Research Topics
Species | L G ClelandSummaryAffiliation: South Australia Country: Australia Publications
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Publications
Paradoxical effect of n-3-containing vegetable oils on long-chain n-3 fatty acids in rat heartLeslie G Cleland
Hanson Institute and Rheumatology Unit, Royal Adelaide Hospital, SA, Australia
Lipids 40:995-8. 2005..e., flaxseed > echium > canola > sunflower oil. This paradox may be explained by lower ALA intake leading to decreased competition for Delta6 desaturase activity between ALA and the 24:5n-3 FA precursor to DHA formation...
Recruitment of dendritic cells and macrophages during T cell-mediated synovial inflammationMahin Moghaddami
Arthritis Research Laboratory, Hanson Research Institute, Institute of Medical and Veterinary Science, Frome Road, Adelaide, South Australia, 5000, Australia
Arthritis Res Ther 9:R120. 2007..However, it is possible also that the MHC IIhiCD11c+ cells originate from a specific subset of DC-like circulating mononuclear cells...- Fish oil: what the prescriber needs to knowLeslie G Cleland
Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, Australia
Arthritis Res Ther 8:202. 2006..This review provides an evidence-based resource for doctors and patients who may choose to prescribe or take fish oil... - Reduction of cardiovascular risk factors with longterm fish oil treatment in early rheumatoid arthritisLeslie G Cleland
Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, Australia
J Rheumatol 33:1973-9. 2006..Fish oil has been shown to reduce symptoms in RA and to reduce CV risk. We assessed the effect of an antiinflammatory dose of fish oil on CV risk factors within a program of combination chemotherapy for patients with early RA... - Omega-6/omega-3 fatty acids and arthritisLeslie G Cleland
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, S.A, Australia
World Rev Nutr Diet 92:152-68. 2003 - A biomarker of n-3 compliance in patients taking fish oil for rheumatoid arthritisLeslie G Cleland
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, SA 5000, Australia
Lipids 38:419-24. 2003..It may also provide a guide to the effectiveness of therapeutic and preventive messages designed to increase n-3 PUFA intake... - The role of fish oils in the treatment of rheumatoid arthritisLeslie G Cleland
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Drugs 63:845-53. 2003..Collectively, these issues highlight the challenges in advancing the use of fish oil amid the complexities of modern management of RA, with its emphasis on combination chemotherapy applied early... - Temporal changes in the distribution of thoracic duct lymphoblasts to synovium and other tissues of rats with adjuvant-induced arthritisLeslie G Cleland
The Arthritis Research Laboratory of the Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, University of Adelaide, Adelaide, South Australia, Australia
Immunol Cell Biol 80:148-55. 2002.... - Recruitment of mononuclear leucocytes to osteoarthritic human synovial xenografts in the ears of SCID miceL G Cleland
The Arthritis Research Laboratory of the Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, University of Adelaide, Adelaide, Australia
Immunol Cell Biol 79:309-19. 2001.... - Differential regulation of prostaglandin E2 and thromboxane A2 production in human monocytes: implications for the use of cyclooxygenase inhibitorsP S Penglis
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia
J Immunol 165:1605-11. 2000.... - Roles of cyclooxygenase (COX)-1 and COX-2 in prostanoid production by human endothelial cells: selective up-regulation of prostacyclin synthesis by COX-2G E Caughey
Rheumatology Unit, Royal Adelaide Hospital, and Division of Human Immunology, Hanson Centre for Cancer Research, Adelaide, South Australia, Australia
J Immunol 167:2831-8. 2001..These findings have particular importance with regard to the potential for cardiovascular consequences of COX-2 inhibition... - Effect of dietary oils on the production of n-3 and n-6 metabolites of leukocyte 5-lipoxygenase in five rat strainsL G Cleland
Morialta Trust Bone and Joint Research Laboratory, Royal Adelaide Hospital, Australia
Biochim Biophys Acta 1043:253-8. 1990.... - Accessible xenografts of human synovium in the subcutaneous tissues of the ears of SCID miceS M Proudman
Arthritis Research Laboratory, Hanson Centre for Cancer Research, Adelaide, South Australia, Australia
Immunol Cell Biol 77:109-20. 1999..Percutaneous injection of TNF-alpha induced up-regulation of VCAM-1. Human synovium can be engrafted into subcutaneous ear pouches in SCID mice. The xenografts are accessible and respond to injection of a pro-inflammatory cytokine... - Response-driven combination therapy with conventional disease-modifying antirheumatic drugs can achieve high response rates in early rheumatoid arthritis with minimal glucocorticoid and nonsteroidal anti-inflammatory drug useSusanna M Proudman
Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, Australia
Semin Arthritis Rheum 37:99-111. 2007..To assess the safety and efficacy of combination therapy in recent-onset rheumatoid arthritis (RA), with dose adjustments determined by response, in a clinic setting over 3 years... - Characterization of thoracic duct cells that transfer polyarthritisL D Spargo
The Arthritis Research Laboratory of the Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, SA, Australia
Clin Exp Immunol 126:560-9. 2001..Recruitment of these arthritogenic cells to synovium probably determines the polyarticular pattern of AA... - Cyclooxygenase inhibitors: any reservations?P S Penglis
Rheumatology Unit, Royal Adelaide Hospital, South Australia
Intern Med J 31:37-41. 2001..Thus, despite the relatively safe gastrointestinal profile, vigilant post-marketing surveillance for other adverse effects is required... - Eicosanoid production by human monocytes: does COX-2 contribute to a self-limiting inflammatory response?M J James
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, SA, Australia
Inflamm Res 50:249-53. 2001..The findings have implications for the use of NSAIDs and selective COX-2 inhibitors whose actions can increase the monocyte TXA2/PGE2 ratio... - Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acidsMichael J James
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia
Am J Clin Nutr 77:1140-5. 2003.... - COX-2 inhibition and thrombotic tendency: a need for surveillanceL G Cleland
Rheumatology Unit, Royal Adelaide Hospital, SA
Med J Aust 175:214-7. 2001..It is important to canvass the possibility that use of these agents could be associated with thrombotic events... - A practical approach to increasing intakes of n-3 polyunsaturated fatty acids: use of novel foods enriched with n-3 fatsR G Metcalf
Department of Rheumatology, Royal Adelaide Hospital, North Tce, Adelaide, SA 5000, Australia
Eur J Clin Nutr 57:1605-12. 2003..To assess the effects of providing a wide range of foodstuffs containing n-3 polyunsaturated fatty acids (PUFA), occurring naturally or from fortification, on intake and blood and tissue proportions of n-3 PUFA... - Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinaseM Pouliot
Rheumatology Unit, Royal Adelaide Hospital, South Australia
J Immunol 158:4930-7. 1997..These results indicate a new and potentially important anti-inflammatory property of SK&F 86002, namely the specific suppression of PGHS-2 induction... - Recruitment and proliferation of CD4+ T cells in synovium following adoptive transfer of adjuvant-induced arthritisLlewellyn D J Spargo
Arthritis Research Laboratory, Hanson Research Institute, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
Int Immunol 18:897-910. 2006..However, without a continuous supply, adoptively transferred effector cells do not produce autonomous local disease, due to limits to their lifespan and ability to replicate indefinitely... 
Treatment-induced stable, moderate reduction in blood cell counts correlate to disease control in early rheumatoid arthritisS E Lester
Arthritis Research Laboratory, Hanson Research Institute, Adelaide, South Australia, Australia
Intern Med J 39:296-303. 2009..The objective was to analyse cell counts obtained as routine surveillance for adverse effects to assess the effect of intensive treatment and treatment dosage and to examine correlations to disease activity scores...- IL-3 and granulocyte-macrophage colony-stimulating factor stimulate two distinct phases of adhesion in human monocytesM J Elliott
Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia
J Immunol 145:167-76. 1990..These findings may be relevant to the pathogenesis of inflammatory disease and may have implications for the clinical use of these cytokines... - MHC II+ CD45+ cells from synovium-rich tissues of normal rats: phenotype, comparison with macrophage and dendritic cell lineages and differentiation into mature dendritic cells in vitroMahin Moghaddami
Arthritis Research Laboratory, Hanson Institute for Medical Research, Institute of Medical and Veterinary Science, Adelaide, South Australia
Int Immunol 17:1103-15. 2005..These results demonstrate that SRTs contain indeterminate cells that can differentiate into mature DCs in vitro in response to GM-CSF, plus mature synovial lining macrophages... - Cyclooxygenase-2 inhibitors: what went wrong?Michael J James
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Curr Opin Clin Nutr Metab Care 9:89-94. 2006.... - Effects of fish-oil supplementation on myocardial fatty acids in humansRobert G Metcalf
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia
Am J Clin Nutr 85:1222-8. 2007..This benefit putatively arises from the incorporation of the long-chain n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into cardiomyocyte phospholipids... - Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritisHeather M James
