John F Thompson

Summary

Affiliation: Royal Prince Alfred Hospital
Country: Australia

Publications

  1. ncbi Cutaneous melanoma
    John F Thompson
    Sydney Melanoma Unit, University of Sydney at Royal Prince Alfred Hospital, Sydney, Camperdown, New South Wales, Australia
    Lancet 365:687-701. 2005
  2. ncbi Surgical management of primary cutaneous melanoma: excision margins and the role of sentinel lymph node examination
    John F Thompson
    Sydney Melanoma Unit, Level 3, Gloucester House, Sydney Cancer Centre, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2006, Australia
    Surg Oncol Clin N Am 15:301-18. 2006
  3. ncbi Cooperation between surgical oncologists and pathologists: a key element of multidisciplinary care for patients with cancer
    John F Thompson
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia
    Pathology 36:496-503. 2004
  4. ncbi The history and future of melanoma staging
    John F Thompson
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    J Surg Oncol 86:224-35. 2004
  5. ncbi Lymphatic mapping in management of patients with primary cutaneous melanoma
    John F Thompson
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Lancet Oncol 6:877-85. 2005
  6. ncbi Sentinel node biopsy for melanoma: Where have we been and where are we going?
    John F Thompson
    Sydney Melanoma Unit and the Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital, New South Wales, Australia
    Ann Surg Oncol 11:147S-51S. 2004
  7. ncbi False negative sentinel lymph node biopsies in melanoma may result from deficiencies in nuclear medicine, surgery, or pathology
    Rooshdiya Z Karim
    Department of Anatomical Pathology, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Ann Surg 247:1003-10. 2008
  8. ncbi Reduced p16 and increased cyclin D1 and pRb expression are correlated with progression in cutaneous melanocytic tumors
    Rooshdiya Z Karim
    Discipline of Pathology, The University of Sydney, Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital and Melanoma Institute Australia
    Int J Surg Pathol 17:361-7. 2009
  9. ncbi Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins
    Liqing Zhuang
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Mod Pathol 23:45-53. 2010
  10. ncbi Clinical and pathologic factors associated with distant metastasis and survival in patients with thin primary cutaneous melanoma
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Ann Surg Oncol 19:1782-9. 2012

Collaborators

Detail Information

Publications103 found, 100 shown here

  1. ncbi Cutaneous melanoma
    John F Thompson
    Sydney Melanoma Unit, University of Sydney at Royal Prince Alfred Hospital, Sydney, Camperdown, New South Wales, Australia
    Lancet 365:687-701. 2005
    ....
  2. ncbi Surgical management of primary cutaneous melanoma: excision margins and the role of sentinel lymph node examination
    John F Thompson
    Sydney Melanoma Unit, Level 3, Gloucester House, Sydney Cancer Centre, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2006, Australia
    Surg Oncol Clin N Am 15:301-18. 2006
    ..Minimally invasive and noninvasive methods of SN assessment, such as magnetic resonance spectroscopy, are being evaluated...
  3. ncbi Cooperation between surgical oncologists and pathologists: a key element of multidisciplinary care for patients with cancer
    John F Thompson
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia
    Pathology 36:496-503. 2004
    ..By cooperating fully and communicating freely with each other, surgical oncologists and pathologists can ensure high standards of initial and subsequent care for cancer patients...
  4. ncbi The history and future of melanoma staging
    John F Thompson
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    J Surg Oncol 86:224-35. 2004
    ..A further advantage would be that because there would be a direct link between staging and prognostic estimate, such a system would be more readily able to be understood in an intuitive fashion...
  5. ncbi Lymphatic mapping in management of patients with primary cutaneous melanoma
    John F Thompson
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Lancet Oncol 6:877-85. 2005
    ..Because it is impossible to predict the site or sites of sentinel nodes clinically in individual patients, routine preoperative lymphoscintigraphy is a prerequisite if reliable results are to be obtained from sentinel-node biopsy...
  6. ncbi Sentinel node biopsy for melanoma: Where have we been and where are we going?
    John F Thompson
    Sydney Melanoma Unit and the Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital, New South Wales, Australia
    Ann Surg Oncol 11:147S-51S. 2004
    ..Techniques such as in vivo proton magnetic resonance spectroscopy hold great promise and suggest that this goal might be achievable...
  7. ncbi False negative sentinel lymph node biopsies in melanoma may result from deficiencies in nuclear medicine, surgery, or pathology
    Rooshdiya Z Karim
    Department of Anatomical Pathology, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Ann Surg 247:1003-10. 2008
    ..To investigate a cohort of melanoma patients with false negative (FN) sentinel node (SN) biopsies (SNBs) to identify the reasons for the FN result...
  8. ncbi Reduced p16 and increased cyclin D1 and pRb expression are correlated with progression in cutaneous melanocytic tumors
    Rooshdiya Z Karim
    Discipline of Pathology, The University of Sydney, Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital and Melanoma Institute Australia
    Int J Surg Pathol 17:361-7. 2009
    ..Alterations in cell cycle proteins involved in G1/S transition are implicated in melanocytic tumor progression and have a potential role in diagnosis and prognostication...
