Stan Gronthos

Summary

Affiliation: South Australia
Country: Australia

Publications

  1. ncbi request reprint The role of the chemokine CXCL12 in osteoclastogenesis
    Stan Gronthos
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute, Adelaide, South Australia, Australia
    Trends Endocrinol Metab 18:108-13. 2007
  2. doi request reprint A method to isolate and purify human bone marrow stromal stem cells
    Stan Gronthos
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute, University of Adelaide, SA, Australia
    Methods Mol Biol 449:45-57. 2008
  3. doi request reprint Methods for the purification and characterization of human adipose-derived stem cells
    Stan Gronthos
    Mesenchymal Stem Cell Group, Department of Haematology, Institute of Medical and Veterinary Science Hanson Institute and Centre for Stem Cell Research, University of Adelaide, Adelaide, SA, Australia
    Methods Mol Biol 702:109-20. 2011
  4. pmc Immunomodulatory properties of stem cells from human exfoliated deciduous teeth
    Takayoshi Yamaza
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Stem Cell Res Ther 1:5. 2010
  5. pmc Pentosan polysulfate promotes proliferation and chondrogenic differentiation of adult human bone marrow-derived mesenchymal precursor cells
    Peter Ghosh
    Proteobioactives Pty Ltd, 27 9 Powells Road, Brookvale, New South Wales 2100, Australia
    Arthritis Res Ther 12:R28. 2010
  6. ncbi request reprint Reconstruction of human mandible by tissue engineering
    Stan Gronthos
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide 5000, South Australia, Australia
    Lancet 364:735-6. 2004
  7. ncbi request reprint Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow
    Stan Gronthos
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    J Cell Sci 116:1827-35. 2003
  8. doi request reprint Heat shock protein-90 beta is expressed at the surface of multipotential mesenchymal precursor cells: generation of a novel monoclonal antibody, STRO-4, with specificity for mesenchymal precursor cells from human and ovine tissues
    Stan Gronthos
    Mesenchymal Stem Cell Group, University of Adelaide, Adelaide SA 5000, Australia
    Stem Cells Dev 18:1253-62. 2009
  9. doi request reprint A method to isolate and culture expand human dental pulp stem cells
    Stan Gronthos
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science Hanson Institute CSCR, University of Adelaide, Adelaide, SA, Australia
    Methods Mol Biol 698:107-21. 2011
  10. ncbi request reprint Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of myeloma-associated bone loss
    Peter Diamond
    Myeloma Research Program, Bone and Cancer Laboratories, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute and the Department of Medicine, University of Adelaide, Adelaide, Australia
    J Bone Miner Res 24:1150-61. 2009

Collaborators

Detail Information

Publications69

  1. ncbi request reprint The role of the chemokine CXCL12 in osteoclastogenesis
    Stan Gronthos
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute, Adelaide, South Australia, Australia
    Trends Endocrinol Metab 18:108-13. 2007
    ..Recent studies have highlighted an emerging role for CXCL12 in the processes of physiological and pathological bone remodelling...
  2. doi request reprint A method to isolate and purify human bone marrow stromal stem cells
    Stan Gronthos
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute, University of Adelaide, SA, Australia
    Methods Mol Biol 449:45-57. 2008
    ....
  3. doi request reprint Methods for the purification and characterization of human adipose-derived stem cells
    Stan Gronthos
    Mesenchymal Stem Cell Group, Department of Haematology, Institute of Medical and Veterinary Science Hanson Institute and Centre for Stem Cell Research, University of Adelaide, Adelaide, SA, Australia
    Methods Mol Biol 702:109-20. 2011
    ....
  4. pmc Immunomodulatory properties of stem cells from human exfoliated deciduous teeth
    Takayoshi Yamaza
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Stem Cell Res Ther 1:5. 2010
    ..Herein we have characterized mesenchymal stem cell properties of SHED in comparison to human bone marrow mesenchymal stem cells (BMMSCs)...
  5. pmc Pentosan polysulfate promotes proliferation and chondrogenic differentiation of adult human bone marrow-derived mesenchymal precursor cells
    Peter Ghosh
    Proteobioactives Pty Ltd, 27 9 Powells Road, Brookvale, New South Wales 2100, Australia
    Arthritis Res Ther 12:R28. 2010
    ..This study was undertaken to determine whether the anti-osteoarthritis drug pentosan polysulfate (PPS) influenced mesenchymal precursor cell (MPC) proliferation and differentiation...
