Kate Leslie

Summary

Affiliation: Royal Melbourne Hospital
Country: Australia

Publications

  1. ncbi request reprint Dreaming during anaesthesia in patients at high risk of awareness
    K Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Australia
    Anaesthesia 60:239-44. 2005
  2. ncbi request reprint Awareness during anesthesia: a problem without solutions?
    K Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Department of Pharmacology, University of Melbourne, Melbourne, Australia
    Minerva Anestesiol 76:624-8. 2010
  3. doi request reprint Nitrous oxide and serious morbidity and mortality in the POISE trial
    Kate Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, VIC 3050, Australia
    Anesth Analg 116:1034-40. 2013
  4. ncbi request reprint Beta-blocker management in high-risk patients presenting for non-cardiac surgery: before and after the POISE Trial
    K Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, University of Melbourne, Australia
    Anaesth Intensive Care 40:319-27. 2012
  5. ncbi request reprint Venous air embolism and the sitting position: a case series
    K Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    J Clin Neurosci 13:419-22. 2006
  6. ncbi request reprint Introduction to cognitive activity during anaesthesia
    Kate Leslie
    Department of Pahrmacology, University of Melbourne, Melbourne, Australia
    Best Pract Res Clin Anaesthesiol 21:291-5. 2007
  7. doi request reprint Dreaming and electroencephalographic changes during anesthesia maintained with propofol or desflurane
    Kate Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Anesthesiology 111:547-55. 2009
  8. doi request reprint Nitrous oxide and long-term morbidity and mortality in the ENIGMA trial
    Kate Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Australia
    Anesth Analg 112:387-93. 2011
  9. doi request reprint Posttraumatic stress disorder in aware patients from the B-aware trial
    Kate Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Anesth Analg 110:823-8. 2010
  10. doi request reprint Risk factors for severe postoperative nausea and vomiting in a randomized trial of nitrous oxide-based vs nitrous oxide-free anaesthesia
    K Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Grattan St, Parkville, Vic, 3050, Australia
    Br J Anaesth 101:498-505. 2008

Detail Information

Publications56

  1. ncbi request reprint Dreaming during anaesthesia in patients at high risk of awareness
    K Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Australia
    Anaesthesia 60:239-44. 2005
    ..Dreaming patients were younger (p = 0.001); healthier (p < 0.001) and more likely to be women (p < 0.001), and were less satisfied with anaesthetic care (p = 0.004) than other patients...
  2. ncbi request reprint Awareness during anesthesia: a problem without solutions?
    K Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Department of Pharmacology, University of Melbourne, Melbourne, Australia
    Minerva Anestesiol 76:624-8. 2010
    ..More trials are needed and two large ongoing trials are exploring the value of monitoring end-tidal gas concentrations and maintaining adequate age-adjusted values during surgery as an alternative method to prevent awareness...
  3. doi request reprint Nitrous oxide and serious morbidity and mortality in the POISE trial
    Kate Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, VIC 3050, Australia
    Anesth Analg 116:1034-40. 2013
    ....
  4. ncbi request reprint Beta-blocker management in high-risk patients presenting for non-cardiac surgery: before and after the POISE Trial
    K Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, University of Melbourne, Australia
    Anaesth Intensive Care 40:319-27. 2012
    ..The rate of implementation of effective beta-blockade was low before POISE and this did not change significantly after publication. Our finding does not provide reliable evidence of a change in practice as a result of the POISE Trial...
  5. ncbi request reprint Venous air embolism and the sitting position: a case series
    K Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    J Clin Neurosci 13:419-22. 2006
    ..3-14.7%). These patients did not have a significantly higher rate of hypotension or desaturation. Our results suggest that the sitting position can be safely used in neurosurgery...
  6. ncbi request reprint Introduction to cognitive activity during anaesthesia
    Kate Leslie
    Department of Pahrmacology, University of Melbourne, Melbourne, Australia
    Best Pract Res Clin Anaesthesiol 21:291-5. 2007
  7. doi request reprint Dreaming and electroencephalographic changes during anesthesia maintained with propofol or desflurane
    Kate Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Anesthesiology 111:547-55. 2009
    ....
  8. doi request reprint Nitrous oxide and long-term morbidity and mortality in the ENIGMA trial
    Kate Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Australia
    Anesth Analg 112:387-93. 2011
    ..We conducted a follow-up study of the ENIGMA patients to evaluate the risk of cardiovascular events in the longer term...
