisbane, Australia
    Curr Opin Hematol 18:220-5. 2011
    ..Extrinsic instructions provided by unique microenvironments (niches) regulate the fate of individual HSCs and progenitors. This review discusses the latest findings in respect to the organization and function of these niches...
  5. ncbi Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1
    Ingrid G Winkler
    Adhesive Interactions and Cell Trafficking Laboratory, Peter MacCallum Cancer Centre, Melbourne, Vic, Australia
    Blood 103:1685-92. 2004
    ..These data demonstrate that an E-selectin ligand(s) other than PSGL-1 transduces growth inhibitory and proapoptotic signals and requires posttranslational fucosylation to be functional...
  6. ncbi Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells
    Jean Pierre Levesque
    Stem Cell Laboratory, Peter MacCallum Cancer Institute, Locked Bag 1, A Beckett Street, Melbourne, Victoria 3000, Australia
    Exp Hematol 31:109-17. 2003
    ..We sought to determine the mechanisms responsible for the reduced expression of c-KIT on mobilized hematopoietic progenitor cells...
  7. ncbi Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide
    Jean Pierre Levesque
    Stem Cell Biology Laboratory, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
    J Clin Invest 111:187-96. 2003
    ....
  8. ncbi A novel monoclonal antibody recognizing a cation-dependent epitope within the regulatory loop of human beta(1) integrin (CD29)
    Jean Pierre Levesque
    The Peter MacCallum Cancer Institute, Stem Cell Biology Laboratory, East Melbourne, Australia
    Hybrid Hybridomics 21:253-60. 2002
    ..9H9 binding. Our data therefore suggest that the regulatory epitope of the human beta(1) integrin chain is flexible with multiple conformations according to the cationic environment...
  9. ncbi Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment
    Jean Pierre Levesque
    Stem Cell Biology Laboratory, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
    Exp Hematol 30:440-9. 2002
    ..We sought to determine whether mobilization induced by G-CSF or chemotherapy was triggered by common or distinct mechanisms...
  10. ncbi Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor
    J P Levesque
    Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
    Blood 98:1289-97. 2001
    ....
  11. ncbi CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor
    R Doyonnas
    Medical Research Council Molecular Haematology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    J Immunol 165:840-51. 2000
    ....
  12. ncbi Functionally defined CD164 epitopes are expressed on CD34(+) cells throughout ontogeny but display distinct distribution patterns in adult hematopoietic and nonhematopoietic tissues
    S M Watt
    MRC Molecular Haematology Unit and from the Neurosciences Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, England
    Blood 95:3113-24. 2000
    ..It therefore seems highly likely that these CD164 class I and II epitopes will mediate reciprocal homing functions in these tissue types...
  13. ncbi PSGL-1-mediated adhesion of human hematopoietic progenitors to P-selectin results in suppression of hematopoiesis
    J P Levesque
    Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, SA, Australia
    Immunity 11:369-78. 1999
    ....
  14. ncbi CD44 isoforms in normal and leukemic hematopoiesis
    S Ghaffari
    Terry Fox Laboratory, British Columbia Cancer Agency and the University of British Columbia, Vancouver, Canada
    Exp Hematol 27:978-93. 1999
  15. ncbi Cytoskeleton and integrin-mediated adhesion signaling in human CD34+ hemopoietic progenitor cells
    J P Levesque
    Matthew Roberts Laboratory, Division of Haematology, Hanson Centre for Cancer Research, Adelaide, South Australia, Australia
    Exp Hematol 27:579-86. 1999
    ..The intention of this article is to give a critical review of the current knowledge about the cytoskeleton and integrin-mediated signaling in hemopoietic progenitor cells...
  16. ncbi Dual control by divalent cations and mitogenic cytokines of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity expressed by human hemopoietic cells
    Y Takamatsu
    Matthew Roberts Foundation Laboratory, Leukaemia Research Unit, Hanson Centre for Cancer Research, Adelaide, Australia
    Cell Adhes Commun 5:349-66. 1998
    ....
  17. ncbi Osteoclast-mediated bone resorption is stimulated during short-term administration of granulocyte colony-stimulating factor but is not responsible for hematopoietic progenitor cell mobilization
    Y Takamatsu
    Matthew Roberts Laboratory, and the Leukaemia Research Unit, the Division of Haematology, Hanson Centre for Cancer Research, Medical and Veterinary Science, Adelaide, Australia
    Blood 92:3465-73. 1998
    ....