  6. ncbi request reprint Reconstruction of human mandible by tissue engineering
    Stan Gronthos
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide 5000, South Australia, Australia
    Lancet 364:735-6. 2004
  7. ncbi request reprint Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow
    Stan Gronthos
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    J Cell Sci 116:1827-35. 2003
    ..Our novel selection protocol provides a means to generate purified populations of BMSSCs for use in a range of different tissue engineering and gene therapy strategies...
  8. doi request reprint Heat shock protein-90 beta is expressed at the surface of multipotential mesenchymal precursor cells: generation of a novel monoclonal antibody, STRO-4, with specificity for mesenchymal precursor cells from human and ovine tissues
    Stan Gronthos
    Mesenchymal Stem Cell Group, University of Adelaide, Adelaide SA 5000, Australia
    Stem Cells Dev 18:1253-62. 2009
    ..In addition to identifying an antibody reagent that identifies a highly conserved epitope expressed by MSCs from different species, our study also points to a potential role for Hsp90beta in MSC biology...
  9. doi request reprint A method to isolate and culture expand human dental pulp stem cells
    Stan Gronthos
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science Hanson Institute CSCR, University of Adelaide, Adelaide, SA, Australia
    Methods Mol Biol 698:107-21. 2011
    ..This process involves the enzymatic digestion of fresh samples of human dental pulp tissue followed by the isolation of DPSC using magnetic bead cell separation, based on their expression of mesenchymal stem cell associated markers...
  10. ncbi request reprint Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of myeloma-associated bone loss
    Peter Diamond
    Myeloma Research Program, Bone and Cancer Laboratories, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute and the Department of Medicine, University of Adelaide, Adelaide, Australia
    J Bone Miner Res 24:1150-61. 2009
    ..These findings confirm our hypothesis that MM PC-derived CXCL12 stimulates the recruitment and activity of OC, thereby contributing to the formation of MM osteolytic lesions...
  11. doi request reprint Human foreskin fibroblasts exert immunomodulatory properties by a different mechanism to bone marrow stromal/stem cells
    Naohisa Wada
    Division of Haematology, Institute of Medical and Veterinary Science Hanson Institute CSCR, Adelaide, Australia
    Stem Cells Dev 20:647-59. 2011
    ..These results suggest that the HFFs possess immunosuppressive properties, which are mediated by alternate mechanisms to that reported for BMSCs...
  12. ncbi request reprint TWIST family of basic helix-loop-helix transcription factors mediate human mesenchymal stem cell growth and commitment
    Sandra Isenmann
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science Hanson Institute CSCR, University of Adelaide, SA, Australia
    Stem Cells 27:2457-68. 2009
    ..These findings implicate the TWIST gene family members as potential mediators of MSC self-renewal and lineage commitment in postnatal skeletal tissues by exerting their effects on genes involved in the early stages of bone development...
  13. ncbi request reprint Regeneration of periodontal tissues using allogeneic periodontal ligament stem cells in an ovine model
    Krzysztof Marek Mrozik
    School of Dentistry, Colgate Australian Clinical Dental Research Centre, University of Adelaide, Adelaide, SA, Australia
    Regen Med 8:711-23. 2013
    ..To investigate the capacity of allogeneic periodontal ligament stem cells (PDLSCs) to regenerate periodontal tissues using an ovine periodontal defect model...
  14. doi request reprint Optimization of the cardiovascular therapeutic properties of mesenchymal stromal/stem cells-taking the next step
    James D Richardson
    Cardiovascular Research Centre, Royal Adelaide Hospital and Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia
    Stem Cell Rev 9:281-302. 2013
    ....
  15. doi request reprint Effect of coating Straumann Bone Ceramic with Emdogain on mesenchymal stromal cell hard tissue formation
    Krzysztof Marek Mrozik
    Colgate Australian Clinical Dental Research Centre, Dental School, University of Adelaide, Frome Road Adelaide, South Australia 5005, Australia
    Clin Oral Investig 16:867-78. 2012
    ..While used in clinical applications, whether Emdogain and other commercial preparations of EMPs truly possess the capacity to induce the regeneration of bone or other components of the periodontium remains to be established...
