Paul Monagle

Summary

Affiliation: Royal Children's Hospital
Country: Australia

Publications

  1. doi request reprint Diagnosis and management of deep venous thrombosis and pulmonary embolism in neonates and children
    Paul Monagle
    Department of Clinical Haematology, Royal Children s Hospital, Victoria, Australia
    Semin Thromb Hemost 38:683-90. 2012
  2. doi request reprint Infant deaths due to heparin overdose: time for a concerted action on prevention
    Paul Monagle
    Department of Clinical Haematology, The Royal Children s Hospital, Melbourne, Victoria, Australia
    J Paediatr Child Health 48:380-1. 2012
  3. doi request reprint Anticoagulation in neonates and children: Pitfalls and dilemmas
    Paul Monagle
    Department of Clinical Haematology, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Blood Rev 24:151-62. 2010
  4. ncbi request reprint Developmental haemostasis. Impact for clinical haemostasis laboratories
    Paul Monagle
    Department of Haematology, Royal Children s Hospital Melbourne, and University of Melbourne, Grattan Street, Parkville, Victoria 3051, Australia
    Thromb Haemost 95:362-72. 2006
  5. doi request reprint Hemostasis in neonates and children: pitfalls and dilemmas
    Paul Monagle
    Department of Clinical Haematology, University of Melbourne, Royal Children s Hospital, Flemington Road, Parkville, Victoria 3052, Australia
    Blood Rev 24:63-8. 2010
  6. doi request reprint Developmental haemostasis: secondary haemostasis
    Paul Monagle
    Department of Clinical Haematology, Royal Children s Hospital, Melbourne, Australia
    Semin Fetal Neonatal Med 16:294-300. 2011
  7. doi request reprint Antithrombotic therapy in neonates and children: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Paul Monagle
    Haematology Department, Royal Children s Hospital, Flemington Road, Parkville, Melbourne, Victoria 3052, Australia
    Chest 133:887S-968S. 2008
  8. doi request reprint Hemostatic response in paediatric patients undergoing cardiopulmonary bypass surgery
    Vera Ignjatovic
    Haematology Research Laboratory, Murdoch Children s Research Institute, Flemington Road, Parkville, Melbourne, VIC 3052, Australia
    Pediatr Cardiol 32:621-7. 2011
  9. doi request reprint Clinical use of unfractionated heparin therapy in children: time for change?
    Fiona Newall
    Department of Paediatrics, The University of Melbourne, Parkville, Vic, Australia
    Br J Haematol 150:674-8. 2010
  10. ncbi request reprint Antithrombotic therapy in children: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
    Paul Monagle
    Division of Laboratory Services, Royal Children s Hospital, Department of Paediatrics, University of Melbourne, Flemington Rd, Parkville, Melbourne, Vic, Australia 3052
    Chest 126:645S-687S. 2004

Detail Information

Publications63

  1. doi request reprint Diagnosis and management of deep venous thrombosis and pulmonary embolism in neonates and children
    Paul Monagle
    Department of Clinical Haematology, Royal Children s Hospital, Victoria, Australia
    Semin Thromb Hemost 38:683-90. 2012
    ..Finally, there will be a brief discussion of the latest American College of Chest Physician guidelines for antithrombotic treatment in neonates and children...
  2. doi request reprint Infant deaths due to heparin overdose: time for a concerted action on prevention
    Paul Monagle
    Department of Clinical Haematology, The Royal Children s Hospital, Melbourne, Victoria, Australia
    J Paediatr Child Health 48:380-1. 2012
    ..This short report highlights the need for united and concerted action to develop strategies aimed at minimising avoidable infant deaths related to heparin errors...
  3. doi request reprint Anticoagulation in neonates and children: Pitfalls and dilemmas
    Paul Monagle
    Department of Clinical Haematology, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Blood Rev 24:151-62. 2010
    ..There remains much research to be done in this field, in the meantime clinicians need to carefully consider the evidence available to them and manage each individual patient accordingly...
  4. ncbi request reprint Developmental haemostasis. Impact for clinical haemostasis laboratories
    Paul Monagle
    Department of Haematology, Royal Children s Hospital Melbourne, and University of Melbourne, Grattan Street, Parkville, Victoria 3051, Australia
    Thromb Haemost 95:362-72. 2006
    ..Finally we present age related reference ranges for D-dimers, TFPI, and endogenous thrombin potential, previously not described...