  9. ncbi Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins
    Liqing Zhuang
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Mod Pathol 23:45-53. 2010
    ..The strong correlation of LDH-5 expression with Mcl-1 expression suggests that treatment strategies inhibiting the activity of Mcl-1 in melanoma patients should be investigated...
  10. ncbi Clinical and pathologic factors associated with distant metastasis and survival in patients with thin primary cutaneous melanoma
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Ann Surg Oncol 19:1782-9. 2012
    ..We sought to identify clinical and pathologic factors associated with distant metastasis and survival in a large number of patients with thin melanoma treated at a single institution...
  11. ncbi Outcome in 846 cutaneous melanoma patients from a single center after a negative sentinel node biopsy
    Vivian S K Yee
    Sydney Melanoma Unit, Sydney Cancer Centre, Gloucester House, Royal Prince Alfred Hospital, Missenden Road, Camperdown, 2050 New South Wales, Australia
    Ann Surg Oncol 12:429-39. 2005
    ..In those with a negative SNB, primary tumor thickness and ulceration are independent predictors of survival. Incorrect pathologic diagnosis contributed to only a minority of the false-negative results in this study...
  12. ncbi False-negative sentinel node biopsy because of obstruction of lymphatics by metastatic melanoma: the value of ultrasound in conjunction with preoperative lymphoscintigraphy
    Tai K Lam
    Melanoma Institute Australia, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Melanoma Res 19:94-9. 2009
    ..They also highlight the advantages of using ultrasound to assess lymph nodes in any node fields to which lymphatic drainage occurs from a primary tumour site...
  13. ncbi Progression in melanoma is associated with decreased expression of death receptors for tumor necrosis factor-related apoptosis-inducing ligand
    Liqing Zhuang
    Discipline of Pathology, Faculty of Medicine, University of Sydney, Sydney, New South Wales 2006, Australia
    Hum Pathol 37:1286-94. 2006
    ..This suggests that melanoma may not respond to treatment with TRAIL unless given with agents that increase the expression of TRAIL death receptors...
  14. ncbi Confirmation of sentinel lymph node identity by analysis of fine-needle biopsy samples using inductively coupled plasma-mass spectrometry
    Alison Beavis
    Department of Chemistry, Materials and Forensic Science, University of Technology, Sydney, New South Wales, Australia
    Ann Surg Oncol 15:934-40. 2008
    ..This involved the use of inductively coupled plasma-mass spectrometry (ICP-MS) to analyze antimony concentrations in fine-needle biopsy (FNB) samples from surgically procured lymph nodes...
  15. ncbi Diagnostic accuracy of fine needle biopsy for metastatic melanoma and its implications for patient management
    Anna Doubrovsky
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia
    Ann Surg Oncol 15:323-32. 2008
    ..In this study, the accuracy of FNB for the diagnosis of metastatic melanoma was investigated...
  16. ncbi Antimony concentrations in nodal tissue can confirm sentinel node identity
    Richard A Scolyer
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Mod Pathol 17:1191-7. 2004
    ....
  17. ncbi Targeted high-resolution ultrasound is not an effective substitute for sentinel lymph node biopsy in patients with primary cutaneous melanoma
    Amira Sanki
    Melanoma Institute Australia and Sydney Melanoma Unit, Royal Prince Alfred and Mater Hospitals, Sydney, New South Wales, Australia
    J Clin Oncol 27:5614-9. 2009
    ....
  18. ncbi Failure to remove true sentinel nodes can cause failure of the sentinel node biopsy technique: evidence from antimony concentrations in false-negative sentinel nodes from melanoma patients
    Richard A Scolyer
    Sydney Melanoma Unit and Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital, Camperdown, Australia
    Ann Surg Oncol 11:174S-8S. 2004
    ..Our results suggest that an FN SNB can occur because of failure to remove the true SN as well as histopathologic misdiagnosis...
  19. ncbi Sentinel lymph nodes containing very small (<0.1 mm) deposits of metastatic melanoma cannot be safely regarded as tumor-negative
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, and Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia
    Ann Surg Oncol 19:1089-99. 2012
    ....
  20. ncbi Sentinel lymph node biopsy in pediatric and adolescent cutaneous melanoma patients
    Robert Howman-Giles
    Sydney Melanoma Unit and Melanoma Institute Australia, Royal Prince Alfred and Mater Hospitals, Sydney, NSW, Australia
    Ann Surg Oncol 17:138-43. 2010
    ..The present study takes advantage of the large Sydney Melanoma Unit (SMU) database to clarify this issue...
  21. ncbi The prognostic importance of tumor mitotic rate confirmed in 1317 patients with primary cutaneous melanoma and long follow-up
    Anne Brecht Francken
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Ann Surg Oncol 11:426-33. 2004
    ..However, its predictive value was less than it was when assessed according to the 1982 revisions of the 1972 TMR recommendations...
