Carl D Kirkwood

Summary

Affiliation: Royal Children's Hospital
Country: Australia

Publications

  1. pmc Klassevirus 1, a previously undescribed member of the family Picornaviridae, is globally widespread
    Lori R Holtz
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Virol J 6:86. 2009
  2. ncbi request reprint Australian Rotavirus Surveillance Program annual report, 2008/2009
    Carl D Kirkwood
    National Rotavirus Reference Centre, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria
    Commun Dis Intell Q Rep 33:382-8. 2009
  3. pmc Identification and characterisation of Pseudomonas 16S ribosomal DNA from ileal biopsies of children with Crohn's disease
    Josef Wagner
    Enteric Virus Group, Murdoch Childrens Research Institute, Department of Paediatrics, Royal Children s Hospital, Parkville, Victoria, Australia
    PLoS ONE 3:e3578. 2008
  4. pmc Rare rotavirus strains in children with severe diarrhea, malaysia
    Ling Sing Ch'ng
    Murdoch Childrens Research Institute, Parkville, Victoria, Australia L S Ch ng, C D Kirkwood University of Melbourne, Melbourne, Victoria, Australia L S Ch ng, C D Kirkwood and University of Malaya, Kuala Lumpur, Malaysia W S Lee
    Emerg Infect Dis 17:948-50. 2011
  5. ncbi request reprint Australian Rotavirus Surveillance Program annual report, 2010/11
    Carl D Kirkwood
    Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria
    Commun Dis Intell Q Rep 35:281-7. 2011
  6. pmc Complete genome sequence of a highly divergent astrovirus isolated from a child with acute diarrhea
    Stacy R Finkbeiner
    Departments of Molecular Microbiology and Pathology and Immunology, Washington University School of Medicine, St, Louis, MO, USA
    Virol J 5:117. 2008
  7. pmc Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea
    Lori R Holtz
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO USA
    Virol J 5:159. 2008
  8. ncbi request reprint National Rotavirus Surveillance Program annual report, 2005-06
    Carl D Kirkwood
    Murdoch Childrens Research Institute, Parkville, Victoria
    Commun Dis Intell Q Rep 30:434-8. 2006
  9. doi request reprint Calicivirus shedding in children after recovery from diarrhoeal disease
    Carl D Kirkwood
    Enteric Virus Research Group, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    J Clin Virol 43:346-8. 2008
  10. ncbi request reprint Australian Rotavirus Surveillance Program: annual report, 2009/2010
    Carl D Kirkwood
    Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria
    Commun Dis Intell Q Rep 34:427-34. 2010

Detail Information

Publications61

  1. pmc Klassevirus 1, a previously undescribed member of the family Picornaviridae, is globally widespread
    Lori R Holtz
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Virol J 6:86. 2009
    ..In an effort to identify novel viruses that may be causal agents of diarrhea, we used high throughput mass sequencing to analyze stool samples collected from patients with acute diarrhea...
  2. ncbi request reprint Australian Rotavirus Surveillance Program annual report, 2008/2009
    Carl D Kirkwood
    National Rotavirus Reference Centre, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria
    Commun Dis Intell Q Rep 33:382-8. 2009
    ..This is the first report to describe G2P[4] as the dominant genotype nationally. Whether vaccine pressure has resulted in emergence of this genotype is not yet known...
  3. pmc Identification and characterisation of Pseudomonas 16S ribosomal DNA from ileal biopsies of children with Crohn's disease
    Josef Wagner
    Enteric Virus Group, Murdoch Childrens Research Institute, Department of Paediatrics, Royal Children s Hospital, Parkville, Victoria, Australia
    PLoS ONE 3:e3578. 2008
    ..Pseudomonas species were less diverse in CD patients compared with non-IBD patients. In particular P.aeruginosa was only identified in non-IBD patients...