  9. doi request reprint Posttraumatic stress disorder in aware patients from the B-aware trial
    Kate Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Anesth Analg 110:823-8. 2010
    ..In this study, we compared the incidence of posttraumatic stress disorder (PTSD) in patients with and without confirmed awareness who were randomized in the B-Aware Trial...
  10. doi request reprint Risk factors for severe postoperative nausea and vomiting in a randomized trial of nitrous oxide-based vs nitrous oxide-free anaesthesia
    K Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Grattan St, Parkville, Vic, 3050, Australia
    Br J Anaesth 101:498-505. 2008
    ..As risk stratification may aid in prophylaxis and treatment, we explored risk factors for severe PONV in patients enrolled in a large international, randomized controlled trial (the ENIGMA trial)...
  11. ncbi request reprint Quality of recovery from anesthesia in neurosurgical patients
    Kate Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia
    Anesthesiology 99:1158-65. 2003
    ..Therefore, the authors measured quality of recovery using the QoR-40 score (a 40-item questionnaire on quality of recovery from anesthesia)...
  12. ncbi request reprint Cardiac output and propofol concentrations in prone surgical patients
    K Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria
    Anaesth Intensive Care 39:868-74. 2011
    ..55 [0.89] and 2.53 [0.90] microg/ml; P = 0.93). We conclude that prone positioning on the Wilson frame does not affect cardiac output or plasma propofol concentration...
  13. doi request reprint The effect of bispectral index monitoring on long-term survival in the B-aware trial
    Kate Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Anesth Analg 110:816-22. 2010
    ..We tested the hypothesis that the risks of death, myocardial infarction (MI), and stroke would be lower in patients allocated to BIS-guided management than in those allocated to routine care...
  14. ncbi request reprint Closed loop control of sedation for colonoscopy using the Bispectral Index
    K Leslie
    University Department of Anaesthesia, Southern General Hospital, Glasgow, Scotland, UK
    Anaesthesia 57:693-7. 2002
    ..Patient and surgeon satisfaction were high. We conclude that BIS may be a suitable control variable for closed-loop control of sedation with propofol...
  15. ncbi request reprint Does anaesthesia care affect the outcome following craniotomy?
    Kate Leslie
    Staff Anaesthetist, Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Australia
    J Clin Neurosci 9:231-6. 2002
  16. ncbi request reprint Mild core hypothermia and anesthetic requirement for loss of responsiveness during propofol anesthesia for craniotomy
    Kate Leslie
    Outcomes Research Group, Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Parkville, Vic, Australia
    Anesth Analg 94:1298-303, table of contents. 2002
    ..76; 95% confidence interval, 2.40-57.63; P < 0.01). Core temperature did not alter the relationship between bispectral index and response to command. Propofol infusion regimens may not require adjustment during mild hypothermia...
  17. ncbi request reprint Dreaming during anesthesia and anesthetic depth in elective surgery patients: a prospective cohort study
    Kate Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, and Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia
    Anesthesiology 106:33-42. 2007
    ..Therefore, the authors tested the hypothesis that dreaming during anesthesia is associated with light anesthesia, as evidenced by higher Bispectral Index values during maintenance of anesthesia...
  18. ncbi request reprint Dreaming during anaesthesia in adult patients
    Kate Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Australia
    Best Pract Res Clin Anaesthesiol 21:403-14. 2007
    ..Dreaming is a common, fascinating, usually pleasant and harmless phenomenon...
  19. doi request reprint Early cognitive impairment after sedation for colonoscopy: the effect of adding midazolam and/or fentanyl to propofol
    Usha Padmanabhan
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia
    Anesth Analg 109:1448-55. 2009
    ..We sought to determine if the use of propofol alone results in less cognitive impairment at discharge than the use of propofol plus midazolam and/or fentanyl in patients presenting for elective outpatient colonoscopy...
  20. ncbi request reprint Avoidance of nitrous oxide for patients undergoing major surgery: a randomized controlled trial
    Paul S Myles
    Department of Anaesthesia and Perioperative Medicine, Alfred Hospital, Academic Board of Anaesthesia and Perioperative Medicine, Monash University, Melbourne, Victoria, Australia
    Anesthesiology 107:221-31. 2007
    ..Although nitrous oxide interferes with vitamin B12, folate metabolism, and deoxyribonucleic acid synthesis and prevents the use of high inspired oxygen concentrations, the consequences of these effects are unclear...
