Research Topics
Species | D M KeefeSummaryAffiliation: South Australia Country: Australia Publications
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Publications
Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humansD M Keefe
Department of Gastroenterology, Queen Elizabeth Hospital, Woodville South, South Australia 5011, Australia
Gut 47:632-7. 2000..The mechanism of gastrointestinal damage (mucositis) induced by cancer chemotherapy remains uncertain. The aims of this study were to define the time course and mechanism of small intestinal damage following chemotherapy in humans...
Gastrointestinal mucositis: a new biological modelDorothy M K Keefe
Department of Medical Oncology, Royal Adelaide Hospital, SA 5000 Adelaide, Australia
Support Care Cancer 12:6-9. 2004....- Gemcitabine and carboplatin in carcinoma of unknown primary site: a phase 2 Adelaide Cancer Trials and Education Collaborative studyK B Pittman
Department of Oncology, The Queen Elizabeth Hospital, Woodville Road, Woodville, South Australia, Australia
Br J Cancer 95:1309-13. 2006..The regimen was very well tolerated, particularly in the elderly. The GC regimen is an active regimen in CUP with excellent tolerability and should be considered particularly for elderly patients with CUP... - Irinotecan causes severe small intestinal damage, as well as colonic damage, in the rat with implanted breast cancerRachel J Gibson
Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia
J Gastroenterol Hepatol 18:1095-100. 2003..The aim of the present study was to investigate the time-course of apoptosis and whole intestinal damage after irinotecan to further elucidate the mechanism behind the diarrhea... - Role of p53 in irinotecan-induced intestinal cell death and mucosal damageJoanne M Bowen
Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia
Anticancer Drugs 18:197-210. 2007..Temporary inhibition of p53 activation does not markedly prevent intestinal cell death or mucositis following irinotecan treatment. Irinotecan may act through upregulation of proapoptotic proteins Bax and Bak to induce cell death... - Chemotherapy-induced diarrhea is associated with changes in the luminal environment in the DA ratAndrea M Stringer
Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia
Exp Biol Med (Maywood) 232:96-106. 2007..These changes in flora may have systemic effects and in particular may contribute to the development of chemotherapy-induced mucositis... - Velafermin improves gastrointestinal mucositis following irinotecan treatment in tumor-bearing DA ratsRachel J Gibson
Department of Medical Oncology, The Ropl Adelaide Hospital, North Terrace, Adelaide 5000 South Australia, Australia
Cancer Biol Ther 6:541-7. 2007..Other dosing regimens were not as effective. This has important implications for the use of velafermin in GI mucositis in humans, and should be further studied... - The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugsRichard M Logan
Oral Pathology, School of Dentistry, Faculty of Health Sciences, The University of Adelaide, North Terrace, Adelaide SA 5005, Australia
Cancer Treat Rev 33:448-60. 2007.... - Gene expression analysis of multiple gastrointestinal regions reveals activation of common cell regulatory pathways following cytotoxic chemotherapyJoanne M Bowen
Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, Australia
Int J Cancer 121:1847-56. 2007..Many of these changes are highly likely to be specifically related to the subsequent development of gastrointestinal mucositis... - Chemotherapy-induced mucositis: the role of gastrointestinal microflora and mucins in the luminal environmentAndrea M Stringer
Department of Medical Oncology, Royal Adelaide Hospital, South Australia
J Support Oncol 5:259-67. 2007.... - A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-kappaB, COX-1, and COX-2Ann S J Yeoh
Department of Medical Oncology, Royal Adelaide Hospital, South Australia, Australia
Mol Cancer Ther 6:2319-27. 2007..Further studies investigating the molecular mechanisms underlying radiation-induced mucositis are planned to ultimately achieve anti-mucotoxic-targeted therapies... - Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositisRichard M Logan
Oral Pathology, School of Dentistry, Faculty of Health Sciences, The University of Adelaide, North Terrace, SA 5005, Australia
Cancer Chemother Pharmacol 62:33-41. 2008.... - Establishment of a single-dose irinotecan model of gastrointestinal mucositisRachel J Gibson
Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, Australia
Chemotherapy 53:360-9. 2007..The secondary aim was to determine if the presence of tumour altered the development of mucositis... - VSL#3 probiotic treatment reduces chemotherapy-induced diarrhea and weight lossJoanne M Bowen
Department of Medical Oncology, Royal Adelaide Hospital, South Australia, Australia
Cancer Biol Ther 6:1449-54. 2007..One of the most common toxicities of cancer treatment is diarrhea. Probiotics have been shown effective at preventing diarrhea in inflammatory bowel disease and may prove useful in the oncology setting... - Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugsRichard M Logan
Oral Pathology, School of Dentistry, Faculty of Health Sciences, The University of Adelaide, South Australia, Australia