  4. pmc Rare rotavirus strains in children with severe diarrhea, malaysia
    Ling Sing Ch'ng
    Murdoch Childrens Research Institute, Parkville, Victoria, Australia L S Ch ng, C D Kirkwood University of Melbourne, Melbourne, Victoria, Australia L S Ch ng, C D Kirkwood and University of Malaya, Kuala Lumpur, Malaysia W S Lee
    Emerg Infect Dis 17:948-50. 2011
    ..These viruses have been sporadically associated with diarrhea in infants in countries such as Thailand, Italy, United States, Japan, Malaysia, and China (2-7) and thus represent a rare but widely distributed group of viruses...
  5. ncbi request reprint Australian Rotavirus Surveillance Program annual report, 2010/11
    Carl D Kirkwood
    Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria
    Commun Dis Intell Q Rep 35:281-7. 2011
    ..This survey continues to highlight the fluctuations in rotavirus genotypes, with an annual change in dominant genotypes suggesting a more dynamic wild-type population...
  6. pmc Complete genome sequence of a highly divergent astrovirus isolated from a child with acute diarrhea
    Stacy R Finkbeiner
    Departments of Molecular Microbiology and Pathology and Immunology, Washington University School of Medicine, St, Louis, MO, USA
    Virol J 5:117. 2008
    ..We have previously described the identification of several sequence fragments with limited sequence identity to known astroviruses in a stool specimen obtained from a child with acute diarrhea, suggesting that a novel virus was present...
  7. pmc Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea
    Lori R Holtz
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO USA
    Virol J 5:159. 2008
    ..Based on the analysis discussed here, we propose that this virus represents a new species in the Cosavirus genus, and it has tentatively been named Human Cosavirus E1 (HCoSV-E1)...
  8. ncbi request reprint National Rotavirus Surveillance Program annual report, 2005-06
    Carl D Kirkwood
    Murdoch Childrens Research Institute, Parkville, Victoria
    Commun Dis Intell Q Rep 30:434-8. 2006
    ..6%), serotype G9 (15.1%) and serotype G3 (14.7%). Genotype G12 strains were identified for the first time in Australia. As in previous years, there was substantial geographic variation in the prevalence of rotavirus serotypes...
  9. doi request reprint Calicivirus shedding in children after recovery from diarrhoeal disease
    Carl D Kirkwood
    Enteric Virus Research Group, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    J Clin Virol 43:346-8. 2008
    ..Human norovirus is a major cause of acute gastroenteritis in all age groups. Recent evidence suggests that virus can be shed after resolution of disease symptoms, but little is known about duration of shedding...
  10. ncbi request reprint Australian Rotavirus Surveillance Program: annual report, 2009/2010
    Carl D Kirkwood
    Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria
    Commun Dis Intell Q Rep 34:427-34. 2010
    ..However, the large G1P[8] outbreak of gastroenteritis in the Northern Territory may have resulted from vaccine pressure on wild-type strains...
  11. ncbi request reprint Australian Rotavirus Surveillance Program: annual report, 2006-07
    Carl D Kirkwood
    National Rotavirus Reference Centre, Murdoch Childrens Research Institute, Royal Children s Hospital Parkville, Victoria
    Commun Dis Intell Q Rep 31:375-9. 2007
    ..Uncommon rotavirus genotypes, G8 (n = 1) and G12 (n = 2) were identified in children with acute gastroenteritis during this study period...
  12. ncbi request reprint National Rotavirus Surveillance Program annual report, 2004-05
    Carl D Kirkwood
    Enteric Virus Research Group, Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville, VIC 3052
    Commun Dis Intell Q Rep 30:133-6. 2006
    ..3 per cent of all strains, followed by serotype G3 (36.7%) and serotype G9 (6.9%). As in previous years, there was substantial geographic variation in the prevalence of rotavirus serotypes...
