D M Keefe

Summary

Affiliation: South Australia
Country: Australia

Publications

  1. pmc Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans
    D M Keefe
    Department of Gastroenterology, Queen Elizabeth Hospital, Woodville South, South Australia 5011, Australia
    Gut 47:632-7. 2000
  2. ncbi request reprint Gastrointestinal mucositis: a new biological model
    Dorothy M K Keefe
    Department of Medical Oncology, Royal Adelaide Hospital, SA 5000 Adelaide, Australia
    Support Care Cancer 12:6-9. 2004
  3. pmc Gemcitabine and carboplatin in carcinoma of unknown primary site: a phase 2 Adelaide Cancer Trials and Education Collaborative study
    K B Pittman
    Department of Oncology, The Queen Elizabeth Hospital, Woodville Road, Woodville, South Australia, Australia
    Br J Cancer 95:1309-13. 2006
  4. ncbi request reprint Irinotecan causes severe small intestinal damage, as well as colonic damage, in the rat with implanted breast cancer
    Rachel J Gibson
    Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia
    J Gastroenterol Hepatol 18:1095-100. 2003
  5. ncbi request reprint Role of p53 in irinotecan-induced intestinal cell death and mucosal damage
    Joanne M Bowen
    Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia
    Anticancer Drugs 18:197-210. 2007
  6. ncbi request reprint Chemotherapy-induced diarrhea is associated with changes in the luminal environment in the DA rat
    Andrea M Stringer
    Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia
    Exp Biol Med (Maywood) 232:96-106. 2007
  7. ncbi request reprint Velafermin improves gastrointestinal mucositis following irinotecan treatment in tumor-bearing DA rats
    Rachel J Gibson
    Department of Medical Oncology, The Ropl Adelaide Hospital, North Terrace, Adelaide 5000 South Australia, Australia
    Cancer Biol Ther 6:541-7. 2007
  8. ncbi request reprint The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs
    Richard M Logan
    Oral Pathology, School of Dentistry, Faculty of Health Sciences, The University of Adelaide, North Terrace, Adelaide SA 5005, Australia
    Cancer Treat Rev 33:448-60. 2007
  9. ncbi request reprint Gene expression analysis of multiple gastrointestinal regions reveals activation of common cell regulatory pathways following cytotoxic chemotherapy
    Joanne M Bowen
    Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, Australia
    Int J Cancer 121:1847-56. 2007
  10. ncbi request reprint Chemotherapy-induced mucositis: the role of gastrointestinal microflora and mucins in the luminal environment
    Andrea M Stringer
    Department of Medical Oncology, Royal Adelaide Hospital, South Australia
    J Support Oncol 5:259-67. 2007

