G Hodge

Summary

Affiliation: South Australia
Country: Australia

Publications

  1. ncbi request reprint Effect of factor VIII concentrate on antigen-presenting cell (APC)/T-cell interactions in vitro: relevance to inhibitor formation and tolerance induction
    G Hodge
    Haematology Department, Women s and Children s Hospital, North Adelaide, South Australia
    Br J Haematol 109:195-200. 2000
  2. ncbi request reprint Increased intracellular pro- and anti-inflammatory cytokines in bronchoalveolar lavage T cells of stable lung transplant patients
    Greg Hodge
    Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, Australia
    Transplantation 80:1040-5. 2005
  3. ncbi request reprint Effect of blood storage conditions on leucocyte intracellular cytokine production
    G Hodge
    Haematology Department, Adelaide Women s and Children s Hospital, 72 King William Road, North Adelaide 5006, Australia
    Cytokine 32:7-11. 2005
  4. ncbi request reprint Poststorage leuko-depleted plasma inhibits T-cell proliferation and Th1 response in vitro: characterization of TGFbeta-1 as an important immunomodulatory component in stored blood
    Greg L Hodge
    Haematology Department, Women s and Children s Hospital, North Adelaide, South Australia
    Transplantation 80:95-101. 2005
  5. ncbi request reprint Up-regulation of interleukin-8, interleukin-10, monocyte chemotactic protein-1, and monocyte chemotactic protein-3 in peripheral blood monocytes in stable lung transplant recipients: are immunosuppression regimens working?
    Greg Hodge
    Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, Australia
    Transplantation 79:387-91. 2005
  6. pmc Intracellular cytokines in blood T cells in lung transplant patients--a more relevant indicator of immunosuppression than drug levels
    G Hodge
    Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia
    Clin Exp Immunol 139:159-64. 2005
  7. pmc Rapid simultaneous measurement of multiple cytokines using 100 microl sample volumes--association with neonatal sepsis
    G Hodge
    Department of Haematology, Women s and Children s Hospital, North Adelaide, South Australia
    Clin Exp Immunol 137:402-7. 2004
  8. ncbi request reprint A marked decrease in L-selectin expression by leucocytes in infants with Bordetella pertussis infection: leucocytosis explained?
    Greg Hodge
    Haematology Department, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    Respirology 8:157-62. 2003
  9. ncbi request reprint Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: potential therapeutic use in the treatment of inflammatory bowel disease
    Greg Hodge
    Haematology Department, Women s and Children s Hospital, North Adelaide, South Australia
    Cytometry 48:209-15. 2002
  10. ncbi request reprint Airway infection in stable lung transplant patients is associated with decreased intracellular T-helper type 1 pro-inflammatory cytokines in bronchoalveolar lavage T-cell subsets
    G Hodge
    Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Transpl Infect Dis 10:99-105. 2008

