Glyn Chidlow

Summary

Affiliation: South Australia
Country: Australia

Publications

  1. doi request reprint Glial cell and inflammatory responses to retinal laser treatment: comparison of a conventional photocoagulator and a novel, 3-nanosecond pulse laser
    Glyn Chidlow
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, South Australia, Australia
    Invest Ophthalmol Vis Sci 54:2319-32. 2013
  2. doi request reprint Interleukin-6 is an efficacious marker of axonal transport disruption during experimental glaucoma and stimulates neuritogenesis in cultured retinal ganglion cells
    Glyn Chidlow
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Frome Rd, Adelaide, SA 5000, Australia
    Neurobiol Dis 48:568-81. 2012
  3. pmc Localization of a wide-ranging panel of antigens in the rat retina by immunohistochemistry: comparison of Davidson's solution and formalin as fixatives
    Glyn Chidlow
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, Australia
    J Histochem Cytochem 59:884-98. 2011
  4. pmc The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma
    Glyn Chidlow
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, SA, Australia
    Acta Neuropathol 121:737-51. 2011
  5. doi request reprint Spatiotemporal characterization of optic nerve degeneration after chronic hypoperfusion in the rat
    Glyn Chidlow
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, SA, Australia
    Invest Ophthalmol Vis Sci 51:1483-97. 2010
  6. doi request reprint Protection of retinal ganglion cells and the optic nerve during short-term hyperglycemia in experimental glaucoma
    Andreas Ebneter
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, and Department of Ophthalmology, Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia
    Arch Ophthalmol 129:1337-44. 2011
  7. doi request reprint The effect of hyperglycemia on hypoperfusion-induced injury
    Matthew C Holman
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, South Australia, Australia
    Invest Ophthalmol Vis Sci 51:2197-207. 2010
  8. doi request reprint Estimation of axon counts in a rat model of glaucoma: comparison of fixed-pattern sampling with targeted sampling
    Andreas Ebneter
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Frome Road, Adelaide, SA 5000, Australia
    Clin Experiment Ophthalmol 40:626-33. 2012
  9. doi request reprint Mechanisms of neuroprotection by glucose in rat retinal cell cultures subjected to respiratory inhibition
    Guoge Han
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, Australia
    Invest Ophthalmol Vis Sci 54:7567-77. 2013
  10. doi request reprint Retinal damage profiles and neuronal effects of laser treatment: comparison of a conventional photocoagulator and a novel 3-nanosecond pulse laser
    John P M Wood
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, South Australia, Australia
    Invest Ophthalmol Vis Sci 54:2305-18. 2013