Detail Information

Publications30

  1. pmc Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humans
    D M Keefe
    Department of Gastroenterology, Queen Elizabeth Hospital, Woodville South, South Australia 5011, Australia
    Gut 47:632-7. 2000
    ..The mechanism of gastrointestinal damage (mucositis) induced by cancer chemotherapy remains uncertain. The aims of this study were to define the time course and mechanism of small intestinal damage following chemotherapy in humans...
  2. ncbi request reprint Gastrointestinal mucositis: a new biological model
    Dorothy M K Keefe
    Department of Medical Oncology, Royal Adelaide Hospital, SA 5000 Adelaide, Australia
    Support Care Cancer 12:6-9. 2004
    ....
  3. pmc Gemcitabine and carboplatin in carcinoma of unknown primary site: a phase 2 Adelaide Cancer Trials and Education Collaborative study
    K B Pittman
    Department of Oncology, The Queen Elizabeth Hospital, Woodville Road, Woodville, South Australia, Australia
    Br J Cancer 95:1309-13. 2006
    ..The regimen was very well tolerated, particularly in the elderly. The GC regimen is an active regimen in CUP with excellent tolerability and should be considered particularly for elderly patients with CUP...
  4. ncbi request reprint Irinotecan causes severe small intestinal damage, as well as colonic damage, in the rat with implanted breast cancer
    Rachel J Gibson
    Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia
    J Gastroenterol Hepatol 18:1095-100. 2003
    ..The aim of the present study was to investigate the time-course of apoptosis and whole intestinal damage after irinotecan to further elucidate the mechanism behind the diarrhea...
  5. ncbi request reprint Role of p53 in irinotecan-induced intestinal cell death and mucosal damage
    Joanne M Bowen
    Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia
    Anticancer Drugs 18:197-210. 2007
    ..Temporary inhibition of p53 activation does not markedly prevent intestinal cell death or mucositis following irinotecan treatment. Irinotecan may act through upregulation of proapoptotic proteins Bax and Bak to induce cell death...
  6. ncbi request reprint Chemotherapy-induced diarrhea is associated with changes in the luminal environment in the DA rat
    Andrea M Stringer
    Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia
    Exp Biol Med (Maywood) 232:96-106. 2007
    ..These changes in flora may have systemic effects and in particular may contribute to the development of chemotherapy-induced mucositis...
  7. ncbi request reprint Velafermin improves gastrointestinal mucositis following irinotecan treatment in tumor-bearing DA rats
    Rachel J Gibson
    Department of Medical Oncology, The Ropl Adelaide Hospital, North Terrace, Adelaide 5000 South Australia, Australia
    Cancer Biol Ther 6:541-7. 2007
    ..Other dosing regimens were not as effective. This has important implications for the use of velafermin in GI mucositis in humans, and should be further studied...
  8. ncbi request reprint The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs
    Richard M Logan
    Oral Pathology, School of Dentistry, Faculty of Health Sciences, The University of Adelaide, North Terrace, Adelaide SA 5005, Australia
    Cancer Treat Rev 33:448-60. 2007
    ....
  9. ncbi request reprint Gene expression analysis of multiple gastrointestinal regions reveals activation of common cell regulatory pathways following cytotoxic chemotherapy
    Joanne M Bowen
    Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, Australia
    Int J Cancer 121:1847-56. 2007
    ..Many of these changes are highly likely to be specifically related to the subsequent development of gastrointestinal mucositis...
  10. ncbi request reprint Chemotherapy-induced mucositis: the role of gastrointestinal microflora and mucins in the luminal environment
    Andrea M Stringer
    Department of Medical Oncology, Royal Adelaide Hospital, South Australia
    J Support Oncol 5:259-67. 2007
    ....
  11. ncbi request reprint A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-kappaB, COX-1, and COX-2
    Ann S J Yeoh
    Department of Medical Oncology, Royal Adelaide Hospital, South Australia, Australia
    Mol Cancer Ther 6:2319-27. 2007
    ..Further studies investigating the molecular mechanisms underlying radiation-induced mucositis are planned to ultimately achieve anti-mucotoxic-targeted therapies...
  12. ncbi request reprint Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis
    Richard M Logan
    Oral Pathology, School of Dentistry, Faculty of Health Sciences, The University of Adelaide, North Terrace, SA 5005, Australia
    Cancer Chemother Pharmacol 62:33-41. 2008
    ....
  13. ncbi request reprint Establishment of a single-dose irinotecan model of gastrointestinal mucositis
    Rachel J Gibson
    Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, Australia
    Chemotherapy 53:360-9. 2007
    ..The secondary aim was to determine if the presence of tumour altered the development of mucositis...
  14. ncbi request reprint VSL#3 probiotic treatment reduces chemotherapy-induced diarrhea and weight loss
    Joanne M Bowen
    Department of Medical Oncology, Royal Adelaide Hospital, South Australia, Australia
    Cancer Biol Ther 6:1449-54. 2007
    ..One of the most common toxicities of cancer treatment is diarrhea. Probiotics have been shown effective at preventing diarrhea in inflammatory bowel disease and may prove useful in the oncology setting...
  15. ncbi request reprint Serum levels of NFkappaB and pro-inflammatory cytokines following administration of mucotoxic drugs
    Richard M Logan
    Oral Pathology, School of Dentistry, Faculty of Health Sciences, The University of Adelaide, South Australia, Australia
    Cancer Biol Ther 7:1139-45. 2008