  16. doi request reprint Immunomodulatory properties of human periodontal ligament stem cells
    Naohisa Wada
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science Hanson Institute CSCR, University of Adelaide, Adelaide, South Australia, Australia
    J Cell Physiol 219:667-76. 2009
    ..These results suggest that PDLSCs, BMSSCs, DPSCs, and GFs possess immunosuppressive properties mediated, in part, by soluble factors, produced by activated PBMNCs. J. Cell. Physiol. 219: 667-676, 2009. (c) 2009 Wiley-Liss, Inc...
  17. doi request reprint Reparative effects of allogeneic mesenchymal precursor cells delivered transendocardially in experimental nonischemic cardiomyopathy
    Peter J Psaltis
    Cardiovascular Research Centre, Royal Adelaide Hospital and Department of Medicine, University of Adelaide, Adelaide, Australia
    JACC Cardiovasc Interv 3:974-83. 2010
    ..This study set out to evaluate the safety and efficacy of allogeneic bone marrow mesenchymal precursor cells (MPC) delivered by multisegmental, transendocardial implantation in the setting of nonischemic cardiomyopathy (NICM)...
  18. doi request reprint EphB/ephrin-B interactions mediate human MSC attachment, migration and osteochondral differentiation
    Agnieszka Arthur
    Mesenchymal Stem Cell Group, Department of Haematology, Institute of Medical and Veterinary Science Hanson Institute and Centre for Stem Cell Research Robinson Institute, University of Adelaide, Adelaide, SA, Australia
    Bone 48:533-42. 2011
    ..These observations suggest that EphB/ephrin-B interactions may mediate the recruitment, migration and differentiation of MSC during bone repair...
  19. ncbi request reprint A novel monoclonal antibody (STRO-3) identifies an isoform of tissue nonspecific alkaline phosphatase expressed by multipotent bone marrow stromal stem cells
    Stan Gronthos
    Mesenchymal Research Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute and University of Adelaide, Australia 5000
    Stem Cells Dev 16:953-63. 2007
    ..Finally, these studies suggest that antibodies to TNSALP may be used as an effective single marker of enrichment of BMSSCs from various tissues...
  20. pmc Epithelial cell rests of Malassez contain unique stem cell populations capable of undergoing epithelial-mesenchymal transition
    Jimin Xiong
    Colgate Australian Clinical Dental Research Centre, Dental School, University of Adelaide, Adelaide, South Australia, Australia
    Stem Cells Dev 21:2012-25. 2012
    ....
  21. doi request reprint Genomic profiling of mesenchymal stem cells
    Danijela Menicanin
    Mesenchymal Stem Cell Group, Bone and Cancer Laboratories, Division of Haematology, Institute of Medical and Veterinary Science Hanson Institute and CSCR, University of Adelaide, SA, Australia
    Stem Cell Rev 5:36-50. 2009
    ..The present review summarizes studies characterizing the gene expression profile of MSCs...
  22. ncbi request reprint Characterisation and developmental potential of ovine bone marrow derived mesenchymal stem cells
    Rosa C McCarty
    Department of Orthopaedic Surgery, Women s and Children s Hospital, Adelaide, Australia
    J Cell Physiol 219:324-33. 2009
    ..The comprehensive characterisation of ovine MSC described herein provides important information for future translational studies involving ovine MSC...
  23. doi request reprint Identification of a common gene expression signature associated with immature clonal mesenchymal cell populations derived from bone marrow and dental tissues
    Danijela Menicanin
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science Hanson Institute Centre for Stem Cell Research, Robinson Institute, University of Adelaide, Adelaide, Australia
    Stem Cells Dev 19:1501-10. 2010
    ..These findings provide a model system for identifying a common molecular fingerprint associated with immature mesenchymal stem-like cells from different organs and implicate a potential role for these genes in MSC growth and development...
  24. doi request reprint Assessment of myocardial fibrosis by endoventricular electromechanical mapping in experimental nonischemic cardiomyopathy
    Peter J Psaltis
    Department of Medicine and Physiology, University of Adelaide, North Terrace, Adelaide, SA, 5000, Australia
    Int J Cardiovasc Imaging 27:25-37. 2011
    ..Pending clinical evaluation, it may therefore have applicability for directing targeted intramyocardial interventions in nonischemic heart disease...