  13. doi request reprint Genetic and antigenic diversity of human rotaviruses: potential impact on vaccination programs
    Carl D Kirkwood
    Murdoch Childrens Research Institute, Royal Children s Hospital, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia
    J Infect Dis 202:S43-8. 2010
    ..This review describes the diversity of rotavirus strains and the mechanism by which wild-type rotavirus strains can evolve, including genetic drift and genetic reassortment...
  14. doi request reprint Rotavirus strain surveillance--an Australian perspective of strains causing disease in hospitalised children from 1997 to 2007
    Carl D Kirkwood
    Enteric Virus Group, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Vaccine 27:F102-7. 2009
    ..To be optimally effective, rotavirus vaccines must prevent disease caused by all common rotavirus genotypes...
  15. doi request reprint Distribution of rotavirus genotypes after introduction of rotavirus vaccines, Rotarix® and RotaTeq®, into the National Immunization Program of Australia
    Carl D Kirkwood
    Enteric Virus Research Group, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    Pediatr Infect Dis J 30:S48-53. 2011
    ..This report describes the rotavirus genotypes responsible for the hospitalization of children during the first 2-year period after vaccine introduction...
  16. ncbi request reprint Mycobacterium avium subspecies paratuberculosis in children with early-onset Crohn's disease
    Carl D Kirkwood
    Enteric Virus Group, Murdoch Childrens Research Institute, Parkville, Victoria, Australia
    Inflamm Bowel Dis 15:1643-55. 2009
    ....
  17. ncbi request reprint Viral gastroenteritis in Europe: a new norovirus variant?
    Carl Kirkwood
    Enteric Virus Research Group, Murdoch Childrens Research Institute, Department of Gastroenterology and Clinical Nutrition, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    Lancet 363:671-2. 2004
  18. pmc Rotavirus serotype G9P[8] and acute gastroenteritis outbreak in children, Northern Australia
    Carl Kirkwood
    Murdoch Childrens Research Institute, Parkville, Victoria, Australia
    Emerg Infect Dis 10:1593-600. 2004
    ..Rotavirus serotype surveillance should continue with methods capable of identifying new and emerging types...
  19. ncbi request reprint Australian Rotavirus Surveillance Program annual report, 2007/08
    Carl D Kirkwood
    National Rotavirus Reference Centre, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria
    Commun Dis Intell Q Rep 32:425-9. 2008
    ..There was no evidence of unexpected changes in serotype distribution during the first 12 months of rotavirus vaccine use in the National Immunisation Program...
  20. ncbi request reprint A 5-year study of the prevalence and genetic diversity of human caliciviruses associated with sporadic cases of acute gastroenteritis in young children admitted to hospital in Melbourne, Australia (1998-2002)
    Carl D Kirkwood
    Enteric Virus Research Group, Murdoch Childrens Research Institute, Royal Children s Hospital, Victoria, Australia
    J Med Virol 77:96-101. 2005
    ..Five sapovirus strains were also identified. These results highlight the divergence of norovirus strains identified in a pediatric population...
  21. pmc Non-structural protein NSP2 induces heterotypic antibody responses during primary rotavirus infection and reinfection in children
    Carl D Kirkwood
    Enteric Virus Research Group, Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    J Med Virol 80:1090-8. 2008
    ..Sequential estimation of anti-NSP2 EIA levels in sera could be a sensitive index of rotavirus infection and re-infection. The potential of anti-NSP2 to limit viral replication after re-infection deserves further study...
  22. ncbi request reprint Report of the Australian rotavirus surveillance program 2002-03
    Carl D Kirkwood
    National Rotavirus Reference Centre, Murdoch Children s Research Institute, Royal Children s Hospital, Flemington Road, Parkville, VIC 3052
    Commun Dis Intell Q Rep 27:492-5. 2003
    ..Serotype G1 strains were the second most prevalent type (11.3%), identified in four of the centres. These findings have implications for vaccine development strategies which have targeted protection of disease due to serotypes G1-G4...