  22. ncbi Sentinel lymph node biopsy in patients with thin primary cutaneous melanoma
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
    Ann Surg 255:128-33. 2012
    ....
  23. ncbi Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma
    Liqing Zhuang
    Discipline of Pathology, Faculty of Medicine, The University of Sydney, Sydney, NSW, Australia
    Mod Pathol 20:416-26. 2007
    ..These findings have important implications for the development of treatments targeting antiapoptotic proteins in patients with melanoma...
  24. ncbi Adjuvant postoperative radiotherapy to the cervical lymph nodes in cutaneous melanoma: is there any benefit for high-risk patients?
    Marc D Moncrieff
    The Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
    Ann Surg Oncol 15:3022-7. 2008
    ..The use of adjuvant radiotherapy after lymph node dissection for metastatic melanoma remains controversial. This study examined the effectiveness of adjuvant radiotherapy in controlling regional disease in high-risk patients...
  25. ncbi Prognosis and determinants of outcome following locoregional or distant recurrence in patients with cutaneous melanoma
    Anne Brecht Francken
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Ann Surg Oncol 15:1476-84. 2008
    ..Information on prognosis for patients with cutaneous melanoma after locoregional or distant recurrence is sparse and controversial. The aim of this study was to analyze factors influencing outcome after the development of a first relapse...
  26. ncbi Management of merkel cell carcinoma: the roles of lymphoscintigraphy, sentinel lymph node biopsy and adjuvant radiotherapy
    Ross E Warner
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, 2050, Australia
    Ann Surg Oncol 15:2509-18. 2008
    ..However, its optimal treatment is uncertain. In this study, we aimed to assess the roles of lymphoscintigraphy and sentinel node (SN) biopsy, as well as radiotherapy, in the treatment of MCC...
  27. ncbi Isolated limb infusion for advanced soft tissue sarcoma of the extremity
    Marc D Moncrieff
    The Sydney Melanoma Unit, Gloucester House, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Ann Surg Oncol 15:2749-56. 2008
    ..Isolated limb infusion (ILI) is a minimally invasive technique for delivering high-dose regional chemotherapy. We report our experience with ILI for the treatment of soft tissue sarcoma (STS)...
  28. ncbi Diagnosis of metastatic melanoma by fine-needle biopsy: analysis of 2,204 cases
    Rajmohan Murali
    Department of Anatomical Pathology, Sydney Cancer Centre, Australia
    Am J Clin Pathol 127:385-97. 2007
    ..FNB is a highly accurate, rapid, and cost-effective procedure for the diagnosis of metastatic melanoma and should be considered as the initial diagnostic procedure of choice in patients with melanoma with clinically suspected metastases...
  29. ncbi Expression of glucose-regulated stress protein GRP78 is related to progression of melanoma
    Liquing Zhuang
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Histopathology 54:462-70. 2009
    ..The aim of this study was to investigate its expression and role in the development and progression of human melanoma...
  30. ncbi Synchronous and metachronous malignancies in patients with melanoma: a clinicopathologic study highlighting the role of fine-needle biopsy cytology and potential diagnostic pitfalls
    Caroline L Cooper
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia
    Melanoma Res 20:203-11. 2010
    ..Careful assessment of the FNB cytologic features and directed use of ancillary studies should enable accurate diagnosis in most cases and facilitate appropriate patient management...
  31. ncbi A sentinel node biopsy does not increase the incidence of in-transit metastasis in patients with primary cutaneous melanoma
    Daan van Poll
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales 2050, Australia
    Ann Surg Oncol 12:597-608. 2005
    ..2%, compared with 10.8% in patients with a tumor-positive sentinel node treated with immediate dissection (n = 102; P = .03). CONCLUSIONS: Performing an SNB in patients with melanoma treated by WLE does not increase the incidence of ITM...
  32. ncbi Detection of first relapse in cutaneous melanoma patients: implications for the formulation of evidence-based follow-up guidelines
    Anne Brecht Francken
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, 1A Eden Street, North Sydney, New South Wales, 2050, Australia
    Ann Surg Oncol 14:1924-33. 2007
    ..In this prospective study the frequency of detection of first melanoma recurrence (FMR) by patient or doctor was analyzed to assist in the future design of evidence-based follow-up guidelines...
  33. ncbi Prognostic factors in cutaneous desmoplastic melanoma: a study of 252 patients
    Rajmohan Murali
    Diagnostic Oncology and Tissue Pathology, Royal Prince Alfred Hospital, Camperdown, Sydney, New South Wales, Australia
    Cancer 116:4130-8. 2010
    ..Primary melanomas either may be entirely desmoplastic or almost entirely desmoplastic (pure DM [pDM]) or may exhibit a desmoplastic component admixed with a nondesmoplastic component (combined DM [cDM])...
