Lee H Wong

Summary

Affiliation: Royal Children's Hospital
Country: Australia

Publications

  1. ncbi Transcription within a functional human centromere
    Richard Saffery
    The Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Melbourne, 3052, Australia
    Mol Cell 12:509-16. 2003
  2. pmc Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere
    Lee H Wong
    Chromosome and Chromatin Research Laboratory, Murdoch Children s Research Institute and Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Parkville, Victoria, Australia
    Genome Res 17:1146-60. 2007
  3. pmc Histone H3.3 incorporation provides a unique and functionally essential telomeric chromatin in embryonic stem cells
    Lee H Wong
    Chromosome and Chromatin Research Laboratory, Murdoch Childrens Research Institute, Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Parkville 3052, Victoria, Australia
    Genome Res 19:404-14. 2009
  4. doi Epigenetic regulation of telomere chromatin integrity in pluripotent embryonic stem cells
    Lee H Wong
    Chromosome and Chromatin Research, Murdoch Children s Research Institute, Parkville, Victoria 3052, Australia
    Epigenomics 2:639-55. 2010
  5. pmc ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells
    Lee H Wong
    Chromosome and Chromatin Research, Murdoch Childrens Research Institute, Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Genome Res 20:351-60. 2010
  6. ncbi Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc
    Alka Saxena
    The Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville 3052, Australia
    Hum Mol Genet 11:2319-29. 2002
  7. pmc PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells
    Fiona T M Chang
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Nucleic Acids Res 41:4447-58. 2013
  8. pmc LINE retrotransposon RNA is an essential structural and functional epigenetic component of a core neocentromeric chromatin
    Anderly C Chueh
    Department of Paediatrics, Chromosome and Chromatin Research Laboratory, Murdoch Children s Research Institute, Melbourne University, Royal Children s Hospital, Parkville, Victoria, Australia
    PLoS Genet 5:e1000354. 2009
  9. pmc Active transcription and essential role of RNA polymerase II at the centromere during mitosis
    F Lyn Chan
    Chromosome and Chromatin Research, Department of Paediatrics, Murdoch Childrens Research Institute, Royal Children s Hospital, University of Melbourne, Parkville, Victoria 3052, Australia
    Proc Natl Acad Sci U S A 109:1979-84. 2012
  10. ncbi Analysis of mitotic and expression properties of human neocentromere-based transchromosomes in mice
    Lee H Wong
    Murdoch Childrens Research Institute and Department of Pediatrics, University of Melbourne, Royal Children s Hospital, Flemington Road, Parkville 3052, Victoria, Australia
    J Biol Chem 280:3954-62. 2005