  18. ncbi Contrasting effects of P-selectin and E-selectin on the differentiation of murine hematopoietic progenitor cells
    Tetsuya Eto
    Cell Adhesion and Trafficking Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Exp Hematol 33:232-42. 2005
    ....
  19. ncbi Epitope recognition of antibodies that define the sialomucin, endolyn (CD164), a negative regulator of haematopoiesis
    B Jorgensen-Tye
    Stem Cell Laboratory, National Blood Service and Nuffield Department of Clinical Laboratory Sciences, The John Radcliffe Hospital, Headington, Oxford, UK
    Tissue Antigens 65:220-39. 2005
    ....
  20. ncbi 38th Annual Meeting of the International Society of Experimental Hematology
    Jean Pierre Levesque
    Haematopoietic Stem Cell Laboratory, Mater Medical Research Institute, Aubigny Place, Raymond Terrace, South Brisbane, QLD 4101, Australia
    Expert Rev Hematol 2:645-7. 2009
    ..Owing to the large number of keynote speakers, this report focuses on the most novel, unpublished data presented during the meeting...
  21. ncbi The endosteal 'osteoblastic' niche and its role in hematopoietic stem cell homing and mobilization
    J P Levesque
    Biotherapies Program, Haematopoietic Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, Queensland, Australia
    Leukemia 24:1979-92. 2010
    ..The second part of this article reviews the current knowledge of the mechanisms of HSC lodgment into, retention in and mobilization from osteoblastic niches...
  22. ncbi Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs
    Ingrid G Winkler
    Haematopoietic Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, Australia
    Blood 116:4815-28. 2010
    ..Together, these results establish that bone marrow macrophages are pivotal to maintain the endosteal HSC niche and that the loss of such macrophages leads to the egress of HSCs into the blood...
  23. ncbi Mobilization of hematopoietic stem cells: state of the art
    Jean Pierre Levesque
    Mater Medical Research Institute, South Brisbane, Queensland, Australia
    Curr Opin Organ Transplant 13:53-8. 2008
    ..This article reviews recent advances in understanding the molecular mechanisms responsible for the retention of HSCs in the bone marrow, which are perturbed during HSC mobilization, and the clinical application of these findings...
  24. ncbi Molecular trafficking mechanisms of multipotent mesenchymal stem cells derived from human bone marrow and placenta
    Gary Brooke
    Adult Stem Cell and Haematopoietic Stem Cell Laboratories, Mater Medical Research Institute, Brisbane, Queensland, Australia
    Stem Cells Dev 17:929-40. 2008
    ..However, at the functional level, hpMSC likely utilise VLA-4-mediated binding in a superior manner to hbmMSC and thus may have superior engraftment properties to hbmMSC in vivo...
  25. ncbi The use of experimental murine models to assess novel agents of hematopoietic stem and progenitor cell mobilization
    Kirsten E Herbert
    Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Biol Blood Marrow Transplant 14:603-21. 2008
    ..Technical aspects regarding mobilization regimens and control arms, and choice of experimental animals are also discussed...
  26. ncbi Mobilization of bone marrow-derived progenitors
    J P Levesque
    Biotherapy Program, Mater Medical Research Institute, University of Queensland, Aubigny Place, Raymond Terrace, 4101 South Brisbane, Queensland, Australia
    Handb Exp Pharmacol . 2007
    ....
  27. ncbi Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1 alpha and vascular endothelial growth factor A in bone marrow
    Jean Pierre Levesque
    Mater Medical Research Institute, Raymond Terrace, Aubigny Place, South Brisbane, QLD, Australia
    Stem Cells 25:1954-65. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  28. ncbi Granulocyte colony-stimulating factor and an RARalpha specific agonist, VTP195183, synergize to enhance the mobilization of hematopoietic progenitor cells
    Kirsten E Herbert
    Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Transplantation 83:375-84. 2007
    ....
  29. ncbi Mechanisms of hematopoietic stem cell mobilization: when innate immunity assails the cells that make blood and bone
    Ingrid G Winkler
    Haematopoietic Stem Cell Laboratory, Cancer Biotherapies Program, Mater Medical Research Institute, University of Queensland, South Brisbane, Queensland, Australia
    Exp Hematol 34:996-1009. 2006
    ....
  30. ncbi Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization
    Ingrid G Winkler
    Haematopoietic Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia
    J Exp Med 201:1077-88. 2005
    ..These data suggest an unexpected role for serpina1 and serpina3 in regulating the bone marrow hematopoietic microenvironment as well as influencing the migratory behavior of hematopoietic precursors...
