Research Topics
| Glyn ChidlowSummaryAffiliation: South Australia Country: Australia Publications
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Detail Information
Publications
Glial cell and inflammatory responses to retinal laser treatment: comparison of a conventional photocoagulator and a novel, 3-nanosecond pulse laserGlyn Chidlow
Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, South Australia, Australia
Invest Ophthalmol Vis Sci 54:2319-32. 2013..We studied inflammatory and glial responses resulting from treatment of rats with a conventional laser and with a novel short-duration, nonthermal laser (retinal regeneration therapy [2RT]) at clinically relevant energy levels...- Interleukin-6 is an efficacious marker of axonal transport disruption during experimental glaucoma and stimulates neuritogenesis in cultured retinal ganglion cellsGlyn Chidlow
Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Frome Rd, Adelaide, SA 5000, Australia
Neurobiol Dis 48:568-81. 2012..These data comprise clear evidence that IL-6 is actively involved in the attempt of injured retinal ganglion cells to regenerate their axons... 
Localization of a wide-ranging panel of antigens in the rat retina by immunohistochemistry: comparison of Davidson's solution and formalin as fixativesGlyn Chidlow
Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, Australia
J Histochem Cytochem 59:884-98. 2011....- Spatiotemporal characterization of optic nerve degeneration after chronic hypoperfusion in the ratGlyn Chidlow
Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, SA, Australia
Invest Ophthalmol Vis Sci 51:1483-97. 2010..The present study was conducted to investigate these topics... - The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucomaGlyn Chidlow
Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, SA, Australia
Acta Neuropathol 121:737-51. 2011.... - Protection of retinal ganglion cells and the optic nerve during short-term hyperglycemia in experimental glaucomaAndreas Ebneter
Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, and Department of Ophthalmology, Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia
Arch Ophthalmol 129:1337-44. 2011..To evaluate the neuroprotective effect of short-term hyperglycemia on the retinal ganglion cell body and axon in a rat model of experimental glaucoma... - Estimation of axon counts in a rat model of glaucoma: comparison of fixed-pattern sampling with targeted samplingAndreas Ebneter
Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Frome Road, Adelaide, SA 5000, Australia
Clin Experiment Ophthalmol 40:626-33. 2012.... - The effect of hyperglycemia on hypoperfusion-induced injuryMatthew C Holman
Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, South Australia, Australia
Invest Ophthalmol Vis Sci 51:2197-207. 2010..The mechanism of this retinal hyperglycemia-induced neuroprotection requires further study... - Evaluation of Fluoro-Jade C as a marker of degenerating neurons in the rat retina and optic nerveGlyn Chidlow
Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, SA, Australia
Exp Eye Res 88:426-37. 2009..Since the ganglion cell layer is adjacent to astrocytes within the nerve fibre layer, caution is needed when using FJC as a quantitative tool for detecting ganglion cell death... - Translational neuroprotection research in glaucoma: a review of definitions and principlesRobert J Casson
South Australian Institute of Ophthalmology, Hanson Institute and Adelaide University, Adelaide, South Australia, Australia
Clin Experiment Ophthalmol 40:350-7. 2012..Here, we suggest a set of definitions, postulates and principles to form a foundation for the successful translation of novel glaucoma therapies from the laboratory to the clinic... - A comparison of differentiation protocols for RGC-5 cellsJohn P M Wood
Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, Australia
Invest Ophthalmol Vis Sci 51:3774-83. 2010..Hence, TSA provided the best tested means to terminally differentiate the cells to a neuronal phenotype from a precursor-like lineage... - Mitochondrial inhibition in rat retinal cell cultures as a model of metabolic compromise: mechanisms of injury and neuroprotectionJohn P M Wood
Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, SA, Australia
Invest Ophthalmol Vis Sci 53:4897-909. 2012..Methods. Mixed rat retinal cultures comprising neurons and glia were treated with a range of NaN(3) concentrations for up to 24 hours and toxicity levels were determined by immunologic.. - Expression of osteopontin in the rat retina: effects of excitotoxic and ischemic injuriesGlyn Chidlow
Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, SA, Australia
Invest Ophthalmol Vis Sci 49:762-71. 2008..In the present study, we characterized the time course and cellular localization of OPN expression in the rat retina after excitotoxic and ischemic injuries... - Microglial activation in the visual pathway in experimental glaucoma: spatiotemporal characterization and correlation with axonal injuryAndreas Ebneter
South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, Australia
Invest Ophthalmol Vis Sci 51:6448-60. 2010..The aim of the current work was to characterize the microglial response within the visual pathway in a rat model of experimental glaucoma and to correlate the microglial response with the severity of axonal degeneration... - Definition of glaucoma: clinical and experimental conceptsRobert J Casson
South Australian Institute of Ophthalmology, Hanson Institute and Adelaide University, Adelaide, South Australia, Australia
Clin Experiment Ophthalmol 40:341-9. 2012..A fundamental inadequacy in this framework is any reference to the pathogenesis of GON, which remains unclear... - Rapid and delayed death of cultured trabecular meshwork cells after selective laser trabeculoplastyJohn P M Wood
South Australian Institute of Ophthalmology, Ophthalmic Research Laboratories, Level 2 Hanson Institute, IMVS, Frome Road, Adelaide, SA 5000, Australia
Lasers Surg Med 42:326-37. 2010..The aim of the present study, therefore, was to investigate the modes of death of cultured bovine TM cells subjected to SLT in vitro... - Nanosecond pulse lasers for retinal applicationsJohn P M Wood
South Australian Institute of Ophthalmology, Ophthalmic Research Laboratories, Level 2 Hanson Institute, IMVS, Adelaide, South Australia, Australia
Lasers Surg Med 43:499-510. 2011..Data were compared with that obtained from a standard thermal laser... - Bioenergetic-based neuroprotection and glaucomaMichael S Schober
South Australian Institute of Ophthalmology, Adelaide, South Australia, Australia
Clin Experiment Ophthalmol 36:377-85. 2008.... - Retinal damage profiles and neuronal effects of laser treatment: comparison of a conventional photocoagulator and a novel 3-nanosecond pulse laserJohn P M Wood
Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, South Australia, Australia
Invest Ophthalmol Vis Sci 54:2305-18. 2013..Furthermore, to determine whether a novel 3 ns pulse laser (retinal regeneration therapy; 2RT) could specifically ablate retinal pigment epithelium (RPE) cells without causing collateral damage to other retinal cells... 
Pharmacological neuroprotection for glaucomaGlyn Chidlow
Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute, Adelaide, South Australia, Australia
Drugs 67:725-59. 2007....- Heat shock protein induction in fetal mouse brain as a measure of stress after whole of gestation exposure to mobile telephony radiofrequency fieldsJohn W Finnie
Hanson Institute Centre for Neurological Diseases, Institute of Medical and Veterinary Science, PO Box 14 Rundle Mall, Adelaide, SA 5000, Australia
Pathology 41:276-9. 2009..To determine whether whole of gestation exposure of fetal mouse brain to mobile telephone radiofrequency fields produces a stress response detectable by induction of heat shock proteins (HSPs)... - Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1Kathryn P Burdon
Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, Australia
Nat Genet 43:574-8. 2011..35 × 10(-14), OR = 1.39, 95% CI 1.28-1.51). We show retinal expression of genes at both loci in human ocular tissues. We also show that CDKN2A and CDKN2B are upregulated in the retina of a rat model of glaucoma...