Detail Information

Publications26

  1. doi request reprint Glial cell and inflammatory responses to retinal laser treatment: comparison of a conventional photocoagulator and a novel, 3-nanosecond pulse laser
    Glyn Chidlow
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, South Australia, Australia
    Invest Ophthalmol Vis Sci 54:2319-32. 2013
    ..We studied inflammatory and glial responses resulting from treatment of rats with a conventional laser and with a novel short-duration, nonthermal laser (retinal regeneration therapy [2RT]) at clinically relevant energy levels...
  2. doi request reprint Interleukin-6 is an efficacious marker of axonal transport disruption during experimental glaucoma and stimulates neuritogenesis in cultured retinal ganglion cells
    Glyn Chidlow
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Frome Rd, Adelaide, SA 5000, Australia
    Neurobiol Dis 48:568-81. 2012
    ..These data comprise clear evidence that IL-6 is actively involved in the attempt of injured retinal ganglion cells to regenerate their axons...
  3. pmc Localization of a wide-ranging panel of antigens in the rat retina by immunohistochemistry: comparison of Davidson's solution and formalin as fixatives
    Glyn Chidlow
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, Australia
    J Histochem Cytochem 59:884-98. 2011
    ....
  4. pmc The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma
    Glyn Chidlow
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, SA, Australia
    Acta Neuropathol 121:737-51. 2011
    ....
  5. doi request reprint Spatiotemporal characterization of optic nerve degeneration after chronic hypoperfusion in the rat
    Glyn Chidlow
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, SA, Australia
    Invest Ophthalmol Vis Sci 51:1483-97. 2010
    ..The present study was conducted to investigate these topics...
  6. doi request reprint Protection of retinal ganglion cells and the optic nerve during short-term hyperglycemia in experimental glaucoma
    Andreas Ebneter
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, and Department of Ophthalmology, Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia
    Arch Ophthalmol 129:1337-44. 2011
    ..To evaluate the neuroprotective effect of short-term hyperglycemia on the retinal ganglion cell body and axon in a rat model of experimental glaucoma...
  7. doi request reprint The effect of hyperglycemia on hypoperfusion-induced injury
    Matthew C Holman
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, South Australia, Australia
    Invest Ophthalmol Vis Sci 51:2197-207. 2010
    ..The mechanism of this retinal hyperglycemia-induced neuroprotection requires further study...
  8. doi request reprint Estimation of axon counts in a rat model of glaucoma: comparison of fixed-pattern sampling with targeted sampling
    Andreas Ebneter
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Frome Road, Adelaide, SA 5000, Australia
    Clin Experiment Ophthalmol 40:626-33. 2012
    ....
  9. doi request reprint Mechanisms of neuroprotection by glucose in rat retinal cell cultures subjected to respiratory inhibition
    Guoge Han
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, Australia
    Invest Ophthalmol Vis Sci 54:7567-77. 2013
    ..Previous experiments have demonstrated that short-term hyperglycemia in rats renders the retina resistant to subsequent metabolic insults. The present study aimed to elucidate putative mechanisms involved in this protective response...
  10. doi request reprint Retinal damage profiles and neuronal effects of laser treatment: comparison of a conventional photocoagulator and a novel 3-nanosecond pulse laser
    John P M Wood
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, South Australia, Australia
    Invest Ophthalmol Vis Sci 54:2305-18. 2013
    ..Furthermore, to determine whether a novel 3 ns pulse laser (retinal regeneration therapy; 2RT) could specifically ablate retinal pigment epithelium (RPE) cells without causing collateral damage to other retinal cells...
  11. doi request reprint Evaluation of Fluoro-Jade C as a marker of degenerating neurons in the rat retina and optic nerve
    Glyn Chidlow
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, SA, Australia
    Exp Eye Res 88:426-37. 2009
    ..Since the ganglion cell layer is adjacent to astrocytes within the nerve fibre layer, caution is needed when using FJC as a quantitative tool for detecting ganglion cell death...
  12. doi request reprint Translational neuroprotection research in glaucoma: a review of definitions and principles
    Robert J Casson
    South Australian Institute of Ophthalmology, Hanson Institute and Adelaide University, Adelaide, South Australia, Australia
    Clin Experiment Ophthalmol 40:350-7. 2012
    ..Here, we suggest a set of definitions, postulates and principles to form a foundation for the successful translation of novel glaucoma therapies from the laboratory to the clinic...
  13. doi request reprint A comparison of differentiation protocols for RGC-5 cells
    John P M Wood
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, Australia
    Invest Ophthalmol Vis Sci 51:3774-83. 2010
    ..Hence, TSA provided the best tested means to terminally differentiate the cells to a neuronal phenotype from a precursor-like lineage...
  14. doi request reprint Mitochondrial inhibition in rat retinal cell cultures as a model of metabolic compromise: mechanisms of injury and neuroprotection
    John P M Wood
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, SA, Australia
    Invest Ophthalmol Vis Sci 53:4897-909. 2012