  34. ncbi Immunohistochemical stains fail to increase the detection rate of micrometastatic melanoma in completion regional lymph node dissection specimens
    Richard A Scolyer
    Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Melanoma Res 14:263-8. 2004
    ..We therefore recommend only H&E staining on sections of all lymph nodes in CLND specimens from melanoma patients...
  35. ncbi Reduced expression of p16 and p27 is correlated with tumour progression in cutaneous melanoma
    Amira Sanki
    Sydney Melanoma Unit, Sydney Cancer Centre, Department of Anatomical Pathology, Royal Prince Alfred Hospital, and Discipline of Surgery, University of Sydney, NSW, Australia
    Pathology 39:551-7. 2007
    ..To determine if the cyclin dependent kinase inhibitors (CDKIs) p16 and p27 show reduced expression in the progression from benign to malignant melanocytic tumours, and to correlate these findings with patient prognosis...
  36. ncbi Pathology of melanocytic lesions: new, controversial, and clinically important issues
    Richard A Scolyer
    Sydney Melanoma Unit and Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    J Surg Oncol 86:200-11. 2004
    ....
  37. ncbi Correlation between preoperative lymphoscintigraphy and metastatic nodal disease sites in 362 patients with cutaneous melanomas of the head and neck
    Johannes H W de Wilt
    Sydney Melanoma Unit and the Melanoma and Skin Cancer Research Institute, Sydney Cancer Centre, Royal Prince Alfred Hospital, New South Wales, Australia
    Ann Surg 239:544-52. 2004
    ..7%). CONCLUSIONS: Metastases from head and neck melanomas can occur in any SN demonstrated by lymphoscintigraphy. SNs in discordant as well as predicted node fields should be removed and examined to optimize the accuracy of staging...
  38. ncbi Outcomes following isolated limb infusion for melanoma. A 14-year experience
    Hidde M Kroon
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Ann Surg Oncol 15:3003-13. 2008
    ..It is essentially a low-flow isolated limb perfusion (ILP) performed via percutaneous catheters without oxygenation...
  39. ncbi Free flap reconstruction for melanoma of the head and neck: indications and outcomes
    Marc D Moncrieff
    Sydney Head and Neck Cancer Institute, Royal Prince Alfred Hospital, Camperdown, New South Wales 2050, Australia
    J Plast Reconstr Aesthet Surg 63:205-12. 2010
    ..The primary aim of this study was to assess whether there was any evidence that adopting an aggressive surgical approach provided a survival benefit for these patients...
  40. ncbi Quality assurance parameters and predictors of outcome for ilioinguinal and inguinal dissection in a contemporary melanoma patient population
    Andrew J Spillane
    Sydney Medical School, The University of Sydney, Sydney, Australia
    Ann Surg Oncol 18:2521-8. 2011
    ..This study was designed to provide LN retrieval parameters for inguinal and ilioinguinal LN dissections, and secondarily, to analyze known predictors for survival outcomes, including LN ratio, i.e., involved/total number LN removed...
  41. ncbi Guidelines for lymphoscintigraphy and F18 FDG PET scans in melanoma
    Roger F Uren
    Sydney Medical School, The University of Sydney, Sydney, NSW, Australia
    J Surg Oncol 104:405-19. 2011
    ..PET using F18-FDG can detect metastases and is used to restage patients with AJCC Stages III and IV disease before planning surgery with curative intent...
  42. ncbi Pathologic review of negative sentinel lymph nodes in melanoma patients with regional recurrence: a clinicopathologic study of 1152 patients undergoing sentinel lymph node biopsy
    Ling-Xi L Li
    Melanoma and Skin Cancer Research Institute, Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NWS, Australia
    Am J Surg Pathol 27:1197-202. 2003
    ....
  43. ncbi Defining lower limb lymphedema after inguinal or ilio-inguinal dissection in patients with melanoma using classification and regression tree analysis
    Andrew J Spillane
    Sydney Melanoma Unit at the Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, Australia
    Ann Surg 248:286-93. 2008
    ..This study aims to objectively define the criteria for assessing the presence of lymphedema and to report the prevalence of lymphedema after inguinal and ilio-inguinal (inguinal and pelvic) lymph node dissection for metastatic melanoma...
  44. ncbi Efficacy of repeat isolated limb infusion with melphalan and actinomycin D for recurrent melanoma
    Hidde M Kroon
    Sydney Melanoma Unit, Sydney Cancer Center, Royal Prince Alfred Hospital, Sydney, Australia
    Cancer 115:1932-40. 2009
    ..Recurrent or progressive disease after an ILI, however, presents a challenge for further treatment. The value of repeat ILI in this situation has not been well documented...
  45. ncbi Melanoma metastases in regional lymph nodes are accurately detected by proton magnetic resonance spectroscopy of fine-needle aspirate biopsy samples
    Jonathan R Stretch
    Sydney Melanoma Unit and Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital, Camperdown, New South Wales 2050, Australia
    Ann Surg Oncol 12:943-9. 2005
    ..These data indicate the potential for SN staging of melanoma without surgical biopsy and histopathological evaluation...