  21. doi request reprint Nitrous oxide and perioperative cardiac morbidity (ENIGMA-II) Trial: rationale and design
    Paul S Myles
    Department of Anaesthesia and Perioperative Medicine, Alfred Hospital, Melbourne, Victoria, Australia
    Am Heart J 157:488-494.e1. 2009
    ....
  22. ncbi request reprint Preoperative folate and homocysteine status in patients undergoing major surgery
    Paul S Myles
    Department of Anaesthesia and Perioperative Medicine, Alfred Hospital, Commercial Road, Academic Board of Anaesthesia and Perioperative Medicine, Monash University, Melbourne, Vic, 3004, Australia
    Clin Nutr 25:736-45. 2006
    ..We also tested the utility of a brief preoperative medical and dietary questionnaire to identify those with low folate or elevated Hcy levels...
  23. doi request reprint Propofol dose and incidence of dreaming during sedation
    Audrey Singyi Eer
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Australia
    Eur J Anaesthesiol 26:833-6. 2009
    ..Dreaming is commonly reported after propofol-based sedation. We measured the incidence of dreaming and bispectral index (BIS) values in colonoscopy patients sedated with combinations of propofol, midazolam and fentanyl...
  24. ncbi request reprint Gender and recovery after general anesthesia combined with neuromuscular blocking drugs
    Frank F Buchanan
    Department of Anesthesia and Pain Management, Alfred Hospital, Melbourne, Australia
    Anesth Analg 102:291-7. 2006
    ....
  25. ncbi request reprint Esmolol and anesthetic requirement for loss of responsiveness during propofol anesthesia
    Ruari Orme
    Department of Anaesthesia, Ballarat Base Hospital, Ballarat, Victoria, Australia
    Anesth Analg 94:112-6, table of contents. 2002
    ..42 microg/mL). Esmolol did not alter the relative risk of response to command. We conclude that the previously observed effect of esmolol on propofol CP50 was not caused by an interaction between these two drugs...
  26. doi request reprint A cost-benefit analysis of the ENIGMA trial
    Alison M Graham
    Department of Anaesthesia and Perioperative Medicine, Alfred Hospital, Melbourne, Australia
    Anesthesiology 115:265-72. 2011
    ..This suggests that, despite a higher consumption of potent inhalational agent, there could be a financial benefit when N₂O is avoided in such settings...
  27. ncbi request reprint Effect-site targeted patient-controlled sedation with propofol: comparison with anaesthetist administration for colonoscopy
    C A Stonell
    Research Fellow, 2 Head of Research, Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Australia
    Anaesthesia 61:240-7. 2006
    ..58 [15]; p = 0.13) than anaesthetist-administered propofol sedation patients. More of the latter patients were hypotensive, but all patients had similar recollection of events during the procedure and similar quality of recovery...
  28. ncbi request reprint Postoperative complications and mortality in older patients having non-cardiac surgery at three Melbourne teaching hospitals
    Larry McNicol
    Austin Health, Melbourne, Victoria, Australia
    Med J Aust 186:447-52. 2007
    ..To determine the incidence of postoperative complications, including 30-day mortality rate, and need for intensive care unit (ICU) admission in older patients after non-cardiac surgery...
  29. ncbi request reprint Perioperative hypothermia in the high-risk surgical patient
    Kate Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Best Pract Res Clin Anaesthesiol 17:485-98. 2003
    ..Proper thermal management may reduce complications and improve the outcome in high-risk surgical patients...
  30. ncbi request reprint Dreaming and recall during sedation for colonoscopy
    M L Stait
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Victoria
    Anaesth Intensive Care 36:685-90. 2008
    ..The only significant predictor of recall was lower propofol dose. Satisfaction with care was generally high, however dreamers were more satisfied with their care than non-dreamers...
  31. ncbi request reprint Bispectral index monitoring to prevent awareness during anaesthesia: the B-Aware randomised controlled trial
    P S Myles
    Department of Anaesthesia and Pain Management, Alfred Hospital, Melbourne, Australia
    Lancet 363:1757-63. 2004
    ..Bispectral index (BIS) monitoring measures the depth of anaesthesia and facilitates anaesthetic titration. In this trial we determined whether BIS-guided anaesthesia reduced the incidence of awareness during surgery in adults...