Cancer Biol Ther 7:1139-45. 2008..The aims of this study were to determine whether changes in serum levels of NFkappaB, TNF, IL-1beta and IL-6 following administration of different drugs predicted histological evidence of tissue damage... - Mucosal injury from targeted anti-cancer therapyDorothy M K Keefe
Department of Medical Oncology, Royal Adelaide Hospital and Discipline of Medicine, Faculty of Health Sciences, University of Adelaide, North Terrace, Adelaide, Australia
Support Care Cancer 15:483-90. 2007..Whilst we increasingly understand the mechanisms underlying the toxicities of chemotherapy and radiotherapy, the addition of targeted treatments requires a new understanding of both toxicity and interacting mechanisms... - The effect of keratinocyte growth factor on tumour growth and small intestinal mucositis after chemotherapy in the rat with breast cancerRachel J Gibson
Department of Gastroenterology, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia
Cancer Chemother Pharmacol 50:53-8. 2002..KGF also reduced tumour size. CONCLUSIONS: We conclude that KGF had a modest effect on intestinal growth prior to chemotherapy. It did not protect the gut from mucositis, nor did it worsen morphometry. It reduced tumour size... - Effect of interleukin-11 on ameliorating intestinal damage after methotrexate treatment of breast cancer in ratsRachel J Gibson
Department of Medical Oncology, The Royal Adelaide Hospital, Adelaide, South Australia, Australia
Dig Dis Sci 47:2751-7. 2002..We conclude that IL-11 attenuated mucositis by maintaining intestinal weight and morphometry. IL-11 did not prevent apoptosis, but rather induced compensatory crypt cell proliferation... - Gastrointestinal mucositisDorothy M K Keefe
Department of Medical Oncology, Royal Adelaide Hospital, South Australia
Semin Oncol Nurs 20:38-47. 2004..IMPLICATIONS FOR NURSING PRACTICE: It is important to document the frequency and severity of gastrointestinal mucositis, and to alleviate symptoms wherever possible... - Novel therapiesDouglas E Peterson
Department of Oral Diagnosis, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030-1605, USA
Semin Oncol Nurs 20:53-8. 2004..IMPLICATIONS FOR NURSING PRACTICE: The oncology nurse plays a pivotal role in assessing and managing mucositis in cancer patients... - Palifermin reduces diarrhea and increases survival following irinotecan treatment in tumor-bearing DA ratsRachel J Gibson
Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, Australia
Int J Cancer 116:464-70. 2005..This positive response warrants further investigation, particularly in humans... - Nuclear factor kappaB (NFkappaB) and cyclooxygenase-2 (Cox-2) expression in the irradiated colorectum is associated with subsequent histopathological changesAnn S J Yeoh
Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Int J Radiat Oncol Biol Phys 63:1295-303. 2005..The purpose of this study was therefore to investigate the expression of NFkappaB and Cox-2 in the irradiated colorectum and to correlate these with the associated histopathologic changes... - Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damageJoanne M Bowen
Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, 5000, South Australia, Australia
Support Care Cancer 14:713-31. 2006..This review will provide an overview of current research as well as identify areas where gaps in knowledge exist... - Mucositis guidelines: what have they achieved, and where to from here?Dorothy M K Keefe
Support Care Cancer 14:489-91. 2006 - Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategiesRachel J Gibson
Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, Australia
Support Care Cancer 14:890-900. 2006..Diarrhoea and constipation are common toxicities of chemotherapy, and both are poorly understood. They are manifestations of alimentary mucositis, a condition which affects the entire gastrointestinal tract... - Irinotecan changes gene expression in the small intestine of the rat with breast cancerJoanne M Bowen
Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, 5000, South Australia, Australia
Cancer Chemother Pharmacol 59:337-48. 2007..The aims of this study were to identify genes that are altered by irinotecan, to determine how these genes contribute to apoptosis and to identify any potential gene families and pathways that are important for mucositis development... - Nuclear factor-kappaB (NF-kappaB) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapyRichard M Logan
Oral Pathology, School of Dentistry, The University of Adelaide, Adelaide, North Terrace, SA 5005, Australia
Oral Oncol 43:395-401. 2007.... - Sucrose breath testing and intestinal mucositisDorothy M K Keefe
Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Cancer Biol Ther 5:1196-8. 2006 - Supportive care silos: time to forge cross-links, using mucositis as an exampleDorothy M K Keefe
RAH Cancer Centre and Discipline of Medicine, Faculty of Health Sciences, University of Adelaide, South Australia, Australia
Curr Opin Support Palliat Care 1:40-2. 2007 
Technological advances in mucositis research: new insights and new issuesRachel J Gibson
Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Cancer Treat Rev 34:476-82. 2008..In addition, some of these technologies have the potential to be implemented immediately in the field of mucositis research...