L K Ashman

Summary

Affiliation: South Australia
Country: Australia

Publications

  1. ncbi Effects of mutant c-kit in early myeloid cells
    L K Ashman
    Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, Australia
    Leuk Lymphoma 37:233-43. 2000
  2. ncbi Effects of mutant c-Kit in early myeloid cells
    L K Ashman
    Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, Australia
    Leuk Lymphoma 34:451-61. 1999
  3. ncbi The biology of stem cell factor and its receptor C-kit
    L K Ashman
    Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, SA, Australia
    Int J Biochem Cell Biol 31:1037-51. 1999
  4. ncbi c-kit is expressed by primitive human hematopoietic cells that give rise to colony-forming cells in stroma-dependent or cytokine-supplemented culture
    P J Simmons
    Leukaemia Research Unit, Hanson Centre for Cancer Research, Adelaide, South Australia
    Exp Hematol 22:157-65. 1994
  5. ncbi A comparative study of the phenotype and proliferative capacity of peripheral blood (PB) CD34+ cells mobilized by four different protocols and those of steady-phase PB and bone marrow CD34+ cells
    L B To
    Leukaemia Research Unit, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, Australia
    Blood 84:2930-9. 1994
  6. ncbi Epitope mapping and functional studies with three monoclonal antibodies to the c-kit receptor tyrosine kinase, YB5.B8, 17F11, and SR-1
    L K Ashman
    Leukaemia Research Unit, Hanson Centre for Cancer Research, Adelaide, South Australia
    J Cell Physiol 158:545-54. 1994
  7. ncbi Transmembrane 4 superfamily protein CD151 (PETA-3) associates with beta 1 and alpha IIb beta 3 integrins in haemopoietic cell lines and modulates cell-cell adhesion
    S Fitter
    Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, SA, Australia
    Biochem J 338:61-70. 1999
  8. ncbi The mobilization of primitive hemopoietic progenitors into the peripheral blood
    P J Simmons
    Division of Haematology, Hanson Centre for Cancer Research, Villejuif, France
    Stem Cells 12:187-201; discussion 201-2. 1994
  9. ncbi Differential tissue expression of epitopes of the tetraspanin CD151 recognised by monoclonal antibodies
    S M Geary
    Division of Haematology, Hanson Centre for Cancer Research, Rundle Mall, Adelaide, SA 5000, Australia
    Tissue Antigens 58:141-53. 2001
  10. ncbi Responses of the murine myeloid cell line FDC-P1 to soluble and membrane-bound forms of steel factor (SLF)
    G Caruana
    Leukaemia Research Unit, Hanson Centre for Cancer Research, Adelaide, South Australia
    Exp Hematol 21:761-8. 1993