  23. doi request reprint Identification of strains of RotaTeq rotavirus vaccine in infants with gastroenteritis following routine vaccination
    Celeste M Donato
    Enteric Virus Group, Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    J Infect Dis 206:377-83. 2012
    ..This study identified and characterised rotavirus strains excreted by infants who presented with symptoms of gastroenteritis following recent RotaTeq vaccination...
  24. doi request reprint The burden of hospitalised rotavirus infections in Fiji
    Adam Jenney
    Centre for International Child Health, Department of Paediatrics, University of Melbourne, Parkville, Victoria 3051, Australia
    Vaccine 27:F108-11. 2009
    ..There is a significant burden of disease due to rotavirus in Fiji and the introduction of rotavirus vaccines into the national immunization schedule may drastically reduce inpatient diarrhoeal disease...
  25. ncbi request reprint Identification and characterization of antibody-binding epitopes on the norovirus GII.3 capsid
    Jackie E Mahar
    Enteric Virus Group, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Vic, Australia
    J Virol 88:1942-52. 2014
    ..Immunological understanding of pediatric norovirus strains is important since norovirus vaccines will likely target high-risk groups such as the pediatric population. ..
  26. doi request reprint TLR4, IL10RA, and NOD2 mutation in paediatric Crohn's disease patients: an association with Mycobacterium avium subspecies paratuberculosis and TLR4 and IL10RA expression
    Josef Wagner
    Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Vic, 3052, Australia
    Med Microbiol Immunol 202:267-76. 2013
    ..031 and 0.005, respectively). TLR4 was significantly higher expressed on NK cells (CD56high) harbouring a NOD2 mutations compared to wildtype cells (p = 0.038). ..
  27. doi request reprint Bacteriophages in gut samples from pediatric Crohn's disease patients: metagenomic analysis using 454 pyrosequencing
    Josef Wagner
    Enteric Virus Group, Murdoch Childrens Research Institute, Melbourne, Australia
    Inflamm Bowel Dis 19:1598-608. 2013
    ..The role of bacteriophage in Crohn's disease (CD) is unknown. This study investigated the abundance of phages in ileal and colonic samples from pediatric CD patients and controls...
  28. doi request reprint Expression profile of genes involved in pathogenesis of pediatric Crohn's disease
    Winnie H Sim
    Enteric Virus Group, Murdoch Children s Research Institute, Victoria, Australia
    J Gastroenterol Hepatol 27:1083-93. 2012
    ..Expression profiling of genes specific to pediatric Crohn's Disease (CD) patients was performed to elucidate the molecular mechanisms underlying disease cause and pathogenesis at disease onset...
  29. doi request reprint Phylogenetic analysis of rotavirus A NSP2 gene sequences and evidence of intragenic recombination
    Nicole C Donker
    Enteric Virus Group, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, Victoria 3052, Australia
    Infect Genet Evol 11:1602-7. 2011
    ..This study increases the understanding of the evolution mechanisms of NSP2 in view of improved vaccine design...
  30. doi request reprint Characterization of norovirus strains in Australian children from 2006 to 2008: prevalence of recombinant strains
    Jackie E Mahar
    Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    J Med Virol 83:2213-9. 2011
    ..This study highlights the importance of norovirus infection as a cause of pediatric gastroenteritis. It also reinforces the high circulation of recombinant strains causing disease in children, particularly the GII.3/GIIb strain...
  31. ncbi request reprint Excretion of serotype G1 rotavirus strains by asymptomatic staff: a possible source of nosocomial infection
    Graeme L Barnes
    Murdoch Childrens Research Institute, Melbourne, Australia
    J Pediatr 142:722-5. 2003
    ..The observed preferential carriage of serotype G1 strains in the adult gastrointestinal tract may explain G1 predominance and persistence in epidemiologic studies worldwide...
  32. pmc Novel G10P[14] rotavirus strain, northern territory, Australia
    Daniel Cowley
    Murdoch Childrens Research Institute, Melbourne, Victoria, Australia
    Emerg Infect Dis 19:1324-7. 2013
    ..This finding suggests artiodactyl-to-human transmission and strengthens the need to continue rotavirus strain surveillance. ..