    ..The aims of this study were to determine whether changes in serum levels of NFkappaB, TNF, IL-1beta and IL-6 following administration of different drugs predicted histological evidence of tissue damage...
  16. ncbi request reprint Mucosal injury from targeted anti-cancer therapy
    Dorothy M K Keefe
    Department of Medical Oncology, Royal Adelaide Hospital and Discipline of Medicine, Faculty of Health Sciences, University of Adelaide, North Terrace, Adelaide, Australia
    Support Care Cancer 15:483-90. 2007
    ..Whilst we increasingly understand the mechanisms underlying the toxicities of chemotherapy and radiotherapy, the addition of targeted treatments requires a new understanding of both toxicity and interacting mechanisms...
  17. ncbi request reprint The effect of keratinocyte growth factor on tumour growth and small intestinal mucositis after chemotherapy in the rat with breast cancer
    Rachel J Gibson
    Department of Gastroenterology, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia
    Cancer Chemother Pharmacol 50:53-8. 2002
    ..The aims of this study were to assess the effect of keratinocyte growth factor (KGF) on breast tumour growth, and in preventing small intestinal mucositis induced by methotrexate (MTX)...
  18. ncbi request reprint Effect of interleukin-11 on ameliorating intestinal damage after methotrexate treatment of breast cancer in rats
    Rachel J Gibson
    Department of Medical Oncology, The Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Dig Dis Sci 47:2751-7. 2002
    ..We conclude that IL-11 attenuated mucositis by maintaining intestinal weight and morphometry. IL-11 did not prevent apoptosis, but rather induced compensatory crypt cell proliferation...
  19. ncbi request reprint Gastrointestinal mucositis
    Dorothy M K Keefe
    Department of Medical Oncology, Royal Adelaide Hospital, South Australia
    Semin Oncol Nurs 20:38-47. 2004
    ..To review the management of radiotherapy- and chemotherapy-induced gastrointestinal mucositis...
  20. ncbi request reprint Novel therapies
    Douglas E Peterson
    Department of Oral Diagnosis, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030 1605, USA
    Semin Oncol Nurs 20:53-8. 2004
    ..To highlight selected research directed to new drug and device technologies to manage mucositis in cancer patients and to illustrate potential impact of successful therapies...
  21. ncbi request reprint Palifermin reduces diarrhea and increases survival following irinotecan treatment in tumor-bearing DA rats
    Rachel J Gibson
    Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, Australia
    Int J Cancer 116:464-70. 2005
    ..This positive response warrants further investigation, particularly in humans...
  22. ncbi request reprint Nuclear factor kappaB (NFkappaB) and cyclooxygenase-2 (Cox-2) expression in the irradiated colorectum is associated with subsequent histopathological changes
    Ann S J Yeoh
    Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Int J Radiat Oncol Biol Phys 63:1295-303. 2005
    ..The purpose of this study was therefore to investigate the expression of NFkappaB and Cox-2 in the irradiated colorectum and to correlate these with the associated histopathologic changes...
  23. ncbi request reprint Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage
    Joanne M Bowen
    Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, 5000, South Australia, Australia
    Support Care Cancer 14:713-31. 2006
    ..This review will provide an overview of current research as well as identify areas where gaps in knowledge exist...
  24. ncbi request reprint Mucositis guidelines: what have they achieved, and where to from here?
    Dorothy M K Keefe
    Support Care Cancer 14:489-91. 2006
  25. ncbi request reprint Cancer chemotherapy-induced diarrhoea and constipation: mechanisms of damage and prevention strategies
    Rachel J Gibson
    Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, Australia
    Support Care Cancer 14:890-900. 2006
    ..Diarrhoea and constipation are common toxicities of chemotherapy, and both are poorly understood. They are manifestations of alimentary mucositis, a condition which affects the entire gastrointestinal tract...
  26. ncbi request reprint Irinotecan changes gene expression in the small intestine of the rat with breast cancer
    Joanne M Bowen
    Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, 5000, South Australia, Australia
    Cancer Chemother Pharmacol 59:337-48. 2007
    ..The aims of this study were to identify genes that are altered by irinotecan, to determine how these genes contribute to apoptosis and to identify any potential gene families and pathways that are important for mucositis development...
  27. ncbi request reprint Nuclear factor-kappaB (NF-kappaB) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy
    Richard M Logan
    Oral Pathology, School of Dentistry, The University of Adelaide, Adelaide, North Terrace, SA 5005, Australia
    Oral Oncol 43:395-401. 2007
    ....
  28. ncbi request reprint Sucrose breath testing and intestinal mucositis
    Dorothy M K Keefe
    Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Cancer Biol Ther 5:1196-8. 2006
  29. doi request reprint Supportive care silos: time to forge cross-links, using mucositis as an example
    Dorothy M K Keefe
    RAH Cancer Centre and Discipline of Medicine, Faculty of Health Sciences, University of Adelaide, South Australia, Australia
    Curr Opin Support Palliat Care 1:40-2. 2007
  30. doi request reprint Technological advances in mucositis research: new insights and new issues
    Rachel J Gibson
    Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Cancer Treat Rev 34:476-82. 2008
    ..In addition, some of these technologies have the potential to be implemented immediately in the field of mucositis research...