Division of Human Immunology, Institute of Medical and Veterinary Science, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia
J Rheumatol 35:562-71. 2008.... - Relation between blood and atrial fatty acids in patients undergoing cardiac bypass surgeryRobert G Metcalf
Royal Adelaide Hospital, Adelaide, Australia
Am J Clin Nutr 91:528-34. 2010..Although dietary intakes of n-3 (omega-3), n-6 (omega-6), and trans fatty acids are reflected in their concentrations in blood, there are few human data on the relation between blood and cardiac concentrations of fatty acids... - MHC class II compartment, endocytosis and phagocytic activity of macrophages and putative dendritic cells isolated from normal tissues rich in synoviumMahin Moghaddami
Arthritis Research Laboratory, Hanson Institute for Medical Research, Institute of Medical and Veterinary Science, Adelaide, South Australia
Int Immunol 17:1117-30. 2005..Intracellular MHC class II-rich compartments (MIIC) were prominent in sMHC IIhi cells in SRT but rare in CD163+ cells. Most MHC IIhi CD11c+ cells did not have a detectable MIIC... - Measurement of hand bone mineral density in early rheumatoid arthritis using dual energy X-ray absorptiometryCatherine L Hill
Rheumatology Unit, The Queen Elizabeth Hospital, Woodville, Australia
Int J Rheum Dis 13:230-4. 2010.... - Selective COX-2 inhibitors, eicosanoid synthesis and clinical outcomes: a case study of system failureM J James
Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, 5000, Australia
Lipids 42:779-85. 2007..The commercial success of rofecoxib provides a case-study of failure of the medical journal literature to guide drug usage. Attention to ethical issues may have provided a more useful guide for prescribers... - Low density lipoprotein of synovial fluid in inflammatory joint disease is mildly oxidizedM J James
Rheumatology Unit, Royal Adelaide Hospital, SA, Australia
Lipids 33:1115-21. 1998..Thus, extensive LDL oxidation is not a necessary correlate of location in a chronic inflammatory site, even though it is characteristic of atherosclerotic lesions... - Blockade of IFN-gamma does not affect the arthritogenicity of T cells generated during the induction of adjuvant arthritis but exacerbates the polyarthritis produced by adoptive transfer of arthritogenic effector cellsMelissa Brasted
Arthritis Research Laboratory, Hanson Research Institute, Institute of Medical and Veterinary Science, University of Adelaide, Adelaide, South Australia, Australia
Immunol Cell Biol 83:189-95. 2005..In contrast, treatment of donors did not appear to affect the generation of arthritogenic cells. The main effect of IFN-gamma appears to be modulation of the arthritogenicity of the migratory effector T cells that can transfer AA... - Effects of hypoxia on the expression and activity of cyclooxygenase 2 in fibroblast-like synoviocytes: interactions with monocyte-derived soluble mediatorsMaryanne Demasi
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Arthritis Rheum 50:2441-9. 2004..Therefore, this study was designed to assess the effect of hypoxia on FLS responses to the monokine interleukin-1beta (IL-1beta) and to monocyte conditioned medium... - Dietary n-3 fats as adjunctive therapy in a prototypic inflammatory disease: issues and obstacles for use in rheumatoid arthritisM J James
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, North Terrace, SA 5000, Adelaide, Australia
Prostaglandins Leukot Essent Fatty Acids 68:399-405. 2003..The implementation of these findings will require among other things, a range of n-3 fat enriched foods, as well as physician awareness of the possibilities for dietary n-3 fat increases to be used as adjunctive therapy in RA... - Up-regulation of endothelial cyclooxygenase-2 and prostanoid synthesis by platelets. Role of thromboxane A2G E Caughey
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
J Biol Chem 276:37839-45. 2001..These observations are of particular importance given the recent observations regarding selective COX-2 inhibitors and the suppression of PGI2 synthesis... - Applying a research ethics committee approach to a medical practice controversy: the case of the selective COX-2 inhibitor rofecoxibM J James
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, SA, Australia
J Med Ethics 30:182-4. 2004..A consideration of the legal tests for disclosure of information suggests that therapeutic medical practice should mirror that within the research environment, in this case... - Auranofin stimulates LTA hydrolase and inhibits 5-lipoxygenase/LTA synthase activity of isolated human neutrophilsW H Betts
Rheumatology Unit, Queen Elizabeth Hospital, Woodville, Adelaide, South Australia