  33. ncbi request reprint Changes in the epidemiology of gastroenteritis in a paediatric short stay unit following the introduction of rotavirus immunisation
    Jonathan D Akikusa
    Department of General Medicine, Royal Children s Hospital, Melbourne, Victoria, Australia
    J Paediatr Child Health 49:120-4. 2013
    ..This study aimed to examine changes in the epidemiology of AGE in the SSU, and RCH overall, between 2005 and 2009 and explore whether this reflects a change specifically in AGE due to rotavirus...
  34. pmc The importance of intergenic recombination in norovirus GII.3 evolution
    Jackie E Mahar
    Enteric Virus Group, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    J Virol 87:3687-98. 2013
    ..In conclusion, evolution of GII.3 noroviruses was primarily driven by intergenic recombination. The acquisition of new RdRps may lead to a faster mutation rate and increased genetic diversity, improving overall GII.3 fitness...
  35. doi request reprint Recurrent intussusception in infants
    Frances A Justice
    Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    J Paediatr Child Health 47:802-5. 2011
    ..Clinical features to identify infants at increased risk of recurrence after a primary episode of intussusception (IS) are poorly defined...
  36. doi request reprint Reduction in rotavirus-associated acute gastroenteritis following introduction of rotavirus vaccine into Australia's National Childhood vaccine schedule
    Jim P Buttery
    Department of General Medicine and Murdoch Children s Research Institute, Royal Children s Hospital Melbourne, Parkville, Victoria, Australia Paediatric Infectious Diseases Unit, Monash Children s Hospital, Department of Paediatrics, Monash University, Melbourne, Victoria
    Pediatr Infect Dis J 30:S25-9. 2011
    ..This allowed comparison of both vaccines in similar populations with high infant vaccination coverage...
  37. ncbi request reprint Genetic characterization of a novel G3P[14] rotavirus strain causing gastroenteritis in 12 year old Australian child
    Celeste M Donato
    Enteric Virus Group, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia Department of Microbiology, La Trobe University, Melbourne, Victoria, Australia Electronic address
    Infect Genet Evol 25:97-109. 2014
    ..However, without screening numerous animal populations it is not possible to determine the origins of this strain. ..
  38. doi request reprint Selection and evolutionary analysis in the nonstructural protein NSP2 of rotavirus A
    Nicole C Donker
    Enteric Virus Research Group, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Melbourne 3052, Australia
    Infect Genet Evol 12:1355-61. 2012
    ..The remaining sites were not located in known functional regions, and the reason for variation at these sites remains to be elucidated...
  39. doi request reprint Characterisation of G8 human rotaviruses in Australian children with gastroenteritis
    Dayna L Swiatek
    Melbourne School of Land and Environment, The University of Melbourne, Parkville, Victoria, Australia
    Virus Res 148:1-7. 2010
    ....
  40. pmc Interaction of Crohn's disease susceptibility genes in an Australian paediatric cohort
    Josef Wagner
    Enteric Virus Group, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia
    PLoS ONE 5:e15376. 2010
    ..Our findings demonstrate that CD genetic susceptibility in paediatric patients presents as a complex interaction between numerous genes...
  41. pmc Exploring the zoonotic potential of Mycobacterium avium subspecies paratuberculosis through comparative genomics
    James W Wynne
    Australian Animal Health Laboratory, CSIRO Livestock Industries, Geelong, Victoria, Australia
    PLoS ONE 6:e22171. 2011
    ....
  42. pmc Genetic and antigenic characterization of rotavirus serotype G9 strains isolated in Australia between 1997 and 2001
    Carl Kirkwood
    Department of Gastroenterology and Clinical Nutrition, Murdoch Childrens Research Institute, Royal Children s Hospital, Vctoria, Australia 3052
    J Clin Microbiol 41:3649-54. 2003
    ....