  5. doi request reprint Hemostasis in neonates and children: pitfalls and dilemmas
    Paul Monagle
    Department of Clinical Haematology, University of Melbourne, Royal Children s Hospital, Flemington Road, Parkville, Victoria 3052, Australia
    Blood Rev 24:63-8. 2010
    ..There remains a need for further study to improve our understanding of the implications of developmental hemostasis in normal growth and development...
  6. doi request reprint Developmental haemostasis: secondary haemostasis
    Paul Monagle
    Department of Clinical Haematology, Royal Children s Hospital, Melbourne, Australia
    Semin Fetal Neonatal Med 16:294-300. 2011
    ....
  7. doi request reprint Antithrombotic therapy in neonates and children: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Paul Monagle
    Haematology Department, Royal Children s Hospital, Flemington Road, Parkville, Melbourne, Victoria 3052, Australia
    Chest 133:887S-968S. 2008
    ..For neonates with a first AIS, in the absence of a documented ongoing cardioembolic source, we recommend against anticoagulation or aspirin therapy (Grade 1B)...
  8. doi request reprint Hemostatic response in paediatric patients undergoing cardiopulmonary bypass surgery
    Vera Ignjatovic
    Haematology Research Laboratory, Murdoch Children s Research Institute, Flemington Road, Parkville, Melbourne, VIC 3052, Australia
    Pediatr Cardiol 32:621-7. 2011
    ....
  9. doi request reprint Clinical use of unfractionated heparin therapy in children: time for change?
    Fiona Newall
    Department of Paediatrics, The University of Melbourne, Parkville, Vic, Australia
    Br J Haematol 150:674-8. 2010
    ..There is an urgent need for change in our approach to the use of UFH in children...
  10. ncbi request reprint Antithrombotic therapy in children: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
    Paul Monagle
    Division of Laboratory Services, Royal Children s Hospital, Department of Paediatrics, University of Melbourne, Flemington Rd, Parkville, Melbourne, Vic, Australia 3052
    Chest 126:645S-687S. 2004
    ..v. gammaglobulin within 10 days of the onset of symptoms (Grade 1A)...
  11. pmc Antithrombotic therapy in neonates and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Paul Monagle
    Haematology Department, The Royal Children s Hospital, Department of Paediatrics, The University of Melbourne, Murdoch Children s Research Institute, Melbourne, Vic, Australia
    Chest 141:e737S-801S. 2012
    ..This guideline addresses optimal strategies for the management of thrombosis in neonates and children...
  12. ncbi request reprint Reduced bone density in children on long-term warfarin
    Chris Barnes
    Department of Haematology, University of Melbourne, Royal Children s Hospital, Parkville, Australia
    Pediatr Res 57:578-81. 2005
    ..The etiology for the reduced bone density is likely to be multifactorial, however, screening of children on long-term warfarin for reduced bone density should be considered...
  13. ncbi request reprint Arterial thromboembolic disease: a single-centre case series study
    Paul Monagle
    Department of Clinical Haematology, Royal Children s Hospital, University of Melbourne, Melbourne, Victoria, Australia
    J Paediatr Child Health 44:28-32. 2008
    ..The aim of this study was to determine the prevalence, aetiology, diagnostic criteria, management and outcome of arterial thromboembolism (TE) in a tertiary paediatric centre...
  14. doi request reprint Age is a determinant factor for measures of concentration and effect in children requiring unfractionated heparin
    Fiona Newall
    Department of Paediatrics, The University of Melbourne, Melbourne, Australia
    Thromb Haemost 103:1085-90. 2010
    ..The trend toward increased UFH serum concentration and anticoagulant activity with age may be related to short-term differences in UFH binding to coagulant and competitive plasma proteins in vivo...
  15. doi request reprint Point-of-care monitoring of oral anticoagulation therapy in children. Comparison of the CoaguChek XS system with venous INR and venous INR using an International Reference Thromboplastin preparation (rTF/95)
    Anthea Greenway
    Department of Haematologg, The Royal Children s Hospital, Parkville, Australia
    Thromb Haemost 102:159-65. 2009
    ..This resulted in infrequent changes to clinical decision making regarding anticoagulation...
  16. doi request reprint Dosing and monitoring of enoxaparin (Low molecular weight heparin) therapy in children
    Vera Ignjatovic
    Murdoch Children s Research Institute, Melbourne, Vic, Australia
    Br J Haematol 149:734-8. 2010
    ..This study demonstrated a 2-3-fold variation in individual dose requirements for LMWH in children <or=5 years of age, and further mandates the need for age-specific dosage requirements in children receiving enoxaparin...