Collaborators

Detail Information

Publications21

  1. ncbi Transcription within a functional human centromere
    Richard Saffery
    The Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Melbourne, 3052, Australia
    Mol Cell 12:509-16. 2003
    ....
  2. pmc Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere
    Lee H Wong
    Chromosome and Chromatin Research Laboratory, Murdoch Children s Research Institute and Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Parkville, Victoria, Australia
    Genome Res 17:1146-60. 2007
    ....
  3. pmc Histone H3.3 incorporation provides a unique and functionally essential telomeric chromatin in embryonic stem cells
    Lee H Wong
    Chromosome and Chromatin Research Laboratory, Murdoch Childrens Research Institute, Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Parkville 3052, Victoria, Australia
    Genome Res 19:404-14. 2009
    ..The distinctive changes in H3.3 distribution suggests the existence of a unique and functionally essential telomere chromatin in ES cells that undergoes dynamic differentiation-dependent remodeling during the process of differentiation...
  4. doi Epigenetic regulation of telomere chromatin integrity in pluripotent embryonic stem cells
    Lee H Wong
    Chromosome and Chromatin Research, Murdoch Children s Research Institute, Parkville, Victoria 3052, Australia
    Epigenomics 2:639-55. 2010
    ..These findings indicate that telomeric chromatin is dynamic and reprogrammable, and has a fundamental role in the maintenance of embryonic stem cell pluripotency...
  5. pmc ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells
    Lee H Wong
    Chromosome and Chromatin Research, Murdoch Childrens Research Institute, Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Genome Res 20:351-60. 2010
    ..These findings suggest a novel function of ATRX, working in conjunction with H3.3 and CBX5, as a key regulator of ES-cell telomere chromatin...
  6. ncbi Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc
    Alka Saxena
    The Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville 3052, Australia
    Hum Mol Genet 11:2319-29. 2002
    ....
  7. pmc PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells
    Fiona T M Chang
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Nucleic Acids Res 41:4447-58. 2013
    ..Our study demonstrates that PML bodies act as epigenetic regulators by serving as platforms for the assembly of the telomeric chromatin to ensure a faithful inheritance of epigenetic information at the telomere...
  8. pmc LINE retrotransposon RNA is an essential structural and functional epigenetic component of a core neocentromeric chromatin
    Anderly C Chueh
    Department of Paediatrics, Chromosome and Chromatin Research Laboratory, Murdoch Children s Research Institute, Melbourne University, Royal Children s Hospital, Parkville, Victoria, Australia
    PLoS Genet 5:e1000354. 2009
    ....
  9. pmc Active transcription and essential role of RNA polymerase II at the centromere during mitosis
    F Lyn Chan
    Chromosome and Chromatin Research, Department of Paediatrics, Murdoch Childrens Research Institute, Royal Children s Hospital, University of Melbourne, Parkville, Victoria 3052, Australia
    Proc Natl Acad Sci U S A 109:1979-84. 2012
    ..These findings demonstrate an essential role of RNAPII in the transcription of α-satellite DNA, binding of centromere protein C, and the proper functioning of the mitotic kinetochore...
  10. ncbi Analysis of mitotic and expression properties of human neocentromere-based transchromosomes in mice
    Lee H Wong
    Murdoch Childrens Research Institute and Department of Pediatrics, University of Melbourne, Royal Children s Hospital, Flemington Road, Parkville 3052, Victoria, Australia
    J Biol Chem 280:3954-62. 2005
    ..They also highlight the need to further understand and overcome the factors that are responsible for the definable rates of instability of these transchromosomes in a mouse model...
  11. pmc Permissive transcriptional activity at the centromere through pockets of DNA hypomethylation
    Nicholas C Wong
    Chromosome Research Laboratory, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    PLoS Genet 2:e17. 2006
    ....
  12. pmc Centromeric chromatin pliability and memory at a human neocentromere
    Jeffrey M Craig
    Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Melbourne, Victoria 3052, Australia
    EMBO J 22:2495-504. 2003
    ..Reversibility of the CENP-A-binding position and the predominant region of delayed replication timing following removal of TSA suggest strong memory at the original site of neocentromeric chromatin formation...
  13. ncbi Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns
    Jeffrey M Craig
    Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Victoria, Australia
    Hum Mol Genet 12:3109-21. 2003
    ..The definition of distinct patterns of chromosomal distribution for these proteins provides a useful basis for the further investigation of the broad-ranging roles of these proteins...
  14. ncbi Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated
    Alka Saxena
    Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Rd, Parkville 3052, Australia
    J Biol Chem 277:26921-6. 2002
    ....
  15. pmc Normal DNA methylation dynamics in DICER1-deficient mouse embryonic stem cells
    Jonathan Ip
    Theme of Genetic Disorders, Murdoch Childrens Research Institute, The Royal Children s Hospital, Parkville, Victoria, Australia
    PLoS Genet 8:e1002919. 2012
    ....
  16. doi Conditional allelic replacement applied to genes encoding the histone variant H3.3 in the mouse
    Michelle C W Tang
    Theme of Genetic Disorders, Murdoch Childrens Research Institute, The Royal Children s Hospital, Victoria, 3052, Australia
    Genesis 51:142-6. 2013
    ..3 protein. Such vectors will allow for the conditional substitution of specific residues in order to dissect the roles of H3.3 post-translational modifications in development and disease...
  17. pmc Neocentromeres: new insights into centromere structure, disease development, and karyotype evolution
    Owen J Marshall
    Chromosome and Chromatin Research, Murdoch Children s Research Institute, Parkville, VIC 3052, Australia
    Am J Hum Genet 82:261-82. 2008
    ..Here, we review recent progress in these areas of research and the significant insights gained...
  18. ncbi Variable and hierarchical size distribution of L1-retroelement-enriched CENP-A clusters within a functional human neocentromere
    Anderly C Chueh
    Chromosome Research Laboratory, Murdoch Childrens Research Institute, Melbourne University Department of Paediatrics, Royal Children s Hospital, Parkville, Australia
    Hum Mol Genet 14:85-93. 2005
    ....
  19. ncbi Evolutionary dynamics of transposable elements at the centromere
    Lee H Wong
    The Murdoch Childrens Research Institute, Department of Paediatrics, Royal Children s Hospital, Flemington Road, Melbourne 3052, Australia
    Trends Genet 20:611-6. 2004
    ..An "extradition" mechanism also appears to have evolved, which enables the developing or established centromere to deal with the potentially disruptive effects of any subsequently arising transposable elements...
  20. ncbi BAC-based PCR fragment microarray: high-resolution detection of chromosomal deletion and duplication breakpoints
    Hua Ren
    Murdoch Childrens Research Institute, University of Melbourne, Royal Children s Hospital, Parkville, Australia
    Hum Mutat 25:476-82. 2005
    ..The results support the potential use of BAC-based PCR fragments to further improve the resolution of the microarray-CGH strategy by an order of magnitude...
  21. ncbi Isolation and characterization of a human STAT1 gene regulatory element. Inducibility by interferon (IFN) types I and II and role of IFN regulatory factor-1
    Lee H Wong
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia
    J Biol Chem 277:19408-17. 2002
    ..Reciprocating regulation between IRF-1 and STAT1 genes and encoded proteins indicates that an intracellular amplifier circuit exists controlling cellular responsiveness to the IFNs...