  43. ncbi request reprint Genetic variation of NSP1 and NSP4 genes among serotype G9 rotaviruses causing hospitalization of children in Melbourne, Australia, 1997-2002
    Kiran Shah
    Environment and Biotechnology Centre, Faculty of Life and Social Sciences, Swinburne University of Technology, Hawthorn, Victoria, Australia
    J Med Virol 78:1124-30. 2006
    ..This study reveals new information about the diversity of non-structural proteins of G9 rotaviruses...
  44. pmc Rotavirus genotypes in Malaysia and universal rotavirus vaccination
    Way Seah Lee
    Department of Paediatrics, University of Malaya Medical Centre, Kuala Lumpur, Malaysia
    Hum Vaccin Immunother 8:1401-6. 2012
    ..A universal RV-A vaccine is efficacious in reducing RVGE-related hospitalizations and mortality in Malaysia...
  45. ncbi request reprint Report of the Australian Rotavirus Surveillance Program, 2001/2002
    Carl Kirkwood
    National Rotavirus Reference Centre, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Vic
    Commun Dis Intell Q Rep 26:537-40. 2002
    ..Serotype G1 strains were the second most prevalent type (38.9%), identified in 5 of the centres. These findings have important implications for vaccine development strategies which target serotypes G1-G4...
  46. ncbi request reprint Rotavirus vaccines in developed countries
    Jim P Buttery
    NHMRC Centre of Clinical Research Excellence in Child and Adolescent Immunisation, Murdoch Children s Research Institute, Infectious Diseases Unit, Royal Children s Hospital, Parkville, Australia
    Curr Opin Infect Dis 20:253-8. 2007
    ..The recent licensure in many nations of vaccines against rotavirus offers promise to significantly reduce this toll. The present review describes recent developments regarding rotavirus vaccines and the challenges they face...
  47. doi request reprint Current knowledge and systematic review of viruses associated with Crohn's disease
    Josef Wagner
    Enteric Virus Group, Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Victoria, Australia
    Rev Med Virol 23:145-71. 2013
    ..There is still some question around whether CD is associated with the presence of a currently known virus...
  48. doi request reprint Identification of an antibody-binding epitope on the rotavirus A non-structural protein NSP2 using phage display analysis
    Nicole C Donker
    Enteric Virus Group, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    J Gen Virol 92:2374-82. 2011
    ..Genetic analysis of the putative binding region of NSP2 revealed a high level of conservation, suggesting that the region is under strict control...
  49. ncbi request reprint Risk factors for intussusception in infants in Vietnam and Australia: adenovirus implicated, but not rotavirus
    Julie E Bines
    Department of Gastroenterology and Clinical Nutrition, Emergency Medicine, Microbiology, Clinical Epidemiology and Biostatistics Unit, Royal Children s Hospital, Parkville, Australia
    J Pediatr 149:452-60. 2006
    ..This study aimed to investigate risk factors for the development of intussusception in infants in a developing country with a suspected high incidence and in a developed country with a low incidence...
  50. doi request reprint Rotavirus cerebellitis: new aspects to an old foe?
    Melanie J Thompson
    Women s and Children s Program, Monash Medical Centre, Clayton, Victoria, Australia
    Pediatr Neurol 46:48-50. 2012
    ..Rotavirus nucleic acid was demonstrated in both serum and cerebrospinal fluid. Severe neurologic sequelae remain after 2 years of follow-up. This report adds further evidence supporting a direct role for rotavirus in neurologic illness...
  51. ncbi request reprint Report of the Australian Rotavirus Surveillance Program 2003-2004
    Carl Kirkwood
    National Rotavirus Reference Centre, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Victoria
    Commun Dis Intell 28:481-5. 2004
    ..7%). However, there is substantial geographic variation in the prevalence of rotavirus serotypes. These findings have implications for vaccine development strategies which have targeted prevention of disease due to serotypes G1-G4...