  25. doi request reprint Incremental benefits of repeated mesenchymal stromal cell administration compared with solitary intervention after myocardial infarction
    James D Richardson
    Cardiovascular Research Centre, Royal Adelaide Hospital, South Australia, Australia Department of Medicine, University of Adelaide, South Australia, Australia Centre for Stem Cell Research, Robinson Institute, School of Medical Sciences, University of Adelaide, South Australia, Australia
    Cytotherapy 16:460-70. 2014
    ..This prospect was evaluated with the use of mesenchymal stromal cells (MSCs)...
  26. doi request reprint Concise review: mesenchymal stromal cells: potential for cardiovascular repair
    Peter J Psaltis
    Cardiovascular Research Centre, Royal Adelaide Hospital and Department of Medicine, University of Adelaide, Adelaide, South Australia 5000, Australia
    Stem Cells 26:2201-10. 2008
    ....
  27. doi request reprint Comparative assessment of the osteoconductive properties of different biomaterials in vivo seeded with human or ovine mesenchymal stem/stromal cells
    Andrew C W Zannettino
    Myeloma Research Laboratory, Department of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Tissue Eng Part A 16:3579-87. 2010
    ..This study demonstrates the differences in bone formation potential between human and ovine MSC in vivo based on the osteoconductive properties of different bioscaffolds currently being used for orthopedic clinical applications...
  28. ncbi request reprint hTERT transcription is repressed by Cbfa1 in human mesenchymal stem cell populations
    Sandra Isenmann
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science University of Adelaide, South Australia, Australia
    J Bone Miner Res 22:897-906. 2007
    ..We showed that Cbfa1 acts as a partial repressor of TERT, which may facilitate cellular differentiation...
  29. ncbi request reprint The nitrogen-containing bisphosphonate, zoledronic acid, increases mineralisation of human bone-derived cells in vitro
    Beiqing Pan
    Myeloma and Mesenchymal Research Group, Matthew Roberts Foundation Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide 5000, Australia
    Bone 34:112-23. 2004
    ..These results show that, in addition to its direct effects on OCs, ZOL also directly affects the proliferation and differentiation of human OB-like cells in vitro and may enhance bone formation in vivo...
  30. doi request reprint Implanted adult human dental pulp stem cells induce endogenous axon guidance
    Agnieszka Arthur
    Mesenchymal Stem Cell Group, CSCR University of Adelaide, Adelaide, South Australia, Australia
    Stem Cells 27:2229-37. 2009
    ..These findings provide the first direct evidence that DPSCs may induce neuroplasticity within a receptive host nervous system...
  31. doi request reprint Proteomic characterization of mesenchymal stem cell-like populations derived from ovine periodontal ligament, dental pulp, and bone marrow: analysis of differentially expressed proteins
    Krzysztof M Mrozik
    Colgate Australian Clinical Dental Research Centre, Dental School, The University of Adelaide, Adelaide, Australia
    Stem Cells Dev 19:1485-99. 2010
    ..These expression patterns can serve as important tools for the regeneration of particular tissues in future stem cell-based tissue engineering studies using animal models...
  32. doi request reprint Impact of timing and dose of mesenchymal stromal cell therapy in a preclinical model of acute myocardial infarction
    James D Richardson
    Cardiovascular Research Centre, Royal Adelaide Hospital and Department of Medicine, University of Adelaide, Adelaide, Australia
    J Card Fail 19:342-53. 2013
    ..We compared immediate and deferred administration of 2 doses of MSC in a rat model of MI...
  33. pmc Twist-1 induces Ezh2 recruitment regulating histone methylation along the Ink4A/Arf locus in mesenchymal stem cells
    Dimitrios Cakouros
    Mesenchymal Stem Cell Group, Department of Haematology, SA Pathology, and Centre for Stem Cell Research, Robinson Institute, University of Adelaide, Adelaide, SA, Australia
    Mol Cell Biol 32:1433-41. 2012
    ..These studies for the first time link Twist-1 to histone methylation of the Ink4A/Arf locus by controlling the expression of histone methyltransferases as well as the expression of other bHLH factors...
  34. pmc Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells
    Sally K Martin
    Myeloma Research Program, Division of Haematology, Centre for Cancer Biology SA Pathology and University of Adelaide, Australia
    Haematologica 95:776-84. 2010
    ..While the mechanisms responsible for aberrant plasma cell expression of CXCL12 remain to be determined, studies in other systems suggest a role for hypoxia and hypoxia-inducible transcription factors...
  35. doi request reprint A method to isolate, purify, and characterize human periodontal ligament stem cells
    Krzysztof Mrozik
    Mesenchymal Stem Cell Group, Division of Hematology, Institute of Medical and Veterinary Science Hanson Institute, Adelaide, Australia
    Methods Mol Biol 666:269-84. 2010
    ....