  46. ncbi Subungual melanoma: a study of 124 cases highlighting features of early lesions, potential pitfalls in diagnosis, and guidelines for histologic reporting
    Kong Bing Tan
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, Australia
    Am J Surg Pathol 31:1902-12. 2007
    ..Guidelines for the reporting of SUMs are also presented. Knowledge and recognition of the pathologic features of SUMs and the important features that distinguish them from nevi should reduce the frequency of misdiagnosis...
  47. ncbi Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma
    Alexander M Menzies
    Melanoma Institute Australia, Disciplines of Medicine, Surgery, Pathology, and Westmead Institute for Cancer Research, Westmead Millennium Institute, The University of Sydney, Sydney, New South Wales, Australia
    Clin Cancer Res 18:3242-9. 2012
    ..Methods: A prospectively assembled cohort of Australian patients were followed from diagnosis of metastatic melanoma (N = 308). Clinicopathologic variables were correlated with BRAF mutational status, genotype, and survival...
  48. ncbi Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma
    James S Wilmott
    Melanoma Institute Australia, Sydney, NSW, Australia
    Clin Cancer Res 18:1386-94. 2012
    ..To evaluate the effects of treatment with the potent mutant BRAF inhibitors GSK2118436 or vemurafenib (PLX4720) on immune responses to metastatic melanoma in tissues taken before and after treatment...
  49. ncbi Safety and efficacy of isolated limb infusion with cytotoxic drugs in elderly patients with advanced locoregional melanoma
    Hidde M Kroon
    Sydney Melanoma Unit, Sydney Cancer Center, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
    Ann Surg 249:1008-13. 2009
    ..Isolated limb infusion (ILI) is an effective minimally invasive alternative to isolated limb perfusion (ILP) and is therefore a potentially valuable therapeutic option for this group...
  50. ncbi Keystone flap reconstruction of primary melanoma excision defects of the leg-the end of the skin graft?
    Marc D Moncrieff
    Sydney Melanoma Unit, 1A Eden Street, North Sydney, NSW, 2060, Australia
    Ann Surg Oncol 15:2867-73. 2008
    ..During the last 4 years, the keystone-design fasciocutaneous island flap has become the principal form of reconstruction in our unit for primary melanoma defects of the leg distal to the knee where primary closure is not possible...
  51. ncbi Sentinel lymph node biopsy in histologically ambiguous melanocytic tumors with spitzoid features (so-called atypical spitzoid tumors)
    Rajmohan Murali
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, 2050, Australia
    Ann Surg Oncol 15:302-9. 2008
    ..The current study evaluated the role of sentinel lymph node (SLN) biopsy in patients with such atypical spitzoid tumors...
  52. ncbi Sentinel lymph node biopsy for melanoma: aspects of pathologic assessment
    Rajmohan Murali
    Royal Prince Alfred Hospital, Department of Anatomical Pathology, Camperdown, Sydney, NSW 2050, Australia
    Future Oncol 4:535-51. 2008
    ..Several non-histopathologic methods of SLN evaluation have been investigated, and while some of them show promise for the future, excision and histopathologic examination currently remains the gold standard for the evaluation of SLNs...
  53. ncbi Factors predicting recurrence and survival in sentinel lymph node-positive melanoma patients
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Ann Surg 253:1155-64. 2011
    ..We investigated in detail the influence of SN tumor characteristics and clinical and primary tumor parameters on clinical outcomes in a large cohort of patients treated in a single center...
  54. ncbi Factors predictive of acute regional toxicity after isolated limb infusion with melphalan and actinomycin D in melanoma patients
    Hidde M Kroon
    Sydney Melanoma Unit and Melanoma Institute Australia, Royal Prince Alfred and Mater Hospitals, Sydney, NSW, Australia
    Ann Surg Oncol 16:1184-92. 2009
    ..Previously we have shown that more significant limb toxicity is not associated with a higher response rate or improved patient outcome. In this study we sought to determine factors predicting toxicity following ILI...
  55. ncbi The Sydney Melanoma Unit--a multidisciplinary melanoma treatment center
    John F Thompson
    Sydney Melanoma Unit, Sydney Cancer Center, Royal Prince Alfred Hospital, Missenden Road, Camperdown, New South Wales, Australia 2050
    Surg Clin North Am 83:431-51. 2003
    ....
  56. ncbi Clinical and pathological features of metastases of primary cutaneous desmoplastic melanoma
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Histopathology 58:886-95. 2011
    ..Our aim was to describe the histological features of metastases of primary DM and to determine whether they were predictive of outcome...
  57. ncbi Use of multiple cytometric markers improves discrimination between benign and malignant melanocytic lesions: a study of DNA microdensitometry, karyometry, argyrophilic staining of nucleolar organizer regions and MIB1-Ki67 immunoreactivity
    Ling-Xi L Li
    Melanoma and Skin Cancer Research Institute, Sydney Melanoma Unit and Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
    Melanoma Res 13:581-6. 2003
    ..This may be of particular significance in the diagnosis of melanocytic lesions whose biological behaviour cannot be confidently predicted by their histological features using conventional microscopy...
