Research Topics
Genomes and Genes
| Lee H WongSummaryAffiliation: Royal Children's Hospital Country: Australia Publications
| Collaborators
|
Detail Information
Publications
Transcription within a functional human centromereRichard Saffery
The Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Melbourne, 3052, Australia
Mol Cell 12:509-16. 2003....
Histone H3.3 incorporation provides a unique and functionally essential telomeric chromatin in embryonic stem cellsLee H Wong
Chromosome and Chromatin Research Laboratory, Murdoch Childrens Research Institute, Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Parkville 3052, Victoria, Australia
Genome Res 19:404-14. 2009..The distinctive changes in H3.3 distribution suggests the existence of a unique and functionally essential telomere chromatin in ES cells that undergoes dynamic differentiation-dependent remodeling during the process of differentiation...- Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromereLee H Wong
Chromosome and Chromatin Research Laboratory, Murdoch Children s Research Institute and Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Parkville, Victoria, Australia
Genome Res 17:1146-60. 2007.... - ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cellsLee H Wong
Chromosome and Chromatin Research, Murdoch Childrens Research Institute, Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Parkville, Victoria 3052, Australia
Genome Res 20:351-60. 2010..These findings suggest a novel function of ATRX, working in conjunction with H3.3 and CBX5, as a key regulator of ES-cell telomere chromatin... 
Epigenetic regulation of telomere chromatin integrity in pluripotent embryonic stem cellsLee H Wong
Chromosome and Chromatin Research, Murdoch Children s Research Institute, Parkville, Victoria 3052, Australia
Epigenomics 2:639-55. 2010..These findings indicate that telomeric chromatin is dynamic and reprogrammable, and has a fundamental role in the maintenance of embryonic stem cell pluripotency...- Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not CenpcAlka Saxena
The Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville 3052, Australia
Hum Mol Genet 11:2319-29. 2002.... - LINE retrotransposon RNA is an essential structural and functional epigenetic component of a core neocentromeric chromatinAnderly C Chueh
Department of Paediatrics, Chromosome and Chromatin Research Laboratory, Murdoch Children s Research Institute, Melbourne University, Royal Children s Hospital, Parkville, Victoria, Australia
PLoS Genet 5:e1000354. 2009.... - Active transcription and essential role of RNA polymerase II at the centromere during mitosisF Lyn Chan
Chromosome and Chromatin Research, Department of Paediatrics, Murdoch Childrens Research Institute, Royal Children s Hospital, University of Melbourne, Parkville, Victoria 3052, Australia
Proc Natl Acad Sci U S A 109:1979-84. 2012..These findings demonstrate an essential role of RNAPII in the transcription of α-satellite DNA, binding of centromere protein C, and the proper functioning of the mitotic kinetochore... - Analysis of mitotic and expression properties of human neocentromere-based transchromosomes in miceLee H Wong
Murdoch Childrens Research Institute and Department of Pediatrics, University of Melbourne, Royal Children's Hospital, Flemington Road, Parkville 3052, Victoria, Australia
J Biol Chem 280:3954-62. 2005..They also highlight the need to further understand and overcome the factors that are responsible for the definable rates of instability of these transchromosomes in a mouse model... - Permissive transcriptional activity at the centromere through pockets of DNA hypomethylationNicholas C Wong
Chromosome Research Laboratory, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia
PLoS Genet 2:e17. 2006.... - Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patternsJeffrey M Craig
Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Victoria, Australia
Hum Mol Genet 12:3109-21. 2003..The definition of distinct patterns of chromosomal distribution for these proteins provides a useful basis for the further investigation of the broad-ranging roles of these proteins... - Centromeric chromatin pliability and memory at a human neocentromereJeffrey M Craig
Murdoch Childrens Research Institute, Royal Children's Hospital, Flemington Road, Melbourne, Victoria 3052, Australia
EMBO J 22:2495-504. 2003..Reversibility of the CENP-A-binding position and the predominant region of delayed replication timing following removal of TSA suggest strong memory at the original site of neocentromeric chromatin formation... - Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)atedAlka Saxena
Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Rd, Parkville 3052, Australia
J Biol Chem 277:26921-6. 2002.... - Normal DNA methylation dynamics in DICER1-deficient mouse embryonic stem cellsJonathan Ip
Theme of Genetic Disorders, Murdoch Childrens Research Institute, The Royal Children s Hospital, Parkville, Victoria, Australia
PLoS Genet 8:e1002919. 2012.... - Neocentromeres: new insights into centromere structure, disease development, and karyotype evolutionOwen J Marshall
Chromosome and Chromatin Research, Murdoch Children s Research Institute, Parkville, VIC 3052, Australia
Am J Hum Genet 82:261-82. 2008..Here, we review recent progress in these areas of research and the significant insights gained... - PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cellsFiona T M Chang
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia and Department of Paediatrics, University of Melbourne, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Flemington Road, Victoria 3052, Australia
Nucleic Acids Res 41:4447-58. 2013..Our study demonstrates that PML bodies act as epigenetic regulators by serving as platforms for the assembly of the telomeric chromatin to ensure a faithful inheritance of epigenetic information at the telomere... - Variable and hierarchical size distribution of L1-retroelement-enriched CENP-A clusters within a functional human neocentromereAnderly C Chueh
Chromosome Research Laboratory, Murdoch Childrens Research Institute, Melbourne University Department of Paediatrics, Royal Children's Hospital, Parkville, Australia
Hum Mol Genet 14:85-93. 2005.... - Evolutionary dynamics of transposable elements at the centromereLee H Wong
The Murdoch Childrens Research Institute, Department of Paediatrics, Royal Children's Hospital, Flemington Road, Melbourne 3052, Australia
Trends Genet 20:611-6. 2004..An "extradition" mechanism also appears to have evolved, which enables the developing or established centromere to deal with the potentially disruptive effects of any subsequently arising transposable elements... - Conditional allelic replacement applied to genes encoding the histone variant H3.3 in the mouseMichelle C W Tang
Theme of Genetic Disorders, Murdoch Childrens Research Institute, The Royal Children s Hospital, Victoria, 3052, Australia
Genesis 51:142-6. 2013..3 protein. Such vectors will allow for the conditional substitution of specific residues in order to dissect the roles of H3.3 post-translational modifications in development and disease... - BAC-based PCR fragment microarray: high-resolution detection of chromosomal deletion and duplication breakpointsHua Ren
Murdoch Childrens Research Institute, University of Melbourne, Royal Children's Hospital, Parkville, Australia
Hum Mutat 25:476-82. 2005..The results support the potential use of BAC-based PCR fragments to further improve the resolution of the microarray-CGH strategy by an order of magnitude... - Isolation and characterization of a human STAT1 gene regulatory element. Inducibility by interferon (IFN) types I and II and role of IFN regulatory factor-1Lee H Wong
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia
J Biol Chem 277:19408-17. 2002..Reciprocating regulation between IRF-1 and STAT1 genes and encoded proteins indicates that an intracellular amplifier circuit exists controlling cellular responsiveness to the IFNs...