Research Topics
Genomes and Genes | G HodgeSummaryAffiliation: South Australia Country: Australia Publications
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Publications
Effect of factor VIII concentrate on antigen-presenting cell (APC)/T-cell interactions in vitro: relevance to inhibitor formation and tolerance inductionG Hodge
Haematology Department, Women s and Children s Hospital, North Adelaide, South Australia
Br J Haematol 109:195-200. 2000..We now provide evidence that the use of pdFVIII, through interfering with APC/T-cell interactions, may be more appropriate than rhFVIII for tolerance induction...- Increased intracellular pro- and anti-inflammatory cytokines in bronchoalveolar lavage T cells of stable lung transplant patientsGreg Hodge
Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, Australia
Transplantation 80:1040-5. 2005..However, analysis of inflammatory cytokine profiles in bronchoalveolar lavage (BAL) T cells may be more relevant than peripheral blood T cells for assessing graft status... - Effect of blood storage conditions on leucocyte intracellular cytokine productionG Hodge
Haematology Department, Adelaide Women s and Children s Hospital, 72 King William Road, North Adelaide 5006, Australia
Cytokine 32:7-11. 2005..Blood stored at 4 degrees C showed less immunomodulatory changes than blood kept at RT although overall a possible Th1 bias at 4 degrees C... - Poststorage leuko-depleted plasma inhibits T-cell proliferation and Th1 response in vitro: characterization of TGFbeta-1 as an important immunomodulatory component in stored bloodGreg L Hodge
Haematology Department, Women s and Children s Hospital, North Adelaide, South Australia
Transplantation 80:95-101. 2005..Although the mechanism of this phenomenon remains to be fully elucidated, it is clear that the immunomodulatory effect is mediated by leukocytes/platelets or their products... - Up-regulation of interleukin-8, interleukin-10, monocyte chemotactic protein-1, and monocyte chemotactic protein-3 in peripheral blood monocytes in stable lung transplant recipients: are immunosuppression regimens working?Greg Hodge
Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, Australia
Transplantation 79:387-91. 2005..We hypothesized that production of these inflammatory mediators by blood monocytes may be up-regulated despite the use of potent immunosuppression therapy... 
Intracellular cytokines in blood T cells in lung transplant patients--a more relevant indicator of immunosuppression than drug levelsG Hodge
Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia
Clin Exp Immunol 139:159-64. 2005..Intracellular cytokine analysis using flow cytometry may be a more appropriate indicator of immunosuppression than drug levels in these patients. This technique may prove useful in optimizing therapy for individual patients...- Rapid simultaneous measurement of multiple cytokines using 100 microl sample volumes--association with neonatal sepsisG Hodge
Department of Haematology, Women s and Children s Hospital, North Adelaide, South Australia
Clin Exp Immunol 137:402-7. 2004..In conclusion, neonatal sepsis is associated with the elevation of multiple plasma cytokines. The use of CBA kits is a rapid, easy, low sample volume and sensitive method to measure multiple plasma cytokines... - A marked decrease in L-selectin expression by leucocytes in infants with Bordetella pertussis infection: leucocytosis explained?Greg Hodge
Haematology Department, Women s and Children s Hospital, North Adelaide, South Australia, Australia
Respirology 8:157-62. 2003..To characterize these cells immunophenotyping using multiparameter flow cytometry was performed on leucocytes from a group of 11 infants aged 3-6 months with proven pertussis and from uninfected control subjects... - Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: potential therapeutic use in the treatment of inflammatory bowel diseaseGreg Hodge
Haematology Department, Women s and Children s Hospital, North Adelaide, South Australia
Cytometry 48:209-15. 2002..Several compounds isolated from Allium sativum (garlic) modulate leukocyte cell proliferation and cytokine production... - Airway infection in stable lung transplant patients is associated with decreased intracellular T-helper type 1 pro-inflammatory cytokines in bronchoalveolar lavage T-cell subsetsG Hodge
Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Transpl Infect Dis 10:99-105. 2008..Modifying immunosuppression by monitoring intracellular Th1 pro-inflammatory cytokines in BAL T cells may help to improve morbidity and infection rates in stable lung transplant patients... - Compartmentalization of intracellular proinflammatory cytokines in bronchial intraepithelial T cells of stable lung transplant patientsG Hodge
Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia
Clin Exp Immunol 145:413-9. 2006..Drugs that effectively reduce CD8 T cell proinflammatory cytokine production in the lung compartment may improve current protocols for reducing graft rejection in these patients... - Time post-lung transplant correlates with increasing peripheral blood T cell granzyme B and proinflammatory cytokinesG Hodge
Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia
Clin Exp Immunol 161:584-90. 2010..Declining FEV(1) is associated with a further increase in these proinflammatory mediators. Drugs that reduce these inflammatory mediators effectively may reduce the incidence of chronic graft rejection... - Increased intracellular T helper 1 proinflammatory cytokine production in peripheral blood, bronchoalveolar lavage and intraepithelial T cells of COPD subjectsG Hodge
Department of Thoracic Medicine, Royal Adelaide Hospital, Australia
Clin Exp Immunol 150:22-9. 2007..Systemic therapeutic targeting of TNF-alpha production by CD8(+) T cells may improve morbidity in COPD patients while targeting of TNF-alpha in the lung may prevent smokers progressing to COPD... - Increased levels of T cell granzyme b in bronchiolitis obliterans syndrome are not suppressed adequately by current immunosuppressive regimensS Hodge
Lung Research Laboratory, Hanson Institute, Adelaide, SA, Australia
Clin Exp Immunol 158:230-6. 2009..Longitudinal investigation of granzyme b in blood may provide an adjunctive non-invasive method for predicting BOS/OB... - Cord blood leucocyte expression of functionally significant molecules involved in the regulation of cellular immunityS Hodge
Haematology Department, Women s and Children s Hospital, 72 King William Street, Adelaide, South Australia
Scand J Immunol 53:72-8. 2001..The findings of lower expression of IL-2R beta and lower production of inflammatory cytokines IL-1 alpha, IL-1 beta and TNF-alpha is a basis for improved understanding of the immunological immaturity of leucocytes in the newborn... 