  17. doi request reprint Unfractionated heparin therapy in infants and children
    Fiona Newall
    MN, BSci, Royal Children s Hospital, Clinical Haematology Department, 9th Floor, Main Building, Flemington Road, Parkville, Victoria 3052, Australia
    Pediatrics 123:e510-8. 2009
    ....
  18. doi request reprint Novel interactions between UFH and TFPI in children
    Fiona Newall
    Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Parkville, Victoria, Australia
    Br J Haematol 151:376-80. 2010
    ....
  19. doi request reprint The quantitative and qualitative responses of platelets in pediatric patients undergoing cardiopulmonary bypass surgery
    Vera Ignjatovic
    Murdoch Childrens Research Institute, Flemington Road, Parkville, Vic, 3052, Australia
    Pediatr Cardiol 33:55-9. 2012
    ..This study provides a new foundation for future studies investigating requirements of platelet supplementation in the setting of pediatric CPB surgery...
  20. doi request reprint Plasmin generation and fibrinolysis in pediatric patients undergoing cardiopulmonary bypass surgery
    Vera Ignjatovic
    Murdoch Childrens Research Institute, Parkville, Australia
    Pediatr Cardiol 33:280-5. 2012
    ..This study establishes the foundation for future studies in this area, particularly those focusing on clinical outcomes after CPB surgery...
  21. ncbi request reprint Venous thromboembolic disease: a single-centre case series study
    Fiona Newall
    Department of Clinical Haematology, Royal Children s Hospital, Parkville, Victoria, Australia
    J Paediatr Child Health 42:803-7. 2006
    ..The Royal Children's Hospital commenced a 4-year prospective registry of venous thrombosis in 1999 to determine the current Australian epidemiology of venous thrombosis in infants and children...
  22. ncbi request reprint Assessing the outcome of systemic tissue plasminogen activator for the management of venous and arterial thrombosis in pediatrics
    Fiona Newall
    Clinical Haematology Department, Royal Children s Hospital, Parkville, Vic, Australia
    J Pediatr Hematol Oncol 29:269-73. 2007
    ..More cohort studies reporting the outcome of uniform protocols of thrombolytic therapy in children are required...
  23. doi request reprint A multicenter, randomized trial comparing heparin/warfarin and acetylsalicylic acid as primary thromboprophylaxis for 2 years after the Fontan procedure in children
    Paul Monagle
    Department of Paediatrics, University of Melbourne, Royal Children s Hospital and Critical Care and Neurosciences Theme, Murdoch Children s Research Institute, Melbourne, Victoria, Australia
    J Am Coll Cardiol 58:645-51. 2011
    ..The purpose of this study was to compare the safety and efficacy of acetylsalicylic acid (ASA) and warfarin for thromboprophylaxis after the Fontan procedure...
  24. ncbi request reprint Anticoagulation clinics for children achieve improved warfarin management
    Fiona Newall
    Royal Children s Hospital, Melbourne, Australia
    Thromb Res 114:5-9. 2004
  25. ncbi request reprint Point of care monitoring of oral anticoagulant therapy in children: comparison of CoaguChek Plus and Thrombotest methods with venous international normalised ratio
    Vera Ignjatovic
    Department of Haematology, Royal Children s Hospital, Melbourne, Victoria, Australia
    Thromb Haemost 92:734-7. 2004
    ..5. The CoaguChek method of INR monitoring is a more accurate and reliable method compared to Thrombotest, in the pediatric population tested, and can be safely used to manage oral anticoagulant therapy in children...
  26. ncbi request reprint Age-related differences in heparin response
    Vera Ignjatovic
    Department of Haematology, Royal Children s Hospital, Flemington Road, Parkville 3052, Victoria, Australia
    Thromb Res 118:741-5. 2006
    ..This study aimed to determine whether heparin therapeutic range determination is affected by the age of plasma donors and whether age-specific therapeutic ranges for heparin therapy may need to be considered in the clinical setting...
  27. doi request reprint Optimising anticoagulant education in the paediatric setting using a validated model of education
    Fiona Newall
    Clinical Haematology Department, Royal Children s Hospital, Melbourne, Australia
    Patient Educ Couns 73:384-8. 2008
    ..Providing education to patients requiring anticoagulant therapy may be associated with improved outcomes. This study investigated the knowledge outcomes of a validated educational intervention...