  36. doi request reprint NVP-BEZ235, a dual pan class I PI3 kinase and mTOR inhibitor, promotes osteogenic differentiation in human mesenchymal stromal cells
    Sally K Martin
    Myeloma Research Program, Division of Haematology, Centre for Cancer Biology, SA Pathology, and University of Adelaide, Adelaide, Australia
    J Bone Miner Res 25:2126-37. 2010
    ..Taken together, our findings suggest that BEZ235 may be useful in treating PI3K/mTOR-dependent tumors associated with bone loss, such as the hematologic malignancy multiple myeloma...
  37. ncbi request reprint Human mulipotential mesenchymal/stromal stem cells are derived from a discrete subpopulation of STRO-1bright/CD34 /CD45(-)/glycophorin-A-bone marrow cells
    Andrew C W Zannettino
    Multiple Myeloma Research Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute and University of Adelaide, Australia
    Haematologica 92:1707-8. 2007
    ..These studies support the view that these are two distinct stem cell compartments in adult bone marrow...
  38. ncbi request reprint Tumor angiogenesis is associated with plasma levels of stromal-derived factor-1alpha in patients with multiple myeloma
    Sally K Martin
    Myeloma and Mesenchymal Research Group, Matthew Roberts Foundation Laboratory, Division of Haematology, Institute of Medical and Veterinary Science, University of Adelaide, Australia
    Clin Cancer Res 12:6973-7. 2006
    ..We have now examined whether SDF-1alpha levels also correlate with angiogenesis...
  39. ncbi request reprint Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells
    Angela Kortesidis
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science Hanson Institute, Frome Rd, Adelaide 5000, South Australia, Australia
    Blood 105:3793-801. 2005
    ..These studies indicate that the chemokine, SDF-1, may play a role in the maintenance, survival, and osteogenic capacity of immature BMSSC populations...
  40. pmc EphB and Ephrin-B interactions mediate human mesenchymal stem cell suppression of activated T-cells
    Thao M Nguyen
    1 Mesenchymal Stem Cell Laboratory, School of Medical Sciences, Faculty of Health Sciences, University of Adelaide, Adelaide, SA, Australia
    Stem Cells Dev 22:2751-64. 2013
    ..Taken together, these observations suggest that EphB/ephrin-B interactions play an important role in mediating human MSC inhibition of activated T cells. ..
  41. pmc Periodontal-ligament-derived stem cells exhibit the capacity for long-term survival, self-renewal, and regeneration of multiple tissue types in vivo
    Danijela Menicanin
    1 Colgate Australian Clinical Dental Research Centre, School of Dentistry, University of Adelaide, Adelaide, Australia
    Stem Cells Dev 23:1001-11. 2014
    ....
  42. doi request reprint EphB4 enhances the process of endochondral ossification and inhibits remodeling during bone fracture repair
    Agnieszka Arthur
    Mesenchymal Stem Cell Group, Department of Haematology, SA Pathology Adelaide and Centre for Stem Cell Research Robinson Institute, University of Adelaide, Adelaide, Australia
    J Bone Miner Res 28:926-35. 2013
    ..Taken together, these observations suggest that EphB4 promotes endochondral ossification while inhibiting osteoclast development during callus formation and may represent a novel drug target for the repair of fractured bones...
  43. ncbi request reprint Intramyocardial navigation and mapping for stem cell delivery
    Peter J Psaltis
    Cardiovascular Research Centre, Department of Cardiology, Royal Adelaide Hospital and the Department of Medicine, University of Adelaide, Adelaide, South Australia, 5000, Australia
    J Cardiovasc Transl Res 3:135-46. 2010
    ....
  44. doi request reprint Home is where the heart is: via the FROUNT
    Andrew C W Zannettino
    Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    Cell Stem Cell 2:513-4. 2008
    ..This process is dependent on the intracellular adaptor molecule FROUNT, which interacts with the chemokine receptor CCR2...
  45. doi request reprint EZH2 and KDM6A act as an epigenetic switch to regulate mesenchymal stem cell lineage specification
    Sarah Hemming
    Mesenchymal Stem Cell Laboratory, School of Medical Sciences, Faculty of Health Sciences, South Australia, Australia
    Stem Cells 32:802-15. 2014
    ..These findings demonstrate an important epigenetic switch centered on H3K27me3 which dictates MSC lineage determination...