Detail Information

Publications28

  1. ncbi request reprint Effect of factor VIII concentrate on antigen-presenting cell (APC)/T-cell interactions in vitro: relevance to inhibitor formation and tolerance induction
    G Hodge
    Haematology Department, Women s and Children s Hospital, North Adelaide, South Australia
    Br J Haematol 109:195-200. 2000
    ..We now provide evidence that the use of pdFVIII, through interfering with APC/T-cell interactions, may be more appropriate than rhFVIII for tolerance induction...
  2. ncbi request reprint Increased intracellular pro- and anti-inflammatory cytokines in bronchoalveolar lavage T cells of stable lung transplant patients
    Greg Hodge
    Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, Australia
    Transplantation 80:1040-5. 2005
    ..However, analysis of inflammatory cytokine profiles in bronchoalveolar lavage (BAL) T cells may be more relevant than peripheral blood T cells for assessing graft status...
  3. ncbi request reprint Effect of blood storage conditions on leucocyte intracellular cytokine production
    G Hodge
    Haematology Department, Adelaide Women s and Children s Hospital, 72 King William Road, North Adelaide 5006, Australia
    Cytokine 32:7-11. 2005
    ..Blood stored at 4 degrees C showed less immunomodulatory changes than blood kept at RT although overall a possible Th1 bias at 4 degrees C...
  4. ncbi request reprint Poststorage leuko-depleted plasma inhibits T-cell proliferation and Th1 response in vitro: characterization of TGFbeta-1 as an important immunomodulatory component in stored blood
    Greg L Hodge
    Haematology Department, Women s and Children s Hospital, North Adelaide, South Australia
    Transplantation 80:95-101. 2005
    ..Although the mechanism of this phenomenon remains to be fully elucidated, it is clear that the immunomodulatory effect is mediated by leukocytes/platelets or their products...
  5. ncbi request reprint Up-regulation of interleukin-8, interleukin-10, monocyte chemotactic protein-1, and monocyte chemotactic protein-3 in peripheral blood monocytes in stable lung transplant recipients: are immunosuppression regimens working?
    Greg Hodge
    Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, Australia
    Transplantation 79:387-91. 2005
    ..We hypothesized that production of these inflammatory mediators by blood monocytes may be up-regulated despite the use of potent immunosuppression therapy...
  6. pmc Intracellular cytokines in blood T cells in lung transplant patients--a more relevant indicator of immunosuppression than drug levels
    G Hodge
    Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia
    Clin Exp Immunol 139:159-64. 2005
    ..Intracellular cytokine analysis using flow cytometry may be a more appropriate indicator of immunosuppression than drug levels in these patients. This technique may prove useful in optimizing therapy for individual patients...
  7. pmc Rapid simultaneous measurement of multiple cytokines using 100 microl sample volumes--association with neonatal sepsis
    G Hodge
    Department of Haematology, Women s and Children s Hospital, North Adelaide, South Australia
    Clin Exp Immunol 137:402-7. 2004
    ..In conclusion, neonatal sepsis is associated with the elevation of multiple plasma cytokines. The use of CBA kits is a rapid, easy, low sample volume and sensitive method to measure multiple plasma cytokines...
  8. ncbi request reprint A marked decrease in L-selectin expression by leucocytes in infants with Bordetella pertussis infection: leucocytosis explained?
    Greg Hodge
    Haematology Department, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    Respirology 8:157-62. 2003
    ..To characterize these cells immunophenotyping using multiparameter flow cytometry was performed on leucocytes from a group of 11 infants aged 3-6 months with proven pertussis and from uninfected control subjects...
  9. ncbi request reprint Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: potential therapeutic use in the treatment of inflammatory bowel disease
    Greg Hodge
    Haematology Department, Women s and Children s Hospital, North Adelaide, South Australia
    Cytometry 48:209-15. 2002
    ..Several compounds isolated from Allium sativum (garlic) modulate leukocyte cell proliferation and cytokine production...
  10. ncbi request reprint Airway infection in stable lung transplant patients is associated with decreased intracellular T-helper type 1 pro-inflammatory cytokines in bronchoalveolar lavage T-cell subsets
    G Hodge
    Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Transpl Infect Dis 10:99-105. 2008
    ..Modifying immunosuppression by monitoring intracellular Th1 pro-inflammatory cytokines in BAL T cells may help to improve morbidity and infection rates in stable lung transplant patients...
  11. pmc Compartmentalization of intracellular proinflammatory cytokines in bronchial intraepithelial T cells of stable lung transplant patients
    G Hodge
    Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia
    Clin Exp Immunol 145:413-9. 2006
    ..Drugs that effectively reduce CD8 T cell proinflammatory cytokine production in the lung compartment may improve current protocols for reducing graft rejection in these patients...
  12. pmc Time post-lung transplant correlates with increasing peripheral blood T cell granzyme B and proinflammatory cytokines
    G Hodge
    Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia
    Clin Exp Immunol 161:584-90. 2010
    ..Declining FEV(1) is associated with a further increase in these proinflammatory mediators. Drugs that reduce these inflammatory mediators effectively may reduce the incidence of chronic graft rejection...
  13. pmc Increased levels of T cell granzyme b in bronchiolitis obliterans syndrome are not suppressed adequately by current immunosuppressive regimens
    S Hodge
    Lung Research Laboratory, Hanson Institute, Adelaide, SA, Australia
    Clin Exp Immunol 158:230-6. 2009
    ..Longitudinal investigation of granzyme b in blood may provide an adjunctive non-invasive method for predicting BOS/OB...
  14. ncbi request reprint Cord blood leucocyte expression of functionally significant molecules involved in the regulation of cellular immunity
    S Hodge
    Haematology Department, Women s and Children s Hospital, 72 King William Street, Adelaide, South Australia
    Scand J Immunol 53:72-8. 2001
    ..The findings of lower expression of IL-2R beta and lower production of inflammatory cytokines IL-1 alpha, IL-1 beta and TNF-alpha is a basis for improved understanding of the immunological immaturity of leucocytes in the newborn...