  58. ncbi Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma
    Georgina V Long
    Melanoma Institute Australia, 40 Rocklands Rd, North Sydney, New South Wales, 2060, Australia
    J Clin Oncol 29:1239-46. 2011
    ..To assess the frequency and type of oncogenic BRAF mutations in metastatic melanoma and correlate BRAF status with clinicopathologic features and outcome...
  59. ncbi The complex relationships between sentinel node positivity, patient age, and primary tumor desmoplasia: analysis of 2303 melanoma patients treated at a single center
    Sander Sassen
    Sydney Melanoma Unit, Sydney Cancer Centre, Gloucester House, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
    Ann Surg Oncol 15:630-7. 2008
    ..In addition, desmoplastic melanomas are associated with a lower frequency of SN positivity, although this is less well documented...
  60. ncbi Sentinel node mapping for melanoma: results of trials and current applications
    John F Thompson
    Discipline of Surgery, The University of Sydney, Royal Prince Alfred Hospital, Missenden Road, Camperdown NSW 2050, Sydney, Australia
    Surg Oncol Clin N Am 16:35-54. 2007
    ..Clinical trials are ongoing to determine whether CLND is necessary in all patients who are found to be SN positive...
  61. ncbi Isolated limb infusion as palliative treatment for advanced limb disease in patients with AJCC stage IV melanoma
    Hidde M Kroon
    Sydney Melanoma Unit and Melanoma Institute Australia, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, Australia
    Ann Surg Oncol 16:1193-201. 2009
    ..Isolated limb infusion (ILI) has proved to be a useful limb-saving treatment and could potentially be of palliative value in patients with American Joint Committee on Cancer (AJCC) stage IV melanoma...
  62. ncbi Pathologic examination of sentinel lymph nodes from melanoma patients
    Richard A Scolyer
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Semin Diagn Pathol 25:100-11. 2008
    ..At present, the role of nonhistopathologic methods of SN evaluation, such as reverse transcription polymerase chain reaction (RT-PCR) and magnetic resonance spectroscopy, remains unclear, and these techniques require further evaluation...
  63. ncbi Interobserver variation in the histopathologic reporting of key prognostic parameters, particularly clark level, affects pathologic staging of primary cutaneous melanoma
    Rajmohan Murali
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
    Ann Surg 249:641-7. 2009
    ..However, detailed quantification of the magnitude of variation between observers and its effect on melanoma staging has not been reported...
  64. ncbi Lymph node ratio provides prognostic information in addition to american joint committee on cancer N stage in patients with melanoma, even if quality of surgery is standardized
    Andrew J Spillane
    Sydney Medical School, The University of Sydney, Sydney, Australia
    Ann Surg 253:109-15. 2011
    ....
  65. ncbi Role of lymphoscintigraphy for selective sentinel lymphadenectomy
    Roger F Uren
    Nuclear Medicine and Diagnostic Ultrasound, RPAH Medical Centre and Discipline of Medicine, The University of Sydney, Sydney, NSW, Australia
    Cancer Treat Res 127:15-38. 2005
    ..LS is an important first step in ensuring that this goal is achieved...
  66. ncbi Selective sentinel lymphadenectomy: progress to date and prospects for the future
    John F Thompson
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia
    Cancer Treat Res 127:269-87. 2005
    ....
  67. ncbi Does increased experience with isolated limb infusion for advanced limb melanoma influence outcome? A comparison of two treatment periods at a single institution
    Anna M Huismans
    Melanoma Institute Australia, Sydney, NSW, Australia
    Ann Surg Oncol 18:1877-83. 2011
    ..Over this time the technique has undergone progressive modification. In this study we evaluated our experience with ILI by analyzing outcome and toxicity from an "early" and a "late" treatment period...
  68. ncbi Desmoplastic neurotropic melanoma: a clinicopathologic analysis of 128 cases
    James Y Chen
    Department of Radiation Oncology, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Cancer 113:2770-8. 2008
    ..The authors investigated the local recurrence rates for patients with DNM after surgery alone or surgery followed by radiotherapy (RT)...
  69. ncbi Merkel cell carcinoma: assessing the effect of wide local excision, lymph node dissection, and radiotherapy on recurrence and survival in early-stage disease--results from a review of 82 consecutive cases diagnosed between 1992 and 2004
    James Jabbour
    Sydney Cancer Centre, Sydney, Australia
    Ann Surg Oncol 14:1943-52. 2007
    ..Wide surgical excision, lymph node dissection, and radiotherapy have been used with varying efficacy in the management of early-stage Merkel cell carcinoma...