  46. doi request reprint Suppression of PDGF-induced PI3 kinase activity by imatinib promotes adipogenesis and adiponectin secretion
    Stephen Fitter
    Myeloma Research Laboratory, Bone and Cancer Research Laboratories, Department of Haematology, Institute of Medical and Veterinary Science, Centre for Cancer Biology, SA Pathology, GPO Box 14, Adelaide, South Australia 5000, Australia
    J Mol Endocrinol 48:229-40. 2012
    ..Taken together, our results suggest that imatinib increases plasma adiponectin levels by promoting adipogenesis through the suppression of PI3 kinase signalling downstream of PDGFR...
  47. doi request reprint Adult human dental pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues
    Agnes Arthur
    The Australian Research Council, Centre for the Molecular Genetics of Development, University of Adelaide, Adelaide, Australia
    Stem Cells 26:1787-95. 2008
    ..We propose that adult human DPSCs provide a readily accessible source of exogenous stem/precursor cells that have the potential for use in cell-therapeutic paradigms to treat neurological disease...
  48. doi request reprint The therapeutic applications of multipotential mesenchymal/stromal stem cells in skeletal tissue repair
    Agnieszka Arthur
    Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute University of Adelaide, Adelaide, South Australia, Australia
    J Cell Physiol 218:237-45. 2009
    ..This review will specifically focus on the skeletal regenerative capacity of bone marrow derived MSC alone or in combination with growth factors, biocompatible scaffolds, and following genetic modification...
  49. ncbi request reprint Stem cells and periodontal regeneration
    P Mark Bartold
    Colgate Australian Clinical Dental Resource Centre, University of Adelaide, South Australia, Australia
    Periodontol 2000 40:164-72. 2006
  50. ncbi request reprint Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients
    Andrew C W Zannettino
    Myeloma and Mesenchymal Research Group, Matthew Roberts Foundation Laboratory and Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Hanson Institute, Adelaide, Australia
    Cancer Res 65:1700-9. 2005
    ..Therefore, we propose that inhibition of the CXCR4-SDF-1alpha axis may provide an effective means of treatment for MM-induced osteolysis...
  51. pmc Human adult dental pulp stem cells enhance poststroke functional recovery through non-neural replacement mechanisms
    Wai Khay Leong
    Centre for Stem Cell Research, Robinson Institute, University of Adelaide, South Australia, Australia
    Stem Cells Transl Med 1:177-87. 2012
    ..Functional improvement is more likely to be mediated through DPSC-dependent paracrine effects. This study provides preclinical evidence for the future use of human DPSCs in cell therapy to improve outcome in stroke patients...
  52. pmc Application of autologous bone marrow derived mesenchymal stem cells to an ovine model of growth plate cartilage injury
    Rosa C McCarty
    Department of Orthopaedic Surgery, Women s and Children s Hospital, Adelaide, Australia
    Open Orthop J 4:204-10. 2010
    ..The current study represents the first work that has utilised this ovine large animal model to investigate whether autologous bone marrow derived MSC can be used to initiate regeneration at the injured growth plate...
  53. ncbi request reprint Bone marrow stromal stem cells for tissue engineering
    Stan Gronthos
    Mesenchymal Stem Cell Group, Division of Haemotology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    Periodontol 2000 41:188-95. 2006
  54. pmc Generation of functional mesenchymal stem cells from different induced pluripotent stem cell lines
    Kim Hynes
    1 Colgate Australian Clinical Dental Research Centre, School of Dentistry, University of Adelaide, Adelaide, Australia
    Stem Cells Dev 23:1084-96. 2014
    ..However, a detailed characterization of the iPSC-MSC-like cells will be important, as MSC-like cells derived from different iPSC lines exhibit variability in their differentiation capacity. ..
  55. ncbi request reprint EphB/ephrin-B interaction mediates adult stem cell attachment, spreading, and migration: implications for dental tissue repair
    Agnieszka Stokowski
    Australian Research Council, Centre for the Molecular Genetics of Development, University of Adelaide, Adelaide, South Australia, Australia
    Stem Cells 25:156-64. 2007
    ..These results may have implications for dental pulp development and regeneration...