  15. pmc Increased intracellular T helper 1 proinflammatory cytokine production in peripheral blood, bronchoalveolar lavage and intraepithelial T cells of COPD subjects
    G Hodge
    Department of Thoracic Medicine, Royal Adelaide Hospital, Australia
    Clin Exp Immunol 150:22-9. 2007
    ..Systemic therapeutic targeting of TNF-alpha production by CD8(+) T cells may improve morbidity in COPD patients while targeting of TNF-alpha in the lung may prevent smokers progressing to COPD...
  16. doi request reprint Posttransplant bronchiolitis obliterans syndrome is associated with bronchial epithelial to mesenchymal transition
    S Hodge
    Lung Research Laboratory, Hanson Institute, Adelaide, Australia
    Am J Transplant 9:727-33. 2009
    ..Flow cytometric evaluation of bronchial epithelium may provide a novel and rapid means to assess lung allografts at risk of BOS...
  17. pmc Up-regulation of alternate co-stimulatory molecules on proinflammatory CD28null T cells in bronchiolitis obliterans syndrome
    G Hodge
    Lung Research, Hanson Institute and Department of Thoracic Medicine, Royal Adelaide Hospital, Australia
    Clin Exp Immunol 173:150-60. 2013
    ..Therapeutic targeting of alternate co-stimulatory molecules on peripheral blood CD28(null) T cells and monitoring response using these assays may help in the management of patients with BOS...
  18. ncbi request reprint Effect of factor VIII concentrate on leucocyte cytokine receptor expression in vitro: relevance to inhibitor formation and tolerance induction
    G Hodge
    Haematology Oncology Department, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    Haemophilia 12:133-9. 2006
    ..The use of pdFVIII, particularly the more inhibitory batches, may be more suitable than rFVIII for tolerance induction protocols. A clinical study needs to be undertaken to determine the significance of these in vitro findings...
  19. ncbi request reprint Effect of intermediate-purity factor VIII (FVIII) concentrate on lymphocyte proliferation and apoptosis: transforming growth factor-beta is a significant immunomodulatory component of FVIII
    G Hodge
    Haematology Department, Women s and Children s Hospital, North Adelaide, South Australia
    Br J Haematol 115:376-81. 2001
    ..Together, these findings suggest that TGF-beta is a significant immunomodulatory component of pdFVIII concentrates...
  20. ncbi request reprint Interleukin-4 and tumour necrosis factor-alpha inhibit transforming growth factor-beta production in a human bronchial epithelial cell line: possible relevance to inflammatory mechanisms in chronic obstructive pulmonary disease
    S Hodge
    Department of Thoracic Medicine, Royal Adelaide Hospital, North Terrrace, South Australia, Australia
    Respirology 6:205-11. 2001
    ..The purpose of this study was to study the effect of TNF-alpha and IL-4 (pro-inflammatory cytokines known to be up-regulated in COPD), on the production of TGF-beta (a negative regulator of inflammation) by epithelial cells...
  21. ncbi request reprint Factor VIII concentrate inhibits T helper type 2 cytokine production in vitro: relevance to inhibitor antibody formation
    G Hodge
    Haematology Department, Women's and Children's Hospital, North Adelaide, South Australia
    Haemophilia 7:490-6. 2001
    ..A clinical study needs to be undertaken to determine the significance of these in vitro findings...
  22. doi request reprint Increased T regulatory cells and decreased Th1 pro-inflammatory cytokines correlate with culture-positive infection in febrile neutropenia childhood oncology patients
    G Hodge
    Haematology Oncology Department, SA Pathology, Women s and Children s Hospital, North Adelaide 5006, Australia
    Cytokine 53:286-8. 2011
    ..We hypothesized that characterization of reduced intracellular Th1 cytokines and increased T regulatory cells (Tregs) may prove useful in identifying infection in childhood oncology patients with febrile neutropenia...
  23. pmc Role of increased CD8/CD28(null) T cells and alternative co-stimulatory molecules in chronic obstructive pulmonary disease
    G Hodge
    Lung Research Laboratory, Hanson Institute and Department of Thoracic Medicine, Royal Adelaide Hospital and University of Adelaide, Adelaide, South Australia, Australia
    Clin Exp Immunol 166:94-102. 2011
    ..Increased production of proinflammatory cytokines and expression of alternative co-stimulatory molecules by CD8/CD28(null) T cells may play a role in inflammatory or autoimmune responses in COPD and identify therapeutic targets...
  24. pmc Potential immaturity of the T-cell and antigen-presenting cell interaction in cord blood with particular emphasis on the CD40-CD40 ligand costimulatory pathway
    P Han
    Department of Haematology, Women s and Children s Hospital, University of Adelaide, North Adelaide, South Australia
    Immunology 113:26-34. 2004
    ..Also the ligand-receptor immaturity may contribute to the increased susceptibility of newborns to certain infections...
  25. ncbi request reprint Azithromycin increases phagocytosis of apoptotic bronchial epithelial cells by alveolar macrophages
    S Hodge
    Dept of Thoracic Medicine, Royal Adelaide Hospital and Lung Research Laboratory, Hanson Institute, Adelaide, Australia
    Eur Respir J 28:486-95. 2006
    ..At higher doses, azithromycin decreased levels of pro-inflammatory cytokines. Thus, low-dose azithromycin therapy could provide an adjunct therapeutic option in chronic obstructive pulmonary disease...
  26. pmc Multiple leucocyte activation markers to detect neonatal infection
    G Hodge
    Haematology Department, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    Clin Exp Immunol 135:125-9. 2004
    ..A combination of this marker with CD45RA, CD45RO, CD25 and CD69 expression on peripheral blood derived T cells is the most sensitive and specific for neonatal infection...
  27. ncbi request reprint Increased airway epithelial and T-cell apoptosis in COPD remains despite smoking cessation
    S Hodge
    Dept of Thoracic Medicine, Royal Adelaide Hospital and Hanson Institute, Adelaide, South Australia 5001, Australia
    Eur Respir J 25:447-54. 2005
    ....
  28. ncbi request reprint Rapid simultaneous measurement of multiple cytokines in childhood oncology patients with febrile neutropenia: increased interleukin (IL)-8 or IL-5 correlates with culture-positive infection
    G Hodge
    Br J Haematol 132:247-8. 2006