  32. ncbi request reprint Propofol anaesthesia via target controlled infusion or manually controlled infusion: effects on the bispectral index as a measure of anaesthetic depth
    T Gale
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Victoria, Australia
    Anaesth Intensive Care 29:579-84. 2001
    ..We conclude that TCI and MCI result in similar depth of anaesthesia and haemodynamic stability when titrated against traditional clinical signs...
  33. ncbi request reprint Intravenous fluid to prevent hypotension in patients undergoing elective colonoscopy
    K Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Victoria, Australia
    Anaesth Intensive Care 34:316-21. 2006
    ..This study does not support the use of 15 ml/kg Hartmann's solution to reduce the incidence of hypotension or postoperative morbidity in patients undergoing elective colonoscopy...
  34. ncbi request reprint Recovery from bispectral index-guided anaesthesia in a large randomized controlled trial of patients at high risk of awareness
    K Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, Vic
    Anaesth Intensive Care 33:443-51. 2005
    ..We conclude that BIS monitoring has statistically significant, but clinically modest, effects on recovery times in high risk surgical patients...
  35. ncbi request reprint Australian anaesthetists' practice of sedation for gastrointestinal endoscopy in adult patients
    U Padmanabhan
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    Anaesth Intensive Care 36:436-41. 2008
    ..Significant variations exist in the practice of sedation and monitoring for endoscopy in adult patients by anaesthetists in Australia...
  36. doi request reprint Dexamethasone for intracranial neurosurgery and anaesthesia
    Brad Hockey
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Grattan Street, Parkville, Victoria 3050, Australia
    J Clin Neurosci 16:1389-93. 2009
    ..This review outlines the rationale for its use by both specialities, and discusses its potential adverse effects...
  37. ncbi request reprint No sex differences in memory formation during general anesthesia
    Christopher A Stonell
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Australia
    Anesthesiology 105:920-6. 2006
    ..However, sex differences in memory formation have not been explored. Therefore, the authors investigated sex differences in the implicit and explicit memory formation during general anesthesia...
  38. ncbi request reprint Remifentanil concentration during target-controlled infusion of propofol
    D P Crankshaw
    Department of Pharmacology, The University of Melbourne Victoria, Australia
    Anaesth Intensive Care 30:578-83. 2002
    ..6 (3.2-5.7) versus 3.8 (1.6-4.9) ng x ml(-1); P=0.73, n=8. Co-administration of propofol and remifentanil may result in greater remifentanil concentrations than when remifentanil is infused alone...
  39. ncbi request reprint A review of the risks and benefits of nitrous oxide in current anaesthetic practice
    P S Myles
    Department ofAnaesthesia and Pain Management, Alfred Hospital, Melbourne, Victoria
    Anaesth Intensive Care 32:165-72. 2004
  40. doi request reprint Effect of nitrous oxide on plasma homocysteine and folate in patients undergoing major surgery
    P S Myles
    Department of Anaesthesia and Perioperative Medicine, Alfred Hospital, Monash University, Commercial Road, Melbourne, Victoria 3004, Australia
    Br J Anaesth 100:780-6. 2008
    ..In epidemiological studies, hyperhomocysteinaemia is associated with increased risk of cardiovascular disease and dementia...
  41. ncbi request reprint Anaesthetists' attitudes towards awareness and depth-of-anaesthesia monitoring
    P S Myles
    Department of Anaesthesia and Pain Management, Alfred Hospital, P O Box 315, Melbourne, Victoria 3004, Australia
    Anaesthesia 58:11-6. 2003
    ..009) and to use awareness monitoring (p = 0.001). Anaesthetists are prepared to use depth-of-anaesthesia monitoring more widely if it can be shown to prevent most cases of awareness in routine practice...
  42. ncbi request reprint Pethidine and skin warming to prevent shivering during endovascular cooling
    K Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Victoria
    Anaesth Intensive Care 32:362-7. 2004
    ..There were no significant complications arising from catheter placement. The combination of skin warming and pethidine was not reliable enough to be recommended for use during endovascular cooling in unanaesthetized patients...
  43. ncbi request reprint Target words for the Word Stem Completion test in Australian patients
    L Lee
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital and Department of Pharmacology, University of Melbourne, Melbourne, Victoria
    Anaesth Intensive Care 31:184-6. 2003
    ..This generated a list of 32 target words that is suitable for use in studies of implicit memory during anaesthesia in Australian patients...