  52. pmc Molecular epidemiology of adenovirus isolates from patients diagnosed with intussusception in Melbourne, Australia
    Gowri Selvaraj
    Enteric Virus Group, Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Vicotria 3052, Australia
    J Clin Microbiol 44:3371-3. 2006
    ..IS-associated isolates are similar to circulating non-IS-associated strains...
  53. doi request reprint Impact of ethnicity, geography, and disease on the microbiota in health and inflammatory bowel disease
    Lani Prideaux
    1Department of Gastroenterology, St Vincent s Hospital Melbourne, Australia 2Department of Medicine, The University of Melbourne, Parkville, Australia 3Preventative Health National Research Flagship Program, Commonwealth Scientific and Industrial Research Organisation CSIRO, Australia 4Enteric Virus Group, Murdoch Childrens Research Institute, Parkville, Australia 5Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China 6Department of Gastroenterology, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan, China 7Department of Gastroenterology, Box Hill Hospital, Melbourne, Australia 8Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China 9The Ohio State University, Columbus, Ohio 10Department of Microbiology, La Trobe University, Bundoora, Australia and 11Department of Immunology, Imperial College, London, United Kingdom
    Inflamm Bowel Dis 19:2906-18. 2013
    ..The gut microbiota is central to health and disorders such as inflammatory bowel disease. Differences in microbiota related to geography and ethnicity may hold the key to recent changes in the incidence of microbiota-related disorders...
  54. ncbi request reprint Rotavirus vaccines--an update
    Carl D Kirkwood
    Department of Gastroenterology and Clinical Nutrition, Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Victoria, Australia, 3052
    Expert Opin Biol Ther 3:97-105. 2003
    ..The creation of innovative funding strategies to support vaccine development and production, specifically in developing countries, aim to make vaccines available where rotavirus causes the greatest impact...
  55. ncbi request reprint Rotavirus epidemiology: the Asian Rotavirus Surveillance Network
    E A S Nelson
    Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
    Vaccine 26:3192-6. 2008
    ....
  56. ncbi request reprint Rotavirus antigenaemia and viraemia: a common event?
    Sarah E Blutt
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Lancet 362:1445-9. 2003
    ..We assessed whether rotavirus antigen, RNA, or both, were present in serum samples from immunocompetent rotavirus-infected children and animals...
  57. pmc Metagenomic analysis of human diarrhea: viral detection and discovery
    Stacy R Finkbeiner
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Pathog 4:e1000011. 2008
    ..Using this methodology we detected known enteric viruses as well as multiple sequences from putatively novel viruses with only limited sequence similarity to viruses in GenBank...
  58. ncbi request reprint Serotype diversity and reassortment between human and animal rotavirus strains: implications for rotavirus vaccine programs
    Jon R Gentsch
    Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 192:S146-59. 2005
    ..The enormous diversity and capacity of human rotaviruses for change suggest that rotavirus vaccines must provide good heterotypic protection to be optimally effective...
  59. ncbi request reprint Reductions in cross-neutralizing antibody responses in infants after attenuation of the human rotavirus vaccine candidate 89-12
    Richard L Ward
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Infect Dis 194:1729-36. 2006
    ..Even so, the Rotarix vaccine developed from attenuated 89-12 was found to elicit excellent protection against non-G1 rotaviruses...
  60. ncbi request reprint Rotavirus surveillance in Australia
    Kate A Ward
    Communicable Diseases Branch, NSW Health, North Sydney, New South Wales
    Commun Dis Intell Q Rep 32:82-7. 2008
  61. doi request reprint Human rotavirus vaccines: too early for the strain to tell
    Keith Grimwood
    Queensland Paediatric Infectious Disease Laboratory, Discipline of Paediatrics and Child Health, Royal Children s Hospital and University of Queensland, Brisbane, QLD 4029, Australia
    Lancet 371:1144-5. 2008