Research Topics
Genomes and GenesSpecies | J A EllisSummaryAffiliation: Royal Children's Hospital Country: Australia Publications
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Detail Information
Publications
Independent replication analysis of genetic loci with previous evidence of association with juvenile idiopathic arthritisJustine A Ellis
Genes, Environment and Complex Disease, Murdoch Childrens Research Institute, 50 Flemington Rd, Parkville, Vic, 3052, Australia
Pediatr Rheumatol Online J 11:12. 2013....- CLARITY - ChiLdhood Arthritis Risk factor Identification sTudYJustine A Ellis
Genes, Environment and Complex Disease, Murdoch Childrens Research Institute, Parkville, Vic, Australia
Pediatr Rheumatol Online J 10:37. 2012..abstract:.. - Genome-scale case-control analysis of CD4+ T-cell DNA methylation in juvenile idiopathic arthritis reveals potential targets involved in diseaseJustine A Ellis
Genes, Environment and Complex Disease, Murdoch Childrens Research Institute, 50 Flemington Rd, Parkville, Vic, Australia
Clin Epigenetics 4:20. 2012..abstract:.. - APOE genotype and cardio-respiratory fitness interact to determine adiposity in 8-year-old children from the Tasmanian Infant Health SurveyJustine A Ellis
Environmental and Genetic Epidemiology Research, Murdoch Childrens Research Institute, Parkville, Australia
PLoS ONE 6:e26679. 2011..APOE4 and cardiorespitatory fitness could interact to influence child adiposity. In studies addressing the genetic determinants of childhood obesity, the context of child fitness should also be taken into account... 
A role for the DRD4 exon III VNTR in modifying the association between nicotine dependence and neuroticismJ A Ellis
Environmental and Genetic Epidemiology Research, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
Nicotine Tob Res 13:64-9. 2011....- Male pattern baldness: current treatments, future prospectsJustine A Ellis
Department of Physiology, University of Melbourne, Victoria 3010, Australia
Drug Discov Today 13:791-7. 2008..New treatments under development, and acceleration in our understanding of the underlying molecular genetic aetiology of this condition provide increased hope for future targeted treatment strategies... - Possible environmental determinants of juvenile idiopathic arthritisJustine A Ellis
Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
Rheumatology (Oxford) 49:411-25. 2010..Finally, we discuss future directions including practical study designs to more comprehensively test hypotheses and provide new insight into this important area of research... - Genes controlling postural changes in blood pressure: comprehensive association analysis of ATP-sensitive potassium channel genes KCNJ8 and ABCC9Justine A Ellis
Department of Physiology, University of Melbourne, Melbourne, Victoria, Australia
Physiol Genomics 40:184-8. 2010..We conclude that sequence variants in KCNJ8 and ABCC9 are unlikely to contribute to variation in DeltaSBP. Other genes in the identified chromosome 12p region warrant investigation... 
Sex, genes and blood pressureJ A Ellis
Department of Physiology, The University of Melbourne, Victoria, Australia
Clin Exp Pharmacol Physiol 28:1053-5. 2001..Further genetic and physiological analyses will be required to confirm these observations and to determine the mechanisms of action and the nature of any interactions...- Significant population variation in adult male height associated with the Y chromosome and the aromatase geneJ A Ellis
Department of Physiology, The University of Melbourne, Victoria 3010, Australia
J Clin Endocrinol Metab 86:4147-50. 2001..67-7.3) was detected (P = 0.004). These results suggest that in men, genetic variation in CYP19 and on the Y chromosome are involved in determining normal adult height, and that these loci may interact in an additive fashion... - Male pattern baldness is not associated with established cardiovascular risk factors in the general populationJ A Ellis
Department of Physiology, The University of Melbourne, Victoria 3010, Australia
Clin Sci (Lond) 100:401-4. 2001..The lack of association between baldness and established coronary risk factors implies that baldness may predispose to coronary heart disease through novel mechanisms yet to be defined... - Polymorphism of the androgen receptor gene is associated with male pattern baldnessJ A Ellis
Department of Physiology, The University of Melbourne, Victoria, Australia
J Invest Dermatol 116:452-5. 2001..Functional mutation in or near the androgen receptor gene may explain the reported high levels of expression of this gene in the balding scalp... - Interaction of Crohn's disease susceptibility genes in an Australian paediatric cohortJosef Wagner
Enteric Virus Group, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia
PLoS ONE 5:e15376. 2010..Our findings demonstrate that CD genetic susceptibility in paediatric patients presents as a complex interaction between numerous genes... - Adiposity gain during childhood, ACE I/D polymorphisms and metabolic outcomesAnne Louise Ponsonby
Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Victoria, Australia
Obesity (Silver Spring) 16:2141-7. 2008..Further work is required to confirm and extend these findings... - Genetic analysis of male pattern baldness and the 5alpha-reductase genesJ A Ellis
Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia
J Invest Dermatol 110:849-53. 1998..The relatively strong concordance for baldness between fathers and sons in this study was not consistent with a simple Mendelian autosomal dominant inheritance. A polygenic etiology should be considered... - Selective genotyping reveals association between the epithelial sodium channel gamma-subunit and systolic blood pressureCara J Büsst
Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
Hypertension 50:672-8. 2007..These findings identify relatively common polymorphisms in the SCNN1G gene that are associated with high systolic blood pressure in the general Australian white population... - Sex-dependent association of blood pressure with oestrogen receptor genes ERalpha and ERbetaJustine A Ellis
Department of Physiology, The University of Melbourne, Victoria 3010, Australia
J Hypertens 22:1127-31. 2004..The existence of such sex steroid-related genes may help to explain the observed sex differences in blood pressure... - Microsomal epoxide hydrolase is not associated with COPD in a community-based sampleMelanie C Matheson
Department of Epidemiology and Preventive Medicine, Monash University, Victoria, Australia
Hum Biol 78:705-17. 2006..This finding, along with doubt shed on the accuracy of other studies that have demonstrated positive associations, suggests that a strong role for the EPHX1 polymorphisms in respiratory disease is unlikely... - Baldness and the androgen receptor: the AR polyglycine repeat polymorphism does not confer susceptibility to androgenetic alopeciaJustine A Ellis
Department of Physiology, The University of Melbourne, Melbourne, Vic, 3010, Australia
Hum Genet 121:451-7. 2007..The identification of functional non-coding variants surrounding AR may have significance not only for baldness, but also for the many other complex conditions that have thus far been linked to AR... - The role of genetics and environment in the rise of childhood food allergyT H T Tan
Murdoch Children s Research Institute, The Royal Children s Hospital, Parkville, Vic, Australia
Clin Exp Allergy 42:20-9. 2012.... - The hypertrophic heart rat: a new normotensive model of genetic cardiac and cardiomyocyte hypertrophyStephen B Harrap
Department of Physiology, University of Melbourne, Australia
Physiol Genomics 9:43-8. 2002..The HHR offers a new model of primary cardiomyocyte hypertrophy with normal blood pressure in which to examine genotypic causes and pathogenetic mechanisms of hypertrophy and its complications... - Comprehensive multi-stage linkage analyses identify a locus for adult height on chromosome 3p in a healthy Caucasian populationJustine A Ellis
Department of Physiology, The University of Melbourne, Melbourne, VIC 3010, Australia
Hum Genet 121:213-22. 2007..Association analyses of relevant candidate genes should identify the genetic variants responsible for the chromosome 3p linkage signal in our population... - Association of IL8, CXCR2 and TNF-alpha polymorphisms and airway diseaseMelanie C Matheson
Department of Epidemiology and Preventive Medicine, Monash University, Victoria, Australia
J Hum Genet 51:196-203. 2006..These genes may be important candidates in the modulation of the inflammatory response in the airways... - Androgen receptor copy number variation and androgenetic alopecia: a case-control studyJoanna E Cobb
Department of Physiology, University of Melbourne, Melbourne, Victoria, Australia
PLoS ONE 4:e5081. 2009..The aim of this preliminary case-control study was to determine if AR CNV is associated with AGA, with the hypothesis that CNV is the functional AR variant contributing to this condition... - Androgenetic alopecia: pathogenesis and potential for therapyJustine A Ellis
Department of Physiology, The University of Melbourne, Victoria 3010, Australia
Expert Rev Mol Med 4:1-11. 2002..Discovery of the involvement of the AR gene, and the identification of other genes contributing to the condition, might lead to the development of new and more effective therapies that target the condition at a more fundamental level... - Tall stories: the devilish detail of genetic association studiesJustine A Ellis
Department of Physiology, The University of Melbourne, Victoria, Australia
Clin Endocrinol (Oxf) 59:278-9. 2003 - Androgenic correlates of genetic variation in the gene encoding 5alpha-reductase type 1Justine A Ellis
Department of Physiology, The University of Melbourne, Melbourne, Victoria, 3010, Australia
J Hum Genet 50:534-7. 2005..These results suggest that functional genetic variants might exist in or around SRD5A1 that affect the activity of the 5alpha-reductase enzyme type 1 and influence androgen levels...