  31. ncbi Stem cell factor as a single agent induces selective proliferation of the Philadelphia chromosome positive fraction of chronic myeloid leukemia CD34(+) cells
    S Moore
    Leukemia Research Laboratory, Division of Haematology, Hanson Centre for Cancer Research, IMVS, Adelaide, SA, Australia
    Blood 92:2461-70. 1998
    ..The increased proliferation may contribute to the accumulation of leukemic progenitors, which is a feature of CML...
  32. ncbi Mitogenic effect of fibrinogen on hematopoietic cells: involvement of two distinct specific receptors, MFR and ICAM-1
    A Heron
    Centre National de la Recherche Scientifique, UPR 9044, Villejuif, France
    Biochem Biophys Res Commun 246:231-7. 1998
    ..The inhibition by an anti-MFR serum of the mitogenic effect of fibrinogen confirms the mitogenic function of the MFR...
  33. ncbi Evidence for two functionally different fibrinogen receptors on hemopoietic cells: the glycoprotein IIb-IIIa and the mitogenic fibrinogen receptor
    J P Levesque
    J Cell Physiol 132:303-10. 1987
    ....
  34. ncbi [C3 stimulates the proliferation of human pre-B Raji cells]
    J Hatzfeld
    UA 041163, ICIG, Hopital Paul Brousse, Villejuif, France
    Ann Inst Pasteur Immunol 138:451-5. 1987
    ..This preliminary report provides a defined system for studying the mitogenic effect of human C3 or C3 fragments upon proliferation of human B-cells lines...
  35. ncbi Interleukin-3 and interleukin-1 alpha allow earlier bone marrow progenitors to respond to human colony-stimulating factor 1
    Y Q Zhou
    Laboratory of Cellular and Molecular Biology of Growth Factors, Hopital Paul Brousse, Villejuif, France
    Blood 72:1870-4. 1988
    ..IL-1 alpha alone had little effect. However, IL-1 alpha in combination with optimal concentrations of either CSF-1, GM-CSF, or IL-3 increased the number of colonies containing immature or mature monocytic colonies...
  36. ncbi Fibrinogen mitogenic effect on hemopoietic cell lines: control via receptor modulation
    J P Levesque
    Proc Natl Acad Sci U S A 83:6494-8. 1986
    ..98, n = 5) with an increased growth rate of cells in the presence of fibrinogen. This correlation concludes that the mitogenic effect of fibrinogen is controlled via receptor modulation...
  37. ncbi A method to measure receptor binding of ligands with low affinity. Application to plasma proteins binding assay with hemopoietic cells
    J P Levesque
    Exp Cell Res 156:558-62. 1985
    ..Depending upon the size and the density of the cells, and the nature of the ligand, the assay method can be modified by changing the density or the nature of the hydrophilic and hydrophobic phases...
  38. ncbi Enhanced activity of peritoneal cells after aclacinomycin injection: effect of pretreatment with superoxide dismutase on aclacinomycin-induced cytological alterations and antitumoral activity
    A Bravo-Cuellar
    Institut du Cancer et d Immunogénétique CNRS UA 04 1163, Universite de Paris Sud, Hopital Paul Brousse, Villejuif, France
    Cancer Res 49:1578-86. 1989
    ..The unchanged direct oncostatic activity of ACM following SOD pretreatment suggests that this combination may have some wider perhaps clinical, potential...
  39. ncbi Binding of C3 and C3dg to the CR2 complement receptor induces growth of an Epstein-Barr virus-positive human B cell line
    A Hatzfeld
    Institut de Cancérologie et d Immunogenétique, Hopital Paul Brousse, Villejuif, France
    J Immunol 140:170-5. 1988
    ..Because CR2 also acts as a receptor for Epstein-Barr virus on B cells, our results may pertain to the B cell mitogenic properties of the virus...
  40. ncbi The down-regulation of the mitogenic fibrinogen receptor (MFR) in serum-containing medium does not occur in defined medium
    J P Levesque
    Laboratoire de Biologie Cellulaire et Moleculaire des Facteurs de Croissance, C N R S, Hopital Paul Brousse, Villejuif, France
    Exp Cell Res 186:257-63. 1990
    ..Reexpression of MFRs could be induced in 28 to 42 h by serum removal. The down-regulation of mitogenic receptors in plasma or serum could explain why normal cells do not proliferate in the peripheral blood...
  41. ncbi A mitogenic fibrinogen receptor that differs from glycoprotein IIb-IIIa. Identification by affinity chromatography and by covalent cross-linking
    J P Levesque
    Laboratoire de Biologie Cellulaire et Moleculaire, Institut de Cancérologie et d Immunogénetique Centre National de la Recherche Scientifique Hôpital Paul Brousse, Villejuif, France
    J Biol Chem 265:328-33. 1990
    ..We conclude that fibrinogen binds specifically to a 92-94-kDa MFR which does not belong to the integrin family...