  28. doi request reprint Evaluation of a post-operative thrombin inhibitor replacement protocol to reduce haemorrhagic and thrombotic complications after paediatric liver transplantation
    Winita Hardikar
    Department of Gastroenterology, Royal Children s Hospital, Parkville, Victoria, 3052, Australia
    Thromb Res 126:191-4. 2010
    ..This report consists of two complimentary studies examining the frequency of haemostatic complications before and after the introduction of a post-operative thrombin inhibitor replacement therapy protocol at a single institution...
  29. doi request reprint The in vitro anticoagulant effects of danaparoid, fondaparinux, and lepirudin in children compared to adults
    Vera Ignjatovic
    Department of Clinical Haematology, Royal Children s Hospital, Melbourne, Australia
    Thromb Res 122:709-14. 2008
    ..This study aimed to determine whether age-related differences in effect and impact on monitoring tests exist in vitro for danaparoid, fondaparinux and lepirudin...
  30. ncbi request reprint Brachial artery thrombosis in infants: an algorithm for limb salvage
    Christopher J Coombs
    Department of Plastic and Maxillofacial Surgery, Royal Children s Hospital, Melbourne, Australia
    Plast Reconstr Surg 117:1481-8. 2006
    ..In general, there is agreement regarding the importance of early diagnosis and the reestablishment of limb perfusion with the fewest risks, but the optimal choice and timing of treatment modalities remain unknown...
  31. ncbi request reprint Warfarin therapy in children who require long-term total parenteral nutrition
    Fiona Newall
    Department of Paediatrics, University of Melbourne, Women s and Children s Health, Parkville, Australia
    Pediatrics 112:e386. 2003
    ..To determine whether warfarin can be safely administered to children who require long-term total parenteral nutrition (TPN), for the purpose of preventing central venous access device (CVAD)-related thrombosis...
  32. doi request reprint Stability and sterility of diluted enoxaparin under three different storage conditions
    Robyn Summerhayes
    Murdoch Childrens Research Institute, The University of Melbourne, Melbourne, Victoria, Australia
    J Paediatr Child Health 47:299-301. 2011
    ..This study assessed whether enoxaparin sodium diluted to a concentration of 20 mg/mL for clinical use with 0.9% sodium chloride remained stable and sterile for up to 43 days under three different storage conditions...
  33. doi request reprint A clinical audit of antithrombin concentrate use in a tertiary paediatric centre
    Christina Kozul
    Haematology Research Group, Murdoch Childrens Research Institute, Flemington Road, Parkville, VIC 3052, Australia
    J Paediatr Child Health 48:681-4. 2012
    ..The aim of this study was to investigate the clinical use of antithrombin concentrate (ATC) in children and specifically to determine the current practice of ATC administration, including dosing and indications for administration...
  34. doi request reprint Evidence for age-related differences in human fibrinogen
    Vera Ignjatovic
    Haematology Research, Murdoch Children s Research Institute, Parkville, VIC 3052, Australia
    Blood Coagul Fibrinolysis 22:110-7. 2011
    ....
  35. ncbi request reprint Monitoring Unfractionated Heparin (UFH) therapy: which Anti-Factor Xa assay is appropriate?
    Vera Ignjatovic
    Department of Clinical Haematology, Royal Children s Hospital, Melbourne, Australia
    Thromb Res 120:347-51. 2007
    ..Recent improvements in the automation, cost-effectiveness and accessibility of the assay to clinicians, have resulted in the Anti-Xa assay becoming a part of daily clinical practice in many institutions...
  36. ncbi request reprint Home INR monitoring of oral anticoagulant therapy in children using the CoaguChek S point-of-care monitor and a robust education program
    Fiona Newall
    Department of Clinical Haematology, Royal Children s Hospital, Melbourne, Australia
    Thromb Res 118:587-93. 2006
    ..This study aimed to improve the outcomes of home monitoring of warfarin therapy in children through the development and implementation of a robust intervention, based upon the PRECEDE model of education...
  37. doi request reprint Anticoagulation in children
    Paul Monagle
    Department of Clinical Haematology, Royal Children s Hospital, Melbourne, Victoria, Australia
    Thromb Res 130:142-6. 2012
    ..There remains just as much research required into how best to manage these populations and circumstances as is required to understand the basic mechanisms of anticoagulant interactions with paediatric plasma...