Collaborators

Detail Information

Publications18

  1. ncbi Effects of mutant c-kit in early myeloid cells
    L K Ashman
    Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, Australia
    Leuk Lymphoma 37:233-43. 2000
    ..Thus the extent to which c-Kit mutations contribute to malignancies of early myeloid phenotype remains unknown, and resolution of this issue is complicated by the heterogeneity of this family of diseases...
  2. ncbi Effects of mutant c-Kit in early myeloid cells
    L K Ashman
    Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, Australia
    Leuk Lymphoma 34:451-61. 1999
    ..Thus the extent to which c-Kit mutations contribute to malignancies of early myeloid phenotype remains unknown, and resolution of this issue is complicated by the heterogeneity of this family of diseases...
  3. ncbi The biology of stem cell factor and its receptor C-kit
    L K Ashman
    Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, SA, Australia
    Int J Biochem Cell Biol 31:1037-51. 1999
    ....
  4. ncbi c-kit is expressed by primitive human hematopoietic cells that give rise to colony-forming cells in stroma-dependent or cytokine-supplemented culture
    P J Simmons
    Leukaemia Research Unit, Hanson Centre for Cancer Research, Adelaide, South Australia
    Exp Hematol 22:157-65. 1994
    ..This was confirmed by the finding that only 4% of c-kit+CD34+ cells showed terminal deoxynucleotidyl transferase (TdT) activity, compared with 25% of the c-kit-CD34+ cells...
  5. ncbi A comparative study of the phenotype and proliferative capacity of peripheral blood (PB) CD34+ cells mobilized by four different protocols and those of steady-phase PB and bone marrow CD34+ cells
    L B To
    Leukaemia Research Unit, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, Australia
    Blood 84:2930-9. 1994
    ..0001). These observations are novel and suggest that different mobilization protocols may act via similar pathways involving the down-regulation of c-kit and may be independent of cell-cycle status...
  6. ncbi Epitope mapping and functional studies with three monoclonal antibodies to the c-kit receptor tyrosine kinase, YB5.B8, 17F11, and SR-1
    L K Ashman
    Leukaemia Research Unit, Hanson Centre for Cancer Research, Adelaide, South Australia
    J Cell Physiol 158:545-54. 1994
    ..As expected, SR-1 potently inhibited the proliferative response to SLF, while 17F11 weakly inhibited and YB5.B8 had negligible effect. In the absence of SLF both 17F11 and YB5.B8 displayed very weak but reproducible agonist activity...
  7. ncbi Transmembrane 4 superfamily protein CD151 (PETA-3) associates with beta 1 and alpha IIb beta 3 integrins in haemopoietic cell lines and modulates cell-cell adhesion
    S Fitter
    Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, SA, Australia
    Biochem J 338:61-70. 1999
    ..Taken together, these results indicate that the ligation of CD151 does not induce the up-regulation of integrin avidity, but might act as a component of integrin signalling complexes...
  8. ncbi The mobilization of primitive hemopoietic progenitors into the peripheral blood
    P J Simmons
    Division of Haematology, Hanson Centre for Cancer Research, Villejuif, France
    Stem Cells 12:187-201; discussion 201-2. 1994
    ..Downregulation of c-kit is invariably associated with successful mobilization which, when combined with data from in vitro studies, implies a key role for stem cell factor (SCF) as an orchestrator of mobilization...
  9. ncbi Differential tissue expression of epitopes of the tetraspanin CD151 recognised by monoclonal antibodies
    S M Geary
    Division of Haematology, Hanson Centre for Cancer Research, Rundle Mall, Adelaide, SA 5000, Australia
    Tissue Antigens 58:141-53. 2001
    ..Of six monoclonal antibodies from four laboratories, 11B1 was found to be the most reliable for detection of CD151 in different cell and tissue contexts...
  10. ncbi Responses of the murine myeloid cell line FDC-P1 to soluble and membrane-bound forms of steel factor (SLF)
    G Caruana
    Leukaemia Research Unit, Hanson Centre for Cancer Research, Adelaide, South Australia
    Exp Hematol 21:761-8. 1993
    ..Thus, functional downregulation of c-kit by GM-CSF and IL-3 was unidirectional...
  11. ncbi PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function
    P M Sincock
    Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, Australia
    J Cell Sci 112:833-44. 1999
    ..The broad range of integrin associations and the presence of PETA-3 with integrins both on the plasma membrane and within intracellular vesicles, suggests a primary role for PETA-3 in regulating integrin trafficking and/or function...
  12. ncbi CD151
    L K Ashman
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW, Australia
    J Biol Regul Homeost Agents 16:223-6. 2002
  13. ncbi Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms
    S Fitter
    The Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Post Office Box 14, Rundle Mall, Adelaide, South Australia 5000, Australia
    Biochim Biophys Acta 1398:75-85. 1998
    ..Cd151 maps to chromosome 7, in close linkage to the p gene (OCA2 in humans), and helps define a boundary in the human/mouse homology relationships...
  14. ncbi Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin
    P M Sincock
    Department of Medicine, The University of Adelaide, Australia
    J Histochem Cytochem 45:515-25. 1997
    ..However, the lack of co-localization of these antigens in other tissues also implies distinct roles for these molecules...
  15. ncbi Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3
    S Fitter
    Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, Australia
    Blood 86:1348-55. 1995
    ..This pattern correlates well with previous protein expression data. Northern blot analysis of RNA from a range of human tissues indicated that the transcript was present in most tissues, the notable exception being brain...
  16. ncbi Human mast cells derived from fetal liver cells cultured with stem cell factor express a functional CD51/CD61 (alpha v beta 3) integrin
    Y Shimizu
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, USA
    Blood 86:930-9. 1995
    ..This may be important for the recruitment, localization, and retention of developing mast cells...
  17. ncbi The murine monoclonal antibody, 14A2.H1, identifies a novel platelet surface antigen
    L K Ashman
    Department of Microbiology and Immunology, University of Adelaide, South Australia
    Br J Haematol 79:263-70. 1991
    ..Expression of the antigen was not restricted to haemopoietic cells as epithelial cells in tonsillar crypts and endothelial cells were positive...
  18. ncbi Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow
    L K Ashman
    Department of Microbiology and Immunology, University of Adelaide, South Australia
    Blood 78:30-7. 1991
    ..Definition of a reference range of c-kit expression in normal human bone marrow will provide a sound basis for further studies of this marker in diagnosis and prognosis in AML...