Biochem Pharmacol 39:1233-7. 1990.... - Upregulation of synoviocyte COX-2 through interactions with T lymphocytes: role of interleukin 17 and tumor necrosis factor-alphaLisa K Stamp
Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide SA 5000, Australia
J Rheumatol 31:1246-54. 2004..These data provide additional evidence for the contribution of T cells in rheumatoid inflammation and highlight the potential of IL-17 as a therapeutic target... - Interleukin-17: the missing link between T-cell accumulation and effector cell actions in rheumatoid arthritis?Lisa K Stamp
Rheumatology Unit, Eleanor Harrald Building, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Immunol Cell Biol 82:1-9. 2004..As such, IL-17 warrants consideration for its potential as a therapeutic target in rheumatoid arthritis... - Effects of hypoxia on monocyte inflammatory mediator production: Dissociation between changes in cyclooxygenase-2 expression and eicosanoid synthesisMaryanne Demasi
Rheumatology Unit, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
J Biol Chem 278:38607-16. 2003.... - Dietary omega-3 fats for treatment of inflammatory joint disease: efficacy and utilitySusanna M Proudman
Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia
Rheum Dis Clin North Am 34:469-79. 2008..This is an important aspect of fish oil use, given the increased cardiovascular risk in rheumatoid arthritis. Perceived barriers to clinical use are readily addressed... - Paracrine upregulation of monocyte cyclooxygenase-2 by mediators produced by T lymphocytes: role of interleukin 17 and interferon-gammaLisa K Stamp
Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide SA 5000, Australia
J Rheumatol 31:1255-64. 2004..In rheumatoid joints, previously observed high concentrations of IL-17 and low concentrations of IFN-g could contribute to T cell-driven upregulation of monocyte COX-2... - Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophilsMireille St-Onge
Centre de Recherche en Rhumatologie et Immunologie du CHUQ CHUL, Sainte Foy, and Department of Anatomy Physiology, Faculty of Medicine, Laval University, Quebec, Canada, and Rheumatology Unit, Royal Adelaide Hospital, SA, Australia
Biochim Biophys Acta 1771:1235-45. 2007..These results highlight key differences in regulatory processes of the 5-LO and COX pathways, and enhance our knowledge at several levels in the PGE2 biosynthesis in neutrophils... - Effect of dietary n-3 polyunsaturated fatty acids on the inducibility of ventricular tachycardia in patients with ischemic cardiomyopathyRobert G Metcalf
The Cardiovascular Research Centre, Department of Rheumatology, Royal Adelaide Hospital, Adelaide, Australia
Am J Cardiol 101:758-61. 2008..In conclusion, dietary n-3 fatty acid supplementation decreased the inducibility of VT in patients at risk of SCD. These findings suggest that dietary fish oil can have an antiarrhythmic effect... - CD36/fatty acid translocase in rats: distribution, isolation from hepatocytes, and comparison with the scavenger receptor SR-B1Xingqi Zhang
The Arthritis Research Laboratory, Hanson Centre for Cancer Research, Adelaide, South Australia, Australia
Lab Invest 83:317-32. 2003..We suggest that CD36/FAT might function in the liver as a sex-regulated accessory molecule, either in reverse cholesterol transport and/or in fatty acid uptake... - Importance of the carboxyl terminus of FAT/CD36 for plasma membrane localization and function in long-chain fatty acid uptakeNicholas S Eyre
School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia, Australia
J Lipid Res 48:528-42. 2007..We conclude that the C terminus of FAT/CD36 is required for localization of the receptor to the cell surface and its ability to enhance cellular oleate uptake... - Endothelial cell COX-2 expression and activity in hypoxiaRebecca J Cook-Johnson
Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia
Biochim Biophys Acta 1761:1443-9. 2006..The endothelial cell response to hypoxia involves increased production of the anti-thrombotic eicosanoid, PGI(2), which is dependent on COX-2 upregulation by a HIF-mediated process... - Marine oils for antiinflammatory effect -- time to take stockLeslie G Cleland
J Rheumatol 33:207-9. 2006 - Early combination disease modifying antirheumatic drug treatment for rheumatoid arthritisLynden J Roberts
Department of Rheumatology, Royal Melbourne Hospital, Parkville, VIC 3050, Australia
Med J Aust 184:122-5. 2006.... - Diet and rheumatoid arthritis: a review of the literatureLisa K Stamp
Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, New Zealand
Semin Arthritis Rheum 35:77-94. 2005..A large number of patients seek alternative or complementary therapies of which diet is an important component. This article reviews the evidence for diet in rheumatoid arthritis along with the associated concept of oral tolerization... - COX-2 selectivity varies across classLeslie G Cleland
Med J Aust 182:197-8; author reply 199. 2005