  44. ncbi request reprint Patients' knowledge of and attitudes towards awareness and depth of anaesthesia monitoring
    K Leslie
    Departments of Anaesthesia and Pain Management, The Royal Melbourne Hospital and The Alfred Hospital, Melbourne, Victoria
    Anaesth Intensive Care 31:63-8. 2003
    ..Perceived risk and a previous awareness experience were significant predictors of willingness to pay for awareness monitoring...
  45. ncbi request reprint Anaesthesia for neurosurgery in the sitting position
    T Gale
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    J Clin Neurosci 11:693-6. 2004
    ..These are largely in the domain of the neuroanaesthetist. In this paper, therefore, we will review the advantages, disadvantages and management of complications of the sitting position, from the neuroanaesthetist's perspective...
  46. ncbi request reprint What are we telling our patients? A survey of risk disclosure for anaesthesia in Australia and New Zealand
    A R Braun
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    Anaesth Intensive Care 38:935-8. 2010
    ..This large variation should be of concern to all anaesthetists. More work is needed to understand the reasons for this variation, and to develop a stronger consensus among anaesthetists about what risks should be disclosed...
  47. ncbi request reprint Effectiveness of bupropion as an aid to stopping smoking before elective surgery: a randomised controlled trial
    P S Myles
    Department of Anaesthesia and Pain Management, Alfred Hospital, Commercial Road, Melbourne, VIC 3004, Australia
    Anaesthesia 59:1053-8. 2004
    ..036), but not at the 6-week visit (p = 0.25) or at the time of hospital admission for surgery (p > 0.99). This study found that smokers waiting for elective surgery are more likely to reduce or stop smoking when treated with bupropion...
  48. ncbi request reprint Perioperative mortality risk score using pre- and postoperative risk factors in older patients
    D A Story
    Trials Group and Perioperative Medicine Committee, Australian and New Zealand College of Anaesthetists, Melbourne, Victoria, Australia
    Anaesth Intensive Care 37:392-8. 2009
    ..Risk associated with surgical complexity and urgency could be added to this baseline patient factor Perioperative Mortality score...
  49. ncbi request reprint Nitrous oxide and anesthetic requirement for loss of response to command during propofol anesthesia
    Dharshi Karalapillai
    Department of Anaesthesia, Ballarat Base Hospital, Australia
    Anesth Analg 102:1088-93. 2006
    ..14-15.36) and 2.67 microg/mL (95% CI, 2.28-3.17) in the propofol-N2O group. The BIS value when 50% of patients responded to command was 60 (95% CI, 55-65) in the propofol-alone group and 75 (95% CI, 73-83) in the propofol-N2O group...
  50. ncbi request reprint Awareness in a community-based anesthesia practice
    Kate Leslie
    Anesthesiology 107:671-2; author reply 673. 2007
  51. ncbi request reprint Anesthesia awareness and the bispectral index
    Paul S Myles
    N Engl J Med 359:428-9; author reply 430-1. 2008
  52. pmc How strong is the evidence for the use of perioperative beta blockers in non-cardiac surgery? Systematic review and meta-analysis of randomised controlled trials
    P J Devereaux
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    BMJ 331:313-21. 2005
    ..To determine the effect of perioperative beta blocker treatment in patients having non-cardiac surgery...
  53. ncbi request reprint A large trial is vital to prove perioperative beta-blockade effectiveness and safety before widespread use
    Kate Leslie
    Anesthesiology 101:803; author reply 804-6. 2004
  54. ncbi request reprint Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) trial: a randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery
    P J Devereaux
    Faculty of Health Sciences, Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
    Am Heart J 152:223-30. 2006
    ..We have initiated the POISE trial to definitively establish the effects of beta-blocker therapy in patients undergoing noncardiac surgery...
  55. ncbi request reprint Anaesthesia and neurosurgery: new developments in a long and interesting relationship
    Kate Leslie
    J Clin Neurosci 11:355. 2004
  56. doi request reprint Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial
    P J Devereaux
    McMaster University, Faculty of Health Sciences, Clinical Epidemiology and Biostatistics, Room 2C8, 1200 Main Street West, Hamilton, ON, L8N 3Z5, Canada
    Lancet 371:1839-47. 2008
    ..This randomised controlled trial, done in 190 hospitals in 23 countries, was designed to investigate the effects of perioperative beta blockers...