  42. ncbi DNA transfection in COS cells: a low-cost serum-free method compared to lipofection
    J P Levesque
    Laboratoire C N R S, I C I G Hôpital Paul Brousse, Villejuif, France
    Biotechniques 11:313-4, 316-8. 1991
    ..Moreover, it should allow investigations dealing with the role of serum or other exogenous factors on mRNA stability or post-translation events during protein synthesis...
  43. ncbi Mitogenic properties of major extracellular proteins
    J P Levesque
    Laboratoire de Biologie Cellulaire et Moléculaire des Facteurs de Croissance Centre National de la Recherche Scientifique, Hopital Paul Brousse, Villejuif, France
    Immunol Today 12:258-62. 1991
    ....
  44. ncbi Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides
    J Hatzfeld
    Laboratoire C N R S de Biologie Cellulaire et Moléculaire des Facteurs de Croissance, ICIG, Hopital Paul Brousse, Villejuif, France
    J Exp Med 174:925-9. 1991
    ..Our results are consistent with the model that autocrine production of TGF-beta negatively regulates the cycling status of early hematopoietic progenitors through interaction with the Rb gene product...
  45. ncbi Cryopreservative effect of leupeptin on early human bone marrow progenitors
    M L Li
    Laboratoire C N R S de Biologie Cellulaire et Moléculaire des Facteurs de Croissance, ICIG, Hopital Paul Brousse, Villejuif, France
    In Vitro Cell Dev Biol 28:459-60. 1992
    ..The protective effect of leupeptin is particularly useful to freeze cells difficult to cryopreserve or when freezing-control equipment are not available...
  46. ncbi Additive effects of steel factor and antisense TGF-beta 1 oligodeoxynucleotide on CD34+ hematopoietic progenitor cells
    M L Li
    Centre National de la Recherche Scientifique, UPR 272, Villejuif, France
    Leukemia 8:441-5. 1994
    ..These data correlate well with our previous observations that umbilical cord blood contains 4-fold more CD34+ CD38- cells, the population found to respond to TGF-beta 1 antisense oligodeoxynucleotides...
  47. ncbi Human umbilical cord blood CD34+ cell purification with high yield of early progenitors
    A A Cardoso
    Laboratoire de Biologie Cellulaire et Moleculaire des Facteurs de Croissance, Centre National de la Recherche Scientifique UPR 272, Villejuif, France
    J Hematother 2:275-9. 1993
    ..A high recovery of CFU-GEMM progenitors (73.9%) was also observed. These data suggest the possibility of purifying CD34+ umbilical cord blood cells for clinical applications, in particular for umbilical cord blood banking...
  48. ncbi The mobilization of primitive hemopoietic progenitors into the peripheral blood
    P J Simmons
    Division of Haematology, Hanson Centre for Cancer Research, Villejuif, France
    Stem Cells 12:187-201; discussion 201-2. 1994
    ..Downregulation of c-kit is invariably associated with successful mobilization which, when combined with data from in vitro studies, implies a key role for stem cell factor (SCF) as an orchestrator of mobilization...
  49. ncbi Adhesion molecules in haemopoiesis
    P J Simmons
    Matthew Roberts Laboratory, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    Baillieres Clin Haematol 10:485-505. 1997
    ....
  50. ncbi A rapid streptavidin-capture ELISA specific for the detection of antibodies to feline foamy virus
    I G Winkler
    School of Pharmacy and Medical Science, University of South Australia, Adelaide, Australia
    J Immunol Methods 207:69-77. 1997
    ..There was a 100% correlation between FeFV antibody detected by ELISA, immunoblot, serum neutralisation and virus isolation, confirming that this test is sensitive and specific...
  51. ncbi CD44 and hyaluronan binding by human myeloid cells
    F Smadja-Joffe
    Unite d Oncogenese Appliquee, INSERM U268, Hopital Paul Brousse, Villejuif, France
    Leuk Lymphoma 21:407-20, color plates following 528. 1996
    ..Considering that the production of cytokines is enhanced in this disease, we discuss whether CD44-hyaluronan interaction may have a role in the pathophysiology of this myeloproliferative syndrome...
