Philip A Gregory

Summary

Affiliation: South Australia
Country: Australia

Publications

  1. pmc MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells
    Kayoko Matsushima
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Sakamoto, Nagasaki, Japan
    J Transl Med 9:30. 2011
  2. ncbi request reprint MicroRNAs as regulators of epithelial-mesenchymal transition
    Philip A Gregory
    Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    Cell Cycle 7:3112-8. 2008
  3. doi request reprint The microRNA-200 family regulates epithelial to mesenchymal transition
    Emily L Paterson
    Hanson Institute and Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
    ScientificWorldJournal 8:901-4. 2008
  4. doi request reprint A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
    Cameron P Bracken
    Hanson Institute, Institute of Medical and Veterinary Science, The University of Adelaide, Adelaide, SA, Australia
    Cancer Res 68:7846-54. 2008
  5. pmc Specificity protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: implications for epithelial-mesenchymal transition
    Natasha Kolesnikoff
    From the Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia 5000, Australia
    J Biol Chem 289:11194-205. 2014
  6. pmc An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
    Philip A Gregory
    Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, SA 5000, Australia
    Mol Biol Cell 22:1686-98. 2011
  7. doi request reprint Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state
    Yat Yuen Lim
    Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, SA 5000, Australia
    J Cell Sci 126:2256-66. 2013
  8. doi request reprint The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    Philip A Gregory
    Hanson Institute and Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
    Nat Cell Biol 10:593-601. 2008
  9. ncbi request reprint Identification and characterization of functional hepatocyte nuclear factor 1-binding sites in UDP-glucuronosyltransferase genes
    Dione A Gardner-Stephen
    Department of Clinical Oncology, Flinders University School of Medicine, Flinders Medical Center, Adelaide, Australia
    Methods Enzymol 400:22-46. 2005
  10. ncbi request reprint Mechanisms of vitamin D₃ metabolite repression of IgE-dependent mast cell activation
    Kwok Ho Yip
    Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia
    J Allergy Clin Immunol 133:1356-64, 1364.e1-14. 2014

Collaborators

Detail Information

Publications12

  1. pmc MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells
    Kayoko Matsushima
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Sakamoto, Nagasaki, Japan
    J Transl Med 9:30. 2011
    ..Accumulating evidence indicates that deregulation of miR is associated with human malignancies including ESCC. The aim of this study was to identify miR that could be specifically expressed and exert distinct biological actions in ESCC...
  2. ncbi request reprint MicroRNAs as regulators of epithelial-mesenchymal transition
    Philip A Gregory
    Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    Cell Cycle 7:3112-8. 2008
    ..This review summarises these recent findings and their implications in both developmental EMT and tumor progression...
  3. doi request reprint The microRNA-200 family regulates epithelial to mesenchymal transition
    Emily L Paterson
    Hanson Institute and Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
    ScientificWorldJournal 8:901-4. 2008
    ..Expression of these miRNAs was lost in invasive breast cancer cell lines displaying mesenchymal-like morphology suggesting these microRNAs may play a role in cancer metastasis...
  4. doi request reprint A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
    Cameron P Bracken
    Hanson Institute, Institute of Medical and Veterinary Science, The University of Adelaide, Adelaide, SA, Australia
    Cancer Res 68:7846-54. 2008
    ..These findings establish a double-negative feedback loop controlling ZEB1-SIP1 and miR-200 family expression that regulates cellular phenotype and has direct relevance to the role of these factors in tumor progression...
  5. pmc Specificity protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: implications for epithelial-mesenchymal transition
    Natasha Kolesnikoff
    From the Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia 5000, Australia
    J Biol Chem 289:11194-205. 2014
    ..Together, these findings indicate that miR-200 family members require Sp1 to drive basal expression and to maintain an epithelial state. ..
  6. pmc An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
    Philip A Gregory
    Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, SA 5000, Australia
    Mol Biol Cell 22:1686-98. 2011
    ....
  7. doi request reprint Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state
    Yat Yuen Lim
    Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, SA 5000, Australia
    J Cell Sci 126:2256-66. 2013
    ..Therapy targeted against miR-200 family members and epigenetic modifications might therefore be applicable to breast cancer...
  8. doi request reprint The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    Philip A Gregory
    Hanson Institute and Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
    Nat Cell Biol 10:593-601. 2008
    ..Expression of the miR-200 family was also lost in regions of metaplastic breast cancer specimens lacking E-cadherin. These data suggest that downregulation of the microRNAs may be an important step in tumour progression...
  9. ncbi request reprint Identification and characterization of functional hepatocyte nuclear factor 1-binding sites in UDP-glucuronosyltransferase genes
    Dione A Gardner-Stephen
    Department of Clinical Oncology, Flinders University School of Medicine, Flinders Medical Center, Adelaide, Australia
    Methods Enzymol 400:22-46. 2005
    ..Finally, possible scenarios in which HNF1-mediated regulation of UGT expression may be clinically relevant are suggested...
  10. ncbi request reprint Mechanisms of vitamin D₃ metabolite repression of IgE-dependent mast cell activation
    Kwok Ho Yip
    Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia
    J Allergy Clin Immunol 133:1356-64, 1364.e1-14. 2014
    ....
  11. pmc Polymorphisms in the mitochondrial ribosome recycling factor EF-G2mt/MEF2 compromise cell respiratory function and increase atorvastatin toxicity
    Sylvie Callegari
    School of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Adelaide, South Australia, Australia
    PLoS Genet 8:e1002755. 2012
    ..These findings constitute the first reported phenotype associated with SNPs in the EF-G2mt gene and implicate the human EF-G2mt gene as a pharmacogenetic candidate gene for statin toxicity in humans...
  12. ncbi request reprint The homeodomain Pbx2-Prep1 complex modulates hepatocyte nuclear factor 1alpha-mediated activation of the UDP-glucuronosyltransferase 2B17 gene
    Philip A Gregory
    Department of Clinical Pharmacology, Flinders University School of Medicine, Flinders Medical Centre, Adelaide, Australia
    Mol Pharmacol 62:154-61. 2002
    ..Modulation of transcription by restricting the binding of transcriptional effectors to their target site is a novel role for Pbx2-Prep1 complexes...