  38. doi request reprint Heparin in the long-term management of ligneous conjunctivitis: a case report and review of literature
    Mandira Hiremath
    Department of Clinical Haematology, Royal Children s Hospital, Melbourne, Australia
    Blood Coagul Fibrinolysis 22:606-9. 2011
    ..Furthermore, this study is one of the first to present over 5-year follow-up of a patient with ligneous conjunctivitis effectively managed with long-term heparin eye drops...
  39. pmc Age-related differences in plasma proteins: how plasma proteins change from neonates to adults
    Vera Ignjatovic
    Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    PLoS ONE 6:e17213. 2011
    ....
  40. pmc Anticoagulation in the young
    Paul Monagle
    Divisional of Laboratory Services, Royal Children s Hospital, Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia
    Heart 90:808-12. 2004
  41. doi request reprint Clinical outcomes of management of CVAD occlusions
    Calvin Peng
    Department of Paediatrics, The University of Melbourne, Melbourne, Australia
    Arch Dis Child 96:885-7. 2011
    ..The authors conclude that tPA is safe and effective in extending the life of occluded CVADs occlusions by months to years but is less effective in implantable ports...
  42. ncbi request reprint Bleeding disorders in teenagers presenting with menorrhagia
    Yasmin Jayasinghe
    Department of Paediatric and Adolescent Gynaecology, Royal Children s Hospital, Melbourne, Australia
    Aust N Z J Obstet Gynaecol 45:439-43. 2005
    ..To assess the prevalence of bleeding disorders and establish the clinical variables that are predictive of a bleeding disorder in adolescent women...
  43. doi request reprint In vivo age dependency of unfractionated heparin in infants and children
    Fiona Newall
    Department of Pathology, The University of Melbourne, Parkville, VIC 3010
    Thromb Res 123:710-4. 2009
    ..In vitro studies have shown that this practice may be suboptimal. This study aimed to improve the understanding of the impact of age upon UFH response in vivo...
  44. doi request reprint Quality of life assessment in children commencing home INR self-testing
    Sophie Jones
    Department of Clinical Haematology, Royal Children s Hospital, Australia
    Thromb Res 132:37-43. 2013
    ..The aim of the study was to determine if participation in a home ST program improves QoL for children requiring long-term OAT and their families...
  45. pmc Remote ischemic preconditioning (RIPC) modifies plasma proteome in humans
    Michele Hepponstall
    Haematology Research, Murdoch Childrens Research Institute Melbourne, Victoria, Australia
    PLoS ONE 7:e48284. 2012
    ..The RIPC stimulus modifies the plasma protein content in blood taken from the ischemic arm in a cumulative fashion and evokes a proteomic response in peripheral blood...
  46. doi request reprint An adolescent patient with post-thrombotic syndrome achieves excellence in sport
    Sophie Jones
    Department of Clinical Haematology, The Royal Children s Hospital, Melbourne, Victoria, Australia
    J Paediatr Child Health 48:E190-3. 2012
    ..This case highlights that reliance on the severity of only clinical signs without an understanding of a child's physical abilities limits the assessment of PTS...
  47. doi request reprint Hospitalisations for sickle-cell disease in an Australian paediatric population
    Yvonne Teoh
    Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia
    J Paediatr Child Health 49:68-71. 2013
    ..This study aimed to identify the demographic features of and quantify the hospital resource utilisation in the SCD population at The Royal Children's Hospital in Victoria...
  48. doi request reprint HEEADSSS assessment for adolescents requiring anticoagulation therapy
    Sophie Jones
    Department of Paediatrics, The University of Melbourne, Melbourne, Australia
    Arch Dis Child 97:430-3. 2012
    ..Adolescent anticoagulant management strategies employing developmentally appropriate assessment and education will likely result in improved therapeutic outcomes for the patient and potentially facilitate transition to adult-based care...
  49. ncbi request reprint Thrombophilia interpretation in childhood stroke: a cautionary tale
    Chris Barnes
    Department of Haematology, Royal Children s Hospital, Melbourne, Australia
    J Child Neurol 19:218-9. 2004
    ..We present a case that highlights the need for clinical and radiologic examinations to remain the definitive criteria used to diagnose stroke in children. The diagnosis should not be influenced by the finding of a thrombophilic marker...
  50. ncbi request reprint Patient understanding of warfarin therapy: a review of education strategies
    Fiona Newall
    Department of Haematology, Royal Children s Hospital, Parkville, 3053, Australia
    Hematology 10:437-42. 2005
    ....