  56. doi request reprint An ovine model of toxic, nonischemic cardiomyopathy--assessment by cardiac magnetic resonance imaging
    Peter J Psaltis
    Cardiovascular Research Centre, Royal Adelaide Hospital Departments of Medicine and Physiology, The University of Adelaide, Adelaide, Australia
    J Card Fail 14:785-95. 2008
    ..We set out to validate an ovine model of doxorubicin-induced cardiomyopathy, using cardiac magnetic resonance (CMR) to assess cardiac function...
  57. ncbi request reprint RANKL expression is related to the differentiation state of human osteoblasts
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia, Australia
    J Bone Miner Res 18:1088-98. 2003
    ..Additionally, the dual roles of osteoblasts, in supporting osteoclastogenesis or forming bone, may be performed by the same lineage of cells at different stages of their maturation...
  58. ncbi request reprint Mesenchymal stem cell-organized bone marrow elements: an alternative hematopoietic progenitor resource
    Yasuo Miura
    National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland
    Stem Cells 24:2428-36. 2006
    ..These results indicate that the BMMSC-organized BM niche system represents a unique hematopoietic progenitor resource possessing potential clinical value...
  59. ncbi request reprint Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp
    Songtao Shi
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    J Bone Miner Res 18:696-704. 2003
    ....
  60. ncbi request reprint Telomerase accelerates osteogenesis of bone marrow stromal stem cells by upregulation of CBFA1, osterix, and osteocalcin
    Stan Gronthos
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Bone Miner Res 18:716-22. 2003
    ..Taken together, these findings show that telomerase can accelerate cell cycle progression from G1-to-S phase and enhance osteogenic differentiation of BMSSCs, because of the upregulation of CBFA1, osterix, and osteocalcin...
  61. pmc SHED: stem cells from human exfoliated deciduous teeth
    Masako Miura
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:5807-12. 2003
    ..Thus, exfoliated teeth may be an unexpected unique resource for stem-cell therapies including autologous stem-cell transplantation and tissue engineering...
  62. ncbi request reprint Investigation of multipotent postnatal stem cells from human periodontal ligament
    Byoung Moo Seo
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Lancet 364:149-55. 2004
    ..We investigated the notion that human PDL contains stem cells that could be used to regenerate periodontal tissue...
  63. pmc Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents
    Takayoshi Yamaza
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, California, United States of America
    PLoS ONE 3:e2615. 2008
    ....
  64. ncbi request reprint Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression
    Songtao Shi
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Biotechnol 20:587-91. 2002
    ..These results show that telomerase expression can overcome critical technical barriers to the ex vivo expansion of BMSSCs, and suggest that telomerase therapy may be a useful strategy for bone regeneration and repair...
  65. pmc A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells
    Masako Miura
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research NIDCR, NIH, Bethesda, MD 20892, USA
    J Clin Invest 114:1704-13. 2004
    ..This study demonstrates that caspase-3 is crucial for the differentiation of BMSSCs by influencing TGF-beta/Smad2 pathway and cell cycle progression...
  66. pmc Defective osteogenesis of the stromal stem cells predisposes CD18-null mice to osteoporosis
    Yasuo Miura
    Department of Physiology, University of Maryland School of Medicine, Rockville, MD 20855, USA
    Proc Natl Acad Sci U S A 102:14022-7. 2005
    ..Altogether, this work demonstrates that CD18 functions critically in the osteogenesis of BMSSCs, and thus lack of CD18 expression in the leukocyte adhesion deficiency patients may predispose them to osteoporosis...
  67. ncbi request reprint Circulating connective tissue precursors: extreme rarity in humans and chondrogenic potential in guinea pigs
    Sergei A Kuznetsov
    Craniofacial Research and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4370, USA
    Stem Cells 25:1830-9. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  68. ncbi request reprint Dental pulp stem cells
    He Liu
    Peking University School of Stomatology, Beijing, China
    Methods Enzymol 419:99-113. 2006
    ..In this review, we introduce methodologies for isolating postnatal stem cells from human dental pulp and discuss their potential role in tissue regeneration...
  69. ncbi request reprint Mesenchymal lineage precursor cells induce vascular network formation in ischemic myocardium
    Timothy P Martens
    Division of Cardiothoracic Surgery, Columbia University, New York, NY, USA
    Nat Clin Pract Cardiovasc Med 3:S18-22. 2006
    ..Intramyocardial injection of human STRO-1-selected precursors in an athymic rat model of acute myocardial infarction results in induction of vascular network formation and arteriogenesis coupled with global functional cardiac recovery...