Damien F Hudson

Summary

Affiliation: Royal Children's Hospital
Country: Australia

Publications

  1. pmc Molecular and genetic analysis of condensin function in vertebrate cells
    Damien F Hudson
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    Mol Biol Cell 19:3070-9. 2008
  2. ncbi request reprint Condensin is required for nonhistone protein assembly and structural integrity of vertebrate mitotic chromosomes
    Damien F Hudson
    Wellcome Trust Centre for Cell Biology, Institute of Cell, University of Edinburgh, Swann Building, King s Buildings, Mayfield Road, EH9 3JR, Edinburgh, United Kingdom
    Dev Cell 5:323-36. 2003
  3. ncbi request reprint Condensin: Architect of mitotic chromosomes
    Damien F Hudson
    Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    Chromosome Res 17:131-44. 2009
  4. pmc INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization
    Zhenjie Xu
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK
    J Cell Biol 187:637-53. 2009
  5. pmc Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis
    Paola Vagnarelli
    Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Swann Building, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
    Nat Cell Biol 8:1133-42. 2006
  6. pmc Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase IIα
    Kumiko Samejima
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, Scotland, UK
    J Cell Biol 199:755-70. 2012
  7. pmc Condensin regulates the stiffness of vertebrate centromeres
    Susana A Ribeiro
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    Mol Biol Cell 20:2371-80. 2009
  8. ncbi request reprint Condensin I associates with structural and gene regulatory regions in vertebrate chromosomes
    Ji Hun Kim
    1 Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Melbourne, Victoria 3052, Australia 2 Department of Paediatrics, University of Melbourne, Parkville, Melbourne, Victoria 3052, Australia
    Nat Commun 4:2537. 2013
  9. pmc Contrasting roles of condensin I and condensin II in mitotic chromosome formation
    Lydia C Green
    Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    J Cell Sci 125:1591-604. 2012
  10. pmc A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes
    Kumiko Samejima
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Swann Building, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, United Kingdom
    Proc Natl Acad Sci U S A 105:2457-62. 2008

Collaborators

Detail Information

Publications13

  1. pmc Molecular and genetic analysis of condensin function in vertebrate cells
    Damien F Hudson
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    Mol Biol Cell 19:3070-9. 2008
    ..Thus, despite their similar molecular organization, condensin and cohesin exhibit fundamental differences in their structure and function...
  2. ncbi request reprint Condensin is required for nonhistone protein assembly and structural integrity of vertebrate mitotic chromosomes
    Damien F Hudson
    Wellcome Trust Centre for Cell Biology, Institute of Cell, University of Edinburgh, Swann Building, King s Buildings, Mayfield Road, EH9 3JR, Edinburgh, United Kingdom
    Dev Cell 5:323-36. 2003
    ..Thus, a major function of condensin is to promote the correct association of nonhistone proteins with mitotic chromosomes, and this is essential for establishment of a robust chromosome structure...
  3. ncbi request reprint Condensin: Architect of mitotic chromosomes
    Damien F Hudson
    Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    Chromosome Res 17:131-44. 2009
    ..The wide variety of biochemical and genetic tools available are gradually unravelling the numerous roles condensin plays during the cell cycle and shedding light on its mechanism of action...
  4. pmc INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization
    Zhenjie Xu
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK
    J Cell Biol 187:637-53. 2009
    ..These experiments reveal that INCENP interactions with aurora B in vivo modulate the level of kinase activity, thus regulating CPC localization and functions during mitosis...
  5. pmc Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis
    Paola Vagnarelli
    Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Swann Building, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
    Nat Cell Biol 8:1133-42. 2006
    ..This activity, provisionally termed 'regulator of chromosome architecture' (RCA), cooperates with condensin to preserve the characteristic chromosome architecture during mitosis...
  6. pmc Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase IIα
    Kumiko Samejima
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, Scotland, UK
    J Cell Biol 199:755-70. 2012
    ..These three proteins are major determinants in shaping the characteristic mitotic chromosome morphology...
  7. pmc Condensin regulates the stiffness of vertebrate centromeres
    Susana A Ribeiro
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    Mol Biol Cell 20:2371-80. 2009
    ..Loss of stiffness caused by condensin-depletion produces abnormal uncoordinated sister kinetochore movements, leads to an increase in Mad2(+) kinetochores near the metaphase plate and delays anaphase onset...
  8. ncbi request reprint Condensin I associates with structural and gene regulatory regions in vertebrate chromosomes
    Ji Hun Kim
    1 Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Melbourne, Victoria 3052, Australia 2 Department of Paediatrics, University of Melbourne, Parkville, Melbourne, Victoria 3052, Australia
    Nat Commun 4:2537. 2013
    ..Thus in three kingdoms of life, condensin is enriched on promoters of actively transcribed genes and at loci important for chromosome segregation. ..
  9. pmc Contrasting roles of condensin I and condensin II in mitotic chromosome formation
    Lydia C Green
    Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    J Cell Sci 125:1591-604. 2012
    ..We conclude that condensin II is required primarily to provide rigidity by establishing an initial chromosome axis around which condensin I can arrange loops of chromatin...
  10. pmc A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes
    Kumiko Samejima
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Swann Building, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, United Kingdom
    Proc Natl Acad Sci U S A 105:2457-62. 2008
    ..We used chicken DT40 cells, but the same strategy should be applicable to ES cells and, eventually, to mice...
  11. pmc The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics
    Shinya Ohta
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    Cell 142:810-21. 2010
    ..Our integrated analysis predicts that up to 97 new centromere-associated proteins remain to be discovered in our data set...
  12. pmc Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle
    Reto Gassmann
    Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Kings Buildings, Mayfield Rd, Edinburgh EH9 3JR, Scotland, UK
    J Cell Biol 166:179-91. 2004
    ..These results implicate the chromosomal passenger holocomplex in the maintenance of spindle integrity and suggest that histone H3 serine10 phosphorylation is performed by an Aurora B-INCENP subcomplex...
  13. pmc Streptavidin-Binding Peptide (SBP)-tagged SMC2 allows single-step affinity fluorescence, blotting or purification of the condensin complex
    Ji Hun Kim
    Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Victoria, Australia
    BMC Biochem 11:50. 2010
    ..Often protein purification, cellular localisation and Western blot analyses can be multi-step processes, where protein is lost, activity is destroyed or effective antibodies have not yet been generated...