    ..Methods. Mixed rat retinal cultures comprising neurons and glia were treated with a range of NaN(3) concentrations for up to 24 hours and toxicity levels were determined by immunologic..
  15. doi request reprint Expression of osteopontin in the rat retina: effects of excitotoxic and ischemic injuries
    Glyn Chidlow
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, SA, Australia
    Invest Ophthalmol Vis Sci 49:762-71. 2008
    ..In the present study, we characterized the time course and cellular localization of OPN expression in the rat retina after excitotoxic and ischemic injuries...
  16. doi request reprint Microglial activation in the visual pathway in experimental glaucoma: spatiotemporal characterization and correlation with axonal injury
    Andreas Ebneter
    South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, Australia
    Invest Ophthalmol Vis Sci 51:6448-60. 2010
    ..The aim of the current work was to characterize the microglial response within the visual pathway in a rat model of experimental glaucoma and to correlate the microglial response with the severity of axonal degeneration...
  17. doi request reprint Definition of glaucoma: clinical and experimental concepts
    Robert J Casson
    South Australian Institute of Ophthalmology, Hanson Institute and Adelaide University, Adelaide, South Australia, Australia
    Clin Experiment Ophthalmol 40:341-9. 2012
    ..A fundamental inadequacy in this framework is any reference to the pathogenesis of GON, which remains unclear...
  18. doi request reprint Rapid and delayed death of cultured trabecular meshwork cells after selective laser trabeculoplasty
    John P M Wood
    South Australian Institute of Ophthalmology, Ophthalmic Research Laboratories, Level 2 Hanson Institute, IMVS, Frome Road, Adelaide, SA 5000, Australia
    Lasers Surg Med 42:326-37. 2010
    ..The aim of the present study, therefore, was to investigate the modes of death of cultured bovine TM cells subjected to SLT in vitro...
  19. doi request reprint Nanosecond pulse lasers for retinal applications
    John P M Wood
    South Australian Institute of Ophthalmology, Ophthalmic Research Laboratories, Level 2 Hanson Institute, IMVS, Adelaide, South Australia, Australia
    Lasers Surg Med 43:499-510. 2011
    ..Data were compared with that obtained from a standard thermal laser...
  20. ncbi request reprint Bioenergetic-based neuroprotection and glaucoma
    Michael S Schober
    South Australian Institute of Ophthalmology, Adelaide, South Australia, Australia
    Clin Experiment Ophthalmol 36:377-85. 2008
    ....
  21. ncbi request reprint Glucose-induced temporary visual recovery in primary open-angle glaucoma: a double-blind, randomized study
    Robert J Casson
    South Australian Institute of Ophthalmology, University of Adelaide, Adelaide, South Australia Electronic address
    Ophthalmology 121:1203-11. 2014
    ..To investigate the effect of topical glucose on visual parameters in individuals with primary open-angle glaucoma (POAG)...
  22. pmc Ocular expression and distribution of products of the POAG-associated chromosome 9p21 gene region
    Glyn Chidlow
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, South Australia, Australia Department of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, South Australia, Australia
    PLoS ONE 8:e75067. 2013
    ..The presented data provide the basis for future studies that can explore the roles that these gene products may play in the pathogenesis of glaucoma and other models of optic nerve damage. ..
  23. ncbi request reprint Retinal microvascular damage and vasogenic edema produced by Clostridium perfringens type D epsilon toxin in rats
    John W Finnie
    SA Pathology Finnie, Manavis, Hanson Institute Centre for Neurological Diseases, Adelaide, South Australia, AustraliaOphthalmic Research Laboratories, South Australian Institute of Ophthalmology Casson, Chidlow, Hanson Institute Centre for Neurological Diseases, Adelaide, South Australia, AustraliaSchool of Veterinary Science Finnie, University of Adelaide, Adelaide, South Australia, AustraliaDepartment of Ophthalmology and Visual Sciences Casson, Chidlow, University of Adelaide, Adelaide, South Australia, Australia
    J Vet Diagn Invest 26:470-472. 2014
    ..As laboratory rodents are a good model of the domestic livestock disease produced by ETX, it is probable that the latter sustain some visual deficit when exposed to large doses of this potent neurotoxin...
  24. ncbi request reprint Pharmacological neuroprotection for glaucoma
    Glyn Chidlow
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute, Adelaide, South Australia, Australia
    Drugs 67:725-59. 2007
    ....
  25. doi request reprint Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1
    Kathryn P Burdon
    Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, Australia
    Nat Genet 43:574-8. 2011
    ..35 × 10(-14), OR = 1.39, 95% CI 1.28-1.51). We show retinal expression of genes at both loci in human ocular tissues. We also show that CDKN2A and CDKN2B are upregulated in the retina of a rat model of glaucoma...
  26. doi request reprint Heat shock protein induction in fetal mouse brain as a measure of stress after whole of gestation exposure to mobile telephony radiofrequency fields
    John W Finnie
    Hanson Institute Centre for Neurological Diseases, Institute of Medical and Veterinary Science, PO Box 14 Rundle Mall, Adelaide, SA 5000, Australia
    Pathology 41:276-9. 2009
    ..To determine whether whole of gestation exposure of fetal mouse brain to mobile telephone radiofrequency fields produces a stress response detectable by induction of heat shock proteins (HSPs)...