Posttransplant bronchiolitis obliterans syndrome is associated with bronchial epithelial to mesenchymal transitionS Hodge
Lung Research Laboratory, Hanson Institute, Adelaide, Australia
Am J Transplant 9:727-33. 2009..Flow cytometric evaluation of bronchial epithelium may provide a novel and rapid means to assess lung allografts at risk of BOS...- Effect of factor VIII concentrate on leucocyte cytokine receptor expression in vitro: relevance to inhibitor formation and tolerance inductionG Hodge
Haematology Oncology Department, Women s and Children s Hospital, North Adelaide, South Australia, Australia
Haemophilia 12:133-9. 2006..The use of pdFVIII, particularly the more inhibitory batches, may be more suitable than rFVIII for tolerance induction protocols. A clinical study needs to be undertaken to determine the significance of these in vitro findings... - Interleukin-4 and tumour necrosis factor-alpha inhibit transforming growth factor-beta production in a human bronchial epithelial cell line: possible relevance to inflammatory mechanisms in chronic obstructive pulmonary diseaseS Hodge
Department of Thoracic Medicine, Royal Adelaide Hospital, North Terrrace, South Australia, Australia
Respirology 6:205-11. 2001..The purpose of this study was to study the effect of TNF-alpha and IL-4 (pro-inflammatory cytokines known to be up-regulated in COPD), on the production of TGF-beta (a negative regulator of inflammation) by epithelial cells... - Effect of intermediate-purity factor VIII (FVIII) concentrate on lymphocyte proliferation and apoptosis: transforming growth factor-beta is a significant immunomodulatory component of FVIIIG Hodge
Haematology Department, Women s and Children s Hospital, North Adelaide, South Australia
Br J Haematol 115:376-81. 2001..Together, these findings suggest that TGF-beta is a significant immunomodulatory component of pdFVIII concentrates... - Increased T regulatory cells and decreased Th1 pro-inflammatory cytokines correlate with culture-positive infection in febrile neutropenia childhood oncology patientsG Hodge
Haematology Oncology Department, SA Pathology, Women s and Children s Hospital, North Adelaide 5006, Australia
Cytokine 53:286-8. 2011..We hypothesized that characterization of reduced intracellular Th1 cytokines and increased T regulatory cells (Tregs) may prove useful in identifying infection in childhood oncology patients with febrile neutropenia... - Factor VIII concentrate inhibits T helper type 2 cytokine production in vitro: relevance to inhibitor antibody formationG Hodge
Haematology Department, Women's and Children's Hospital, North Adelaide, South Australia
Haemophilia 7:490-6. 2001..A clinical study needs to be undertaken to determine the significance of these in vitro findings... - Azithromycin increases phagocytosis of apoptotic bronchial epithelial cells by alveolar macrophagesS Hodge
Dept of Thoracic Medicine, Royal Adelaide Hospital and Lung Research Laboratory, Hanson Institute, Adelaide, Australia
Eur Respir J 28:486-95. 2006..At higher doses, azithromycin decreased levels of pro-inflammatory cytokines. Thus, low-dose azithromycin therapy could provide an adjunct therapeutic option in chronic obstructive pulmonary disease... - Role of increased CD8/CD28(null) T cells and alternative co-stimulatory molecules in chronic obstructive pulmonary diseaseG Hodge
Lung Research Laboratory, Hanson Institute and Department of Thoracic Medicine, Royal Adelaide Hospital and University of Adelaide, Adelaide, South Australia, Australia
Clin Exp Immunol 166:94-102. 2011..Increased production of proinflammatory cytokines and expression of alternative co-stimulatory molecules by CD8/CD28(null) T cells may play a role in inflammatory or autoimmune responses in COPD and identify therapeutic targets... - Potential immaturity of the T-cell and antigen-presenting cell interaction in cord blood with particular emphasis on the CD40-CD40 ligand costimulatory pathwayP Han
Department of Haematology, Women s and Children s Hospital, University of Adelaide, North Adelaide, South Australia
Immunology 113:26-34. 2004..Also the ligand-receptor immaturity may contribute to the increased susceptibility of newborns to certain infections... - Multiple leucocyte activation markers to detect neonatal infectionG Hodge
Haematology Department, Women s and Children s Hospital, North Adelaide, South Australia, Australia
Clin Exp Immunol 135:125-9. 2004..A combination of this marker with CD45RA, CD45RO, CD25 and CD69 expression on peripheral blood derived T cells is the most sensitive and specific for neonatal infection... - Increased airway epithelial and T-cell apoptosis in COPD remains despite smoking cessationS Hodge
Dept of Thoracic Medicine, Royal Adelaide Hospital and Hanson Institute, Adelaide, South Australia 5001, Australia
Eur Respir J 25:447-54. 2005.... - Rapid simultaneous measurement of multiple cytokines in childhood oncology patients with febrile neutropenia: increased interleukin (IL)-8 or IL-5 correlates with culture-positive infectionG Hodge
Br J Haematol 132:247-8. 2006