  52. ncbi CD44-mediated adhesiveness of human hematopoietic progenitors to hyaluronan is modulated by cytokines
    S Legras
    Institut National de la Santé et de la Recherche Médicale U268, Hopital Paul Brousse, Villejuif, France
    Blood 89:1905-14. 1997
    ..These data, which show for the first time that CD34+ HPC can directly adhere to HA via CD44, point out that this adhesive interaction to HA is a process that may also be physiologically regulated by cytokines...
  53. ncbi Cytokine regulation of proliferation and cell adhesion are correlated events in human CD34+ hemopoietic progenitors
    J P Levesque
    Department of Haematology, Hanson Centre for Cancer Research, Adelaide, Australia
    Blood 88:1168-76. 1996
    ....
  54. ncbi CSF-1 control of C-FMS expression in normal human bone marrow progenitors
    B Panterne
    Laboratoire de Biologie Cellulaire et Moléculaire des Factueurs de Croissance, C N R S, UPR 272, 94800 Villejuif, France
    J Cell Physiol 155:282-9. 1993
    ..No down-regulation was observed with low concentration of CSF-1 (1 ng/ml). The possibility that different concentrations of CSF-1 could modulate the development of monocytic progenitors is discussed...
  55. ncbi [Positive and negative controls on hematopoietic progenitor development: models and facts]
    B Panterne
    Laboratoire CNRS de Biologie Cellulaire et Moléculaire des Facteurs de Croissance, UPR 272, IRSC, Villejuif, France
    Nouv Rev Fr Hematol 35:281-3. 1993
    ..We discuss how positive and negative controls by cytokines and inhibitors could maintain homeostasis, even though progenitor commitment towards the various hematopoietic lineages may be stochastic...
  56. ncbi Release from quiescence of CD34+ CD38- human umbilical cord blood cells reveals their potentiality to engraft adults
    A A Cardoso
    Centre National de la Recherche Scientifique UPR 272, Villejuif, France
    Proc Natl Acad Sci U S A 90:8707-11. 1993
    ..This deficit is partially compensated by the higher growth capacity of the resulting CFU-GM. These studies suggest that umbilical cord blood is a suitable source of cells for adult transplantation...
  57. ncbi Fibrinogen potentiates the effect of interleukin-3 on early human hematopoietic progenitors
    Y Q Zhou
    Laboratoire de Biologie Cellulaire et Moleculaire des Facteurs de Croissance, Centre National de la Recherche Scientifique, Villejuif, France
    Blood 82:800-6. 1993
    ....
  58. ncbi Co-stimulatory effects of steel factor, the c-kit ligand, on purified human hematopoietic progenitors in low cell density culture
    M L Li
    Laboratoire CNRS de Biologie Cellulaire et Moléculaire des Facteurs de Croissance, ICIG, Hopital Paul Brousse, Villejuif, France
    Nouv Rev Fr Hematol 35:81-6. 1993
    ..These multipotential progenitors required the presence of multi-lineage factors, such as interleukin 3 (IL3) or granulocytic-macrophage CSF(GM-CSF) for their development...
  59. ncbi Early CD34high cells can be separated into KIThigh cells in which transforming growth factor-beta (TGF-beta) downmodulates c-kit and KITlow cells in which anti-TGF-beta upmodulates c-kit
    P Sansilvestri
    Centre National de la Recherche Scientifique UPR 9044, Villejuif, France
    Blood 86:1729-35. 1995
    ..Autocrine TGF-beta 1 appears to maintain these cells in a quiescent state, suppressing cell division by downmodulating the receptor of SF, a key cytokine costimulator of early progenitors...
  60. ncbi Purification and release from quiescence of umbilical cord blood early progenitors reveal their potential to engraft adults
    J Hatzfeld
    Centre National de la Recherche Scientifique, Villejuif, France
    Blood Cells 20:430-4; discussion 434-5. 1994
    ..These results suggest that umbilical cord blood is a suitable source of cells for adult transplantation...
  61. ncbi Cytokines increase human hemopoietic cell adhesiveness by activation of very late antigen (VLA)-4 and VLA-5 integrins
    J P Levesque
    Department of Immunology, Hanson Centre for Cancer Research, Adelaide, Australia
    J Exp Med 181:1805-15. 1995
    ....
  62. ncbi c-fos mRNA constitutive expression by mature human megakaryocytes
    B Panterne
    Laboratoire CNRS de Biologie Cellulaire et Moléculaire des Facteurs de Croissance, Hopital Paul Brousse, Villejuif, France
    Oncogene 7:2341-4. 1992
    ..These results suggest that c-fos could play a role in megakaryocytic terminal differentiation, either in the polyploidization or in the thrombopoietic function unique to these cells...