  70. ncbi Sentinel node positive melanoma patients: prediction and prognostic significance of nonsentinel node metastases and development of a survival tree model
    Martin Wiener
    Melanoma Institute Australia formerly Sydney Melanoma Unit, Sydney, NSW, Australia
    Ann Surg Oncol 17:1995-2005. 2010
    ..This study aimed to establish whether NSN status can be predicted, to determine its effect on survival, and to develop survival tree models for the sentinel node (SN) positive population...
  71. ncbi Case records of the Massachusetts General Hospital. Case 2-2007. A 49-year-old woman with a pigmented lesion on the arm
    John F Thompson
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, Australia
    N Engl J Med 356:285-92. 2007
  72. ncbi The role of surveillance chest X-rays in the follow-up of high-risk melanoma patients
    Rachael L Morton
    School of Public Health, The University of Sydney, Sydney, NSW, Australia
    Ann Surg Oncol 16:571-7. 2009
    ..Further, they may cause unnecessary patient anxiety, given the high rate of false-positive findings...
  73. ncbi Treatment of metastatic melanoma using electroporation therapy with bleomycin (electrochemotherapy)
    Christopher M Byrne
    The Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown and Discipline of Surgery, The University of Sydney, Sydney, NSW, Australia
    Melanoma Res 15:45-51. 2005
    ..Of the total of 54 lesions treated with bleomycin+EPT, there was a 72% objective response rate. EPT treatment was well tolerated and was performed on an outpatient basis...
  74. ncbi Prognostic factors after isolated limb infusion with cytotoxic agents for melanoma
    Per Lindner
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, USA
    Ann Surg Oncol 9:127-36. 2002
    ..Isolated limb infusion (ILI), essentially a low-flow ILP performed without oxygenation via percutaneous catheters, has been developed as a simpler alternative...
  75. ncbi Patterns of lymphatic drainage from the skin in patients with melanoma
    Roger F Uren
    Nuclear Medicine and Diagnostic Ultrasound, RPAH Medical Centre, 100 Carillon Avenue, Newtown, Sydney, New South Wales 2042, Australia
    J Nucl Med 44:570-82. 2003
    ..Micrometastatic disease can be present in any sentinel node regardless of its location, and for the SLNB technique to be accurate, all true sentinel nodes must be biopsied in every patient...
  76. ncbi Adjuvant immunotherapy of patients with high-risk melanoma using vaccinia viral lysates of melanoma: results of a randomized trial
    Peter Hersey
    Sydney Melanoma Unit, University of Sydney and Royal Prince Alfred Hospital, and the Cancer Council Australia, Sydney
    J Clin Oncol 20:4181-90. 2002
    ..We therefore elected to test this therapy in a phase III study...
  77. ncbi Proposed quality standards for regional lymph node dissections in patients with melanoma
    Andrew J Spillane
    Melanoma Institute of Australia, and University of Sydney, North Sydney, Australia
    Ann Surg 249:473-80. 2009
    ..The experience of the Sydney Melanoma Unit (SMU) is documented to offer quality assurance (QA) standards and an acceptable range for lymph node yield for regional lymph node dissection (RLND) in melanoma patients...
  78. ncbi The value of sentinel node biopsy in patients with primary cutaneous melanoma
    John F Thompson
    Sydney Cancer Centre, Royal Prince Alfred Hospital and Discipline of Surgery, The University of Sydney, Australia
    Dermatol Surg 34:550-4; discussion 554-5. 2008
  79. ncbi Current status of isolated limb infusion with mild hyperthermia for melanoma
    John F Thompson
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Int J Hyperthermia 24:219-25. 2008
    ..Regional chemotherapy by isolated limb perfusion (ILP) provides effective treatment but is invasive, complex and costly. Isolated limb infusion (ILI) is a simple yet effective alternative to ILP...
  80. ncbi The reproducibility in routine clinical practice of sentinel lymph node identification by pre-operative lymphoscintigraphy in patients with cutaneous melanoma
    Roger F Uren
    Nuclear Medicine and Diagnostic Ultrasound, RPAH Medical Centre and Discipline of Medicine, The University of Sydney, Sydney, NSW, Australia
    Ann Surg Oncol 14:899-905. 2007
    ..These results indicate that in routine clinical practice LS is a highly reproducible procedure to locate and radiolabel the SLNs prior to biopsy in patients with melanoma...
  81. ncbi Teaching points on lymphatic mapping for melanoma from the Sydney Melanoma Unit
    John F Thompson
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Semin Oncol 31:349-56. 2004
    ....
  82. ncbi Non-Sentinel Node Risk Score (N-SNORE): a scoring system for accurately stratifying risk of non-sentinel node positivity in patients with cutaneous melanoma with positive sentinel lymph nodes
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    J Clin Oncol 28:4441-9. 2010
    ..We investigated clinicopathologic factors that predict NSN positivity in an attempt to identify patients who may be safely spared completion lymph node dissection (CLND)...
  83. ncbi Chemoablation of metastatic melanoma using intralesional Rose Bengal
    John F Thompson
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Melanoma Res 18:405-11. 2008
    ..These findings indicate that intralesional Rose Bengal is nontoxic and could benefit patients with metastatic melanoma...
