Enzo R Porrello
Affiliation: Royal Children's Hospital
Quaife Ryan G, Sim C, Ziemann M, Kaspi A, Rafehi H, Ramialison M, et al
. Multicellular Transcriptional Analysis of Mammalian Heart Regeneration. Circulation. 2017;136:1123-1139 pubmed publisher
..Our findings define a regulatory program underpinning the neonatal regenerative state and identify alterations in the chromatin landscape that could limit reinduction of the regenerative program in adult cardiomyocytes. ..
Mills R, Titmarsh D, Koenig X, Parker B, Ryall J, Quaife Ryan G, et al
. Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Proc Natl Acad Sci U S A. 2017;114:E8372-E8381 pubmed publisher
..These studies highlight that human organoids coupled with higher-throughput screening platforms have the potential to rapidly expand our knowledge of human biology and potentially unlock therapeutic strategies. ..
Mills R, Parker B, Quaife Ryan G, Voges H, Needham E, Bornot A, et al
. Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway. Cell Stem Cell. 2019;: pubmed publisher
..This study highlights the utility of human cardiac organoids for pro-regenerative drug development, including identification of underlying biological mechanisms and minimization of adverse side effects. ..
Mills R, Parker B, Monnot P, Needham E, Vivien C, Ferguson C, et al
. Development of a human skeletal micro muscle platform with pacing capabilities. Biomaterials. 2019;198:217-227 pubmed publisher
..Taken together, our miniaturized approach provides a new platform to enable high-throughput studies of human skeletal muscle biology and exercise physiology. ..