Research Topics
Genomes and Genes | Damien F HudsonSummaryAffiliation: Royal Children's Hospital Country: Australia Publications
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Publications
Molecular and genetic analysis of condensin function in vertebrate cellsDamien F Hudson
Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
Mol Biol Cell 19:3070-9. 2008..Thus, despite their similar molecular organization, condensin and cohesin exhibit fundamental differences in their structure and function...
Condensin is required for nonhistone protein assembly and structural integrity of vertebrate mitotic chromosomesDamien F Hudson
Wellcome Trust Centre for Cell Biology, Institute of Cell, University of Edinburgh, Swann Building, King's Buildings, Mayfield Road, EH9 3JR, Edinburgh, United Kingdom
Dev Cell 5:323-36. 2003..Thus, a major function of condensin is to promote the correct association of nonhistone proteins with mitotic chromosomes, and this is essential for establishment of a robust chromosome structure...
Condensin: Architect of mitotic chromosomesDamien F Hudson
Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
Chromosome Res 17:131-44. 2009..The wide variety of biochemical and genetic tools available are gradually unravelling the numerous roles condensin plays during the cell cycle and shedding light on its mechanism of action...- INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localizationZhenjie Xu
Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK
J Cell Biol 187:637-53. 2009..These experiments reveal that INCENP interactions with aurora B in vivo modulate the level of kinase activity, thus regulating CPC localization and functions during mitosis... - Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosisPaola Vagnarelli
Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Swann Building, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
Nat Cell Biol 8:1133-42. 2006..This activity, provisionally termed 'regulator of chromosome architecture' (RCA), cooperates with condensin to preserve the characteristic chromosome architecture during mitosis... - Condensin regulates the stiffness of vertebrate centromeresSusana A Ribeiro
Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
Mol Biol Cell 20:2371-80. 2009..Loss of stiffness caused by condensin-depletion produces abnormal uncoordinated sister kinetochore movements, leads to an increase in Mad2(+) kinetochores near the metaphase plate and delays anaphase onset... - A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genesKumiko Samejima
Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Swann Building, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, United Kingdom
Proc Natl Acad Sci U S A 105:2457-62. 2008..We used chicken DT40 cells, but the same strategy should be applicable to ES cells and, eventually, to mice... - Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindleReto Gassmann
Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Kings Buildings, Mayfield Rd, Edinburgh EH9 3JR, Scotland, UK
J Cell Biol 166:179-91. 2004..These results implicate the chromosomal passenger holocomplex in the maintenance of spindle integrity and suggest that histone H3 serine10 phosphorylation is performed by an Aurora B-INCENP subcomplex... - The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomicsShinya Ohta
Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
Cell 142:810-21. 2010..Our integrated analysis predicts that up to 97 new centromere-associated proteins remain to be discovered in our data set... - Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase IIαKumiko Samejima
Wellcome Trust Centre for Cell Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, Scotland, UK
J Cell Biol 199:755-70. 2012..These three proteins are major determinants in shaping the characteristic mitotic chromosome morphology... - Contrasting roles of condensin I and condensin II in mitotic chromosome formationLydia C Green
Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
J Cell Sci 125:1591-604. 2012..We conclude that condensin II is required primarily to provide rigidity by establishing an initial chromosome axis around which condensin I can arrange loops of chromatin... - Streptavidin-Binding Peptide (SBP)-tagged SMC2 allows single-step affinity fluorescence, blotting or purification of the condensin complexJi Hun Kim
Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Victoria, Australia
BMC Biochem 11:50. 2010..Often protein purification, cellular localisation and Western blot analyses can be multi-step processes, where protein is lost, activity is destroyed or effective antibodies have not yet been generated...