  84. ncbi The detection and significance of melanoma micrometastases in sentinel nodes
    Richard A Scolyer
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
    Surg Oncol 17:165-74. 2008
    ....
  85. ncbi Internal mammary node metastasis from primary cutaneous melanoma on the anterior chest
    John F Thompson
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
    ANZ J Surg 75:723-5. 2005
    ....
  86. ncbi Antimony by ICP-MS as a marker for sentinel lymph nodes in melanoma patients
    Michael Dawson
    Department of Chemistry, Materials and Forensic Science, University of Technology, Sydney, 1 Broadway, Broadway, NSW 2007, Australia
    Analyst 128:217-9. 2003
    ..A sensitive, accurate and specific method for the analysis of antimony by ICP-MS is presented as a marker of the sentinel lymph node in melanoma patients...
  87. ncbi Sentinel-node biopsy or nodal observation in melanoma
    Donald L Morton
    Department of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
    N Engl J Med 355:1307-17. 2006
    ..We evaluated the contribution of sentinel-node biopsy to outcomes in patients with newly diagnosed melanoma...
  88. ncbi The risk of in-transit melanoma metastasis depends on tumor biology and not the surgical approach to regional lymph nodes
    Timothy M Pawlik
    Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA
    J Clin Oncol 23:4588-90. 2005
  89. ncbi The role of lymphoscintigraphy in the detection of lymph node drainage in melanoma
    Roger F Uren
    Nuclear Medicine and Diagnostic Ultrasound, RPAH Medical Centre, 100 Carillon Avenue, Newtown, NSW 2042, Australia
    Surg Oncol Clin N Am 15:285-300. 2006
    ..In this way, lymphoscintigraphy has a direct beneficial impact on the surgical management of patients who have melanoma...
  90. ncbi Melanoma patients with positive sentinel nodes who did not undergo completion lymphadenectomy: a multi-institutional study
    Sandra L Wong
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Ann Surg Oncol 13:809-16. 2006
    ..CONCLUSIONS: This study underscores the importance of ongoing prospective randomized trials in determining the therapeutic value of CLND after positive SLN biopsy in melanoma patients...
  91. ncbi The prognosis of patients with thick primary melanomas: is regional lymph node status relevant, and does removing positive regional nodes influence outcome?
    John F Thompson
    Ann Surg Oncol 9:719-22. 2002
  92. ncbi Is sentinel lymph node biopsy appropriate in patients with thin melanomas: too early to tell?
    John F Thompson
    Ann Surg Oncol 13:279-81. 2006
  93. ncbi Frequency of nonsentinel lymph node metastasis in melanoma
    Helen M Shaw
    Ann Surg Oncol 9:934;author reply 934-5. 2002
  94. ncbi Sentinel node biopsy for early-stage melanoma: accuracy and morbidity in MSLT-I, an international multicenter trial
    Donald L Morton
    John Wayne Cancer Institute, Santa Monica, CA 90404, USA
    Ann Surg 242:302-11; discussion 311-3. 2005
    ..LM/SNB should become standard care for staging the regional lymph nodes of patients with primary cutaneous melanoma...
  95. ncbi Re: Selective lymphadenectomy in sentinel node-positive patients may increase the risk of local/in-transit recurrence in malignant melanoma, Thomas and Clark
    Timothy M Pawlik
    Eur J Surg Oncol 31:323-4. 2005
  96. ncbi Authors' response to a letter to the editor re: Sentinel node biopsy for early-stage melanoma
    Donald L Morton
    Ann Surg 245:828-9. 2007
  97. ncbi Three-dimensional visualisation of lymphatic drainage patterns in patients with cutaneous melanoma
    Hayley M Reynolds
    Bioengineering Institute, University of Auckland, Auckland, New Zealand
    Lancet Oncol 8:806-12. 2007
    ..We aimed to map these data onto a three-dimensional computer model to provide improved visualisation and analysis of lymphatic drainage from sites of cutaneous melanoma...
  98. ncbi An evidence-based staging system for cutaneous melanoma
    Charles M Balch
    American Society of Clinical Oncology, Alexandria, VA, USA
    CA Cancer J Clin 54:131-49; quiz 182-4. 2004
    ..6) A new convention was implemented for defining clinical and pathological staging so as to take into account the new staging information gained from lymphatic mapping and sentinel node biopsy...
  99. ncbi Lymphatic mapping and sentinel node biopsy: the data unclouded by speculation
    Alistair J Cochran
    Arch Dermatol 144:687-8; author reply 688-9. 2008
  100. ncbi New TNM melanoma staging system: linking biology and natural history to clinical outcomes
    Charles M Balch
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Semin Surg Oncol 21:43-52. 2003
    ....
  101. ncbi The prognostic significance of isolated immunohistochemically positive cells in sentinel lymph nodes of melanoma patients
    Rajmohan Murali
    Am J Surg Pathol 32:1106-7; author reply 1107-8. 2008