  51. pmc First report of elevated monocyte-platelet aggregates in healthy children
    Christina Yip
    School of Medical Sciences, Royal Melbourne Institute of Technology University, Melbourne, Australia
    PLoS ONE 8:e67416. 2013
    ..9±28.6 respectively, p = ns), surface P-selectin expression per platelet-bound monocyte was lower in children compared to adults. We therefore provide the first data of elevated monocyte-platelet aggregates in healthy children. ..
  52. doi request reprint The economic costs of routine INR monitoring in infants and children--examining point-of-care devices used within the home setting compared to traditional anticoagulation clinic monitoring
    James R Gaw
    Clinical Haematology, The Royal Children s Hospital, Melbourne, Australia
    Thromb Res 132:26-31. 2013
    ..The aim of this study was to compare the estimated societal costs of attending anticoagulation clinics for routine INR monitoring to using a POC test in the home...
  53. doi request reprint Assessing outcome measures of oral anticoagulation management in children
    Sophie Jones
    Department of Paediatrics, The University of Melbourne, The Royal Children s Hospital, Flemington Road, Parkville, Victoria, Australia
    Thromb Res 127:75-80. 2011
    ....
  54. doi request reprint Bereaved parents' perceptions of the autopsy examination of their child
    Jane Sullivan
    Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Parkville, Melbourne, Victoria 3052, Australia
    Pediatrics 127:e1013-20. 2011
    ..In this study we explored parental views of their child's autopsy, their experiences with autopsy-related processes, and the impact of the examination on their grief...
  55. ncbi request reprint Thrombosis in pediatric cardiac patients
    Paul Monagle
    Division of Laboratory Services, Royal Children s Hospital, Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia
    Semin Thromb Hemost 29:547-55. 2003
    ..The current evidence for prophylaxis in different clinical situations is presented. Additional study is required in all areas to improve the outcome for children affected by cardiac disease and thrombosis...
  56. doi request reprint Perinatal and early childhood stroke and thrombophilia
    Mark T Mackay
    Children s Neuroscience Centre, The Royal Children s Hospital, Victoria, Australia
    Pathology 40:116-23. 2008
    ....
  57. ncbi request reprint Fibrinolytic system in adolescents: response to venous occlusion stress tests
    Paul Monagle
    Division of Laboratory Services, Royal Children s Hospital, Department of Paediatrics, University of Melbourne, Melbourne, Australia
    Pediatr Res 53:333-7. 2003
    ..The age-related differences in fibrinolytic response to venous occlusion of younger children and the significance of these differences on the pathophysiology of thromboembolic events in children require further studies...
  58. ncbi request reprint Thromboembolic problems after the Fontan operation
    Paul Monagle
    Division of Laboratory Services, Royal Children s Hospital, Parkville, Victoria, Australia
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 5:36-47. 2002
    ..Multicenter randomized controlled trials comparing prophylactic antiplatelet with anticoagulation therapies are needed to provide rational scientific guidelines for future management of Fontan patients...
  59. ncbi request reprint Reduced bone density among children with severe hemophilia
    Chris Barnes
    Department of Haematology, Royal Children s Hospital, Flemington Rd, Melbourne, Parkville 3052, Australia
    Pediatrics 114:e177-81. 2004
    ..Children with severe hemophilia are at risk for reduced bone mineral density (BMD) because of reduced weight-bearing exercise and hepatitis C infection. Reduced bone density in childhood is a risk factor for osteoporosis in later life...
  60. ncbi request reprint Fibrinolytic response to venous occlusion is decreased in patients after Kawasaki disease
    Manuela Albisetti
    Hamilton Civic Hospitals Research Centre, Hamilton, Ontario, Canada
    Blood Coagul Fibrinolysis 14:181-6. 2003
    ....
  61. ncbi request reprint Temporal aspects of anti-heparin-PF4 antibodies in heparin-induced thrombocytopenia
    Fiona Newall
    Ann Thorac Surg 81:1944; author reply 1944-5. 2006
  62. ncbi request reprint Thromboembolism in infants and children with gastrointestinal failure receiving long-term parenteral nutrition
    Vered Kakzanov
    Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
    JPEN J Parenter Enteral Nutr 32:88-93. 2008
    ....
  63. ncbi request reprint Binding of heparin to plasma proteins and endothelial surfaces is inhibited by covalent linkage to antithrombin
    Anthony K C Chan
    Henderson Research Centre, 711 Concession Street, Hamilton, ON, L8V 1C3, Canada
    Thromb Haemost 91:1009-18. 2004
    ..This model is consistent with ATH's better bioavailability and more predictable dose response...